{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:39:49Z","timestamp":1770352789733,"version":"3.49.0"},"reference-count":80,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"16","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Primary spinal cord tumors, especially primary spinal cord glioblastoma multiforme (PSC-GBM), are exceptionally rare, accounting for less than 1.5% of all spinal tumors. Their infrequency and aggressive yet atypical presentation make diagnosis challenging. In uncertain cases, a surgical approach for tissue diagnosis is often optimal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 76-year-old male presented with a rapidly progressing clinical history marked by worsening extremity weakness, urinary retention, and periodic fecal incontinence alongside diffuse changes on neuraxis imaging. The patient, in whom subacute polyneuropathy was initially diagnosed, received multiple rounds of steroids and intravenous immunoglobulin without clinical improvement. Histopathological review of the biopsy tissue yielded an initial diagnosis of spindle cell neoplasm. Next-generation sequencing (NGS) is done routinely on all neuropathology specimens at the authors\u2019 institution, and methylation profiling is pursued in difficult cases. Ultimately, NGS and methylation profiling results were essential to an integrated final diagnosis of GBM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>PSC-GBM is a rare but highly aggressive occurrence of this tumor. Prolonged back pain, rapid neurological decline, and imaging changes warrant the consideration of lesional biopsy for precise disease characterization. In inconclusive cases, NGS has proved invaluable for clinical clarification and diagnosis, underscoring its importance for integrated diagnoses in guiding appropriate treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case24103","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T02:42:58Z","timestamp":1713148978000},"source":"Crossref","is-referenced-by-count":1,"title":["A rare case of atypical intradural extramedullary glioblastoma diagnosed utilizing next-generation sequencing and methylation profiling: illustrative case"],"prefix":"10.3171","volume":"7","author":[{"given":"William J","family":"Shelton","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karrar","family":"Aljiboori","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Stephen","family":"Nix","sequence":"additional","affiliation":[{"name":"Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Gokden","sequence":"additional","affiliation":[{"name":"Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Analiz","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"Curr Neurol Neurosci Rep","first-page":"320","article-title":"Adult primary intradural spinal cord tumors: a review","volume":"11","author":"Chamberlain MC","year":"2011","unstructured":"Chamberlain MC, Tredway TL. Adult primary intradural spinal cord tumors: a review. 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