{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:57:47Z","timestamp":1770353867971,"version":"3.49.0"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"20","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,13]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Hemispherectomy is a surgical procedure reserved for hemispheric intractable epilepsy. Sagittal craniosynostosis is a congenital disorder treated with open or endoscope-assisted approaches for synostosis correction. These procedures are not commonly performed in the same setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>In this report, the authors present a 6-month-old female with sagittal craniosynostosis, hemimegalencephaly, and intractable epilepsy who underwent a left hemispherotomy with open sagittal synostosis correction followed by cranial molding orthosis therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>The report highlights the technical nuances of the procedure, but also discusses the possible genetic disorder responsible for both conditions, megalencephaly-capillary malformation syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case23379","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T18:53:50Z","timestamp":1699901630000},"source":"Crossref","is-referenced-by-count":0,"title":["Tandem pediatric neurosurgery: treatment of synostosis and intractable epilepsy. Illustrative case"],"prefix":"10.3171","volume":"6","author":[{"given":"Ogechukwu","family":"Ariwodo","sequence":"first","affiliation":[{"name":"Philadelphia Colleges of Osteopathic Medicine South Georgia, Moultrie, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R","family":"Nordli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic Florida, Jacksonville, Florida; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan J","family":"Ranalli","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, University of Florida Health Science Center, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra D","family":"Beier","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, University of Florida Health Science Center, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"Transl Pediatr","first-page":"208","article-title":"Hemispherectomy in the treatment of seizures: a review","volume":"3","author":"Lew SM","year":"2014","unstructured":"Lew SM. Hemispherectomy in the treatment of seizures: a review. Transl Pediatr. 2014;3(3):208\u2013217."},{"issue":"8","key":"b2","series-title":"Nat Genet","first-page":"934","article-title":"De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes","volume":"44","author":"Rivi\u00e8re JB","year":"2012","unstructured":"Rivi\u00e8re JB, Mirzaa GM, O\u2019Roak BJ,  De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. Nat Genet. 2012;44(8):934\u2013940."},{"issue":"1","key":"b3","series-title":"Am J Med Genet A","first-page":"162","article-title":"Growth hormone deficiency in megalencephaly-capillary malformation syndrome: An association with activating mutations in PIK3CA","volume":"182","author":"Davis S","year":"2020","unstructured":"Davis S, Ware MA, Zeiger J,  Growth hormone deficiency in megalencephaly-capillary malformation syndrome: An association with activating mutations in PIK3CA. Am J Med Genet A. 2020;182(1):162\u2013168."},{"issue":"2","key":"b4","series-title":"Am J Med Genet C Semin Med Genet","first-page":"122","article-title":"Megalencephaly syndromes and activating mutations in the PI3K-AKT pathway: MPPH and MCAP","volume":"163C","author":"Mirzaa GM","year":"2013","unstructured":"Mirzaa GM, Rivi\u00e8re JB, Dobyns WB. Megalencephaly syndromes and activating mutations in the PI3K-AKT pathway: MPPH and MCAP. Am J Med Genet C Semin Med Genet. 2013;163C(2):122\u2013130."},{"issue":"5","key":"b5","series-title":"Clin Genet","first-page":"650","article-title":"Clinical and neuroimaging findings in 33 patients with MCAP syndrome: a survey to evaluate relevant endpoints for future clinical trials","volume":"99","author":"Garde A","year":"2021","unstructured":"Garde A, Guibaud L, Goldenberg A,  Clinical and neuroimaging findings in 33 patients with MCAP syndrome: a survey to evaluate relevant endpoints for future clinical trials. Clin Genet. 2021;99(5):650\u2013661."},{"issue":"1","key":"b6","series-title":"Orphanet J Rare Dis","first-page":"205","article-title":"Detailed analysis of phenotypes and genotypes in megalencephaly-capillary malformation-polymicrogyria syndrome caused by somatic mosaicism of PIK3CA mutations","volume":"15","author":"Park HJ","year":"2020","unstructured":"Park HJ, Shin CH, Yoo WJ,  Detailed analysis of phenotypes and genotypes in megalencephaly-capillary malformation-polymicrogyria syndrome caused by somatic mosaicism of PIK3CA mutations. Orphanet J Rare Dis. 2020;15(1):205."},{"issue":"1","key":"b7","series-title":"Am J Med Genet A","first-page":"45","article-title":"Macrocephaly-cutis marmorata telangiectatica congenita: report of six new patients and a review","volume":"130A","author":"Lapunzina P","year":"2004","unstructured":"Lapunzina P, Gair\u00ed A, Delicado A,  Macrocephaly-cutis marmorata telangiectatica congenita: report of six new patients and a review. Am J Med Genet A. 2004;130A(1):45\u201351."},{"issue":"3","key":"b8","series-title":"Cold Spring Harb Mol Case Stud","first-page":"a006188","article-title":"The utility of cerebrospinal fluid-derived cell-free DNA in molecular diagnostics for the PIK3CA-related megalencephaly-capillary malformation (MCAP) syndrome: a case report","volume":"8","author":"Chen WL","year":"2022","unstructured":"Chen WL, Pao E, Owens J,  The utility of cerebrospinal fluid-derived cell-free DNA in molecular diagnostics for the PIK3CA-related megalencephaly-capillary malformation (MCAP) syndrome: a case report. Cold Spring Harb Mol Case Stud. 2022;8(3):a006188."},{"issue":"4","key":"b9","series-title":"Am J Med Genet A","first-page":"862","article-title":"Diagnosis of 9q22.3 microdeletion syndrome in utero following identification of craniosynostosis, overgrowth, and skeletal anomalies","volume":"167A","author":"Reichert SC","year":"2015","unstructured":"Reichert SC, Zelley K, Nichols KE, Eberhard M, Zackai EH, Martinez-Poyer J. Diagnosis of 9q22.3 microdeletion syndrome in utero following identification of craniosynostosis, overgrowth, and skeletal anomalies. Am J Med Genet A. 2015;167A(4):862\u2013865."},{"issue":"5","key":"b10","series-title":"Ann Plast Surg","first-page":"574","article-title":"The effect of multiple surgeries on psychosocial outcomes in pediatric patients: a scoping review","volume":"85","author":"Hu AC","year":"2020","unstructured":"Hu AC, Bertrand AA, Dang BN, Chan CH, Lee JC. The effect of multiple surgeries on psychosocial outcomes in pediatric patients: a scoping review. Ann Plast Surg. 2020;85(5):574\u2013583."},{"issue":"3","key":"b11","series-title":"Anesth Analg","first-page":"723","article-title":"Exposure to surgery and anesthesia in early childhood and subsequent use of attention deficit hyperactivity disorder medications","volume":"131","author":"Ing C","year":"2020","unstructured":"Ing C, Ma X, Sun M,  Exposure to surgery and anesthesia in early childhood and subsequent use of attention deficit hyperactivity disorder medications. Anesth Analg. 2020;131(3):723\u2013733."},{"issue":"5","key":"b12","series-title":"J Anesth","first-page":"765","article-title":"General anesthesia affecting on developing brain: evidence from animal to clinical research","volume":"34","author":"Liu X","year":"2020","unstructured":"Liu X, Ji J, Zhao GQ. General anesthesia affecting on developing brain: evidence from animal to clinical research. J Anesth. 2020;34(5):765\u2013772."},{"issue":"3","key":"b1","series-title":"Transl Pediatr","first-page":"208","article-title":"Hemispherectomy in the treatment of seizures: a review","volume":"3","author":"Lew SM","year":"2014","unstructured":"Lew SM. Hemispherectomy in the treatment of seizures: a review. Transl Pediatr. 2014;3(3):208\u2013217."},{"issue":"8","key":"b2","series-title":"Nat Genet","first-page":"934","article-title":"De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes","volume":"44","author":"Rivi\u00e8re JB","year":"2012","unstructured":"Rivi\u00e8re JB, Mirzaa GM, O\u2019Roak BJ,  De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. Nat Genet. 2012;44(8):934\u2013940."},{"issue":"1","key":"b3","series-title":"Am J Med Genet A","first-page":"162","article-title":"Growth hormone deficiency in megalencephaly-capillary malformation syndrome: An association with activating mutations in PIK3CA","volume":"182","author":"Davis S","year":"2020","unstructured":"Davis S, Ware MA, Zeiger J,  Growth hormone deficiency in megalencephaly-capillary malformation syndrome: An association with activating mutations in PIK3CA. Am J Med Genet A. 2020;182(1):162\u2013168."},{"issue":"2","key":"b4","series-title":"Am J Med Genet C Semin Med Genet","first-page":"122","article-title":"Megalencephaly syndromes and activating mutations in the PI3K-AKT pathway: MPPH and MCAP","volume":"163C","author":"Mirzaa GM","year":"2013","unstructured":"Mirzaa GM, Rivi\u00e8re JB, Dobyns WB. Megalencephaly syndromes and activating mutations in the PI3K-AKT pathway: MPPH and MCAP. 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Clin Genet. 2021;99(5):650\u2013661."},{"issue":"1","key":"b6","series-title":"Orphanet J Rare Dis","first-page":"205","article-title":"Detailed analysis of phenotypes and genotypes in megalencephaly-capillary malformation-polymicrogyria syndrome caused by somatic mosaicism of PIK3CA mutations","volume":"15","author":"Park HJ","year":"2020","unstructured":"Park HJ, Shin CH, Yoo WJ,  Detailed analysis of phenotypes and genotypes in megalencephaly-capillary malformation-polymicrogyria syndrome caused by somatic mosaicism of PIK3CA mutations. Orphanet J Rare Dis. 2020;15(1):205."},{"issue":"1","key":"b7","series-title":"Am J Med Genet A","first-page":"45","article-title":"Macrocephaly-cutis marmorata telangiectatica congenita: report of six new patients and a review","volume":"130A","author":"Lapunzina P","year":"2004","unstructured":"Lapunzina P, Gair\u00ed A, Delicado A,  Macrocephaly-cutis marmorata telangiectatica congenita: report of six new patients and a review. 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Cold Spring Harb Mol Case Stud. 2022;8(3):a006188."},{"issue":"4","key":"b9","series-title":"Am J Med Genet A","first-page":"862","article-title":"Diagnosis of 9q22.3 microdeletion syndrome in utero following identification of craniosynostosis, overgrowth, and skeletal anomalies","volume":"167A","author":"Reichert SC","year":"2015","unstructured":"Reichert SC, Zelley K, Nichols KE, Eberhard M, Zackai EH, Martinez-Poyer J. Diagnosis of 9q22.3 microdeletion syndrome in utero following identification of craniosynostosis, overgrowth, and skeletal anomalies. Am J Med Genet A. 2015;167A(4):862\u2013865."},{"issue":"5","key":"b10","series-title":"Ann Plast Surg","first-page":"574","article-title":"The effect of multiple surgeries on psychosocial outcomes in pediatric patients: a scoping review","volume":"85","author":"Hu AC","year":"2020","unstructured":"Hu AC, Bertrand AA, Dang BN, Chan CH, Lee JC. 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