{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:59:48Z","timestamp":1770353988461,"version":"3.49.0"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"23","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Adipose lesions of nerve are rare tumors that can cause nerve symptoms from either intrinsic or extrinsic compression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors present a case of a patient with a 10-year history of progressive, persistent leg pain and dorsal foot paresthesias\/dysesthesias. Imaging revealed several nondistinct nodules of indeterminate significance along the course of the superficial peroneal nerve (SPN). Surgery demonstrated six distinct extraneural lipomas studded on a 10-cm segment of the main SPN and one of its muscular branches in the midleg. The lesions were adherent to the SPN, without an easy dissection plane; therefore, a neurectomy was performed. Histology revealed the nerve was associated with multiple extraneural lipomas with focal evidence of prior trauma. At 4 months postoperatively, the patient\u2019s pain had resolved completely, and she was able to resume normal physical activities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>The current classification of adipose lesions of nerve includes intraneural and extraneural lipomas and lipomatosis of nerve (fibrolipomatous hamartoma). The unique features of the present case include the discrete and segmental nature of the extraneural lipomas adherent to the nerve. Its etiology is unknown, and the histology would be suggestive of either a traumatic or a degenerative process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case23557","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T18:54:18Z","timestamp":1701716058000},"source":"Crossref","is-referenced-by-count":0,"title":["Segmental extraneural lipomatosis of the superficial peroneal nerve: illustrative case"],"prefix":"10.3171","volume":"6","author":[{"given":"Kitty Y","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Plastic Surgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Raghunathan","sequence":"additional","affiliation":[{"name":"Departments of Anatomic Pathology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J","family":"Spinner","sequence":"additional","affiliation":[{"name":"Neurologic Surgery, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"Acta Neurochir (Wien)","first-page":"835","article-title":"What\u2019s known and what\u2019s new in adipose lesions of peripheral nerves?","volume":"163","author":"Marek T","year":"2021","unstructured":"Marek T, Mahan MA, Carter JM, et\u00a0al.. What\u2019s known and what\u2019s new in adipose lesions of peripheral nerves? Acta Neurochir (Wien). 2021;163(3):835\u2013842."},{"issue":"2","key":"b2","series-title":"J Neurosurg","first-page":"418","article-title":"Adipose lesions of nerve: the need for a modified classification","volume":"116","author":"Spinner RJ","year":"2012","unstructured":"Spinner RJ, Scheithauer BW, Amrami KK, Wenger DE, H\u00e9bert-Blouin MN. Adipose lesions of nerve: the need for a modified classification. J Neurosurg. 2012;116(2):418\u2013431."},{"issue":"4","key":"b3","series-title":"J Neurosurg","first-page":"1286","article-title":"Strengthening the association of lipomatosis of nerve and nerve-territory overgrowth: a systematic review","volume":"132","author":"Marek T","year":"2019","unstructured":"Marek T, Spinner RJ, Syal A, Mahan MA. Strengthening the association of lipomatosis of nerve and nerve-territory overgrowth: a systematic review. J Neurosurg. 2019;132(4):1286\u20131294."},{"issue":"2","key":"b4","series-title":"Am J Med Genet A","first-page":"287","article-title":"PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation","volume":"167A","author":"Keppler-Noreuil KM","year":"2015","unstructured":"Keppler-Noreuil KM, Rios JJ, Parker VE, et\u00a0al.. PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation. Am J Med Genet A. 2015;167A(2):287\u2013295."},{"issue":"5","key":"b5","series-title":"Skeletal Radiol","first-page":"260","article-title":"Fibrolipomatous hamartoma: pathognomonic on MR imaging","volume":"28","author":"Marom EM","year":"1999","unstructured":"Marom EM, Helms CA. Fibrolipomatous hamartoma: pathognomonic on MR imaging. Skeletal Radiol. 1999;28(5):260\u2013264."},{"key":"b6","series-title":"World Neurosurg","first-page":"4","article-title":"Circumferential adipose lesion of the sciatic nerve","volume":"140","author":"Davis GA","year":"2020","unstructured":"Davis GA, Marek T, Amrami KK, Mahan MA, Spinner RJ. Circumferential adipose lesion of the sciatic nerve. World Neurosurg. 2020;140:4\u20139."},{"issue":"5","key":"b7","series-title":"J Orthop Sci","first-page":"919","article-title":"Entrapment of the dorsal sensory branch of the ulnar nerve by circumferential extraneural lipoma","volume":"20","author":"Lee HM","year":"2015","unstructured":"Lee HM, Kim YS, Kim JP, Huh DJ. Entrapment of the dorsal sensory branch of the ulnar nerve by circumferential extraneural lipoma. J Orthop Sci. 2015;20(5):919\u2013922."},{"issue":"12","key":"b8","series-title":"Radiol Case Rep","first-page":"4893","article-title":"Upper extremity mass with lipomatous axillary involvement and multiple level encasement of the brachial plexus","volume":"17","author":"Moorefield AK","year":"2022","unstructured":"Moorefield AK, Singhal V. Upper extremity mass with lipomatous axillary involvement and multiple level encasement of the brachial plexus. Radiol Case Rep. 2022;17(12):4893\u20134898."},{"issue":"1","key":"b9","series-title":"Rom J Morphol Embryol","first-page":"137","article-title":"Superficial peroneal nerve lipoma","volume":"50","author":"Terrence Jose Jerome J","year":"2009","unstructured":"Terrence Jose Jerome J. Superficial peroneal nerve lipoma. Rom J Morphol Embryol. 2009;50(1):137\u2013139."},{"issue":"7","key":"b10","series-title":"Clin Anat","first-page":"925","article-title":"The subparaneurial compartment: a new concept in the clinicoanatomic classification of peripheral nerve lesions","volume":"28","author":"Prasad NK","year":"2015","unstructured":"Prasad NK, Capek S, de Ruiter GC, Amrami KK, Spinner RJ. The subparaneurial compartment: a new concept in the clinicoanatomic classification of peripheral nerve lesions. Clin Anat. 2015;28(7):925\u2013930."},{"key":"b11","series-title":"J Med Case Reports","first-page":"318","article-title":"Giant inframuscular lipoma disclosed 14 years after a blunt trauma: a case report","volume":"2","author":"Nigri G","year":"2008","unstructured":"Nigri G, Dente M, Valabrega S, et\u00a0al.. Giant inframuscular lipoma disclosed 14 years after a blunt trauma: a case report. J Med Case Reports. 2008;2:318."},{"issue":"3","key":"b12","series-title":"Plast Reconstr Surg","first-page":"699","article-title":"Posttraumatic lipomas: where do they really come from?","volume":"101","author":"Signorini M","year":"1998","unstructured":"Signorini M, Campiglio GL. Posttraumatic lipomas: where do they really come from? Plast Reconstr Surg. 1998;101(3):699\u2013705."},{"issue":"4","key":"b13","series-title":"Plast Reconstr Surg","first-page":"1159","article-title":"Posttraumatic lipoma","volume":"101","author":"Lemperle G","year":"1998","unstructured":"Lemperle G. Posttraumatic lipoma. Plast Reconstr Surg. 1998;101(4):1159."},{"issue":"2","key":"b14","series-title":"Oral Surg Oral Med Oral Pathol","first-page":"223","article-title":"Traumatic pseudolipoma of the buccal mucosa","volume":"28","author":"Brooke RI","year":"1969","unstructured":"Brooke RI, MacGregor AJ. Traumatic pseudolipoma of the buccal mucosa. Oral Surg Oral Med Oral Pathol. 1969;28(2):223\u2013225."},{"issue":"2","key":"b15","series-title":"Spine J","first-page":"202","article-title":"Spinal epidural lipomatosis: case reports, literature review and meta-analysis","volume":"5","author":"Fogel GR","year":"2005","unstructured":"Fogel GR, Cunningham PY 3rd, Esses SI. Spinal epidural lipomatosis: case reports, literature review and meta-analysis. Spine J. 2005;5(2):202\u2013211."},{"issue":"4","key":"b16","series-title":"J Neurosurg Spine","first-page":"463","article-title":"Epidural lipomatosis","volume":"7","author":"Borr\u00e9 DG","year":"2007","unstructured":"Borr\u00e9 DG. Epidural lipomatosis. J Neurosurg Spine. 2007;7(4):463\u2013464."},{"issue":"2","key":"b17","series-title":"J Orthop Surg (Hong Kong)","first-page":"23094990211027391","article-title":"Obesity is a risk factor for epidural lipomatosis: a meta-analysis","volume":"29","author":"Zhang B","year":"2021","unstructured":"Zhang B, Yuan H, Hu L, Saad M. Obesity is a risk factor for epidural lipomatosis: a meta-analysis. J Orthop Surg (Hong Kong). 2021;29(2):23094990211027391."},{"issue":"8","key":"b18","series-title":"J Atheroscler Thromb","first-page":"629","article-title":"The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism","volume":"18","author":"Matsuzawa Y","year":"2011","unstructured":"Matsuzawa Y, Funahashi T, Nakamura T. The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism. J Atheroscler Thromb. 2011;18(8):629\u2013639."},{"issue":"3","key":"b1","series-title":"Acta Neurochir (Wien)","first-page":"835","article-title":"What\u2019s known and what\u2019s new in adipose lesions of peripheral nerves?","volume":"163","author":"Marek T","year":"2021","unstructured":"Marek T, Mahan MA, Carter JM, et\u00a0al.. What\u2019s known and what\u2019s new in adipose lesions of peripheral nerves? Acta Neurochir (Wien). 2021;163(3):835\u2013842."},{"issue":"2","key":"b2","series-title":"J Neurosurg","first-page":"418","article-title":"Adipose lesions of nerve: the need for a modified classification","volume":"116","author":"Spinner RJ","year":"2012","unstructured":"Spinner RJ, Scheithauer BW, Amrami KK, Wenger DE, H\u00e9bert-Blouin MN. Adipose lesions of nerve: the need for a modified classification. J Neurosurg. 2012;116(2):418\u2013431."},{"issue":"4","key":"b3","series-title":"J Neurosurg","first-page":"1286","article-title":"Strengthening the association of lipomatosis of nerve and nerve-territory overgrowth: a systematic review","volume":"132","author":"Marek T","year":"2019","unstructured":"Marek T, Spinner RJ, Syal A, Mahan MA. Strengthening the association of lipomatosis of nerve and nerve-territory overgrowth: a systematic review. J Neurosurg. 2019;132(4):1286\u20131294."},{"issue":"2","key":"b4","series-title":"Am J Med Genet A","first-page":"287","article-title":"PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation","volume":"167A","author":"Keppler-Noreuil KM","year":"2015","unstructured":"Keppler-Noreuil KM, Rios JJ, Parker VE, et\u00a0al.. PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation. Am J Med Genet A. 2015;167A(2):287\u2013295."},{"issue":"5","key":"b5","series-title":"Skeletal Radiol","first-page":"260","article-title":"Fibrolipomatous hamartoma: pathognomonic on MR imaging","volume":"28","author":"Marom EM","year":"1999","unstructured":"Marom EM, Helms CA. Fibrolipomatous hamartoma: pathognomonic on MR imaging. Skeletal Radiol. 1999;28(5):260\u2013264."},{"key":"b6","series-title":"World Neurosurg","first-page":"4","article-title":"Circumferential adipose lesion of the sciatic nerve","volume":"140","author":"Davis GA","year":"2020","unstructured":"Davis GA, Marek T, Amrami KK, Mahan MA, Spinner RJ. Circumferential adipose lesion of the sciatic nerve. World Neurosurg. 2020;140:4\u20139."},{"issue":"5","key":"b7","series-title":"J Orthop Sci","first-page":"919","article-title":"Entrapment of the dorsal sensory branch of the ulnar nerve by circumferential extraneural lipoma","volume":"20","author":"Lee HM","year":"2015","unstructured":"Lee HM, Kim YS, Kim JP, Huh DJ. Entrapment of the dorsal sensory branch of the ulnar nerve by circumferential extraneural lipoma. J Orthop Sci. 2015;20(5):919\u2013922."},{"issue":"12","key":"b8","series-title":"Radiol Case Rep","first-page":"4893","article-title":"Upper extremity mass with lipomatous axillary involvement and multiple level encasement of the brachial plexus","volume":"17","author":"Moorefield AK","year":"2022","unstructured":"Moorefield AK, Singhal V. Upper extremity mass with lipomatous axillary involvement and multiple level encasement of the brachial plexus. Radiol Case Rep. 2022;17(12):4893\u20134898."},{"issue":"1","key":"b9","series-title":"Rom J Morphol Embryol","first-page":"137","article-title":"Superficial peroneal nerve lipoma","volume":"50","author":"Terrence Jose Jerome J","year":"2009","unstructured":"Terrence Jose Jerome J. Superficial peroneal nerve lipoma. Rom J Morphol Embryol. 2009;50(1):137\u2013139."},{"issue":"7","key":"b10","series-title":"Clin Anat","first-page":"925","article-title":"The subparaneurial compartment: a new concept in the clinicoanatomic classification of peripheral nerve lesions","volume":"28","author":"Prasad NK","year":"2015","unstructured":"Prasad NK, Capek S, de Ruiter GC, Amrami KK, Spinner RJ. The subparaneurial compartment: a new concept in the clinicoanatomic classification of peripheral nerve lesions. Clin Anat. 2015;28(7):925\u2013930."},{"key":"b11","series-title":"J Med Case Reports","first-page":"318","article-title":"Giant inframuscular lipoma disclosed 14 years after a blunt trauma: a case report","volume":"2","author":"Nigri G","year":"2008","unstructured":"Nigri G, Dente M, Valabrega S, et\u00a0al.. Giant inframuscular lipoma disclosed 14 years after a blunt trauma: a case report. J Med Case Reports. 2008;2:318."},{"issue":"3","key":"b12","series-title":"Plast Reconstr Surg","first-page":"699","article-title":"Posttraumatic lipomas: where do they really come from?","volume":"101","author":"Signorini M","year":"1998","unstructured":"Signorini M, Campiglio GL. Posttraumatic lipomas: where do they really come from? Plast Reconstr Surg. 1998;101(3):699\u2013705."},{"issue":"4","key":"b13","series-title":"Plast Reconstr Surg","first-page":"1159","article-title":"Posttraumatic lipoma","volume":"101","author":"Lemperle G","year":"1998","unstructured":"Lemperle G. Posttraumatic lipoma. Plast Reconstr Surg. 1998;101(4):1159."},{"issue":"2","key":"b14","series-title":"Oral Surg Oral Med Oral Pathol","first-page":"223","article-title":"Traumatic pseudolipoma of the buccal mucosa","volume":"28","author":"Brooke RI","year":"1969","unstructured":"Brooke RI, MacGregor AJ. Traumatic pseudolipoma of the buccal mucosa. Oral Surg Oral Med Oral Pathol. 1969;28(2):223\u2013225."},{"issue":"2","key":"b15","series-title":"Spine J","first-page":"202","article-title":"Spinal epidural lipomatosis: case reports, literature review and meta-analysis","volume":"5","author":"Fogel GR","year":"2005","unstructured":"Fogel GR, Cunningham PY 3rd, Esses SI. Spinal epidural lipomatosis: case reports, literature review and meta-analysis. Spine J. 2005;5(2):202\u2013211."},{"issue":"4","key":"b16","series-title":"J Neurosurg Spine","first-page":"463","article-title":"Epidural lipomatosis","volume":"7","author":"Borr\u00e9 DG","year":"2007","unstructured":"Borr\u00e9 DG. Epidural lipomatosis. J Neurosurg Spine. 2007;7(4):463\u2013464."},{"issue":"2","key":"b17","series-title":"J Orthop Surg (Hong Kong)","first-page":"23094990211027391","article-title":"Obesity is a risk factor for epidural lipomatosis: a meta-analysis","volume":"29","author":"Zhang B","year":"2021","unstructured":"Zhang B, Yuan H, Hu L, Saad M. Obesity is a risk factor for epidural lipomatosis: a meta-analysis. J Orthop Surg (Hong Kong). 2021;29(2):23094990211027391."},{"issue":"8","key":"b18","series-title":"J Atheroscler Thromb","first-page":"629","article-title":"The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism","volume":"18","author":"Matsuzawa Y","year":"2011","unstructured":"Matsuzawa Y, Funahashi T, Nakamura T. The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism. 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