{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:21:40Z","timestamp":1770351700587,"version":"3.49.0"},"reference-count":12,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"14","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Choroid plexus hyperplasia has been described as a rare cause of communicating hydrocephalus due to cerebrospinal fluid (CSF) overproduction. However, this is the first report of symptomatic obstructive hydrocephalus caused by mechanical obstruction of the aqueduct by a hyperplastic choroid plexus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 4-year-old male presented with headaches and intermittent emesis. Magnetic resonance imaging (MRI) of the brain showed abnormal enlargement of the choroid plexus in the lateral ventricles with extension into the third ventricle, resulting in obstruction of the aqueduct of Sylvius, leading to obstructive hydrocephalus. Endoscopic third ventriculostomy (ETV) was chosen as the surgical treatment. During the procedure, high pressure flow of clear CSF was noted. Normal intraventricular anatomy was identified, and no cyst or tumor was found. The postoperative MRI showed a patent third ventriculostomy, without complication, and a significant decrease in supratentorial ventricular size. The patient was discharged 3 days after surgery with a complete resolution of symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Choroid plexus hyperplasia has the potential to cause obstructive hydrocephalus, and it can be effectively treated with ETV. Our hypothesis is that the change in pressure caused by the procedure may have led to an uncorking of the aqueduct by the hyperplastic choroid plexus, contributing to the observed improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case23239","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:25:13Z","timestamp":1696281913000},"source":"Crossref","is-referenced-by-count":1,"title":["Symptomatic obstructive hydrocephalus caused by choroid plexus hyperplasia in a pediatric patient: illustrative case"],"prefix":"10.3171","volume":"6","author":[{"given":"Ana Sofia","family":"Alvarez","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Fundacion Jimenez Diaz University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P","family":"McGinnis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Baylor College of Medicine, Houston, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajan","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Baylor College of Medicine, Houston, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard L","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Division of Pediatric Neurosurgery, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"5","key":"b1","series-title":"J Med Res","first-page":"521","article-title":"A physio-pathologic study of the choroid plexus with the report of a case of villous hypertrophy","volume":"44","author":"Davis LE","year":"1924","unstructured":"Davis LE. A physio-pathologic study of the choroid plexus with the report of a case of villous hypertrophy. J Med Res. 1924;44(5):521\u2013534.11."},{"issue":"4","key":"b2","series-title":"J Neurosurg","first-page":"317","article-title":"Papilloma of the choroid plexus of the lateral ventricles causing hydrocephalus in an infant","volume":"13","author":"Ray BS","year":"1956","unstructured":"Ray BS, Peck FC Jr. Papilloma of the choroid plexus of the lateral ventricles causing hydrocephalus in an infant. J Neurosurg. 1956;13(4):317\u2013322."},{"issue":"2","key":"b3","series-title":"Pediatr Neurosurg","first-page":"91","article-title":"Villous hypertrophy versus choroid plexus papilloma: a case report demonstrating a diagnostic role for the proliferation index","volume":"39","author":"D\u2019Ambrosio AL","year":"2003","unstructured":"D\u2019Ambrosio AL, O\u2019Toole JE, Connolly ES Jr, Feldstein NA. Villous hypertrophy versus choroid plexus papilloma: a case report demonstrating a diagnostic role for the proliferation index. Pediatr Neurosurg. 2003;39(2):91\u201396."},{"issue":"19","key":"b4","series-title":"Neurology","first-page":"2058","article-title":"Choroid plexus hyperplasia: a possible cause of hydrocephalus in adults","volume":"87","author":"Cox JT","year":"2016","unstructured":"Cox JT, Gaglani SM, Jusu\u00e9-Torres I,  Choroid plexus hyperplasia: a possible cause of hydrocephalus in adults. Neurology. 2016;87(19):2058\u20132060."},{"issue":"8","key":"b5","series-title":"Pediatr Radiol","first-page":"815","article-title":"Diffuse choroid plexus hyperplasia: an under-diagnosed cause of hydrocephalus in children?","volume":"35","author":"Aziz AA","year":"2005","unstructured":"Aziz AA, Coleman L, Morokoff A, Maixner W. Diffuse choroid plexus hyperplasia: an under-diagnosed cause of hydrocephalus in children? Pediatr Radiol. 2005;35(8):815\u2013818."},{"issue":"1","key":"b6","series-title":"Pediatr Neurosurg","first-page":"32","article-title":"Hydrocephalus due to diffuse villous hyperplasia of the choroid plexus. Case report and review of the literature","volume":"40","author":"Fujimoto Y","year":"2004","unstructured":"Fujimoto Y, Matsushita H, Plese JP, Marino R Jr. Hydrocephalus due to diffuse villous hyperplasia of the choroid plexus. Case report and review of the literature. Pediatr Neurosurg. 2004;40(1):32\u201336."},{"issue":"5","key":"b1","series-title":"J Med Res","first-page":"521","article-title":"A physio-pathologic study of the choroid plexus with the report of a case of villous hypertrophy","volume":"44","author":"Davis LE","year":"1924","unstructured":"Davis LE. A physio-pathologic study of the choroid plexus with the report of a case of villous hypertrophy. J Med Res. 1924;44(5):521\u2013534.11."},{"issue":"4","key":"b2","series-title":"J Neurosurg","first-page":"317","article-title":"Papilloma of the choroid plexus of the lateral ventricles causing hydrocephalus in an infant","volume":"13","author":"Ray BS","year":"1956","unstructured":"Ray BS, Peck FC Jr. Papilloma of the choroid plexus of the lateral ventricles causing hydrocephalus in an infant. J Neurosurg. 1956;13(4):317\u2013322."},{"issue":"2","key":"b3","series-title":"Pediatr Neurosurg","first-page":"91","article-title":"Villous hypertrophy versus choroid plexus papilloma: a case report demonstrating a diagnostic role for the proliferation index","volume":"39","author":"D\u2019Ambrosio AL","year":"2003","unstructured":"D\u2019Ambrosio AL, O\u2019Toole JE, Connolly ES Jr, Feldstein NA. Villous hypertrophy versus choroid plexus papilloma: a case report demonstrating a diagnostic role for the proliferation index. Pediatr Neurosurg. 2003;39(2):91\u201396."},{"issue":"19","key":"b4","series-title":"Neurology","first-page":"2058","article-title":"Choroid plexus hyperplasia: a possible cause of hydrocephalus in adults","volume":"87","author":"Cox JT","year":"2016","unstructured":"Cox JT, Gaglani SM, Jusu\u00e9-Torres I,  Choroid plexus hyperplasia: a possible cause of hydrocephalus in adults. Neurology. 2016;87(19):2058\u20132060."},{"issue":"8","key":"b5","series-title":"Pediatr Radiol","first-page":"815","article-title":"Diffuse choroid plexus hyperplasia: an under-diagnosed cause of hydrocephalus in children?","volume":"35","author":"Aziz AA","year":"2005","unstructured":"Aziz AA, Coleman L, Morokoff A, Maixner W. Diffuse choroid plexus hyperplasia: an under-diagnosed cause of hydrocephalus in children? Pediatr Radiol. 2005;35(8):815\u2013818."},{"issue":"1","key":"b6","series-title":"Pediatr Neurosurg","first-page":"32","article-title":"Hydrocephalus due to diffuse villous hyperplasia of the choroid plexus. Case report and review of the literature","volume":"40","author":"Fujimoto Y","year":"2004","unstructured":"Fujimoto Y, Matsushita H, Plese JP, Marino R Jr. Hydrocephalus due to diffuse villous hyperplasia of the choroid plexus. Case report and review of the literature. 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