{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:48:46Z","timestamp":1788414526353,"version":"build-2803163510"},"reference-count":82,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Ionizing radiation and alkylating chemotherapies increase secondary malignancy risk in patients with cancer predisposition syndromes (CPSs), such as Li-Fraumeni syndrome. Laser interstitial thermal therapy (LITT) is a minimally invasive ablation technique that has not been associated with mutagenic risks. We describe the case of a child with LFS and a history of treated choroid plexus carcinoma (CPC) who developed a second primary glial tumor that was safely treated with magnetic resonance imaging (MRI)\u2013guided LITT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>\n                      A 4-year-old male with left parietal World Health Organization grade III CPC associated with a\n                      <jats:italic>TP53<\/jats:italic>\n                      germline mutation was evaluated. The patient underwent neoadjuvant platinum-based chemotherapy before near-total resection, followed by\n                      <jats:sup>131<\/jats:sup>\n                      I-8H9 immunotherapy and 30 fractions of 54-Gy proton radiotherapy. He remained without evidence of disease for 2 years before developing a slow-growing mass adjacent to the left frontal ventricular horn. Stereotactic biopsy revealed a glial neoplasm. Given the nonsuperficial location and focality of the lesion, MRI-guided LITT was performed for ablative therapy. There were no complications, and 2 years of surveillance revealed continued retraction of the ablated tumor focus and no subsequent disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Alternatives to mutagenic therapies for brain tumors should be explored for patients with CPS. LITT paired with imaging surveillance is a logical strategy to ensure durable outcomes and mitigate treatment-related secondary neoplasms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case23595","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T18:54:46Z","timestamp":1707159286000},"source":"Crossref","is-referenced-by-count":6,"title":["Laser interstitial thermal therapy as a radiation-sparing approach for central nervous system tumors in children with cancer predisposition syndromes: report of a child with Li-Fraumeni syndrome. Illustrative case"],"prefix":"10.3171","volume":"7","author":[{"given":"Sergio W","family":"Guadix","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Weill Cornell Medicine, New York, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Weill Cornell Medicine, New York, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson","family":"Gundlach","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Weill Cornell Medicine, New York, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson S","family":"Moss","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M","family":"Souweidane","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Weill Cornell Medicine, New York, New York; and"},{"name":"Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"GeneReviews\u00ae","article-title":"Li-Fraumeni Syndrome","author":"Schneider K","year":"1993","unstructured":"Schneider K, Zelley K, Nichols KE, Garber J Li-Fraumeni Syndrome. Pagon RA, Adam MP, Ardinger HH, et\u00a0al., eds. GeneReviews\u00ae. University of Washington; 1993."},{"issue":"6","key":"b2","series-title":"Pediatr Blood Cancer","first-page":"905","article-title":"Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: the Children\u2019s Hospital Los Angeles (CHLA) experience, 1991\u20132010","volume":"58","author":"Gozali AE","year":"2012","unstructured":"Gozali AE, Britt B, Shane L, et\u00a0al.. Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: the Children\u2019s Hospital Los Angeles (CHLA) experience, 1991\u20132010. Pediatr Blood Cancer. 2012;58(6):905\u2013909."},{"issue":"1","key":"b3","series-title":"Future Oncol","first-page":"9","article-title":"Brain tumors in Li-Fraumeni syndrome: a commentary and a case of a gliosarcoma patient","volume":"13","author":"Guidi M","year":"2017","unstructured":"Guidi M, Giunti L, Lucchesi M, et\u00a0al.. Brain tumors in Li-Fraumeni syndrome: a commentary and a case of a gliosarcoma patient. Future Oncol. 2017;13(1):9\u201312."},{"issue":"4","key":"b4","series-title":"Acta Neuropathol","first-page":"669","article-title":"An update on the central nervous system manifestations of Li-Fraumeni syndrome","volume":"139","author":"Orr BA","year":"2020","unstructured":"Orr BA, Clay MR, Pinto EM, Kesserwan C. An update on the central nervous system manifestations of Li-Fraumeni syndrome. Acta Neuropathol. 2020;139(4):669\u2013687."},{"issue":"2","key":"b5","series-title":"J Neurosurg Pediatr","first-page":"126","article-title":"Neoadjuvant chemotherapy reduces blood loss during the resection of pediatric choroid plexus carcinomas","volume":"16","author":"Schneider C","year":"2015","unstructured":"Schneider C, Kamaly-Asl I, Ramaswamy V, et\u00a0al.. Neoadjuvant chemotherapy reduces blood loss during the resection of pediatric choroid plexus carcinomas. 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Radiation-induced intracranial osteosarcoma after radiation for acute lymphocytic leukemia associated with Li-Fraumeni syndrome. Article in Japanese. No Shinkei Geka. 2013;41(6):499\u2013505."},{"key":"b8","series-title":"Clin Transl Radiat Oncol","first-page":"71","article-title":"Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome","volume":"7","author":"Schuler N","year":"2017","unstructured":"Schuler N, Palm J, Schmitz S, Lorat Y, R\u00fcbe CE. Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome. Clin Transl Radiat Oncol. 2017;7:71\u201378."},{"issue":"1","key":"b9","series-title":"Mo Med","first-page":"50","article-title":"Laser interstitial thermal therapy","volume":"117","author":"Patel B","year":"2020","unstructured":"Patel B, Kim AH. Laser interstitial thermal therapy. 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