{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:47:19Z","timestamp":1770353239855,"version":"3.49.0"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"26","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,26]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Radiation-induced glioblastoma (GBM) in patients previously treated for craniopharyngioma is a rare phenomenon. To the authors\u2019 knowledge, only seven cases have previously been documented in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>Herein, the authors report a case of a patient presenting with a new diagnosis of multifocal GBM 15 years after having received adjuvant radiotherapy for a craniopharyngioma. Magnetic resonance imaging revealed an extensive enhancing infiltrative lesion in the right frontal lobe as well as two satellite lesions in the contralateral frontal lobe. Histopathology on biopsy was consistent with GBM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Even though this case is rare, it is nevertheless important to recognize GBM as a potential side effect of radiation. Long-term follow-up in postradiation craniopharyngioma patients is crucial for early detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case2377","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T02:15:26Z","timestamp":1687832126000},"source":"Crossref","is-referenced-by-count":0,"title":["Development of multifocal glioblastoma after radiotherapy for craniopharyngioma: illustrative case"],"prefix":"10.3171","volume":"5","author":[{"given":"Edith","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J.","family":"Attenello","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Nat Rev Dis Primers","first-page":"75","article-title":"Craniopharyngioma","volume":"5","author":"M\u00fcller HL","year":"2019","unstructured":"M\u00fcller HL, Merchant TE, Warmuth-Metz M, Martinez-Barbera JP, Puget S. Craniopharyngioma. Nat Rev Dis Primers. 2019;5(1):75.31699993"},{"issue":"4","key":"b2","series-title":"Am Fam Physician","first-page":"381","article-title":"Managing the adverse effects of radiation therapy","volume":"82","author":"Berkey FJ","year":"2010","unstructured":"Berkey FJ. Managing the adverse effects of radiation therapy. Am Fam Physician. 2010;82(4):381\u2013388, 394.20704169"},{"issue":"1","key":"b3","series-title":"J Korean Neurosurg Soc","first-page":"54","article-title":"Should adjuvant radiotherapy be recommended for pediatric craniopharyngiomas?","volume":"55","author":"Dadlani R","year":"2014","unstructured":"Dadlani R, Ghosal N, Hegde AS. Should adjuvant radiotherapy be recommended for pediatric craniopharyngiomas? J Korean Neurosurg Soc. 2014;55(1):54\u201356.24570821"},{"issue":"7","key":"b4","series-title":"Clin Neurol Neurosurg","first-page":"591","article-title":"Radiation-induced gliomas following radiotherapy for craniopharyngiomas: a case report and review of the literature","volume":"111","author":"Enchev Y","year":"2009","unstructured":"Enchev Y, Ferdinandov D, Kounin G, Encheva E, Bussarsky V. Radiation-induced gliomas following radiotherapy for craniopharyngiomas: a case report and review of the literature. Clin Neurol Neurosurg. 2009;111(7):591\u2013596.19447544"},{"issue":"6","key":"b5","series-title":"J Int Med Res","first-page":"3000605211019258","article-title":"Estimation of the occurrence rates of IDH1 and IDH2 mutations in gliomas and the reconsideration of IDH-wildtype anaplastic astrocytomas: an institutional experience","volume":"49","author":"Cho U","year":"2021","unstructured":"Cho U, Yang SH, Yoo C. Estimation of the occurrence rates of IDH1 and IDH2 mutations in gliomas and the reconsideration of IDH-wildtype anaplastic astrocytomas: an institutional experience. J Int Med Res. 2021;49(6):3000605211019258.34162262"},{"key":"b6","series-title":"Ann Diagn Pathol","first-page":"151653","article-title":"IDH mutations in older patients with diffuse astrocytic gliomas","volume":"49","author":"Andrews C","year":"2020","unstructured":"Andrews C, Prayson RA. IDH mutations in older patients with diffuse astrocytic gliomas. Ann Diagn Pathol. 2020;49:151653.33137656"},{"issue":"12","key":"b7","series-title":"Front Biosci","first-page":"328","article-title":"Current approaches to craniopharyngioma management","volume":"27","author":"Diaz MJ","year":"2022","unstructured":"Diaz MJ, Kwak SH, Root KT,  Current approaches to craniopharyngioma management. Front Biosci. 2022;27(12):328."},{"issue":"1","key":"b8","series-title":"Pituitary","first-page":"26","article-title":"Radiotherapy for craniopharyngioma","volume":"16","author":"Aggarwal A","year":"2013","unstructured":"Aggarwal A, Fersht N, Brada M. Radiotherapy for craniopharyngioma. Pituitary. 2013;16(1):26\u201333.22948229"},{"key":"b9","series-title":"Front Endocrinol (Lausanne)","first-page":"39","article-title":"Intracystic therapies for cystic craniopharyngioma in childhood","volume":"3","author":"Bartels U","year":"2012","unstructured":"Bartels U, Laperriere N, Bouffet E, Drake J. Intracystic therapies for cystic craniopharyngioma in childhood. Front Endocrinol (Lausanne). 2012;3:39.22654864"},{"issue":"5","key":"b10","series-title":"Int J Radiat Oncol Biol Phys","first-page":"1480","article-title":"Proton radiation therapy for pediatric craniopharyngioma","volume":"110","author":"Jimenez RB","year":"2021","unstructured":"Jimenez RB, Ahmed S, Johnson A,  Proton radiation therapy for pediatric craniopharyngioma. Int J Radiat Oncol Biol Phys. 2021;110(5):1480\u20131487.33662460"},{"issue":"4","key":"b11","series-title":"Neurosurg Focus","first-page":"E13","article-title":"Intracystic treatments for craniopharyngioma","volume":"28","author":"Steinbok P","year":"2010","unstructured":"Steinbok P, Hukin J. Intracystic treatments for craniopharyngioma. Neurosurg Focus. 2010;28(4):E13.20367357"},{"issue":"7","key":"b12","series-title":"Cancer","first-page":"2227","article-title":"Glioma arising after radiation therapy for pituitary adenoma. 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