{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:33:02Z","timestamp":1769729582906,"version":"3.49.0"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Neurolymphomatosis (NL) is a rare disease defined as an invasion of lymphoma into peripheral nerves, nerve roots, or nerve plexuses, including the cranial nerves. No clear treatment protocols have yet been defined for this pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>\n                      A woman in her 40s had a primary central nervous system lymphoma diagnosed from an intracranial tumor biopsy and underwent chemotherapy and radiation therapy. After she complained of pain in the trunk and extremities, magnetic resonance imaging and [\n                      <jats:sup>18<\/jats:sup>\n                      F]fluorodeoxyglucose (FDG) positron emission tomography (PET) performed 25 months after initial diagnosis revealed multiple lesions in the nerve ganglia, plexuses, and peripheral nerves from the cervical to the sacral spinal cord. Cerebrospinal fluid cytology revealed atypical lymphocytes and lymphoma dissemination in the spinal cavity. Based on these findings, NL was diagnosed. An intrathecal antineoplastic regimen temporarily reduced abnormal uptake of FDG, but the lesion recurred. After additional high-dose methotrexate therapy, FDG accumulation in the previously identified lesions disappeared. However, peripheral neuropathic pain and paraplegia remained. The patient died 9 months after the initial diagnosis of NL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>The authors reported a case of NL following primary central nervous system lymphoma. In this case, FDG-PET proved useful for diagnosis, and high-dose methotrexate therapy was temporarily effective.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/suppl\/10.3171\/CASE24107\">https:\/\/thejns.org\/doi\/suppl\/10.3171\/CASE24107<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case24107","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T02:48:52Z","timestamp":1719802132000},"source":"Crossref","is-referenced-by-count":0,"title":["Neurolymphomatosis secondary to primary central nervous system lymphoma: illustrative case"],"prefix":"10.3171","volume":"8","author":[{"given":"Hirofumi","family":"Asano","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishi","family":"Horiguchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chinatsu","family":"Kakinuma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohito","family":"Nagaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Aishima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Tosaka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhei","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"3","key":"bib1","series-title":"Muscle Nerve","first-page":"301","article-title":"Lymphoma and peripheral neuropathy: a clinical review","volume":"31","author":"Kelly","year":"2005","unstructured":"Kelly JJKarcher DS. Lymphoma and peripheral neuropathy: a clinical review. Muscle Nerve. 2005;31(3):301-313."},{"issue":"2","key":"bib2","series-title":"Neuro Oncol","first-page":"104","article-title":"Neurolymphomatosis","volume":"5","author":"Baehring","year":"2003","unstructured":"Baehring JMDamek DMartin ECBetensky RAHochberg FH. Neurolymphomatosis. Neuro Oncol. 2003;5(2):104-115."},{"issue":"24","key":"bib3","series-title":"Blood","first-page":"5005","article-title":"Neurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report","volume":"115","author":"Grisariu","year":"2010","unstructured":"Grisariu SAvni BBatchelor TT, et al. Neurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report. Blood. 2010;115(24):5005-5011."},{"key":"bib4","series-title":"Case Rep Oncol Med","first-page":"492329","article-title":"Neurolymphomatosis of brachial plexus in patients with non-Hodgkin\u2019s lymphoma","volume":"2013","author":"Choi","year":"2013","unstructured":"Choi YJShin JAKim YH, et al. Neurolymphomatosis of brachial plexus in patients with non-Hodgkin\u2019s lymphoma. Case Rep Oncol Med. 2013;2013:492329."},{"issue":"4","key":"bib5","series-title":"Neurology","first-page":"722","article-title":"Diagnosis of neurolymphomatosis with FDG PET","volume":"67","author":"Rosso","year":"2006","unstructured":"Rosso SMBruin HGWu KLBent MJ. Diagnosis of neurolymphomatosis with FDG PET. Neurology. 2006;67(4):722-723."},{"issue":"14","key":"bib6","series-title":"Neurology","first-page":"1102","article-title":"Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients","volume":"71","author":"Fischer","year":"2008","unstructured":"Fischer LMartus PWeller M, et al. Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients. Neurology. 2008;71(14):1102-1108."},{"issue":"9","key":"bib7","series-title":"Clin Nucl Med","first-page":"897","article-title":"18F-FDG PET\/CT diagnosis of vagus nerve neurolymphomatosis","volume":"37","author":"Tsang","year":"2012","unstructured":"Tsang HHCLee EYPAnthony MPKhong PL. 18F-FDG PET\/CT diagnosis of vagus nerve neurolymphomatosis. Clin Nucl Med. 2012;37(9):897-898."},{"issue":"6","key":"bib8","series-title":"Clin Nucl Med","first-page":"e261","article-title":"Neurolymphomatosis diagnosed by (18)F-FDG PET-CT","volume":"38","author":"Salm","year":"2013","unstructured":"Salm LPHiel BVStokkel MPM. Neurolymphomatosis diagnosed by (18)F-FDG PET-CT. Clin Nucl Med. 2013;38(6):e261-e262."},{"issue":"2","key":"bib9","series-title":"Neuro Oncol","first-page":"212","article-title":"Neurolymphomatosis: diagnosis, management, and outcomes in patients treated with rituximab","volume":"12","author":"Gan","year":"2010","unstructured":"Gan HKAzad ACher LMitchell PLR. Neurolymphomatosis: diagnosis, management, and outcomes in patients treated with rituximab. Neuro Oncol. 2010;12(2):212-215."},{"key":"bib10","series-title":"J Neurol","first-page":"851","article-title":"Neurolymphomatosis: a single-center experience of neuromuscular manifestations, treatments, and outcomes","volume":"268","author":"Jisun","year":"2021","unstructured":"Jisun JSun WKDuk HS. Neurolymphomatosis: a single-center experience of neuromuscular manifestations, treatments, and outcomes. J Neurol. 2021;268:851-859."},{"key":"bib11","series-title":"Intern Med","first-page":"1193","article-title":"Two cases of neurolymphomatosis with fatal bilateral vocal cord paralysis that were diagnosed with 18F-fluorodeoxyglucose positron emission tomography (FDG PET)\/CT","volume":"56","author":"Yuichiro","year":"2017","unstructured":"Yuichiro OYasuhiro KYotaro O, et al. Two cases of neurolymphomatosis with fatal bilateral vocal cord paralysis that were diagnosed with 18F-fluorodeoxyglucose positron emission tomography (FDG PET)\/CT. Intern Med. 2017;56:1193-1198."},{"issue":"3","key":"bib12","series-title":"Br J Haematol","first-page":"328","article-title":"Diagnosis of intravascular large B cell lymphoma: novel insights into clinicopathological features from 42 patients at a single institution over 20 years","volume":"187","author":"Kosei","year":"2019","unstructured":"Kosei MYoshiaki AKentaro N, et al. Diagnosis of intravascular large B cell lymphoma: novel insights into clinicopathological features from 42 patients at a single institution over 20 years. Br J Haematol. 2019;187(3):328-336."},{"issue":"1","key":"bib13","series-title":"Hematol Oncol","first-page":"43","article-title":"Neurolymphomatosis\u2013diagnosis and assessment of treatment response by FDG PET-CT","volume":"26","author":"Lin","year":"2008","unstructured":"Lin MKilanowska JTaper JChu J. Neurolymphomatosis\u2013diagnosis and assessment of treatment response by FDG PET-CT. Hematol Oncol. 2008;26(1):43-45."},{"issue":"12","key":"bib14","series-title":"J Neurol","first-page":"1159","article-title":"Negative sural nerve biopsy in neurolymphomatosis","volume":"246","author":"Bent","year":"1999","unstructured":"Bent MJBruin HGBos GMRivi\u00e8re GBSmitt PAS. Negative sural nerve biopsy in neurolymphomatosis. J Neurol. 1999;246(12):1159-1163."},{"issue":"3","key":"bib1","series-title":"Muscle Nerve","first-page":"301","article-title":"Lymphoma and peripheral neuropathy: a clinical review","volume":"31","author":"Kelly","year":"2005","unstructured":"Kelly JJKarcher DS. Lymphoma and peripheral neuropathy: a clinical review. Muscle Nerve. 2005;31(3):301-313."},{"issue":"2","key":"bib2","series-title":"Neuro Oncol","first-page":"104","article-title":"Neurolymphomatosis","volume":"5","author":"Baehring","year":"2003","unstructured":"Baehring JMDamek DMartin ECBetensky RAHochberg FH. Neurolymphomatosis. Neuro Oncol. 2003;5(2):104-115."},{"issue":"24","key":"bib3","series-title":"Blood","first-page":"5005","article-title":"Neurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report","volume":"115","author":"Grisariu","year":"2010","unstructured":"Grisariu SAvni BBatchelor TT, et al. Neurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report. Blood. 2010;115(24):5005-5011."},{"key":"bib4","series-title":"Case Rep Oncol Med","first-page":"492329","article-title":"Neurolymphomatosis of brachial plexus in patients with non-Hodgkin\u2019s lymphoma","volume":"2013","author":"Choi","year":"2013","unstructured":"Choi YJShin JAKim YH, et al. Neurolymphomatosis of brachial plexus in patients with non-Hodgkin\u2019s lymphoma. Case Rep Oncol Med. 2013;2013:492329."},{"issue":"4","key":"bib5","series-title":"Neurology","first-page":"722","article-title":"Diagnosis of neurolymphomatosis with FDG PET","volume":"67","author":"Rosso","year":"2006","unstructured":"Rosso SMBruin HGWu KLBent MJ. Diagnosis of neurolymphomatosis with FDG PET. Neurology. 2006;67(4):722-723."},{"issue":"14","key":"bib6","series-title":"Neurology","first-page":"1102","article-title":"Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients","volume":"71","author":"Fischer","year":"2008","unstructured":"Fischer LMartus PWeller M, et al. Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients. Neurology. 2008;71(14):1102-1108."},{"issue":"9","key":"bib7","series-title":"Clin Nucl Med","first-page":"897","article-title":"18F-FDG PET\/CT diagnosis of vagus nerve neurolymphomatosis","volume":"37","author":"Tsang","year":"2012","unstructured":"Tsang HHCLee EYPAnthony MPKhong PL. 18F-FDG PET\/CT diagnosis of vagus nerve neurolymphomatosis. Clin Nucl Med. 2012;37(9):897-898."},{"issue":"6","key":"bib8","series-title":"Clin Nucl Med","first-page":"e261","article-title":"Neurolymphomatosis diagnosed by (18)F-FDG PET-CT","volume":"38","author":"Salm","year":"2013","unstructured":"Salm LPHiel BVStokkel MPM. Neurolymphomatosis diagnosed by (18)F-FDG PET-CT. Clin Nucl Med. 2013;38(6):e261-e262."},{"issue":"2","key":"bib9","series-title":"Neuro Oncol","first-page":"212","article-title":"Neurolymphomatosis: diagnosis, management, and outcomes in patients treated with rituximab","volume":"12","author":"Gan","year":"2010","unstructured":"Gan HKAzad ACher LMitchell PLR. Neurolymphomatosis: diagnosis, management, and outcomes in patients treated with rituximab. Neuro Oncol. 2010;12(2):212-215."},{"key":"bib10","series-title":"J Neurol","first-page":"851","article-title":"Neurolymphomatosis: a single-center experience of neuromuscular manifestations, treatments, and outcomes","volume":"268","author":"Jisun","year":"2021","unstructured":"Jisun JSun WKDuk HS. Neurolymphomatosis: a single-center experience of neuromuscular manifestations, treatments, and outcomes. J Neurol. 2021;268:851-859."},{"key":"bib11","series-title":"Intern Med","first-page":"1193","article-title":"Two cases of neurolymphomatosis with fatal bilateral vocal cord paralysis that were diagnosed with 18F-fluorodeoxyglucose positron emission tomography (FDG PET)\/CT","volume":"56","author":"Yuichiro","year":"2017","unstructured":"Yuichiro OYasuhiro KYotaro O, et al. Two cases of neurolymphomatosis with fatal bilateral vocal cord paralysis that were diagnosed with 18F-fluorodeoxyglucose positron emission tomography (FDG PET)\/CT. Intern Med. 2017;56:1193-1198."},{"issue":"3","key":"bib12","series-title":"Br J Haematol","first-page":"328","article-title":"Diagnosis of intravascular large B cell lymphoma: novel insights into clinicopathological features from 42 patients at a single institution over 20 years","volume":"187","author":"Kosei","year":"2019","unstructured":"Kosei MYoshiaki AKentaro N, et al. Diagnosis of intravascular large B cell lymphoma: novel insights into clinicopathological features from 42 patients at a single institution over 20 years. Br J Haematol. 2019;187(3):328-336."},{"issue":"1","key":"bib13","series-title":"Hematol Oncol","first-page":"43","article-title":"Neurolymphomatosis\u2013diagnosis and assessment of treatment response by FDG PET-CT","volume":"26","author":"Lin","year":"2008","unstructured":"Lin MKilanowska JTaper JChu J. Neurolymphomatosis\u2013diagnosis and assessment of treatment response by FDG PET-CT. Hematol Oncol. 2008;26(1):43-45."},{"issue":"12","key":"bib14","series-title":"J Neurol","first-page":"1159","article-title":"Negative sural nerve biopsy in neurolymphomatosis","volume":"246","author":"Bent","year":"1999","unstructured":"Bent MJBruin HGBos GMRivi\u00e8re GBSmitt PAS. Negative sural nerve biopsy in neurolymphomatosis. J Neurol. 1999;246(12):1159-1163."}],"container-title":["Journal of Neurosurgery: Case Lessons"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/8\/1\/article-CASE24107.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/8\/1\/article-CASE24107.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/8\/1\/article-CASE24107.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:57:07Z","timestamp":1769687827000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/8\/1\/article-CASE24107.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":28,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/case24107","relation":{},"ISSN":["2694-1902"],"issn-type":[{"value":"2694-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,1]]}}}