{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:30:57Z","timestamp":1787679057991,"version":"build-2784847793"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"19","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Cryptococcosis is the most common mycosis of the central nervous system. It may develop in immunocompetent and immunocompromised patients, the latter representing most cases. The most common presentation of the disease is meningitis, whereas intra-axial lesions in the form of cryptococcoma are less frequent with a greater tendency to present in immunocompetent patients. The presentation of pituitary cryptococcoma is exceptional. To the best of the authors\u2019 knowledge, there is only one case published in the medical literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors present the case of a 30-year-old male without a relevant medical history. He was referred to our center with a pituitary mass on magnetic resonance imaging and panhypopituitarism. The patient underwent endonasal endoscopic transsphenoidal tumor resection, and a histopathological diagnosis of pituitary cryptococcoma was made. Medical management included fluconazole and intravenous amphotericin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>This case underscores the neurosurgical and medical management of an exceptional clinical presentation of pituitary cryptococcoma in an immunocompetent patient. To the best of the authors\u2019 knowledge, there is only one case published in the medical literature. This case provides an invaluable review of the clinical, imaging, and therapeutic considerations regarding this exceptional clinical entity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case2372","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T08:37:35Z","timestamp":1684831055000},"source":"Crossref","is-referenced-by-count":2,"title":["Pituitary cryptococcoma in an immunocompetent patient with panhypopituitarism: illustrative case"],"prefix":"10.3171","volume":"5","author":[{"given":"Emmanuel","family":"Maciel-Ramos","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Castillejo-Adalid","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Job J.","family":"Rodr\u00edguez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario G.","family":"V\u00e1zquez-Lima","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blas E.","family":"L\u00f3pez-F\u00e9lix","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Rodr\u00edguez-Florido","sequence":"additional","affiliation":[{"name":"Pathology, Specialties Hospital of the National Medical Center \u201cSiglo XXI,\u201d Mexican Social Security Institute, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"World Neurosurg","first-page":"e349","article-title":"Intracranial cryptococcoma-clinicopathologic correlation and surgical outcome: a single-institution experience","volume":"115","author":"Uppar A","year":"2018","unstructured":"Uppar A, Raj ARP, Konar S,  Intracranial cryptococcoma-clinicopathologic correlation and surgical outcome: a single-institution experience. World Neurosurg. 2018;115:e349\u2013e359.29678697"},{"issue":"1","key":"b2","series-title":"Emerg Infect Dis","first-page":"14","article-title":"Projecting global occurrence of Cryptococcus gattii","volume":"16","author":"Springer DJ","year":"2010","unstructured":"Springer DJ, Chaturvedi V. Projecting global occurrence of Cryptococcus gattii. Emerg Infect Dis. 2010;16(1):14\u201320.20031037"},{"issue":"3","key":"b3","series-title":"Neurol India","first-page":"198","article-title":"Pathobiology of fungal infections of the central nervous system with special reference to the Indian scenario","volume":"55","author":"Shankar SK","year":"2007","unstructured":"Shankar SK, Mahadevan A, Sundaram C,  Pathobiology of fungal infections of the central nervous system with special reference to the Indian scenario. Neurol India. 2007;55(3):198\u2013215."},{"issue":"11","key":"b4","series-title":"Neurology","first-page":"1654","article-title":"Fungal infections of the central nervous system: comparative analysis of risk factors and clinical signs in 57 patients","volume":"35","author":"Walsh TJ","year":"1985","unstructured":"Walsh TJ, Hier DB, Caplan LR. Fungal infections of the central nervous system: comparative analysis of risk factors and clinical signs in 57 patients. Neurology. 1985;35(11):1654\u20131657.4058755"},{"issue":"3","key":"b5","series-title":"Radiol Case Rep","first-page":"824","article-title":"Cerebral cryptococcoma successfully treated by isavuconazole in an immunocompetent patient: a case report","volume":"18","author":"Ramanzini LG","year":"2022","unstructured":"Ramanzini LG, de Medeiros SDP, Lima LMFV,  Cerebral cryptococcoma successfully treated by isavuconazole in an immunocompetent patient: a case report. Radiol Case Rep. 2022;18(3):824\u2013829."},{"issue":"2","key":"b6","series-title":"Pathogens","first-page":"205","article-title":"Cerebral cryptococcomas: a systematic scoping review of available evidence to facilitate diagnosis and treatment","volume":"11","author":"Chastain DB","year":"2022","unstructured":"Chastain DB, Rao A, Yaseyyedi A, Henao-Mart\u00ednez AF, Borges T, Franco-Paredes C. Cerebral cryptococcomas: a systematic scoping review of available evidence to facilitate diagnosis and treatment. Pathogens. 2022;11(2):205.35215148"},{"issue":"6","key":"b7","series-title":"Neuroradiology","first-page":"449","article-title":"MRI of a pituitary cryptococcoma simulating an adenoma","volume":"37","author":"Yu YQ","year":"1995","unstructured":"Yu YQ, Jiang XX, Gao YJ. MRI of a pituitary cryptococcoma simulating an adenoma. Neuroradiology. 1995;37(6):449\u2013450.7477854"},{"issue":"3","key":"b8","series-title":"J Fungi (Basel)","first-page":"71","article-title":"Central nervous system cryptococcal infections in non-HIV infected patients","volume":"5","author":"Beardsley J","year":"2019","unstructured":"Beardsley J, Sorrell TC, Chen SC. Central nervous system cryptococcal infections in non-HIV infected patients. J Fungi (Basel). 2019;5(3):71.31382367"},{"issue":"1","key":"b9","series-title":"Acta Neurochir (Wien)","first-page":"129","article-title":"Central nervous system cryptococcoma in immunocompetent patients: a short review illustrated by a new case","volume":"152","author":"Li Q","year":"2010","unstructured":"Li Q, You C, Liu Q, Liu Y. Central nervous system cryptococcoma in immunocompetent patients: a short review illustrated by a new case. Acta Neurochir (Wien). 2010;152(1):129\u2013136."},{"key":"b10","series-title":"Surg Neurol Int","first-page":"114","article-title":"Brain cryptococcoma mimicking a glioblastoma in an immunocompetent patient: A rare case report and comprehensive review","volume":"13","author":"Boa Sorte AA Jr","year":"2022","unstructured":"Boa Sorte AA Jr, Garcia CC, Neto MR, de Oliveira MF, Rotta JM. Brain cryptococcoma mimicking a glioblastoma in an immunocompetent patient: A rare case report and comprehensive review. Surg Neurol Int. 2022;13:114."},{"key":"b1","series-title":"World Neurosurg","first-page":"e349","article-title":"Intracranial cryptococcoma-clinicopathologic correlation and surgical outcome: a single-institution experience","volume":"115","author":"Uppar A","year":"2018","unstructured":"Uppar A, Raj ARP, Konar S,  Intracranial cryptococcoma-clinicopathologic correlation and surgical outcome: a single-institution experience. 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