{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:50:31Z","timestamp":1770353431773,"version":"3.49.0"},"reference-count":26,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"16","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,16]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Erdheim-Chester disease (ECD) is a rare non\u2013Langerhans cell histiocytosis characterized histologically by foamy histiocytes and Touton giant cells in a background of fibrosis. Bone pain with long bone osteosclerosis is highly specific for ECD. Central nervous system involvement is rare, although dural, hypothalamic, cerebellar, brainstem, and sellar region involvement has been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>\n                      A 59-year-old man with a history of ureteral obstruction, medically managed petit mal seizures, and a left temporal lesion followed with serial magnetic resonance imaging (MRI) presented with worsening seizure control. Repeat MRI identified bilateral amygdala region lesions. Gradual growth of the left temporal lesion over 1 year with increasing seizure frequency prompted resection. A non\u2013Langerhans cell histiocytosis with a\n                      <jats:italic>BRAF<\/jats:italic>\n                      V600E mutation was identified on pathology. Imaging findings demonstrated retroperitoneal fibrosis and long bone osteosclerosis with increased fluorodeoxyglucose uptake that, together with the neuropathologic findings, were diagnostic of ECD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>This case of biopsy-proven ECD is unique in that the singular symptom was seizures well controlled with medical management in the presence of similarly located bilateral anterior mesial temporal lobe lesions. Although ECD is rare intracranially, its variable imaging presentation, including the potential to mimic seizure-associated medial temporal lobe tumors, emphasizes the need for a wide differential diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case23248","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T20:01:52Z","timestamp":1697486512000},"source":"Crossref","is-referenced-by-count":1,"title":["Recurrent petit mal seizures in Erdheim-Chester disease mimicking an intra-axial brain tumor: illustrative case"],"prefix":"10.3171","volume":"6","author":[{"given":"Caren M","family":"Stuebe","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda V","family":"Jenson","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanner W","family":"Lines","sequence":"additional","affiliation":[{"name":"Radiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley M","family":"Holloman","sequence":"additional","affiliation":[{"name":"Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D","family":"Cykowski","sequence":"additional","affiliation":[{"name":"Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve H","family":"Fung","sequence":"additional","affiliation":[{"name":"Radiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald E","family":"Fisher","sequence":"additional","affiliation":[{"name":"Radiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth L","family":"McClain","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\/Oncology, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S","family":"Baskin","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"Department of Neurosurgery, Weill Cornell Medical College, New York, New York"},{"name":"Department of Neurosurgery, Kenneth R. Peak Brain and Pituitary Tumor Treatment Center, Houston, Texas"},{"name":"Department of Graduate Studies, Texas A&M School of Medicine, Bryan, Texas; and"},{"name":"Department of Neurosciences Research, The Houston Methodist Research Institute, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"Radiology","first-page":"586","article-title":"Cerebral, facial, and orbital involvement in Erdheim-Chester disease: CT and MR imaging findings","volume":"255","author":"Drier A","year":"2010","unstructured":"Drier A, Haroche J, Savatovsky J,  Cerebral, facial, and orbital involvement in Erdheim-Chester disease: CT and MR imaging findings. Radiology. 2010;255(2):586\u2013594."},{"issue":"11","key":"b2","series-title":"J Neuropathol Exp Neurol","first-page":"1207","article-title":"Pathology of the central nervous system in Chester-Erdheim disease: report of three cases","volume":"56","author":"Adle-Biassette H","year":"1997","unstructured":"Adle-Biassette H, Chetritt J, Bergemer-Fouquet AM, Wechsler J, Mussini JM, Gray F. Pathology of the central nervous system in Chester-Erdheim disease: report of three cases. J Neuropathol Exp Neurol. 1997;56(11):1207\u20131216."},{"issue":"6","key":"b3","series-title":"J Neurosurg","first-page":"1115","article-title":"Erdheim-Chester disease mimicking a primary brain tumor. Case report","volume":"100","author":"Rushing EJ","year":"2004","unstructured":"Rushing EJ, Bouffard JP, Neal CJ,  Erdheim-Chester disease mimicking a primary brain tumor. Case report. J Neurosurg. 2004;100(6):1115\u20131118."},{"issue":"1","key":"b4","series-title":"J Neurol Neurosurg Psychiatry","first-page":"72","article-title":"Neurological manifestations of Erdheim-Chester disease","volume":"66","author":"Wright RA","year":"1999","unstructured":"Wright RA, Hermann RC, Parisi JE. Neurological manifestations of Erdheim-Chester disease. J Neurol Neurosurg Psychiatry. 1999;66(1):72\u201375."},{"issue":"10","key":"b5","series-title":"J Neurol","first-page":"1267","article-title":"Neurological manifestations and neuroradiological presentation of Erdheim-Chester disease: report of 6 cases and systematic review of the literature","volume":"253","author":"Lachenal F","year":"2006","unstructured":"Lachenal F, Cotton F, Desmurs-Clavel H,  Neurological manifestations and neuroradiological presentation of Erdheim-Chester disease: report of 6 cases and systematic review of the literature. J Neurol. 2006;253(10):1267\u20131277."},{"issue":"11","key":"b6","series-title":"Arthritis Rheum","first-page":"3504","article-title":"Pulmonary involvement in Erdheim-Chester disease: a single-center study of thirty-four patients and a review of the literature","volume":"62","author":"Arnaud L","year":"2010","unstructured":"Arnaud L, Pierre I, Beigelman-Aubry C,  Pulmonary involvement in Erdheim-Chester disease: a single-center study of thirty-four patients and a review of the literature. Arthritis Rheum. 2010;62(11):3504\u20133512."},{"issue":"1","key":"b7","series-title":"Radiology","first-page":"111","article-title":"Case 78: Erdheim-Chester disease with central nervous system involvement","volume":"234","author":"Adem C","year":"2005","unstructured":"Adem C, H\u00e9lie O, L\u00e9v\u00eaque C, Taillia H, Cordoliani YS. Case 78: Erdheim-Chester disease with central nervous system involvement. 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BMJ Case Rep. 2013;2013:bcr2012006823."},{"issue":"5","key":"b11","series-title":"J Nucl Med","first-page":"774","article-title":"18F-FDG PET\/CT in Erdheim-Chester disease: imaging findings and potential BRAF mutation biomarker","volume":"59","author":"Young JR","year":"2018","unstructured":"Young JR, Johnson GB, Murphy RC, Go RS, Broski SM. 18F-FDG PET\/CT in Erdheim-Chester disease: imaging findings and potential BRAF mutation biomarker. J Nucl Med. 2018;59(5):774\u2013779."},{"issue":"2","key":"b12","series-title":"Clin Nucl Med","first-page":"170","article-title":"FDG PET images in a patient with Erdheim-Chester disease","volume":"39","author":"Sioka C","year":"2014","unstructured":"Sioka C, Estrada-Veras J, Maric I, Gahl WA, Chen CC. FDG PET images in a patient with Erdheim-Chester disease. 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Radiology. 2010;255(2):586\u2013594."},{"issue":"11","key":"b2","series-title":"J Neuropathol Exp Neurol","first-page":"1207","article-title":"Pathology of the central nervous system in Chester-Erdheim disease: report of three cases","volume":"56","author":"Adle-Biassette H","year":"1997","unstructured":"Adle-Biassette H, Chetritt J, Bergemer-Fouquet AM, Wechsler J, Mussini JM, Gray F. Pathology of the central nervous system in Chester-Erdheim disease: report of three cases. J Neuropathol Exp Neurol. 1997;56(11):1207\u20131216."},{"issue":"6","key":"b3","series-title":"J Neurosurg","first-page":"1115","article-title":"Erdheim-Chester disease mimicking a primary brain tumor. Case report","volume":"100","author":"Rushing EJ","year":"2004","unstructured":"Rushing EJ, Bouffard JP, Neal CJ,  Erdheim-Chester disease mimicking a primary brain tumor. Case report. 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BMJ Case Rep. 2013;2013:bcr2012006823."},{"issue":"5","key":"b11","series-title":"J Nucl Med","first-page":"774","article-title":"18F-FDG PET\/CT in Erdheim-Chester disease: imaging findings and potential BRAF mutation biomarker","volume":"59","author":"Young JR","year":"2018","unstructured":"Young JR, Johnson GB, Murphy RC, Go RS, Broski SM. 18F-FDG PET\/CT in Erdheim-Chester disease: imaging findings and potential BRAF mutation biomarker. J Nucl Med. 2018;59(5):774\u2013779."},{"issue":"2","key":"b12","series-title":"Clin Nucl Med","first-page":"170","article-title":"FDG PET images in a patient with Erdheim-Chester disease","volume":"39","author":"Sioka C","year":"2014","unstructured":"Sioka C, Estrada-Veras J, Maric I, Gahl WA, Chen CC. FDG PET images in a patient with Erdheim-Chester disease. Clin Nucl Med. 2014;39(2):170\u2013177."},{"issue":"1","key":"b13","series-title":"Neurol Clin Pract","first-page":"15","article-title":"Neuroradiologic manifestations of Erdheim-Chester disease","volume":"8","author":"Parks NE","year":"2018","unstructured":"Parks NE, Goyal G, Go RS, Mandrekar J, Tobin WO. Neuroradiologic manifestations of Erdheim-Chester disease. 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