{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:55:17Z","timestamp":1770353717034,"version":"3.49.0"},"reference-count":14,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,17]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>While hypoglycorrhachia is observed and managed frequently, there are few reports in the literature of clinically significant hyperglycorrhachia after neurosurgery. Understanding the effects and management of severe hyperglycorrhachia is important to the neurosurgeon and neurocritical care teams who care for patients in these rare scenarios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors present the case of a 3-month-old male with congenital hydrocephalus who faced profound hyperglycorrhachia and status epilepticus after an endoscopic aqueductoplasty using an irrigant composed of lactated Ringer\u2019s solution with dextrose 5% in water. A multidisciplinary approach was developed to monitor and treat the patient\u2019s seizures and cerebrospinal fluid (CSF) osmolytes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>This case provides several learning opportunities for understanding CSF physiology, pathogenesis of common brain injuries related to osmotic shifts and inflammatory states, as well as clinical management of hyperglycorrhachia. It also reiterates the significance of meticulous intraoperative assessment to avoid preventable medical errors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case23252","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T10:17:36Z","timestamp":1689675456000},"source":"Crossref","is-referenced-by-count":0,"title":["Severe hyperglycorrhachia and status epilepticus after endoscopic aqueductoplasty: illustrative case"],"prefix":"10.3171","volume":"6","author":[{"given":"Anand A.","family":"Dharia","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The University of Kansas Medical Center, Kansas City, Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Masri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The University of Kansas Medical Center, Kansas City, Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay F.","family":"Rilinger","sequence":"additional","affiliation":[{"name":"University of Missouri Kansas City School of Medicine, Kansas City, Missouri; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian B.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The University of Kansas Medical Center, Kansas City, Kansas"},{"name":"Division of Neurosurgery, Children\u2019s Mercy Hospital Kansas City, Kansas City, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Pediatr Neurol","first-page":"77","article-title":"Neonatal segmental myoclonus associated with hyperglycorrhachia","volume":"13","author":"Bass WT","year":"1995","unstructured":"Bass WT, Lewis DW. Neonatal segmental myoclonus associated with hyperglycorrhachia. Pediatr Neurol. 1995;13(1):77\u201379.7575856"},{"key":"b2","series-title":"Ann Clin Biochem: Int J Lab Med","first-page":"84","article-title":"An unusual cause of hyperglycorrhachia","volume":"33","author":"Katz I","year":"1996","unstructured":"Katz I, Godsel P, Bowen J, Wyndham L: An unusual cause of hyperglycorrhachia. Ann Clin Biochem: Int J Lab Med. 1996;33:84\u201385."},{"key":"b3","series-title":"Youman\u2019s Neurological Surgery","first-page":"42","author":"Winn HR","year":"2004","unstructured":"Winn HR, Youmans JR, Johnson CE. Youman\u2019s Neurological Surgery. 15th ed. Saunders; 2004:42\u2013322."},{"issue":"6","key":"b4","series-title":"N Engl J Med","first-page":"576","article-title":"Relationship between cerebrospinal fluid glucose and serum glucose","volume":"366","author":"Nigrovic LE","year":"2012","unstructured":"Nigrovic LE, Kimia AA, Shah SS, Neuman MI. Relationship between cerebrospinal fluid glucose and serum glucose. N Engl J Med. 2012;366(6):576\u2013578.22316468"},{"key":"b5","series-title":"Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods","year":"2021","unstructured":"McPherson RA, Pincus MR, eds. Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021."},{"key":"b6","series-title":"Neurobiology of Cerebrospinal Fluid","author":"Wood JH","year":"1980","unstructured":"Wood JH. Neurobiology of Cerebrospinal Fluid. Plenum Press; 1980."},{"issue":"43","key":"b7","series-title":"Oncotarget","first-page":"71052","article-title":"Review: traumatic brain injury and hyperglycemia, a potentially modifiable risk factor","volume":"7","author":"Shi J","year":"2016","unstructured":"Shi J, Dong B, Mao Y,  Review: traumatic brain injury and hyperglycemia, a potentially modifiable risk factor. Oncotarget. 2016;7(43):71052\u201371061.27626493"},{"issue":"1","key":"b1","series-title":"Pediatr Neurol","first-page":"77","article-title":"Neonatal segmental myoclonus associated with hyperglycorrhachia","volume":"13","author":"Bass WT","year":"1995","unstructured":"Bass WT, Lewis DW. Neonatal segmental myoclonus associated with hyperglycorrhachia. Pediatr Neurol. 1995;13(1):77\u201379.7575856"},{"key":"b2","series-title":"Ann Clin Biochem: Int J Lab Med","first-page":"84","article-title":"An unusual cause of hyperglycorrhachia","volume":"33","author":"Katz I","year":"1996","unstructured":"Katz I, Godsel P, Bowen J, Wyndham L: An unusual cause of hyperglycorrhachia. Ann Clin Biochem: Int J Lab Med. 1996;33:84\u201385."},{"key":"b3","series-title":"Youman\u2019s Neurological Surgery","first-page":"42","author":"Winn HR","year":"2004","unstructured":"Winn HR, Youmans JR, Johnson CE. Youman\u2019s Neurological Surgery. 15th ed. 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Plenum Press; 1980."},{"issue":"43","key":"b7","series-title":"Oncotarget","first-page":"71052","article-title":"Review: traumatic brain injury and hyperglycemia, a potentially modifiable risk factor","volume":"7","author":"Shi J","year":"2016","unstructured":"Shi J, Dong B, Mao Y,  Review: traumatic brain injury and hyperglycemia, a potentially modifiable risk factor. 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