{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:19:35Z","timestamp":1770351575875,"version":"3.49.0"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Lipomatosis of nerve (LN) is a rare disorder characterized by the massive enlargement of peripheral nerves, frequently accompanied by generalized fibroadipose proliferation and skeletal overgrowth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors have been routinely following a 20-year-old male for lipomatosis of median nerve at the wrist noted shortly after birth. He had undergone resection of the lesion accompanied by sural nerve grafting at another institution. Clinically, although his neurological loss of function has been stable, he has had continued soft tissue growth. Serial magnetic resonance imaging has revealed persistent LN proximal to the repair sites with evidence of fatty proliferation in the sural grafts and continued LN and fatty proliferation distally. There has been a progressive circumferential pattern of fibrosis around the proximal and distal suture lines, which has a similar radiological pattern to desmoid type fibromatosis (a pattern recently described in neuromuscular choristoma [NMC] desmoid-type fibromatosis).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Considering the similar reaction of nerve in both LN and NMC despite differing genetic cascades, the authors believe a unifying process occurs in both lesions. The pattern of circumferential fibroproliferation would be most consistent with neuron-mediated growth from unspecified trophic factors, supporting a previously reported a nerve-derived \u201cinside-out mechanism.\u201d The clinical consequences of this unifying process are presented.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case23661","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T18:54:22Z","timestamp":1705344862000},"source":"Crossref","is-referenced-by-count":0,"title":["Exuberant circumferential fibroproliferative neuromas in lipomatosis of nerve: a unifying theory. Illustrative case"],"prefix":"10.3171","volume":"7","author":[{"given":"Andres A","family":"Maldonado","sequence":"first","affiliation":[{"name":"Departments of Neurologic Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A","family":"Mahan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Utah, Salt Lake City, Utah; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodi M","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly K","family":"Amrami","sequence":"additional","affiliation":[{"name":"Radiology, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Marek","sequence":"additional","affiliation":[{"name":"Departments of Neurologic Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J","family":"Spinner","sequence":"additional","affiliation":[{"name":"Departments of Neurologic Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Am J Surg Pathol","first-page":"7","article-title":"Fibrolipomatous hamartoma of nerve. A clinicopathologic analysis of 26 cases","volume":"9","author":"Silverman TA","year":"1985","unstructured":"Silverman TA, Enzinger FM Fibrolipomatous hamartoma of nerve. A clinicopathologic analysis of 26 cases. Am J Surg Pathol. 1985;9(1):7\u201314."},{"issue":"2","key":"b2","series-title":"J Neurosurg","first-page":"418","article-title":"Adipose lesions of nerve: the need for a modified classification","volume":"116","author":"Spinner RJ","year":"2012","unstructured":"Spinner RJ, Scheithauer BW, Amrami KK, Wenger DE, H\u00e9bert-Blouin MN Adipose lesions of nerve: the need for a modified classification. J Neurosurg. 2012;116(2):418\u2013431."},{"issue":"3-4","key":"b3","series-title":"World Neurosurg","first-page":"492","article-title":"Long-term progression of lipomatosis of nerve","volume":"82","author":"Mahan MA","year":"2014","unstructured":"Mahan MA, Niederhauser BD, Amrami KK, Spinner RJ Long-term progression of lipomatosis of nerve. World Neurosurg. 2014;82(3-4):492\u2013499."},{"issue":"4","key":"b4","series-title":"J Neurosurg","first-page":"1286","article-title":"Strengthening the association of lipomatosis of nerve and nerve-territory overgrowth: a systematic review","volume":"132","author":"Marek T","year":"2019","unstructured":"Marek T, Spinner RJ, Syal A, Mahan MA Strengthening the association of lipomatosis of nerve and nerve-territory overgrowth: a systematic review. J Neurosurg. 2019;132(4):1286\u20131294."},{"issue":"3","key":"b5","series-title":"Acta Neurochir (Wien)","first-page":"835","article-title":"What\u2019s known and what\u2019s new in adipose lesions of peripheral nerves?","volume":"163","author":"Marek T","year":"2021","unstructured":"Marek T, Mahan MA, Carter JM, et\u00a0al. What\u2019s known and what\u2019s new in adipose lesions of peripheral nerves? Acta Neurochir (Wien). 2021;163(3):835\u2013842."},{"issue":"2","key":"b6","series-title":"Neurosurgery","first-page":"271","article-title":"Fibroproliferative neuromas may occur after iatrogenic injury for lipomatosis of nerve","volume":"73","author":"Mahan MA","year":"2013","unstructured":"Mahan MA, Amrami KK, Spinner RJ Fibroproliferative neuromas may occur after iatrogenic injury for lipomatosis of nerve. Neurosurgery. 2013;73(2):271\u2013281."},{"issue":"4","key":"b7","series-title":"Neurosurgery","first-page":"A229","article-title":"Resection and nerve grafting of a lipofibrohamartoma of the median nerve: case report","volume":"65","author":"Cherqui A","year":"2009","unstructured":"Cherqui A, Sulaiman WAR, Kline DG Resection and nerve grafting of a lipofibrohamartoma of the median nerve: case report. Neurosurgery. 2009;65(4)(suppl):A229\u2013A235."},{"issue":"6","key":"b8","series-title":"Acta Neurochir (Wien)","first-page":"1131","article-title":"Progressive nerve territory overgrowth after subtotal resection of lipomatosis of the median nerve in the palm and wrist: a case, a review and a paradigm","volume":"155","author":"Mahan MA","year":"2013","unstructured":"Mahan MA, Amrami KK, Niederhauser BD, Spinner RJ Progressive nerve territory overgrowth after subtotal resection of lipomatosis of the median nerve in the palm and wrist: a case, a review and a paradigm. Acta Neurochir (Wien). 2013;155(6):1131\u20131141."},{"issue":"2","key":"b9","series-title":"J Neurosurg","first-page":"399","article-title":"Fibromatosis: a potential sequela of neuromuscular choristoma","volume":"116","author":"H\u00e9bert-Blouin MN","year":"2012","unstructured":"H\u00e9bert-Blouin MN, Scheithauer BW, Amrami KK, Durham SR, Spinner RJ Fibromatosis: a potential sequela of neuromuscular choristoma. 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J Neurosurg. 2012;116(2):418\u2013431."},{"issue":"3-4","key":"b3","series-title":"World Neurosurg","first-page":"492","article-title":"Long-term progression of lipomatosis of nerve","volume":"82","author":"Mahan MA","year":"2014","unstructured":"Mahan MA, Niederhauser BD, Amrami KK, Spinner RJ Long-term progression of lipomatosis of nerve. World Neurosurg. 2014;82(3-4):492\u2013499."},{"issue":"4","key":"b4","series-title":"J Neurosurg","first-page":"1286","article-title":"Strengthening the association of lipomatosis of nerve and nerve-territory overgrowth: a systematic review","volume":"132","author":"Marek T","year":"2019","unstructured":"Marek T, Spinner RJ, Syal A, Mahan MA Strengthening the association of lipomatosis of nerve and nerve-territory overgrowth: a systematic review. 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World Neurosurg. 2022;159:56\u201362."},{"issue":"4","key":"b11","series-title":"Skeletal Radiol","first-page":"567","article-title":"Neuromuscular choristoma: characteristic magnetic resonance imaging findings and association with post-biopsy fibromatosis","volume":"42","author":"Niederhauser BD","year":"2013","unstructured":"Niederhauser BD, Spinner RJ, Jentoft ME, Everist BM, Matsumoto JM, Amrami KK Neuromuscular choristoma: characteristic magnetic resonance imaging findings and association with post-biopsy fibromatosis. Skeletal Radiol. 2013;42(4):567\u2013577."},{"key":"b12","series-title":"J Neurosurg.","article-title":"Neuromuscular choristoma and circumferential nerve territory desmoid-type fibromatosis: imaging findings supporting a nerve-driven mechanism","author":"Maldonado AA","year":"2023","unstructured":"Maldonado AA, Broski SM, Carter JM, Marek T, Howe BM, Spinner RJ Neuromuscular choristoma and circumferential nerve territory desmoid-type fibromatosis: imaging findings supporting a nerve-driven mechanism. J Neurosurg. Published online June 23, 2023. doi.org\/10.3171\/2023.5.JNS23323."},{"key":"b13","series-title":"Neuroscience","first-page":"101","article-title":"Activation of the Wnt\/\u03b2-catenin signaling cascade after traumatic nerve injury","volume":"294","author":"Kurimoto S","year":"2015","unstructured":"Kurimoto S, Jung J, Tapadia M, et\u00a0al. Activation of the Wnt\/\u03b2-catenin signaling cascade after traumatic nerve injury. 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