{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:25:46Z","timestamp":1769729146460,"version":"3.49.0"},"reference-count":12,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"12","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2024,9,16]]},"abstract":"\n BACKGROUND<\/jats:title>\n Pancreatoblastoma is a malignant neoplasm of the pancreas, occurring usually in children and rarely in adults. Treatment consists of surgery with a variable combination of adjuvant therapies. Liver metastases are common, whereas brain diffusion is exceptionally rare.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n The authors report the case of a 42-year-old man with a 16-year history of metastatic pancreatoblastoma, previously treated with surgery, chemotherapy, and radiotherapy, demonstrating a partial response. He presented with headache and dizziness, and brain magnetic resonance imaging (MRI) showed a cerebellar lesion. A craniotomy was performed with complete tumor removal, and the postoperative course was uneventful. Brain MRI showed gross-total resection of the lesion, and the patient was discharged with an improvement of the preoperative symptoms. Histopathological analysis confirmed the diagnosis of metastasis from pancreatoblastoma. The patient received adjuvant stereotactic radiotherapy and showed further clinical improvement at the last follow-up.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n Brain metastases from pancreatoblastoma are exceptionally rare and poorly described in the literature. There is no standard therapy for this condition; hence, patients usually undergo treatments similar to those for other central nervous system metastases. All the described patients have had good clinical outcomes yet short-term follow-ups; therefore, further investigations are needed to better understand the best treatments for this condition.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE23764<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case23764","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T02:43:46Z","timestamp":1726454626000},"source":"Crossref","is-referenced-by-count":1,"title":["A rare case of central nervous system pancreatoblastoma metastasis: illustrative case"],"prefix":"10.3171","volume":"8","author":[{"given":"Vincenzo","family":"Mastropasqua","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Obersnel","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Stifano","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gessi","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Cristiano Corsi","sequence":"additional","affiliation":[{"name":"Department of Oncology, Ospedale Isola Tiberina Gemelli Isola, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Doglietto","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"26","key":"bib1","series-title":"World J Gastroenterol","first-page":"4172","article-title":"Adult pancreatoblastoma: current concepts in pathology","volume":"27","author":"Omiyale","year":"2021","unstructured":"Omiyale AO. Adult pancreatoblastoma: current concepts in pathology. World J Gastroenterol. 2021;27(26):4172-4181."},{"issue":"3","key":"bib2","series-title":"Pancreatology","first-page":"425","article-title":"Metastatic adult pancreatoblastoma: multimodal treatment and molecular characterization of a very rare disease","volume":"20","author":"Berger","year":"2020","unstructured":"Berger AKMughal SSAllg\u00e4uer M, et al. Metastatic adult pancreatoblastoma: multimodal treatment and molecular characterization of a very rare disease. Pancreatology. 2020;20(3):425-432."},{"issue":"2","key":"bib3","series-title":"J Neurosurg","first-page":"169","article-title":"Pancreatoblastoma metastases to the brain. Case illustration","volume":"106","author":"Szerlip","year":"2007","unstructured":"Szerlip NJFox EManosca FPegram LDLonser RR. Pancreatoblastoma metastases to the brain. Case illustration. J Neurosurg. 2007;106(2suppl):169."},{"key":"bib4","series-title":"World Neurosurg","first-page":"334","article-title":"A rare case of pancreatoblastoma with intracranial seeding","volume":"142","author":"Snyder","year":"2020","unstructured":"Snyder MHAmpie LMandell JWHelm GASyed HR. A rare case of pancreatoblastoma with intracranial seeding. World Neurosurg. 2020;142:334-338."},{"issue":"1","key":"bib5","series-title":"Pancreatology","first-page":"188","article-title":"Successful treatment of metastatic pancreatoblastoma in an adult with autologous hematopoietic cell transplant","volume":"21","author":"Elghawy","year":"2021","unstructured":"Elghawy OWang JSWhitehair RMGrosh WKindwall-Keller TL. Successful treatment of metastatic pancreatoblastoma in an adult with autologous hematopoietic cell transplant. Pancreatology. 2021;21(1):188-191."},{"issue":"12","key":"bib6","series-title":"J Gastrointest Surg","first-page":"2153","article-title":"The diagnosis and surgical treatment of pancreatoblastoma in adults: a case series and review of the literature","volume":"17","author":"Salman","year":"2013","unstructured":"Salman BBrat GYoon YS, et al. The diagnosis and surgical treatment of pancreatoblastoma in adults: a case series and review of the literature. J Gastrointest Surg. 2013;17(12):2153-2161."},{"issue":"26","key":"bib1","series-title":"World J Gastroenterol","first-page":"4172","article-title":"Adult pancreatoblastoma: current concepts in pathology","volume":"27","author":"Omiyale","year":"2021","unstructured":"Omiyale AO. Adult pancreatoblastoma: current concepts in pathology. World J Gastroenterol. 2021;27(26):4172-4181."},{"issue":"3","key":"bib2","series-title":"Pancreatology","first-page":"425","article-title":"Metastatic adult pancreatoblastoma: multimodal treatment and molecular characterization of a very rare disease","volume":"20","author":"Berger","year":"2020","unstructured":"Berger AKMughal SSAllg\u00e4uer M, et al. Metastatic adult pancreatoblastoma: multimodal treatment and molecular characterization of a very rare disease. Pancreatology. 2020;20(3):425-432."},{"issue":"2","key":"bib3","series-title":"J Neurosurg","first-page":"169","article-title":"Pancreatoblastoma metastases to the brain. Case illustration","volume":"106","author":"Szerlip","year":"2007","unstructured":"Szerlip NJFox EManosca FPegram LDLonser RR. Pancreatoblastoma metastases to the brain. Case illustration. J Neurosurg. 2007;106(2suppl):169."},{"key":"bib4","series-title":"World Neurosurg","first-page":"334","article-title":"A rare case of pancreatoblastoma with intracranial seeding","volume":"142","author":"Snyder","year":"2020","unstructured":"Snyder MHAmpie LMandell JWHelm GASyed HR. A rare case of pancreatoblastoma with intracranial seeding. World Neurosurg. 2020;142:334-338."},{"issue":"1","key":"bib5","series-title":"Pancreatology","first-page":"188","article-title":"Successful treatment of metastatic pancreatoblastoma in an adult with autologous hematopoietic cell transplant","volume":"21","author":"Elghawy","year":"2021","unstructured":"Elghawy OWang JSWhitehair RMGrosh WKindwall-Keller TL. Successful treatment of metastatic pancreatoblastoma in an adult with autologous hematopoietic cell transplant. Pancreatology. 2021;21(1):188-191."},{"issue":"12","key":"bib6","series-title":"J Gastrointest Surg","first-page":"2153","article-title":"The diagnosis and surgical treatment of pancreatoblastoma in adults: a case series and review of the literature","volume":"17","author":"Salman","year":"2013","unstructured":"Salman BBrat GYoon YS, et al. The diagnosis and surgical treatment of pancreatoblastoma in adults: a case series and review of the literature. 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