{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:38:25Z","timestamp":1770352705178,"version":"3.49.0"},"reference-count":12,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"16","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Congenital lipomatous overgrowth, vascular malformations, epidermal nevi, spinal\/skeletal anomalies, and\/or scoliosis (CLOVES) syndrome is the most recently described combined vascular anomaly characterized by congenital excessive growth of adipose tissue, vascular malformations, epidermal nevi, and skeletal deformities. This condition exhibits a significant variability in clinical manifestations and a tendency for rapid progression and affects extensive anatomical regions. Information regarding the association of epidural lipomatosis with low-flow venous lymphatic malformations is rare, with few reports in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors present a case of a 6-year-old girl who was admitted to the emergency department complaining of rapidly progressing weakness in her lower extremities and partial loss of sensation in the inguinal area. Radiologically, an extradural mass was identified at the T2\u20136 level, causing acute spinal cord compression. Urgent decompression and partial resection of the mass were performed. Despite satisfactory intraoperative hemo- and lymphostasis, postoperative lymphorrhea\/seroma leakage was encountered as a delayed complication and was managed conservatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>CLOVES syndrome is characterized by the combination of various clinical symptoms, not all of which are included in the abbreviation, as well as a progressively deteriorating course, the emergence of new symptoms, and complications throughout the patient\u2019s life. This necessitates ongoing monitoring of such patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case23772","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T02:42:55Z","timestamp":1713148975000},"source":"Crossref","is-referenced-by-count":1,"title":["Epidural lipomatosis with foci of hemorrhage and acute compression of the spinal cord in a child with CLOVES syndrome: illustrative case"],"prefix":"10.3171","volume":"7","author":[{"given":"Dmytro","family":"Ishchenko","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iryna","family":"Benzar","sequence":"additional","affiliation":[{"name":"Surgery, National Specialized Children\u2019s Hospital Ohmatdyt, Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrii","family":"Holoborodko","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"24","key":"b1","series-title":"Am J Med Genet A","first-page":"2944","article-title":"Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients","volume":"143A","author":"Sapp JC","year":"2007","unstructured":"Sapp JC, Turner JT, van de Kamp JM, van Dijk FS, Lowry RB, Biesecker LG. Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients. Am J Med Genet A. 2007;143A(24):2944\u20132958."},{"issue":"2","key":"b2","series-title":"J Thorac Cardiovasc Surg","first-page":"459","article-title":"CLOVES syndrome with thoracic and central phlebectasia: increased risk of pulmonary embolism","volume":"140","author":"Alomari AI","year":"2010","unstructured":"Alomari AI, Burrows PE, Lee EY, Hedequist DJ, Mulliken JB, Fishman SJ. CLOVES syndrome with thoracic and central phlebectasia: increased risk of pulmonary embolism. J Thorac Cardiovasc Surg. 2010;140(2):459\u2013463."},{"issue":"1","key":"b3","series-title":"Clin Dysmorphol","first-page":"1","article-title":"Characterization of a distinct syndrome that associates complex truncal overgrowth, vascular, and acral anomalies: a descriptive study of 18 cases of CLOVES syndrome","volume":"18","author":"Alomari AI","year":"2009","unstructured":"Alomari AI. Characterization of a distinct syndrome that associates complex truncal overgrowth, vascular, and acral anomalies: a descriptive study of 18 cases of CLOVES syndrome. Clin Dysmorphol. 2009;18(1):1\u20137."},{"issue":"4","key":"b4","series-title":"J Surg Case Rep","first-page":"b122","article-title":"CLOVES syndrome and cervical arteriovenous fistula: a unique association managed by combined microsurgical and endovascular therapy","volume":"2021","author":"Alhazzab A","year":"2021","unstructured":"Alhazzab A, Alkhaibary A, Khairy S, Alshaya W. CLOVES syndrome and cervical arteriovenous fistula: a unique association managed by combined microsurgical and endovascular therapy. J Surg Case Rep. 2021;2021(4):b122."},{"issue":"2","key":"b5","series-title":"Med Rep Case Stud","first-page":"1000135","article-title":"Arteriovenous malformation in CLOVES syndrome","volume":"2","author":"Haniyeh MDAA","year":"2017","unstructured":"Haniyeh MDAA, Alkukhun MDL, Al Natour MDM, Hassan M, Tonelli A. Arteriovenous malformation in CLOVES syndrome. Med Rep Case Stud. 2017;2(2):1000135."},{"key":"b6","series-title":"J Clin Neurosci","first-page":"232","article-title":"Combined endovascular and microsurgical treatment of a complex spinal arteriovenous fistula associated with CLOVES syndrome in an adult patient","volume":"34","author":"Boroumand MR","year":"2016","unstructured":"Boroumand MR, Kalani MYS, Spetzler RF. Combined endovascular and microsurgical treatment of a complex spinal arteriovenous fistula associated with CLOVES syndrome in an adult patient. J Clin Neurosci. 2016;34:232\u2013234."},{"issue":"24","key":"b1","series-title":"Am J Med Genet A","first-page":"2944","article-title":"Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients","volume":"143A","author":"Sapp JC","year":"2007","unstructured":"Sapp JC, Turner JT, van de Kamp JM, van Dijk FS, Lowry RB, Biesecker LG. Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients. Am J Med Genet A. 2007;143A(24):2944\u20132958."},{"issue":"2","key":"b2","series-title":"J Thorac Cardiovasc Surg","first-page":"459","article-title":"CLOVES syndrome with thoracic and central phlebectasia: increased risk of pulmonary embolism","volume":"140","author":"Alomari AI","year":"2010","unstructured":"Alomari AI, Burrows PE, Lee EY, Hedequist DJ, Mulliken JB, Fishman SJ. CLOVES syndrome with thoracic and central phlebectasia: increased risk of pulmonary embolism. J Thorac Cardiovasc Surg. 2010;140(2):459\u2013463."},{"issue":"1","key":"b3","series-title":"Clin Dysmorphol","first-page":"1","article-title":"Characterization of a distinct syndrome that associates complex truncal overgrowth, vascular, and acral anomalies: a descriptive study of 18 cases of CLOVES syndrome","volume":"18","author":"Alomari AI","year":"2009","unstructured":"Alomari AI. Characterization of a distinct syndrome that associates complex truncal overgrowth, vascular, and acral anomalies: a descriptive study of 18 cases of CLOVES syndrome. Clin Dysmorphol. 2009;18(1):1\u20137."},{"issue":"4","key":"b4","series-title":"J Surg Case Rep","first-page":"b122","article-title":"CLOVES syndrome and cervical arteriovenous fistula: a unique association managed by combined microsurgical and endovascular therapy","volume":"2021","author":"Alhazzab A","year":"2021","unstructured":"Alhazzab A, Alkhaibary A, Khairy S, Alshaya W. CLOVES syndrome and cervical arteriovenous fistula: a unique association managed by combined microsurgical and endovascular therapy. J Surg Case Rep. 2021;2021(4):b122."},{"issue":"2","key":"b5","series-title":"Med Rep Case Stud","first-page":"1000135","article-title":"Arteriovenous malformation in CLOVES syndrome","volume":"2","author":"Haniyeh MDAA","year":"2017","unstructured":"Haniyeh MDAA, Alkukhun MDL, Al Natour MDM, Hassan M, Tonelli A. Arteriovenous malformation in CLOVES syndrome. Med Rep Case Stud. 2017;2(2):1000135."},{"key":"b6","series-title":"J Clin Neurosci","first-page":"232","article-title":"Combined endovascular and microsurgical treatment of a complex spinal arteriovenous fistula associated with CLOVES syndrome in an adult patient","volume":"34","author":"Boroumand MR","year":"2016","unstructured":"Boroumand MR, Kalani MYS, Spetzler RF. Combined endovascular and microsurgical treatment of a complex spinal arteriovenous fistula associated with CLOVES syndrome in an adult patient. 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