{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:01:25Z","timestamp":1780585285233,"version":"3.54.1"},"reference-count":46,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"8","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,19]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Brachioradial pruritus (BRP) is a rare form of chronic dysesthesia characterized by persistent itching, burning, or tingling commonly involving the dorsolateral upper extremities. Although the exact pathophysiology remains unclear, the condition may be a manifestation of atypical cervical radiculopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors describe two patients with BRP, a 44-year-old female and a 51-year-old male, both of whom benefited from surgical intervention for atypical cervical radiculopathy, while also highlighting their presentation, diagnostic testing, treatment, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>The cases demonstrate the potential relationship between cervical spondylosis and BRP while examining the role of surgical intervention as a treatment option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case23715","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T19:47:43Z","timestamp":1708372063000},"source":"Crossref","is-referenced-by-count":2,"title":["Atypical cervical radiculopathy presenting with brachioradial pruritus: illustrative cases"],"prefix":"10.3171","volume":"7","author":[{"given":"Kareem","family":"Khalifeh","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of California, San Diego School of Medicine, La Jolla, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneinne","family":"Le","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Hoag Spine Institute, Hoag Hospital, Newport Beach, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basel","family":"Musmar","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Maroon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S","family":"Kanter","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Hoag Spine Institute, Hoag Hospital, Newport Beach, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Ozgur","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Hoag Spine Institute, Hoag Hospital, Newport Beach, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"5","key":"b1","series-title":"Arch Dermatol","first-page":"481","article-title":"Solar pruritus of the elbows (brachioradial summer pruritus)","volume":"98","author":"Waisman M","year":"1968","unstructured":"Waisman M Solar pruritus of the elbows (brachioradial summer pruritus). Arch Dermatol. 1968;98(5):481\u2013485."},{"issue":"5 Pt 1","key":"b2","series-title":"J Am Acad Dermatol","first-page":"803","article-title":"Brachioradial pruritus: a recurrent solar dermopathy","volume":"39","author":"Wallengren J","year":"1998","unstructured":"Wallengren J Brachioradial pruritus: a recurrent solar dermopathy. J Am Acad Dermatol. 1998;39(5 Pt 1):803\u2013806."},{"issue":"2","key":"b3","series-title":"Br J Dermatol","first-page":"177","article-title":"Brachioradial pruritus: a tropical dermopathy","volume":"115","author":"Walcyk PJ","year":"1986","unstructured":"Walcyk PJ, Elpern DJ Brachioradial pruritus: a tropical dermopathy. Br J Dermatol. 1986;115(2):177\u2013180."},{"issue":"2","key":"b4","series-title":"Arch Dermatol","first-page":"115","article-title":"Brachioradial pruritus","volume":"119","author":"Heyl T","year":"1983","unstructured":"Heyl T Brachioradial pruritus. Arch Dermatol. 1983;119(2):115\u2013116."},{"issue":"11","key":"b5","series-title":"Int J Dermatol","first-page":"817","article-title":"Brachioradial pruritus wanted: a sure cause (and cure) for brachioradial pruritus","volume":"36","author":"Fisher DA","year":"1997","unstructured":"Fisher DA Brachioradial pruritus wanted: a sure cause (and cure) for brachioradial pruritus. Int J Dermatol. 1997;36(11):817\u2013818."},{"issue":"4","key":"b6","series-title":"J Am Acad Dermatol","first-page":"521","article-title":"Brachioradial pruritus: cervical spine disease and neurogenic\/neuropathic [corrected] pruritus","volume":"48","author":"Goodkin R","year":"2003","unstructured":"Goodkin R, Wingard E, Bernhard JD Brachioradial pruritus: cervical spine disease and neurogenic\/neuropathic [corrected] pruritus. J Am Acad Dermatol. 2003;48(4):521\u2013524."},{"issue":"6","key":"b7","series-title":"Nat Clin Pract Neurol","first-page":"338","article-title":"A case of neuropathic brachioradial pruritus caused by cervical disc herniation","volume":"4","author":"Binder A","year":"2008","unstructured":"Binder A, F\u00f6lster-Holst R, Sahan G,  A case of neuropathic brachioradial pruritus caused by cervical disc herniation. Nat Clin Pract Neurol. 2008;4(6):338\u2013342."},{"issue":"3","key":"b8","series-title":"Australas J Dermatol","first-page":"168","article-title":"Brachioradial pruritus and cervical spine manipulation","volume":"39","author":"Tait CP","year":"1998","unstructured":"Tait CP, Grigg E, Quirk CJ Brachioradial pruritus and cervical spine manipulation. Australas J Dermatol. 1998;39(3):168\u2013170."},{"issue":"6","key":"b9","series-title":"J Am Acad Dermatol","first-page":"825","article-title":"Brachioradial pruritus: a symptom of neuropathy","volume":"48","author":"Cohen AD","year":"2003","unstructured":"Cohen AD, Masalha R, Medvedovsky E, Vardy DA Brachioradial pruritus: a symptom of neuropathy. J Am Acad Dermatol. 2003;48(6):825\u2013828."},{"issue":"4","key":"b10","series-title":"N Engl J Med","first-page":"392","article-title":"Cervical radiculopathy","volume":"353","author":"Carette S","year":"2005","unstructured":"Carette S, Fehlings MG Cervical radiculopathy. N Engl J Med. 2005;353(4):392\u2013399."},{"key":"b11","series-title":"World Neurosurg","first-page":"207","article-title":"Effect of cervical decompression on atypical symptoms cervical spondylosis\u2014a narrative review and meta-analysis","volume":"157","author":"Garg K","year":"2022","unstructured":"Garg K, Aggarwal A Effect of cervical decompression on atypical symptoms cervical spondylosis\u2014a narrative review and meta-analysis. World Neurosurg. 2022;157:207\u2013217.e1."},{"issue":"6","key":"b12","series-title":"Clin Spine Surg","first-page":"255","article-title":"Mid-term outcomes of anterior cervical fusion for cervical spondylosis with sympathetic symptoms","volume":"29","author":"Li J","year":"2016","unstructured":"Li J, Jiang DJ, Wang XW, Yuan W, Liang L, Wang ZC Mid-term outcomes of anterior cervical fusion for cervical spondylosis with sympathetic symptoms. Clin Spine Surg. 2016;29(6):255\u2013260."},{"issue":"7","key":"b13","series-title":"Eur Spine J","first-page":"1553","article-title":"Effect of total disc replacement on atypical symptoms associated with cervical spondylosis","volume":"22","author":"Sun YQ","year":"2013","unstructured":"Sun YQ, Zheng S, Yu J, Yan K, Tian W Effect of total disc replacement on atypical symptoms associated with cervical spondylosis. Eur Spine J. 2013;22(7):1553\u20131557."},{"issue":"2","key":"b14","series-title":"J Neurosurg","first-page":"169","article-title":"Atypical presentation of C-7 radiculopathy","volume":"99","author":"Ozgur BM","year":"2003","unstructured":"Ozgur BM, Marshall LF Atypical presentation of C-7 radiculopathy. J Neurosurg. 2003;99(2 suppl):169\u2013171."},{"issue":"8","key":"b15","series-title":"J Surg Case Rep","first-page":"rjac277","article-title":"Brachioradial pruritus secondary to cervical disc protrusion \u2013 a case report","volume":"2022","author":"Morosanu CO","year":"2022","unstructured":"Morosanu CO, Etim G, Alalade AF Brachioradial pruritus secondary to cervical disc protrusion \u2013 a case report. J Surg Case Rep. 2022;2022(8):rjac277."},{"issue":"3","key":"b16","series-title":"J Am Acad Orthop Surg Glob Res Rev","first-page":"e19.00178","article-title":"Disabling pruritus in a patient with cervical stenosis","volume":"4","author":"Salzmann SN","year":"2020","unstructured":"Salzmann SN, Okano I, Shue J, Hughes AP Disabling pruritus in a patient with cervical stenosis. J Am Acad Orthop Surg Glob Res Rev. 2020;4(3):e19.00178."},{"issue":"1","key":"b17","series-title":"J Am Acad Dermatol","first-page":"142","article-title":"Brachioradial pruritus is associated with a reduction in cutaneous innervation that normalizes during the symptom-free remissions","volume":"52","author":"Wallengren J","year":"2005","unstructured":"Wallengren J, Sundler F Brachioradial pruritus is associated with a reduction in cutaneous innervation that normalizes during the symptom-free remissions. J Am Acad Dermatol. 2005;52(1):142\u2013145."},{"issue":"3","key":"b18","series-title":"Int J Dermatol","first-page":"206","article-title":"Solar (brachioradial) pruritus\u2014response to capsaicin cream","volume":"33","author":"Knight TE","year":"1994","unstructured":"Knight TE, Hayashi T Solar (brachioradial) pruritus\u2014response to capsaicin cream. Int J Dermatol. 1994;33(3):206\u2013209."},{"issue":"6","key":"b19","series-title":"Clin Exp Dermatol","first-page":"637","article-title":"Brachioradial pruritus\u2014an enigmatic entity","volume":"29","author":"Barry R","year":"2004","unstructured":"Barry R, Rogers S Brachioradial pruritus\u2014an enigmatic entity. Clin Exp Dermatol. 2004;29(6):637\u2013638."},{"issue":"3","key":"b20","series-title":"JMIR Dermatol","first-page":"e39863","article-title":"Brachioradial pruritus due to cervical spine pathology","volume":"5","author":"Grabnar M","year":"2022","unstructured":"Grabnar M, Tiwari M, Vallabh J Brachioradial pruritus due to cervical spine pathology. JMIR Dermatol. 2022;5(3):e39863."},{"issue":"4","key":"b21","series-title":"J Am Acad Dermatol","first-page":"756","article-title":"Brachioradial pruritus as a result of cervical spine pathology: the results of a magnetic resonance tomography study","volume":"65","author":"Marziniak M","year":"2011","unstructured":"Marziniak M, Phan NQ, Raap U,  Brachioradial pruritus as a result of cervical spine pathology: the results of a magnetic resonance tomography study. J Am Acad Dermatol. 2011;65(4):756\u2013762."},{"issue":"4","key":"b22","series-title":"Spine J","first-page":"540","article-title":"Dimensional changes of the neuroforamina in subaxial cervical spine during in\u00a0vivo dynamic flexion-extension","volume":"16","author":"Mao H","year":"2016","unstructured":"Mao H, Driscoll SJ, Li JS, Li G, Wood KB, Cha TD Dimensional changes of the neuroforamina in subaxial cervical spine during in\u00a0vivo dynamic flexion-extension. Spine J. 2016;16(4):540\u2013546."},{"issue":"16","key":"b23","series-title":"Spine (Phila Pa 1976)","first-page":"1850","article-title":"Cervical spine nerve root compression. An analysis of neuroforaminal pressures with varying head and arm positions","volume":"19","author":"Farmer JC","year":"1994","unstructured":"Farmer JC, Wisneski RJ Cervical spine nerve root compression. An analysis of neuroforaminal pressures with varying head and arm positions. Spine (Phila Pa 1976). 1994;19(16):1850\u20131855."},{"issue":"5","key":"b1","series-title":"Arch Dermatol","first-page":"481","article-title":"Solar pruritus of the elbows (brachioradial summer pruritus)","volume":"98","author":"Waisman M","year":"1968","unstructured":"Waisman M Solar pruritus of the elbows (brachioradial summer pruritus). Arch Dermatol. 1968;98(5):481\u2013485."},{"issue":"5 Pt 1","key":"b2","series-title":"J Am Acad Dermatol","first-page":"803","article-title":"Brachioradial pruritus: a recurrent solar dermopathy","volume":"39","author":"Wallengren J","year":"1998","unstructured":"Wallengren J Brachioradial pruritus: a recurrent solar dermopathy. J Am Acad Dermatol. 1998;39(5 Pt 1):803\u2013806."},{"issue":"2","key":"b3","series-title":"Br J Dermatol","first-page":"177","article-title":"Brachioradial pruritus: a tropical dermopathy","volume":"115","author":"Walcyk PJ","year":"1986","unstructured":"Walcyk PJ, Elpern DJ Brachioradial pruritus: a tropical dermopathy. Br J Dermatol. 1986;115(2):177\u2013180."},{"issue":"2","key":"b4","series-title":"Arch Dermatol","first-page":"115","article-title":"Brachioradial pruritus","volume":"119","author":"Heyl T","year":"1983","unstructured":"Heyl T Brachioradial pruritus. Arch Dermatol. 1983;119(2):115\u2013116."},{"issue":"11","key":"b5","series-title":"Int J Dermatol","first-page":"817","article-title":"Brachioradial pruritus wanted: a sure cause (and cure) for brachioradial pruritus","volume":"36","author":"Fisher DA","year":"1997","unstructured":"Fisher DA Brachioradial pruritus wanted: a sure cause (and cure) for brachioradial pruritus. Int J Dermatol. 1997;36(11):817\u2013818."},{"issue":"4","key":"b6","series-title":"J Am Acad Dermatol","first-page":"521","article-title":"Brachioradial pruritus: cervical spine disease and neurogenic\/neuropathic [corrected] pruritus","volume":"48","author":"Goodkin R","year":"2003","unstructured":"Goodkin R, Wingard E, Bernhard JD Brachioradial pruritus: cervical spine disease and neurogenic\/neuropathic [corrected] pruritus. J Am Acad Dermatol. 2003;48(4):521\u2013524."},{"issue":"6","key":"b7","series-title":"Nat Clin Pract Neurol","first-page":"338","article-title":"A case of neuropathic brachioradial pruritus caused by cervical disc herniation","volume":"4","author":"Binder A","year":"2008","unstructured":"Binder A, F\u00f6lster-Holst R, Sahan G,  A case of neuropathic brachioradial pruritus caused by cervical disc herniation. Nat Clin Pract Neurol. 2008;4(6):338\u2013342."},{"issue":"3","key":"b8","series-title":"Australas J Dermatol","first-page":"168","article-title":"Brachioradial pruritus and cervical spine manipulation","volume":"39","author":"Tait CP","year":"1998","unstructured":"Tait CP, Grigg E, Quirk CJ Brachioradial pruritus and cervical spine manipulation. Australas J Dermatol. 1998;39(3):168\u2013170."},{"issue":"6","key":"b9","series-title":"J Am Acad Dermatol","first-page":"825","article-title":"Brachioradial pruritus: a symptom of neuropathy","volume":"48","author":"Cohen AD","year":"2003","unstructured":"Cohen AD, Masalha R, Medvedovsky E, Vardy DA Brachioradial pruritus: a symptom of neuropathy. J Am Acad Dermatol. 2003;48(6):825\u2013828."},{"issue":"4","key":"b10","series-title":"N Engl J Med","first-page":"392","article-title":"Cervical radiculopathy","volume":"353","author":"Carette S","year":"2005","unstructured":"Carette S, Fehlings MG Cervical radiculopathy. N Engl J Med. 2005;353(4):392\u2013399."},{"key":"b11","series-title":"World Neurosurg","first-page":"207","article-title":"Effect of cervical decompression on atypical symptoms cervical spondylosis\u2014a narrative review and meta-analysis","volume":"157","author":"Garg K","year":"2022","unstructured":"Garg K, Aggarwal A Effect of cervical decompression on atypical symptoms cervical spondylosis\u2014a narrative review and meta-analysis. World Neurosurg. 2022;157:207\u2013217.e1."},{"issue":"6","key":"b12","series-title":"Clin Spine Surg","first-page":"255","article-title":"Mid-term outcomes of anterior cervical fusion for cervical spondylosis with sympathetic symptoms","volume":"29","author":"Li J","year":"2016","unstructured":"Li J, Jiang DJ, Wang XW, Yuan W, Liang L, Wang ZC Mid-term outcomes of anterior cervical fusion for cervical spondylosis with sympathetic symptoms. Clin Spine Surg. 2016;29(6):255\u2013260."},{"issue":"7","key":"b13","series-title":"Eur Spine J","first-page":"1553","article-title":"Effect of total disc replacement on atypical symptoms associated with cervical spondylosis","volume":"22","author":"Sun YQ","year":"2013","unstructured":"Sun YQ, Zheng S, Yu J, Yan K, Tian W Effect of total disc replacement on atypical symptoms associated with cervical spondylosis. Eur Spine J. 2013;22(7):1553\u20131557."},{"issue":"2","key":"b14","series-title":"J Neurosurg","first-page":"169","article-title":"Atypical presentation of C-7 radiculopathy","volume":"99","author":"Ozgur BM","year":"2003","unstructured":"Ozgur BM, Marshall LF Atypical presentation of C-7 radiculopathy. J Neurosurg. 2003;99(2 suppl):169\u2013171."},{"issue":"8","key":"b15","series-title":"J Surg Case Rep","first-page":"rjac277","article-title":"Brachioradial pruritus secondary to cervical disc protrusion \u2013 a case report","volume":"2022","author":"Morosanu CO","year":"2022","unstructured":"Morosanu CO, Etim G, Alalade AF Brachioradial pruritus secondary to cervical disc protrusion \u2013 a case report. J Surg Case Rep. 2022;2022(8):rjac277."},{"issue":"3","key":"b16","series-title":"J Am Acad Orthop Surg Glob Res Rev","first-page":"e19.00178","article-title":"Disabling pruritus in a patient with cervical stenosis","volume":"4","author":"Salzmann SN","year":"2020","unstructured":"Salzmann SN, Okano I, Shue J, Hughes AP Disabling pruritus in a patient with cervical stenosis. J Am Acad Orthop Surg Glob Res Rev. 2020;4(3):e19.00178."},{"issue":"1","key":"b17","series-title":"J Am Acad Dermatol","first-page":"142","article-title":"Brachioradial pruritus is associated with a reduction in cutaneous innervation that normalizes during the symptom-free remissions","volume":"52","author":"Wallengren J","year":"2005","unstructured":"Wallengren J, Sundler F Brachioradial pruritus is associated with a reduction in cutaneous innervation that normalizes during the symptom-free remissions. J Am Acad Dermatol. 2005;52(1):142\u2013145."},{"issue":"3","key":"b18","series-title":"Int J Dermatol","first-page":"206","article-title":"Solar (brachioradial) pruritus\u2014response to capsaicin cream","volume":"33","author":"Knight TE","year":"1994","unstructured":"Knight TE, Hayashi T Solar (brachioradial) pruritus\u2014response to capsaicin cream. Int J Dermatol. 1994;33(3):206\u2013209."},{"issue":"6","key":"b19","series-title":"Clin Exp Dermatol","first-page":"637","article-title":"Brachioradial pruritus\u2014an enigmatic entity","volume":"29","author":"Barry R","year":"2004","unstructured":"Barry R, Rogers S Brachioradial pruritus\u2014an enigmatic entity. Clin Exp Dermatol. 2004;29(6):637\u2013638."},{"issue":"3","key":"b20","series-title":"JMIR Dermatol","first-page":"e39863","article-title":"Brachioradial pruritus due to cervical spine pathology","volume":"5","author":"Grabnar M","year":"2022","unstructured":"Grabnar M, Tiwari M, Vallabh J Brachioradial pruritus due to cervical spine pathology. JMIR Dermatol. 2022;5(3):e39863."},{"issue":"4","key":"b21","series-title":"J Am Acad Dermatol","first-page":"756","article-title":"Brachioradial pruritus as a result of cervical spine pathology: the results of a magnetic resonance tomography study","volume":"65","author":"Marziniak M","year":"2011","unstructured":"Marziniak M, Phan NQ, Raap U,  Brachioradial pruritus as a result of cervical spine pathology: the results of a magnetic resonance tomography study. J Am Acad Dermatol. 2011;65(4):756\u2013762."},{"issue":"4","key":"b22","series-title":"Spine J","first-page":"540","article-title":"Dimensional changes of the neuroforamina in subaxial cervical spine during in\u00a0vivo dynamic flexion-extension","volume":"16","author":"Mao H","year":"2016","unstructured":"Mao H, Driscoll SJ, Li JS, Li G, Wood KB, Cha TD Dimensional changes of the neuroforamina in subaxial cervical spine during in\u00a0vivo dynamic flexion-extension. Spine J. 2016;16(4):540\u2013546."},{"issue":"16","key":"b23","series-title":"Spine (Phila Pa 1976)","first-page":"1850","article-title":"Cervical spine nerve root compression. An analysis of neuroforaminal pressures with varying head and arm positions","volume":"19","author":"Farmer JC","year":"1994","unstructured":"Farmer JC, Wisneski RJ Cervical spine nerve root compression. An analysis of neuroforaminal pressures with varying head and arm positions. 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