{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:49:15Z","timestamp":1770353355838,"version":"3.49.0"},"reference-count":86,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"26","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,26]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Rathke\u2019s cleft cyst (RCC) is a benign sellar\/suprasellar lesion often discovered incidentally. Rarely, symptomatic cases can present with headache and may exhibit concomitant aseptic meningitis or apoplexy. The authors describe a patient with an RCC presenting with recurring episodes of aseptic meningitis and ultimately inflammatory-type apoplexy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 30-year-old female presented with three episodes of intractable headaches over 2 months. Each episode\u2019s clinical picture was consistent with meningitis though cerebrospinal fluid cultures, and viral tests remained negative. Imaging demonstrated a sellar lesion, initially thought to be coincidental. On the third presentation, there was rapid interval growth of the lesion, adjacent cerebritis, and new endocrinopathy. Resection was then performed via an endoscopic endonasal approach. Pathology showed an RCC with acute and chronic inflammation and no evidence of hemorrhage. Cultures were negative for organisms. The patient received several weeks of antibiotic treatment with the resolution of all symptoms and no recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Recurrent aseptic meningitis with apoplexy-like symptoms is a rare presentation of RCC. The authors propose the term inflammatory apoplexy to describe such a presentation without evidence of abscess, necrosis, or hemorrhage. The mechanism is unclear although may be due to intermittent microleakage of cyst contents into the subarachnoid space.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case2383","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T02:15:42Z","timestamp":1687832142000},"source":"Crossref","is-referenced-by-count":0,"title":["Rathke\u2019s cleft cyst presenting with recurrent aseptic meningitis and inflammatory apoplexy: illustrative case"],"prefix":"10.3171","volume":"5","author":[{"given":"Roger","family":"Murayi","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery and Rosa Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megh M.","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Rosa Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joao Paulo","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Rosa Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio"},{"name":"Department of Neurosurgery, Mayo Jacksonville, Jacksonville, Florida; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"Yeaney","sequence":"additional","affiliation":[{"name":"Departments of Pathology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Isada","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varun R.","family":"Kshettry","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Rosa Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Handb Clin Neurol","first-page":"255","article-title":"Rathke\u2019s cleft cyst","volume":"124","author":"Larkin S","year":"2014","unstructured":"Larkin S, Karavitaki N, Ansorge O. 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