{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T21:43:05Z","timestamp":1783201385953,"version":"3.54.6"},"reference-count":14,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"15","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2024,10,7]]},"abstract":"\n BACKGROUND<\/jats:title>\n Responsive neurostimulation (RNS) is often considered to be a palliative therapy for drug-resistant epilepsy (DRE) and is generally not considered to be a treatment for patients with tuberous sclerosis complex (TSC). Here, the authors present the case of a 24-year-old male with TSC who obtained seizure freedom following RNS device implantation.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n Prior to RNS device implantation, the patient underwent tuberectomies, subependymal giant cell astrocytoma resection, vagus nerve stimulator placement, and left frontal lobe resection but continued to have frequent seizures. An RNS device was implanted, which initially led to a decrease in seizures, but he continued to have 12 seizures per month. He then underwent lead revision for stimulation via a different electrode. After that lead change, he had no seizures for almost 3 years. In the following 3 years, he had two episodes of breakthrough seizures, both of which occurred with medication weans. Although the patient still requires antiseizure medication, he has had years of seizure freedom with RNS therapy.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n This study exhibits the potential effectiveness of RNS therapy for patients with TSC and DRE. RNS should be considered for patients with TSC when other therapies have not sufficiently treated their epilepsy.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE23411<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case23411","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T02:44:55Z","timestamp":1728269095000},"source":"Crossref","is-referenced-by-count":2,"title":["Responsive neurostimulation of the frontal lobe for the detection and treatment of seizures in intractable epilepsy due to tuberous sclerosis complex: illustrative case"],"prefix":"10.3171","volume":"8","author":[{"given":"Paige J","family":"Brabant","sequence":"first","affiliation":[{"name":"New York Medical College, Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron P","family":"Beaudreault","sequence":"additional","affiliation":[{"name":"New York Medical College, Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M","family":"Wolf","sequence":"additional","affiliation":[{"name":"New York Medical College, Valhalla, New York"},{"name":"Department of Pediatric Neurology, Boston Children\u2019s Health Physicians, Hawthorne, New York"},{"name":"Departments of Pediatrics, Maria Fareri Children\u2019s Hospital, Westchester Medical Center, Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia E","family":"McGoldrick","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Boston Children\u2019s Health Physicians, Hawthorne, New York"},{"name":"Departments of Pediatrics, Maria Fareri Children\u2019s Hospital, Westchester Medical Center, Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadi","family":"Ghatan","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Maria Fareri Children\u2019s Hospital, Westchester Medical Center, Valhalla, New York"},{"name":"Department of Neurosurgery, Mount Sinai Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie R","family":"Muh","sequence":"additional","affiliation":[{"name":"New York Medical College, Valhalla, New York"},{"name":"Departments of Pediatrics, Maria Fareri Children\u2019s Hospital, Westchester Medical Center, Valhalla, New York"},{"name":"Departments of Neurosurgery, Maria Fareri Children\u2019s Hospital, Westchester Medical Center, Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"bib1","series-title":"J Neurol Sci","first-page":"104","article-title":"Epilepsy treatment patterns among patients with tuberous sclerosis complex","volume":"391","author":"Song","year":"2018","unstructured":"Song JSwallow ESaid Q, et al. Epilepsy treatment patterns among patients with tuberous sclerosis complex. J Neurol Sci. 2018;391:104-108."},{"issue":"3","key":"bib2","series-title":"Epilepsia","first-page":"432","article-title":"Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial","volume":"55","author":"Heck","year":"2014","unstructured":"Heck CNKing-Stephens DMassey AD, et al. Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial. Epilepsia. 2014;55(3):432-441."},{"issue":"2","key":"bib3","series-title":"Epilepsia Open","first-page":"419","article-title":"Brain-responsive neurostimulation for the treatment of adults with epilepsy in tuberous sclerosis complex: a case series","volume":"6","author":"McDermott","year":"2021","unstructured":"McDermott DSMirro EAFetrow K, et al. Brain-responsive neurostimulation for the treatment of adults with epilepsy in tuberous sclerosis complex: a case series. Epilepsia Open. 2021;6(2):419-424."},{"key":"bib4","series-title":"Pediatr Neurol","first-page":"97","article-title":"Responsive neurostimulation for the treatment of children with drug-resistant epilepsy in tuberous sclerosis complex","volume":"145","author":"Karakas","year":"2023","unstructured":"Karakas CHouck KHandoko M, et al. Responsive neurostimulation for the treatment of children with drug-resistant epilepsy in tuberous sclerosis complex. Pediatr Neurol. 2023;145:97-101."},{"key":"bib5","series-title":"Epilepsy Behav","first-page":"107494","article-title":"Economic burden associated with tuberous sclerosis complex in patients with epilepsy","volume":"112","author":"Betts","year":"2020","unstructured":"Betts KAStockl KMYin LHollenack KWang MJYang X. Economic burden associated with tuberous sclerosis complex in patients with epilepsy. Epilepsy Behav. 2020;112:107494."},{"issue":"8","key":"bib6","series-title":"Epilepsia","first-page":"1749","article-title":"Real-world experience with direct brain-responsive neurostimulation for focal onset seizures","volume":"61","author":"Razavi","year":"2020","unstructured":"Razavi BRao VRLin C, et al. Real-world experience with direct brain-responsive neurostimulation for focal onset seizures. Epilepsia. 2020;61(8):1749-1757."},{"issue":"5","key":"bib7","series-title":"J Neurosurg Pediatr","first-page":"376","article-title":"Electrocorticographic evidence of perituberal cortex epileptogenicity in tuberous sclerosis complex","volume":"10","author":"Ma","year":"2012","unstructured":"Ma TSElliott RERuppe V, et al. Electrocorticographic evidence of perituberal cortex epileptogenicity in tuberous sclerosis complex. J Neurosurg Pediatr. 2012;10(5):376-382."},{"key":"bib1","series-title":"J Neurol Sci","first-page":"104","article-title":"Epilepsy treatment patterns among patients with tuberous sclerosis complex","volume":"391","author":"Song","year":"2018","unstructured":"Song JSwallow ESaid Q, et al. Epilepsy treatment patterns among patients with tuberous sclerosis complex. J Neurol Sci. 2018;391:104-108."},{"issue":"3","key":"bib2","series-title":"Epilepsia","first-page":"432","article-title":"Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial","volume":"55","author":"Heck","year":"2014","unstructured":"Heck CNKing-Stephens DMassey AD, et al. Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial. Epilepsia. 2014;55(3):432-441."},{"issue":"2","key":"bib3","series-title":"Epilepsia Open","first-page":"419","article-title":"Brain-responsive neurostimulation for the treatment of adults with epilepsy in tuberous sclerosis complex: a case series","volume":"6","author":"McDermott","year":"2021","unstructured":"McDermott DSMirro EAFetrow K, et al. Brain-responsive neurostimulation for the treatment of adults with epilepsy in tuberous sclerosis complex: a case series. Epilepsia Open. 2021;6(2):419-424."},{"key":"bib4","series-title":"Pediatr Neurol","first-page":"97","article-title":"Responsive neurostimulation for the treatment of children with drug-resistant epilepsy in tuberous sclerosis complex","volume":"145","author":"Karakas","year":"2023","unstructured":"Karakas CHouck KHandoko M, et al. Responsive neurostimulation for the treatment of children with drug-resistant epilepsy in tuberous sclerosis complex. Pediatr Neurol. 2023;145:97-101."},{"key":"bib5","series-title":"Epilepsy Behav","first-page":"107494","article-title":"Economic burden associated with tuberous sclerosis complex in patients with epilepsy","volume":"112","author":"Betts","year":"2020","unstructured":"Betts KAStockl KMYin LHollenack KWang MJYang X. Economic burden associated with tuberous sclerosis complex in patients with epilepsy. Epilepsy Behav. 2020;112:107494."},{"issue":"8","key":"bib6","series-title":"Epilepsia","first-page":"1749","article-title":"Real-world experience with direct brain-responsive neurostimulation for focal onset seizures","volume":"61","author":"Razavi","year":"2020","unstructured":"Razavi BRao VRLin C, et al. Real-world experience with direct brain-responsive neurostimulation for focal onset seizures. Epilepsia. 2020;61(8):1749-1757."},{"issue":"5","key":"bib7","series-title":"J Neurosurg Pediatr","first-page":"376","article-title":"Electrocorticographic evidence of perituberal cortex epileptogenicity in tuberous sclerosis complex","volume":"10","author":"Ma","year":"2012","unstructured":"Ma TSElliott RERuppe V, et al. Electrocorticographic evidence of perituberal cortex epileptogenicity in tuberous sclerosis complex. 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