{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:40:48Z","timestamp":1770352848574,"version":"3.49.0"},"reference-count":34,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"10","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The authors describe a 60-year-old female who underwent a correlative examination for an accidental scalp injury, revealing a sellar mass, which was surgically excised and pathologically confirmed to be a non-Hodgkin\u2019s small B-cell lymphoma. These findings in combination with the immunophenotype led to a final diagnosis of chronic lymphocytic leukemia\/small lymphocytic lymphoma. Previous studies have shown that hematological solid tumors occurring in the pituitary gland are extremely rare, and there are only approximately three other cases of living patients with similarities to this case, all of which had ambiguous expression of subsequent hematological treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>In this case, the authors used an endoscopic approach to completely excise the tumor. Follow-up of the patient was continued after surgery, and the patient is currently receiving standardized treatment with zanubrutinib.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>This patient did not have any previous history of tumor, had a good postoperative recovery with a normal quality of life, and still receives hormone replacement and zanubrutinib on a standardized basis. This is a complete case that has not been previously reported and reveals the diagnostic and therapeutic process of rare diseases in the sellar area.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case23773","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T12:23:12Z","timestamp":1709554992000},"source":"Crossref","is-referenced-by-count":1,"title":["Chronic lymphocytic leukemia\/small lymphocytic lymphoma arising in the pituitary gland: illustrative case"],"prefix":"10.3171","volume":"7","author":[{"given":"Hang","family":"Zhou","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Jia","sequence":"additional","affiliation":[{"name":"Pathology, The Second Hospital of Hebei Medical University, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Jia","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingjiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"Eur J Endocrinol.","first-page":"203","article-title":"Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry","volume":"156","author":"Saeger W","year":"2007","unstructured":"Saeger W, L\u00fcdecke DK, Buchfelder M, Fahlbusch R, Quabbe HJ, Petersenn S Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry. Eur J Endocrinol. 2007;156(2):203\u2013216."},{"issue":"4","key":"b2","series-title":"Pathologe.","first-page":"247","article-title":"Space occupying processes of the sellar region with emphasis on tumor-like lesions","volume":"24","author":"Saeger W","year":"2003","unstructured":"Saeger W Space occupying processes of the sellar region with emphasis on tumor-like lesions. Article in German. Pathologe. 2003;24(4):247\u2013254."},{"issue":"8","key":"b3","series-title":"J Neuropathol Exp Neurol.","first-page":"673","article-title":"Very unusual sellar\/suprasellar region masses: a review","volume":"78","author":"Abushamat LA","year":"2019","unstructured":"Abushamat LA, Kerr JM, Lopes MBS, Kleinschmidt-DeMasters BK Very unusual sellar\/suprasellar region masses: a review. J Neuropathol Exp Neurol. 2019;78(8):673\u2013684."},{"issue":"9","key":"b4","series-title":"Endocr J.","first-page":"1079","article-title":"The sellar region as presenting theater for hematologic malignancies-A 17-year single-center experience","volume":"69","author":"Pekic S","year":"2022","unstructured":"Pekic S, Stojanovic M, Manojlovic Gacic E, et\u00a0al. The sellar region as presenting theater for hematologic malignancies-A 17-year single-center experience. Endocr J. 2022;69(9):1079\u20131090."},{"issue":"6","key":"b5","series-title":"J Natl Compr Canc Netw.","first-page":"622","article-title":"NCCN Guidelines\u00ae Insights: Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma, Version 3.2022","volume":"20","author":"Wierda WG","year":"2022","unstructured":"Wierda WG, Brown J, Abramson JS, et\u00a0al. NCCN Guidelines\u00ae Insights: Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma, Version 3.2022. J Natl Compr Canc Netw. 2022;20(6):622\u2013634."},{"issue":"25","key":"b6","series-title":"Blood.","first-page":"2745","article-title":"iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL","volume":"131","author":"Hallek M","year":"2018","unstructured":"Hallek M, Cheson BD, Catovsky D, et\u00a0al. iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018;131(25):2745\u20132760."},{"issue":"1","key":"b7","series-title":"Hum Pathol.","first-page":"110","article-title":"Composite mantle cell lymphoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma: a clinicopathologic and molecular study","volume":"44","author":"Hoeller S","year":"2013","unstructured":"Hoeller S, Zhou Y, Kanagal-Shamanna R, et\u00a0al. Composite mantle cell lymphoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma: a clinicopathologic and molecular study. Hum Pathol. 2013;44(1):110\u2013121."},{"issue":"4","key":"b8","series-title":"J Neurosurg.","first-page":"924","article-title":"Combined chronic lymphocytic leukemia and prolactinoma: a rare occurrence in a patient presenting with pituitary apoplexy","volume":"119","author":"Krisht KM","year":"2013","unstructured":"Krisht KM, Palmer CA, Couldwell WT Combined chronic lymphocytic leukemia and prolactinoma: a rare occurrence in a patient presenting with pituitary apoplexy. J Neurosurg. 2013;119(4):924\u2013928."},{"issue":"4","key":"b9","series-title":"Br J Haematol.","first-page":"718","article-title":"Pituitary infiltration in B-cell chronic lymphocytic leukaemia","volume":"115","author":"Rye AD","year":"2001","unstructured":"Rye AD, Stitson RN, Dyer MJ Pituitary infiltration in B-cell chronic lymphocytic leukaemia. Br J Haematol. 2001;115(4):718."},{"issue":"1","key":"b10","series-title":"Appl Immunohistochem Mol Morphol.","first-page":"1","article-title":"Contribution of immunohistochemistry to small B-cell lymphoma classification","volume":"14","author":"Coelho Siqueira SA","year":"2006","unstructured":"Coelho Siqueira SA, Ferreira Alves VA, Beitler B, Otta MM, Nascimento Saldiva PH Contribution of immunohistochemistry to small B-cell lymphoma classification. Appl Immunohistochem Mol Morphol. 2006;14(1):1\u20136."},{"issue":"4","key":"b11","series-title":"J Clin Exp Hematop.","first-page":"124","article-title":"Differential diagnosis of chronic lymphocytic leukemia\/small lymphocytic lymphoma and other indolent lymphomas, including mantle cell lymphoma","volume":"60","author":"Yoshino T","year":"2020","unstructured":"Yoshino T, Tanaka T, Sato Y Differential diagnosis of chronic lymphocytic leukemia\/small lymphocytic lymphoma and other indolent lymphomas, including mantle cell lymphoma. J Clin Exp Hematop. 2020;60(4):124\u2013129."},{"issue":"2","key":"b12","series-title":"J Neurooncol.","first-page":"339","article-title":"Primary central nervous system lymphoma involving the hypothalamic-pituitary axis: a case series and pooled analysis","volume":"147","author":"Shin DW","year":"2020","unstructured":"Shin DW, Kim JH, Kim YH, Cho YH, Hong SH Primary central nervous system lymphoma involving the hypothalamic-pituitary axis: a case series and pooled analysis. J Neurooncol. 2020;147(2):339\u2013349."},{"key":"b13","series-title":"Adv Tech Stand Neurosurg.","first-page":"139","article-title":"Endoscopic endonasal surgery for uncommon pathologies of the sellar and parasellar regions","volume":"48","author":"Azab WA","year":"2023","unstructured":"Azab WA, Khan T, Alqunaee M, Al Bader A, Yousef W Endoscopic endonasal surgery for uncommon pathologies of the sellar and parasellar regions. Adv Tech Stand Neurosurg. 2023;48:139\u2013205."},{"key":"b14","series-title":"Endocrinol Diabetes Metab Case Rep.","first-page":"140029","article-title":"Burkitt\u2019s lymphoma presenting with hypopituitarism: a case report and review of literature","volume":"2014","author":"Foo SH","year":"2014","unstructured":"Foo SH, Sobah SA Burkitt\u2019s lymphoma presenting with hypopituitarism: a case report and review of literature. Endocrinol Diabetes Metab Case Rep. 2014;2014:140029."},{"issue":"12","key":"b15","series-title":"Eur J Case Rep Intern Med.","first-page":"002980","article-title":"Non-Hodgkin lymphoma causing hypopituitarism can imaging help diagnosis and management?","volume":"8","author":"Khan U","year":"2021","unstructured":"Khan U, Borg A, Beltechi R, et\u00a0al. Non-Hodgkin lymphoma causing hypopituitarism can imaging help diagnosis and management? 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Future Oncol. 2020;16(10):517\u2013523."},{"issue":"2","key":"b1","series-title":"Eur J Endocrinol.","first-page":"203","article-title":"Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry","volume":"156","author":"Saeger W","year":"2007","unstructured":"Saeger W, L\u00fcdecke DK, Buchfelder M, Fahlbusch R, Quabbe HJ, Petersenn S Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry. Eur J Endocrinol. 2007;156(2):203\u2013216."},{"issue":"4","key":"b2","series-title":"Pathologe.","first-page":"247","article-title":"Space occupying processes of the sellar region with emphasis on tumor-like lesions","volume":"24","author":"Saeger W","year":"2003","unstructured":"Saeger W Space occupying processes of the sellar region with emphasis on tumor-like lesions. Article in German. Pathologe. 2003;24(4):247\u2013254."},{"issue":"8","key":"b3","series-title":"J Neuropathol Exp Neurol.","first-page":"673","article-title":"Very unusual sellar\/suprasellar region masses: a review","volume":"78","author":"Abushamat LA","year":"2019","unstructured":"Abushamat LA, Kerr JM, Lopes MBS, Kleinschmidt-DeMasters BK Very unusual sellar\/suprasellar region masses: a review. J Neuropathol Exp Neurol. 2019;78(8):673\u2013684."},{"issue":"9","key":"b4","series-title":"Endocr J.","first-page":"1079","article-title":"The sellar region as presenting theater for hematologic malignancies-A 17-year single-center experience","volume":"69","author":"Pekic S","year":"2022","unstructured":"Pekic S, Stojanovic M, Manojlovic Gacic E, et\u00a0al. The sellar region as presenting theater for hematologic malignancies-A 17-year single-center experience. Endocr J. 2022;69(9):1079\u20131090."},{"issue":"6","key":"b5","series-title":"J Natl Compr Canc Netw.","first-page":"622","article-title":"NCCN Guidelines\u00ae Insights: Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma, Version 3.2022","volume":"20","author":"Wierda WG","year":"2022","unstructured":"Wierda WG, Brown J, Abramson JS, et\u00a0al. NCCN Guidelines\u00ae Insights: Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma, Version 3.2022. J Natl Compr Canc Netw. 2022;20(6):622\u2013634."},{"issue":"25","key":"b6","series-title":"Blood.","first-page":"2745","article-title":"iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL","volume":"131","author":"Hallek M","year":"2018","unstructured":"Hallek M, Cheson BD, Catovsky D, et\u00a0al. iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018;131(25):2745\u20132760."},{"issue":"1","key":"b7","series-title":"Hum Pathol.","first-page":"110","article-title":"Composite mantle cell lymphoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma: a clinicopathologic and molecular study","volume":"44","author":"Hoeller S","year":"2013","unstructured":"Hoeller S, Zhou Y, Kanagal-Shamanna R, et\u00a0al. Composite mantle cell lymphoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma: a clinicopathologic and molecular study. Hum Pathol. 2013;44(1):110\u2013121."},{"issue":"4","key":"b8","series-title":"J Neurosurg.","first-page":"924","article-title":"Combined chronic lymphocytic leukemia and prolactinoma: a rare occurrence in a patient presenting with pituitary apoplexy","volume":"119","author":"Krisht KM","year":"2013","unstructured":"Krisht KM, Palmer CA, Couldwell WT Combined chronic lymphocytic leukemia and prolactinoma: a rare occurrence in a patient presenting with pituitary apoplexy. J Neurosurg. 2013;119(4):924\u2013928."},{"issue":"4","key":"b9","series-title":"Br J Haematol.","first-page":"718","article-title":"Pituitary infiltration in B-cell chronic lymphocytic leukaemia","volume":"115","author":"Rye AD","year":"2001","unstructured":"Rye AD, Stitson RN, Dyer MJ Pituitary infiltration in B-cell chronic lymphocytic leukaemia. Br J Haematol. 2001;115(4):718."},{"issue":"1","key":"b10","series-title":"Appl Immunohistochem Mol Morphol.","first-page":"1","article-title":"Contribution of immunohistochemistry to small B-cell lymphoma classification","volume":"14","author":"Coelho Siqueira SA","year":"2006","unstructured":"Coelho Siqueira SA, Ferreira Alves VA, Beitler B, Otta MM, Nascimento Saldiva PH Contribution of immunohistochemistry to small B-cell lymphoma classification. Appl Immunohistochem Mol Morphol. 2006;14(1):1\u20136."},{"issue":"4","key":"b11","series-title":"J Clin Exp Hematop.","first-page":"124","article-title":"Differential diagnosis of chronic lymphocytic leukemia\/small lymphocytic lymphoma and other indolent lymphomas, including mantle cell lymphoma","volume":"60","author":"Yoshino T","year":"2020","unstructured":"Yoshino T, Tanaka T, Sato Y Differential diagnosis of chronic lymphocytic leukemia\/small lymphocytic lymphoma and other indolent lymphomas, including mantle cell lymphoma. J Clin Exp Hematop. 2020;60(4):124\u2013129."},{"issue":"2","key":"b12","series-title":"J Neurooncol.","first-page":"339","article-title":"Primary central nervous system lymphoma involving the hypothalamic-pituitary axis: a case series and pooled analysis","volume":"147","author":"Shin DW","year":"2020","unstructured":"Shin DW, Kim JH, Kim YH, Cho YH, Hong SH Primary central nervous system lymphoma involving the hypothalamic-pituitary axis: a case series and pooled analysis. J Neurooncol. 2020;147(2):339\u2013349."},{"key":"b13","series-title":"Adv Tech Stand Neurosurg.","first-page":"139","article-title":"Endoscopic endonasal surgery for uncommon pathologies of the sellar and parasellar regions","volume":"48","author":"Azab WA","year":"2023","unstructured":"Azab WA, Khan T, Alqunaee M, Al Bader A, Yousef W Endoscopic endonasal surgery for uncommon pathologies of the sellar and parasellar regions. Adv Tech Stand Neurosurg. 2023;48:139\u2013205."},{"key":"b14","series-title":"Endocrinol Diabetes Metab Case Rep.","first-page":"140029","article-title":"Burkitt\u2019s lymphoma presenting with hypopituitarism: a case report and review of literature","volume":"2014","author":"Foo SH","year":"2014","unstructured":"Foo SH, Sobah SA Burkitt\u2019s lymphoma presenting with hypopituitarism: a case report and review of literature. Endocrinol Diabetes Metab Case Rep. 2014;2014:140029."},{"issue":"12","key":"b15","series-title":"Eur J Case Rep Intern Med.","first-page":"002980","article-title":"Non-Hodgkin lymphoma causing hypopituitarism can imaging help diagnosis and management?","volume":"8","author":"Khan U","year":"2021","unstructured":"Khan U, Borg A, Beltechi R, et\u00a0al. Non-Hodgkin lymphoma causing hypopituitarism can imaging help diagnosis and management? 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