{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:26:27Z","timestamp":1769729187232,"version":"3.49.0"},"reference-count":60,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"7","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2024,8,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Vertebral hemangioma is the most common benign tumor of the spine, diagnosed incidentally in most cases. In 0.4% of patients, the lesion is considered aggressive, causing neurological deficits. This subtype of hemangioma is characterized by strong postcontrast enhancement, cortical lysis, and epidural extension causing myelopathy and\/or radiculopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 52-year-old man presented with myelopathy symptoms, namely lower-limb hypoesthesia up to the T4\u20135 sensory level, right leg hyposthenia, and urinary incontinence. Imaging studies revealed a giant dumbbell-shaped lesion causing spinal cord compression, associated with signal alteration of the T3 vertebral body. The diagnosis of schwannoma was not certain given the radiological features, so a biopsy was planned and confirmed the diagnosis of vertebral hemangioma. Preoperative embolization, spinal fusion, and gross-total resection of the extravertebral component of the lesion were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>This report should raise awareness of the differential diagnosis of dumbbell-shaped spinal tumors and the therapeutic strategies available for aggressive vertebral hemangiomas, a rare lesion that should be managed in a multidisciplinary setting.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE24190\">https:\/\/thejns.org\/doi\/10.3171\/CASE24190<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case24190","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T02:46:05Z","timestamp":1723430765000},"source":"Crossref","is-referenced-by-count":0,"title":["Aggressive giant dumbell-shaped thoracic vertebral hemangioma: illustrative case"],"prefix":"10.3171","volume":"8","author":[{"given":"Matteo","family":"Gionso","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Departments of Neurosurgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Baram","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"De Robertis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Departments of Neurosurgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Tomei","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Ajello","sequence":"additional","affiliation":[{"name":"Departments of Neuroradiology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Cariboni","sequence":"additional","affiliation":[{"name":"Departments of Thoracic Surgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Pessina","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Departments of Neurosurgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Fornari","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Capo","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"bib1","series-title":"Skelet Radiol","first-page":"25","article-title":"A systematic approach to vertebral hemangioma","volume":"44","author":"Gaudino","year":"2015","unstructured":"Gaudino SMartucci MColantonio R, et al. A systematic approach to vertebral hemangioma. Skelet Radiol. 2015;44(1):25-36."},{"issue":"8","key":"bib2","series-title":"Skelet Radiol","first-page":"442","article-title":"Benign vertebral hemangioma: MR-histological correlation","volume":"30","author":"Baudrez","year":"2001","unstructured":"Baudrez VGalant CVande Berg BC. Benign vertebral hemangioma: MR-histological correlation. Skelet Radiol. 2001;30(8):442-446."},{"issue":"1","key":"bib3","series-title":"J Neurosurg","first-page":"36","article-title":"The natural history and management of symptomatic and asymptomatic vertebral hemangiomas","volume":"78","author":"Fox","year":"1993","unstructured":"Fox MWOnofrio BM. The natural history and management of symptomatic and asymptomatic vertebral hemangiomas. J Neurosurg. 1993;78(1):36-45."},{"issue":"1055","key":"bib4","series-title":"Br J Radiol","first-page":"20140771","article-title":"Aggressive spinal haemangiomas: imaging correlates to clinical presentation with analysis of treatment algorithm and clinical outcomes","volume":"88","author":"Cloran","year":"2015","unstructured":"Cloran FJPukenas BALoevner LAAquino CSchuster JMohan S. Aggressive spinal haemangiomas: imaging correlates to clinical presentation with analysis of treatment algorithm and clinical outcomes. Br J Radiol. 2015;88(1055):20140771."},{"issue":"5","key":"bib5","series-title":"AJNR Am J Neuroradiol","first-page":"968","article-title":"Differentiating atypical hemangiomas and metastatic vertebral lesions: the role of T1-weighted dynamic contrast-enhanced MRI","volume":"39","author":"Morales","year":"2018","unstructured":"Morales KAArevalo-Perez JPeck KKHolodny AILis EKarimi S. Differentiating atypical hemangiomas and metastatic vertebral lesions: the role of T1-weighted dynamic contrast-enhanced MRI. AJNR Am J Neuroradiol. 2018;39(5):968-973."},{"issue":"1","key":"bib6","series-title":"Neurosurg Clin N Am","first-page":"17","article-title":"Comprehensive management of symptomatic and aggressive vertebral hemangiomas","volume":"19","author":"Acosta","year":"2008","unstructured":"Acosta FLJr, Sanai NChi JH, et al. Comprehensive management of symptomatic and aggressive vertebral hemangiomas. Neurosurg Clin N Am. 2008;19(1):17-29."},{"issue":"1","key":"bib7","series-title":"Eur J Radiol","first-page":"29","article-title":"Differential diagnosis of dumbbell lesions associated with spinal neural foraminal widening: imaging features","volume":"71","author":"Kivrak","year":"2009","unstructured":"Kivrak ASKoc OEmlik DKiresi DOdev KKalkan E. Differential diagnosis of dumbbell lesions associated with spinal neural foraminal widening: imaging features. Eur J Radiol. 2009;71(1):29-41."},{"issue":"1","key":"bib8","series-title":"J Korean Neurosurg Soc","first-page":"72","article-title":"Thoracic extradural cavernous hemangioma mimicking a dumbbell-shaped tumor","volume":"58","author":"Jeong","year":"2015","unstructured":"Jeong WJChoi ISeong HYRoh SW. Thoracic extradural cavernous hemangioma mimicking a dumbbell-shaped tumor. J Korean Neurosurg Soc. 2015;58(1):72-75."},{"key":"bib9","series-title":"World Neurosurg","first-page":"181","article-title":"Rare case of dumbbell-shaped spinal cavernous hemangioma and literature review","volume":"120","author":"Cossandi","year":"2018","unstructured":"Cossandi CFanti AGerosa A, et al. Rare case of dumbbell-shaped spinal cavernous hemangioma and literature review. 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Management of aggressive vertebral haemangioma and assessment of differentiating pointers between aggressive vertebral haemangioma and metastases\u2014a systematic review. Glob Spine J. 2023;13(4):1120-1133."},{"issue":"3","key":"bib16","series-title":"Asian Spine J","first-page":"483","article-title":"Blood loss in surgery for aggressive vertebral haemangioma with and without embolisation","volume":"9","author":"Robinson","year":"2015","unstructured":"Robinson YSheta RSalci KWillander J. Blood loss in surgery for aggressive vertebral haemangioma with and without embolisation. Asian Spine J. 2015;9(3):483-491."},{"issue":"5","key":"bib17","series-title":"Cancer Nurs","first-page":"E1","article-title":"Management of postembolization syndrome following hepatic transarterial chemoembolization for primary or metastatic liver cancer","volume":"39","author":"Blackburn","year":"2016","unstructured":"Blackburn HWest S. Management of postembolization syndrome following hepatic transarterial chemoembolization for primary or metastatic liver cancer. Cancer Nurs. 2016;39(5):E1-E18."},{"issue":"3","key":"bib18","series-title":"Diseases","article-title":"Preoperative embolization of vertebral metastasis: comprehensive review of the literature","volume":"11","author":"Faiella","year":"2023","unstructured":"Faiella ESantucci DVertulli D, et al. Preoperative embolization of vertebral metastasis: comprehensive review of the literature. Diseases. 2023;11(3):109."},{"issue":"6","key":"bib19","series-title":"Neurochirurgie","first-page":"458","article-title":"Int\u00e9r\u00eat d\u2019une prise en charge multimodale des h\u00e9mangiomes vert\u00e9braux symptomatiques: \u00e0 propos de 27 cas et revue de la litt\u00e9rature","volume":"63","author":"Delabar","year":"2017","unstructured":"Delabar VBruneau MBeuriat PA, et al. 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Asian Spine J. 2023;17(1):37-46."},{"issue":"2","key":"bib26","series-title":"Neurosurg Focus","first-page":"E7","article-title":"Surgical treatment of aggressive vertebral hemangiomas","volume":"41","author":"Vasudeva","year":"2016","unstructured":"Vasudeva VSChi JHGroff MW. Surgical treatment of aggressive vertebral hemangiomas. Neurosurg Focus. 2016;41(2):E7."},{"issue":"2","key":"bib27","series-title":"J Orthop Case Rep","first-page":"33","article-title":"Aggressive vertebral hemangioma causing spinal cord compression: presenting a study of two cases and review of literature","volume":"8","author":"Rai","year":"2018","unstructured":"Rai RRShah SDeogaonkar KDalvie S. Aggressive vertebral hemangioma causing spinal cord compression: presenting a study of two cases and review of literature. J Orthop Case Rep. 2018;8(2):33-37."},{"issue":"3","key":"bib28","series-title":"Orthopade","first-page":"221","article-title":"Surgical treatment of compressive spinal hemangioma: a case series of three patients and literature review","volume":"47","author":"Chen","year":"2018","unstructured":"Chen YLHu XDXu NJJiang WYMa WH. Surgical treatment of compressive spinal hemangioma: a case series of three patients and literature review. Orthopade. 2018;47(3):221-227."},{"issue":"7","key":"bib29","series-title":"Strahlenther Onkol","first-page":"648","article-title":"Radiotherapy for vertebral hemangioma: the single-center experience of 80 patients","volume":"198","author":"Aksoy","year":"2022","unstructured":"Aksoy RAAksu MGKorcum AFGenc M. Radiotherapy for vertebral hemangioma: the single-center experience of 80 patients. Strahlenther Onkol. 2022;198(7):648-653."},{"issue":"1","key":"bib30","series-title":"Int J Radiat Oncol Biol Phys","first-page":"217","article-title":"Radiotherapy for symptomatic vertebral hemangiomas: results of a multicenter study and literature review","volume":"77","author":"Heyd","year":"2010","unstructured":"Heyd RSeegenschmiedt MHRades D, et al. Radiotherapy for symptomatic vertebral hemangiomas: results of a multicenter study and literature review. Int J Radiat Oncol Biol Phys. 2010;77(1):217-225."},{"issue":"1","key":"bib1","series-title":"Skelet Radiol","first-page":"25","article-title":"A systematic approach to vertebral hemangioma","volume":"44","author":"Gaudino","year":"2015","unstructured":"Gaudino SMartucci MColantonio R, et al. A systematic approach to vertebral hemangioma. 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Management of postembolization syndrome following hepatic transarterial chemoembolization for primary or metastatic liver cancer. Cancer Nurs. 2016;39(5):E1-E18."},{"issue":"3","key":"bib18","series-title":"Diseases","article-title":"Preoperative embolization of vertebral metastasis: comprehensive review of the literature","volume":"11","author":"Faiella","year":"2023","unstructured":"Faiella ESantucci DVertulli D, et al. Preoperative embolization of vertebral metastasis: comprehensive review of the literature. Diseases. 2023;11(3):109."},{"issue":"6","key":"bib19","series-title":"Neurochirurgie","first-page":"458","article-title":"Int\u00e9r\u00eat d\u2019une prise en charge multimodale des h\u00e9mangiomes vert\u00e9braux symptomatiques: \u00e0 propos de 27 cas et revue de la litt\u00e9rature","volume":"63","author":"Delabar","year":"2017","unstructured":"Delabar VBruneau MBeuriat PA, et al. 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