{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:40:35Z","timestamp":1770352835387,"version":"3.49.0"},"reference-count":38,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>To date, only a few cases of sellar and suprasellar glioblastomas have been reported even though high-grade glioma constitutes the most common adult brain tumor, commonly arising in the cerebral hemispheres. It arises de novo from astrocytes within the optic nerve, optic chiasm, or optic tracts and is quite challenging to diagnose and treat. To the authors\u2019 knowledge, there are 72 cases (including this one) of optic glioma malignancies in the medical literature, 30 corresponding to glioblastomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors present the diagnostic considerations and challenges, management strategies, and clinical course of a very large sellar-suprasellar glioblastoma in a 19-year-female who had never received radiation therapy or prior surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Sellar-suprasellar glioblastomas, although extremely rare, are known to occur and pose challenges in their diagnosis and preoperative treatment planning. The presence of diffusion restriction on diffusion-weighted magnetic resonance imaging in a mass lesion that has ring and nodular postcontrast enhancement in addition to absent calcification on computed tomography should be alert to the possibility of a high-grade mass. This is extremely important for preoperative patient counseling and planning for the multimodal treatments, because sellar-suprasellar glioblastomas carry a poorer prognosis than the common benign mass lesions in the region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case23565","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T18:54:06Z","timestamp":1705344846000},"source":"Crossref","is-referenced-by-count":1,"title":["A sellar-suprasellar malignant optic pathway glioblastoma in the absence of prior radiation therapy: illustrative case"],"prefix":"10.3171","volume":"7","author":[{"given":"Mestet Yibeltal","family":"Shiferaw","sequence":"first","affiliation":[{"name":"Department of Surgery, Neurosurgery Division, Addis Ababa University, Addis Ababa, Ethiopia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsegazeab Laeke","family":"Teklemariam","sequence":"additional","affiliation":[{"name":"Department of Surgery, Neurosurgery Division, Addis Ababa University, Addis Ababa, Ethiopia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abenezer Tirsit","family":"Aklilu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Neurosurgery Division, Addis Ababa University, Addis Ababa, Ethiopia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejen Teke","family":"Gebrewahd","sequence":"additional","affiliation":[{"name":"Department of Surgery, Neurosurgery Division, Addis Ababa University, Addis Ababa, Ethiopia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bereket Hailu","family":"Mekuria","sequence":"additional","affiliation":[{"name":"Department of Surgery, Neurosurgery Division, Addis Ababa University, Addis Ababa, Ethiopia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ermias Fikru","family":"Yesuf","sequence":"additional","affiliation":[{"name":"Department of Surgery, Neurosurgery Division, Addis Ababa University, Addis Ababa, Ethiopia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taye Jemberu","family":"Robele","sequence":"additional","affiliation":[{"name":"Department of Pathology, MCM Comprehensive Hospital, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"4","key":"b1","series-title":"Brain Tumor Pathol","first-page":"216","article-title":"Rare suprasellar glioblastoma: report of two cases and review of the literature","volume":"29","author":"Lemm D","year":"2012","unstructured":"Lemm D, de Oliveira FH, Bernays RL, et\u00a0al. Rare suprasellar glioblastoma: report of two cases and review of the literature. Brain Tumor Pathol. 2012;29(4):216\u2013220."},{"issue":"11","key":"b2","series-title":"Eye (Lond)","first-page":"1026","article-title":"Primary tumours of the optic nerve and its sheath","volume":"18","author":"Miller NR","year":"2004","unstructured":"Miller NR Primary tumours of the optic nerve and its sheath. Eye (Lond). 2004;18(11):1026\u20131037."},{"key":"b3","series-title":"Am J Ophthalmol Case Rep","first-page":"100862","article-title":"Malignant optic nerve glioma in a young woman with 7 year follow up without recurrence","volume":"19","author":"Alabiad CR","year":"2020","unstructured":"Alabiad CR, Shah VS, Eatz TA, Sternau LL, Lam BL Malignant optic nerve glioma in a young woman with 7 year follow up without recurrence. Am J Ophthalmol Case Rep. 2020;19:100862."},{"issue":"5","key":"b4","series-title":"J Neurosurg Pediatr","first-page":"507","article-title":"Malignant transformation of an optic pathway glioma without prior radiation therapy","volume":"5","author":"Zoeller GK","year":"2010","unstructured":"Zoeller GK, Brathwaite CD, Sandberg DI Malignant transformation of an optic pathway glioma without prior radiation therapy. J Neurosurg Pediatr. 2010;5(5):507\u2013510."},{"issue":"4","key":"b5","series-title":"Acta Radiol","first-page":"375","article-title":"Chiasmatic glioblastoma of childhood. A case report","volume":"41","author":"Cirak B","year":"2000","unstructured":"Cirak B, Unal O, Arslan H, Cinal A Chiasmatic glioblastoma of childhood. A case report. Acta Radiol. 2000;41(4):375\u2013376."},{"issue":"5","key":"b6","series-title":"J Clin Neurosci","first-page":"502","article-title":"Glioblastoma of the optic chiasm","volume":"14","author":"Dinh TT","year":"2007","unstructured":"Dinh TT, Wang YY, Rosenfeld JV, Cherny M Glioblastoma of the optic chiasm. J Clin Neurosci. 2007;14(5):502\u2013505."},{"issue":"4","key":"b7","series-title":"Pediatr Neurol","first-page":"262","article-title":"Long-term outcome in children with gliomas of the anterior visual pathway","volume":"28","author":"Tow SL","year":"2003","unstructured":"Tow SL, Chandela S, Miller NR, Avellino AM Long-term outcome in children with gliomas of the anterior visual pathway. Pediatr Neurol. 2003;28(4):262\u2013270."},{"issue":"7","key":"b8","series-title":"Cancer","first-page":"1937","article-title":"Low grade supratentorial astrocytomas. Management and prognostic factors","volume":"73","author":"Janny P","year":"1994","unstructured":"Janny P, Cure H, Mohr M, et\u00a0al. Low grade supratentorial astrocytomas. Management and prognostic factors. Cancer. 1994;73(7):1937\u20131945."},{"issue":"1","key":"b9","series-title":"J Clin Neurosci","first-page":"207","article-title":"Clinicopathological and molecular features of malignant optic pathway glioma in an adult","volume":"22","author":"Nagaishi M","year":"2015","unstructured":"Nagaishi M, Sugiura Y, Takano I, et\u00a0al. Clinicopathological and molecular features of malignant optic pathway glioma in an adult. J Clin Neurosci. 2015;22(1):207\u2013209."},{"issue":"10","key":"b10","series-title":"AJNR Am J Neuroradiol","first-page":"1963","article-title":"Optic pathway glioma: correlation of imaging findings with the presence of neurofibromatosis","volume":"22","author":"Kornreich L","year":"2001","unstructured":"Kornreich L, Blaser S, Schwarz M, et\u00a0al. Optic pathway glioma: correlation of imaging findings with the presence of neurofibromatosis. AJNR Am J Neuroradiol. 2001;22(10):1963\u20131969."},{"issue":"1","key":"b11","series-title":"Brain","first-page":"121","article-title":"Malignant optic glioma of adulthood","volume":"96","author":"Hoyt WF","year":"1973","unstructured":"Hoyt WF, Meshel LG, Lessell S, Schatz NJ, Suckling RD Malignant optic glioma of adulthood. Brain. 1973;96(1):121\u2013132."},{"issue":"7","key":"b12","series-title":"Graefes Arch Clin Exp Ophthalmol","first-page":"1187","article-title":"Malignant optic glioma\u2014the spectrum of disease in a case series","volume":"253","author":"Traber GL","year":"2015","unstructured":"Traber GL, Pangalu A, Neumann M, et\u00a0al. Malignant optic glioma\u2014the spectrum of disease in a case series. 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Egypt J Radiol Nucl Med. 2013;44(3):617\u2013624."},{"issue":"6","key":"b19","series-title":"Curr Probl Diagn Radiol","first-page":"227","article-title":"Magnetic resonance imaging of sellar and suprasellar pathology: a pictorial review","volume":"36","author":"Kumar J","year":"2007","unstructured":"Kumar J, Kumar A, Sharma R, Vashisht S Magnetic resonance imaging of sellar and suprasellar pathology: a pictorial review. Curr Probl Diagn Radiol. 2007;36(6):227\u2013236."},{"issue":"4","key":"b1","series-title":"Brain Tumor Pathol","first-page":"216","article-title":"Rare suprasellar glioblastoma: report of two cases and review of the literature","volume":"29","author":"Lemm D","year":"2012","unstructured":"Lemm D, de Oliveira FH, Bernays RL, et\u00a0al. Rare suprasellar glioblastoma: report of two cases and review of the literature. 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Low grade supratentorial astrocytomas. Management and prognostic factors. Cancer. 1994;73(7):1937\u20131945."},{"issue":"1","key":"b9","series-title":"J Clin Neurosci","first-page":"207","article-title":"Clinicopathological and molecular features of malignant optic pathway glioma in an adult","volume":"22","author":"Nagaishi M","year":"2015","unstructured":"Nagaishi M, Sugiura Y, Takano I, et\u00a0al. Clinicopathological and molecular features of malignant optic pathway glioma in an adult. J Clin Neurosci. 2015;22(1):207\u2013209."},{"issue":"10","key":"b10","series-title":"AJNR Am J Neuroradiol","first-page":"1963","article-title":"Optic pathway glioma: correlation of imaging findings with the presence of neurofibromatosis","volume":"22","author":"Kornreich L","year":"2001","unstructured":"Kornreich L, Blaser S, Schwarz M, et\u00a0al. Optic pathway glioma: correlation of imaging findings with the presence of neurofibromatosis. 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