{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:42:09Z","timestamp":1770352929290,"version":"3.49.0"},"reference-count":66,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"16","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The primary intracranial peripheral primitive neuroectodermal tumor (pPNET) is a lesion subtype within the Ewing sarcoma family of tumors. pPNETs are extremely uncommon pathologies, accounting for 0.03% of intracranial tumors and 1% to 2% of Ewing sarcoma cases. Given its histological aspect similar to other highly proliferative malignant neuroectodermal neoplasms, pPNET merits extensive workup for accurate diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 36-year-old male presented to the emergency department with a 1-year history of headaches in the right frontoparietal area, generalized tonic-clonic seizures, and a history of the resection of a tumor labeled as a meningioma 5 years before admission. He was neurologically intact. Brain magnetic resonance imaging revealed a heterogeneous focal lesion of 25 \u00d7 35 \u00d7 23 mm with a necrotic center and neoformative appearance in the right frontal cortex. The patient underwent multimodal treatment with gross-total resection, radiotherapy, and chemotherapy. Histopathological examination results supported the diagnosis of pPNET. At the 2-year follow-up, the patient had no new-onset symptoms, and brain imaging revealed absent signs of tumor recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>The present case describes an extraordinary pPNET case, initially confounded as a clear cell meningioma. Managing pPNET requires thorough investigation, careful differentiation from similar neuroectodermal lesions, and multimodal treatment to improve the patient\u2019s prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case24133","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T02:42:59Z","timestamp":1713148979000},"source":"Crossref","is-referenced-by-count":2,"title":["Primary intracranial peripheral primitive neuroectodermal tumor: lessons from an exceptionally rare neoplasm. Illustrative case"],"prefix":"10.3171","volume":"7","author":[{"given":"Jhon E","family":"Bocanegra-Becerra","sequence":"first","affiliation":[{"name":"School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru; and Departments of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Felipe","family":"Novoa-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan Jes\u00fas","family":"Latorre-Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"Pathology, Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norka","family":"Tacas-Gil","sequence":"additional","affiliation":[{"name":"Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolando","family":"Rojas-Apaza","sequence":"additional","affiliation":[{"name":"Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Perspect Pediatr Pathol","first-page":"27","article-title":"Peripheral primitive neuroectodermal tumors. 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