{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:56:39Z","timestamp":1770116199305,"version":"3.49.0"},"reference-count":90,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"12","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,3,24]]},"abstract":"\n BACKGROUND<\/jats:title>\n Histiocytic sarcoma (HS) is a rare malignant tumor of histiocytic origin, both morphologically and immunohistologically. Herein, the authors report the case of a suprasellar tumor confirmed as HS after craniotomy, which presented a diagnostic challenge.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n A 58-year-old man presented with panhypopituitarism. To protect the patient\u2019s visual function and obtain a diagnosis, craniotomy was performed for tumor removal. Based on the immunohistological staining results, the tumor tested positive for both CD68 and CD163 and negative for CD1a, CD21, and MP0. Hence, the patient was diagnosed with HS. The tumor grew rapidly after surgery. Thus, the patient underwent reoperation. The patient\u2019s visual acuity and visual field deficits improved. However, he developed intractable electrolyte abnormalities caused by hypothalamic damage. Then, he exhibited intractable seizures and pneumonia and died 4 months after surgery.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n This report emphasizes the rarity of suprasellar HS and its associated challenges in diagnosis and surgical treatment.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE24297<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case24297","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T16:38:00Z","timestamp":1742920680000},"source":"Crossref","is-referenced-by-count":0,"title":["Histiocytic sarcoma of the suprasellar region: illustrative case"],"prefix":"10.3171","volume":"9","author":[{"given":"Ikuya","family":"Natori","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Showa University School of Medicine, Shinagawa, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Tanioka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Showa University School of Medicine, Shinagawa, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Showa University School of Medicine, Shinagawa, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Showa University School of Medicine, Shinagawa, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Showa University School of Medicine, Shinagawa, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2526-3653","authenticated-orcid":true,"given":"Mutsuko","family":"Omatsu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"5","key":"bib1","series-title":"Arch Pathol Lab Med","first-page":"650","article-title":"Histiocytic sarcoma","volume":"144","author":"Hung","year":"2020","unstructured":"Hung YPQian X.Histiocytic sarcoma. Arch Pathol Lab Med. 2020;144(5):650-654."},{"issue":"9","key":"bib2","series-title":"Am J Surg Pathol","first-page":"1133","article-title":"Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy","volume":"28","author":"Hornick","year":"2004","unstructured":"Hornick JLJaffe ESFletcher CD.Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol. 2004;28(9):1133-1144."},{"issue":"5","key":"bib3","series-title":"Mod Pathol","first-page":"693","article-title":"Histiocytic sarcoma: a study of five cases including the histiocyte marker CD163","volume":"18","author":"Vos","year":"2005","unstructured":"Vos JAAbbondanzo SLBarekman CLAndriko JWMiettinen MAguilera NS.Histiocytic sarcoma: a study of five cases including the histiocyte marker CD163. Mod Pathol. 2005;18(5):693-704."},{"key":"bib4","series-title":"Ann Diagn Pathol","first-page":"56","article-title":"Primary cutaneous histiocytic sarcoma: a report of five cases with primary cutaneous involvement and review of the literature","volume":"32","author":"Magro","year":"2018","unstructured":"Magro CMKazi NAimee ESisinger AE.Primary cutaneous histiocytic sarcoma: a report of five cases with primary cutaneous involvement and review of the literature. Ann Diagn Pathol. 2018;32:56-62."},{"issue":"11","key":"bib5","series-title":"Am J Surg Pathol","first-page":"1372","article-title":"Primary histiocytic lymphoma of the central nervous system: a neoplasm frequently overshadowed by a prominent inflammatory component","volume":"25","author":"Cheuk","year":"2001","unstructured":"Cheuk WWalford NLou JPrimary histiocytic lymphoma of the central nervous system: a neoplasm frequently overshadowed by a prominent inflammatory component. Am J Surg Pathol. 2001;25(11):1372-1379."},{"issue":"19","key":"bib6","series-title":"Blood","first-page":"5019","article-title":"The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications","volume":"117","author":"Campo","year":"2011","unstructured":"Campo ESwerdlow SHHarris NLPileri SStein HJaffe ES.The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011;117(19):5019-5032."},{"issue":"8","key":"bib7","series-title":"Cancer Cytopathol","first-page":"604","article-title":"Histiocytic sarcoma: new insights into FNA cytomorphology and molecular characteristics","volume":"125","author":"Hung","year":"2017","unstructured":"Hung YPLovitch SBQian X.Histiocytic sarcoma: new insights into FNA cytomorphology and molecular characteristics. Cancer Cytopathol. 2017;125(8):604-614."},{"issue":"6","key":"bib8","series-title":"Neuropathology","first-page":"609","article-title":"Case of primary central nervous system histiocytic sarcoma with prominent proliferation of histiocytic cells between the trabeculae of reactive glial cells","volume":"38","author":"Takahashi","year":"2018","unstructured":"Takahashi ESakakibara ATsuzuki TNakamura S.Case of primary central nervous system histiocytic sarcoma with prominent proliferation of histiocytic cells between the trabeculae of reactive glial cells. Neuropathology. 2018;38(6):609-618."},{"issue":"4-5","key":"bib9","series-title":"World Neurosurg","first-page":"523","article-title":"Primary intramedullary histiocytic sarcoma","volume":"74","author":"Toshkezi","year":"2010","unstructured":"Toshkezi GEdalat FO'Hara CDelalle IChin LS.Primary intramedullary histiocytic sarcoma. World Neurosurg. 2010;74(4-5):523-527."},{"issue":"1","key":"bib10","series-title":"TMF","first-page":"31","article-title":"Histiocytic sarcoma: a case of a 52-year-old female with two synchronous primary malignancies at presentation","volume":"11","author":"Gentzler","year":"2009","unstructured":"Gentzler RDKahn D.Histiocytic sarcoma: a case of a 52-year-old female with two synchronous primary malignancies at presentation. TMF. 2009;11(1):31-33."},{"issue":"1","key":"bib11","series-title":"Neuropathol Appl Neurobiol","first-page":"111","article-title":"Primary meningeal histiocytic sarcoma: a report of two unusual cases","volume":"38","author":"Bell","year":"2012","unstructured":"Bell SLHanzely ZAlakandy LMJackson RStewart W.Primary meningeal histiocytic sarcoma: a report of two unusual cases. 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J Neurosurg Pediatr. 2012;10(2):126-129."},{"issue":"3","key":"bib14","series-title":"J Neurosurg Pediatr","first-page":"251","article-title":"Primary histiocytic sarcoma of the brain mimicking cerebral abscess","volume":"12","author":"Almefty","year":"2013","unstructured":"Almefty ROTyree TLFusco DJCoons SWNakaji P.Primary histiocytic sarcoma of the brain mimicking cerebral abscess. J Neurosurg Pediatr. 2013;12(3):251-257."},{"issue":"6","key":"bib15","series-title":"Hum Pathol","first-page":"1177","article-title":"Primary central nervous system histiocytic sarcoma presenting as a postradiation sarcoma: case report and literature review","volume":"44","author":"Wu","year":"2013","unstructured":"Wu WTanrivermis Sayit ATVinters HVPope WMirsadraei LSaid J.Primary central nervous system histiocytic sarcoma presenting as a postradiation sarcoma: case report and literature review. Hum Pathol. 2013;44(6):1177-1183."},{"issue":"3","key":"bib16","series-title":"Brain Tumor Pathol","first-page":"192","article-title":"Primary central nervous system histiocytic sarcoma","volume":"30","author":"Laviv","year":"2013","unstructured":"Laviv YZagzag DFichman-Horn SMichowitz S.Primary central nervous system histiocytic sarcoma. Brain Tumor Pathol. 2013;30(3):192-195."},{"key":"bib17","series-title":"J Med Case Rep","article-title":"Primary leptomeningeal histiocytic sarcoma in a patient with a good outcome: a case report and review of the literature","volume":"7","author":"P\u00e9rez-Ruiz","year":"2013","unstructured":"P\u00e9rez-Ruiz EDelgado MSanz AGil AMDom\u00ednguez AR.Primary leptomeningeal histiocytic sarcoma in a patient with a good outcome: a case report and review of the literature. J Med Case Rep. 2013;7:127."},{"issue":"1","key":"bib18","series-title":"Clin Med Res","first-page":"31","article-title":"Unusual presentation of a rare cancer: histiocytic sarcoma in the brain 16 years after treatment for acute lymphoblastic leukemia","volume":"11","author":"Chalasani","year":"2013","unstructured":"Chalasani SHennick MRHocking WGShaw GRLawler B.Unusual presentation of a rare cancer: histiocytic sarcoma in the brain 16 years after treatment for acute lymphoblastic leukemia. Clin Med Res. 2013;11(1):31-35."},{"issue":"12","key":"bib19","series-title":"J Neuropathol Exp Neurol","first-page":"1120","article-title":"Primary central nervous system histiocytic sarcoma arising after precursor B-cell acute lymphoblastic leukemia","volume":"74","author":"Brown","year":"2015","unstructured":"Brown AFFan HFloyd JRHenry JMHiggins RA.Primary central nervous system histiocytic sarcoma arising after precursor B-cell acute lymphoblastic leukemia. J Neuropathol Exp Neurol. 2015;74(12):1120-1126."},{"issue":"1","key":"bib20","series-title":"Brain Tumor Pathol","first-page":"66","article-title":"Histiocytic sarcoma of the cavernous sinus: case report and literature review","volume":"32","author":"Chen","year":"2015","unstructured":"Chen CJWilliams EAMcAneney TEWilliams BJMandell JWShaffrey ME.Histiocytic sarcoma of the cavernous sinus: case report and literature review. Brain Tumor Pathol. 2015;32(1):66-71."},{"issue":"6","key":"bib21","series-title":"Neuropathology","first-page":"517","article-title":"Primary histiocytic sarcoma presenting as diffuse leptomeningeal disease: case description and review of the literature","volume":"37","author":"Zanelli","year":"2017","unstructured":"Zanelli MRagazzi MMarchetti GPrimary histiocytic sarcoma presenting as diffuse leptomeningeal disease: case description and review of the literature. 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Radiat Oncol. 2018;13(1):167."},{"issue":"3","key":"bib24","series-title":"Neuropathol Appl Neurobiol","first-page":"309","article-title":"Molecular characteristics of multifocal brain histiocytic sarcoma","volume":"45","author":"Marguet","year":"2019","unstructured":"Marguet FPiton NAdle-Biassette HMolecular characteristics of multifocal brain histiocytic sarcoma. Neuropathol Appl Neurobiol. 2019;45(3):309-313."},{"issue":"5","key":"bib25","series-title":"Jpn J Clin Oncol","first-page":"844","article-title":"Histiocytic sarcoma with brainstem and spinal canal involvement detected by [18F]-FDG PET\/CT","volume":"51","author":"Herrera-Mart\u00ednez","year":"2021","unstructured":"Herrera-Mart\u00ednez YFern\u00e1ndez-Rodr\u00edguez PDel Prado Alba CMAcevedo-Ba\u00f1ez I.Histiocytic sarcoma with brainstem and spinal canal involvement detected by [18F]-FDG PET\/CT. Jpn J Clin Oncol. 2021;51(5):844-845."},{"issue":"2","key":"bib26","series-title":"Clin Neuropathol","first-page":"74","article-title":"Primary histiocytic sarcoma of the clivus with focal extension into central nervous system and neurologic manifestations: first description at an unusual site with an overwhelming and rapid progression","volume":"41","author":"Perez","year":"2022","unstructured":"Perez IGokden MDay JDYaziji HPina-Oviedo S.Primary histiocytic sarcoma of the clivus with focal extension into central nervous system and neurologic manifestations: first description at an unusual site with an overwhelming and rapid progression. Clin Neuropathol. 2022;41(2):74-82."},{"issue":"3","key":"bib27","series-title":"Neurol India","first-page":"1254","article-title":"Primary histiocytic sarcoma of brain-illustration of two cases with varied histomorphological features","volume":"70","author":"Rajeshwari","year":"2022","unstructured":"Rajeshwari MSuri VSarkar CGarg ASharma MC.Primary histiocytic sarcoma of brain-illustration of two cases with varied histomorphological features. Neurol India. 2022;70(3):1254-1259."},{"issue":"10","key":"bib28","series-title":"Mult Scler","first-page":"1651","article-title":"A rare neuromyelitis optica mimic: primary CNS histiocytic sarcoma","volume":"28","author":"Rogawski","year":"2022","unstructured":"Rogawski DSNirschl JJMcDonald JA rare neuromyelitis optica mimic: primary CNS histiocytic sarcoma. Mult Scler. 2022;28(10):1651-1654."},{"issue":"4","key":"bib29","series-title":"Radiol Oncol","first-page":"388","article-title":"Advances in the management of craniopharyngioma in children and adults","volume":"53","author":"Jensterle","year":"2019","unstructured":"Jensterle MJazbinsek SBosnjak RAdvances in the management of craniopharyngioma in children and adults. Radiol Oncol. 2019;53(4):388-396."},{"issue":"6","key":"bib30","series-title":"Med Pediatr Oncol","first-page":"547","article-title":"Primary leptomeningeal histiocytic lymphoma in a young child","volume":"27","author":"Torres","year":"1996","unstructured":"Torres CFKorones DNPowers JMVadasz AG.Primary leptomeningeal histiocytic lymphoma in a young child. Med Pediatr Oncol. 1996;27(6):547-550."},{"issue":"2","key":"bib31","series-title":"Cancer Res Treat","first-page":"322","article-title":"Primary histiocytic sarcoma of the central nervous system","volume":"47","author":"So","year":"2015","unstructured":"So HKim SAYoon DHPrimary histiocytic sarcoma of the central nervous system. Cancer Res Treat. 2015;47(2):322-328."},{"issue":"5","key":"bib32","series-title":"Cureus","article-title":"Successful treatment of central nervous system histiocytic sarcoma with craniectomy and adjuvant radiotherapy","volume":"14","author":"Shahrokh","year":"2022","unstructured":"Shahrokh SRakhsha AShahin MSuccessful treatment of central nervous system histiocytic sarcoma with craniectomy and adjuvant radiotherapy. Cureus. 2022;14(5):e24690."},{"issue":"16","key":"bib33","series-title":"Neurology","first-page":"1478","article-title":"Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib","volume":"83","author":"Idbaih","year":"2014","unstructured":"Idbaih AMokhtari KEmile JFDramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib. Neurology. 2014;83(16):1478-1480."},{"issue":"8","key":"bib34","series-title":"Leuk Lymphoma","first-page":"1961","article-title":"High-dose methotrexate-based chemotherapy as treatment for histiocytic sarcoma of the central nervous system","volume":"57","author":"Curry","year":"2016","unstructured":"Curry RCFaivre GAkkari LHigh-dose methotrexate-based chemotherapy as treatment for histiocytic sarcoma of the central nervous system. Leuk Lymphoma. 2016;57(8):1961-1964."},{"issue":"11","key":"bib35","series-title":"Neurol Sci","first-page":"1875","article-title":"An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination","volume":"37","author":"Ueno","year":"2016","unstructured":"Ueno TNishijima HKurotaki HKurose ATomiyama M.An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. Neurol Sci. 2016;37(11):1875-1877."},{"issue":"12","key":"bib36","series-title":"Childs Nerv Syst","first-page":"2363","article-title":"Primary cerebral histiocytic sarcoma in childhood: a case report of protracted survival and review of the literature","volume":"31","author":"Foster","year":"2015","unstructured":"Foster MKamaly-Asl IStivaros SKelsey AGattamenini RKilday JP.Primary cerebral histiocytic sarcoma in childhood: a case report of protracted survival and review of the literature. Childs Nerv Syst. 2015;31(12):2363-2368."},{"issue":"2","key":"bib37","series-title":"Am J Surg Pathol","first-page":"258","article-title":"Histiocytic sarcoma involving the central nervous system: clinical, immunohistochemical, and molecular genetic studies of a case with review of the literature","volume":"27","author":"Sun","year":"2003","unstructured":"Sun WNordberg MLFowler MR.Histiocytic sarcoma involving the central nervous system: clinical, immunohistochemical, and molecular genetic studies of a case with review of the literature. Am J Surg Pathol. 2003;27(2):258-265."},{"issue":"2","key":"bib38","series-title":"Arch Pathol Lab Med","first-page":"301","article-title":"Primary central nervous system histiocytic sarcoma with relapse to mediastinum: a case report and review of the literature","volume":"131","author":"Cao","year":"2007","unstructured":"Cao MEshoa CSchultz CBlack JZu YChang CC.Primary central nervous system histiocytic sarcoma with relapse to mediastinum: a case report and review of the literature. Arch Pathol Lab Med. 2007;131(2):301-305."},{"issue":"10","key":"bib39","series-title":"J Clin Neurosci","first-page":"1456","article-title":"Histiocytic sarcoma of the brain","volume":"19","author":"Gill-Samra","year":"2012","unstructured":"Gill-Samra SNg TDexter MHistiocytic sarcoma of the brain. J Clin Neurosci. 2012;19(10):1456-1458."},{"issue":"7","key":"bib40","series-title":"Clin Neurol Neurosurg","first-page":"1074","article-title":"A case of primary central nervous system histiocytic sarcoma","volume":"114","author":"Wang","year":"2012","unstructured":"Wang JLi TChen HLiu Q.A case of primary central nervous system histiocytic sarcoma. Clin Neurol Neurosurg. 2012;114(7):1074-1076."},{"key":"bib41","series-title":"BMJ Case Rep","first-page":"bcr2014204663","article-title":"Isolated III cranial nerve palsies may point to primary histiocytic sarcoma","volume":"2014","author":"Moulignier","year":"2014","unstructured":"Moulignier AMikol JHeran FGalicier L.Isolated III cranial nerve palsies may point to primary histiocytic sarcoma. BMJ Case Rep. 2014;2014:bcr2014204663."},{"issue":"6","key":"bib42","series-title":"Neurol India","first-page":"684","article-title":"Primary central nervous system histiocytic sarcoma mimicking glioma","volume":"62","author":"Bai","year":"2014","unstructured":"Bai JLi GShen MSui DLin S.Primary central nervous system histiocytic sarcoma mimicking glioma. Neurol India. 2014;62(6):684-685."},{"key":"bib43","series-title":"World Neurosurg","first-page":"1053.e1","article-title":"Infection or glioma? The false dilemma of primary central nervous system histiocytic sarcoma","volume":"106","author":"Clifton","year":"2017","unstructured":"Clifton WAkinduro OOLopez-Chiriboga SWhitaker DAReimer R.Infection or glioma? The false dilemma of primary central nervous system histiocytic sarcoma. World Neurosurg. 2017;106:1053.e1-1053.e5."},{"issue":"6","key":"bib44","series-title":"Neuropathology","first-page":"560","article-title":"Pediatric intracerebral histiocytic sarcoma with rhabdoid features: case report and literature review","volume":"37","author":"Kim","year":"2017","unstructured":"Kim YHYie GTKim NRPediatric intracerebral histiocytic sarcoma with rhabdoid features: case report and literature review. Neuropathology. 2017;37(6):560-568."},{"issue":"6","key":"bib45","series-title":"Clin Neuropathol","first-page":"253","article-title":"Primary central nervous system histiocytic sarcoma with somatic NF2 mutation: case report and review of literature","volume":"41","author":"Wang","year":"2022","unstructured":"Wang WZhang YDong YLi SQin H.Primary central nervous system histiocytic sarcoma with somatic NF2 mutation: case report and review of literature. Clin Neuropathol. 2022;41(6):253-262."},{"issue":"5","key":"bib1","series-title":"Arch Pathol Lab Med","first-page":"650","article-title":"Histiocytic sarcoma","volume":"144","author":"Hung","year":"2020","unstructured":"Hung YPQian X.Histiocytic sarcoma. Arch Pathol Lab Med. 2020;144(5):650-654."},{"issue":"9","key":"bib2","series-title":"Am J Surg Pathol","first-page":"1133","article-title":"Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy","volume":"28","author":"Hornick","year":"2004","unstructured":"Hornick JLJaffe ESFletcher CD.Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. 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TMF. 2009;11(1):31-33."},{"issue":"1","key":"bib11","series-title":"Neuropathol Appl Neurobiol","first-page":"111","article-title":"Primary meningeal histiocytic sarcoma: a report of two unusual cases","volume":"38","author":"Bell","year":"2012","unstructured":"Bell SLHanzely ZAlakandy LMJackson RStewart W.Primary meningeal histiocytic sarcoma: a report of two unusual cases. Neuropathol Appl Neurobiol. 2012;38(1):111-114."},{"issue":"1","key":"bib12","series-title":"Qjm","first-page":"77","article-title":"Histiocytic sarcoma of the central nervous system: a challenging diagnosis","volume":"105","author":"Devic","year":"2012","unstructured":"Devic PAndrodias-Condemine GStreichenberger NHistiocytic sarcoma of the central nervous system: a challenging diagnosis. Qjm. 2012;105(1):77-79."},{"issue":"2","key":"bib13","series-title":"J Neurosurg Pediatr","first-page":"126","article-title":"Primary cerebellar histiocytic sarcoma in a 17-month-old girl","volume":"10","author":"Gomi","year":"2012","unstructured":"Gomi KTanaka MYoshida MPrimary cerebellar histiocytic sarcoma in a 17-month-old girl. J Neurosurg Pediatr. 2012;10(2):126-129."},{"issue":"3","key":"bib14","series-title":"J Neurosurg Pediatr","first-page":"251","article-title":"Primary histiocytic sarcoma of the brain mimicking cerebral abscess","volume":"12","author":"Almefty","year":"2013","unstructured":"Almefty ROTyree TLFusco DJCoons SWNakaji P.Primary histiocytic sarcoma of the brain mimicking cerebral abscess. J Neurosurg Pediatr. 2013;12(3):251-257."},{"issue":"6","key":"bib15","series-title":"Hum Pathol","first-page":"1177","article-title":"Primary central nervous system histiocytic sarcoma presenting as a postradiation sarcoma: case report and literature review","volume":"44","author":"Wu","year":"2013","unstructured":"Wu WTanrivermis Sayit ATVinters HVPope WMirsadraei LSaid J.Primary central nervous system histiocytic sarcoma presenting as a postradiation sarcoma: case report and literature review. Hum Pathol. 2013;44(6):1177-1183."},{"issue":"3","key":"bib16","series-title":"Brain Tumor Pathol","first-page":"192","article-title":"Primary central nervous system histiocytic sarcoma","volume":"30","author":"Laviv","year":"2013","unstructured":"Laviv YZagzag DFichman-Horn SMichowitz S.Primary central nervous system histiocytic sarcoma. Brain Tumor Pathol. 2013;30(3):192-195."},{"key":"bib17","series-title":"J Med Case Rep","article-title":"Primary leptomeningeal histiocytic sarcoma in a patient with a good outcome: a case report and review of the literature","volume":"7","author":"P\u00e9rez-Ruiz","year":"2013","unstructured":"P\u00e9rez-Ruiz EDelgado MSanz AGil AMDom\u00ednguez AR.Primary leptomeningeal histiocytic sarcoma in a patient with a good outcome: a case report and review of the literature. J Med Case Rep. 2013;7:127."},{"issue":"1","key":"bib18","series-title":"Clin Med Res","first-page":"31","article-title":"Unusual presentation of a rare cancer: histiocytic sarcoma in the brain 16 years after treatment for acute lymphoblastic leukemia","volume":"11","author":"Chalasani","year":"2013","unstructured":"Chalasani SHennick MRHocking WGShaw GRLawler B.Unusual presentation of a rare cancer: histiocytic sarcoma in the brain 16 years after treatment for acute lymphoblastic leukemia. Clin Med Res. 2013;11(1):31-35."},{"issue":"12","key":"bib19","series-title":"J Neuropathol Exp Neurol","first-page":"1120","article-title":"Primary central nervous system histiocytic sarcoma arising after precursor B-cell acute lymphoblastic leukemia","volume":"74","author":"Brown","year":"2015","unstructured":"Brown AFFan HFloyd JRHenry JMHiggins RA.Primary central nervous system histiocytic sarcoma arising after precursor B-cell acute lymphoblastic leukemia. J Neuropathol Exp Neurol. 2015;74(12):1120-1126."},{"issue":"1","key":"bib20","series-title":"Brain Tumor Pathol","first-page":"66","article-title":"Histiocytic sarcoma of the cavernous sinus: case report and literature review","volume":"32","author":"Chen","year":"2015","unstructured":"Chen CJWilliams EAMcAneney TEWilliams BJMandell JWShaffrey ME.Histiocytic sarcoma of the cavernous sinus: case report and literature review. Brain Tumor Pathol. 2015;32(1):66-71."},{"issue":"6","key":"bib21","series-title":"Neuropathology","first-page":"517","article-title":"Primary histiocytic sarcoma presenting as diffuse leptomeningeal disease: case description and review of the literature","volume":"37","author":"Zanelli","year":"2017","unstructured":"Zanelli MRagazzi MMarchetti GPrimary histiocytic sarcoma presenting as diffuse leptomeningeal disease: case description and review of the literature. Neuropathology. 2017;37(6):517-525."},{"issue":"26","key":"bib22","series-title":"Med (Baltim)","article-title":"Primary central nervous system histiocytic sarcoma: a case report and review of literature","volume":"97","author":"Ma","year":"2018","unstructured":"Ma SSchild MTran DPrimary central nervous system histiocytic sarcoma: a case report and review of literature. Med (Baltim). 2018;97(26):e11271."},{"issue":"1","key":"bib23","series-title":"Radiat Oncol","first-page":"167","article-title":"Primary histiocytic sarcoma of the central nervous system: a case report with platelet derived growth factor receptor mutation and PD-L1\/PD-L2 expression and literature review","volume":"13","author":"May","year":"2018","unstructured":"May JMWaddle MRMiller DHPrimary histiocytic sarcoma of the central nervous system: a case report with platelet derived growth factor receptor mutation and PD-L1\/PD-L2 expression and literature review. Radiat Oncol. 2018;13(1):167."},{"issue":"3","key":"bib24","series-title":"Neuropathol Appl Neurobiol","first-page":"309","article-title":"Molecular characteristics of multifocal brain histiocytic sarcoma","volume":"45","author":"Marguet","year":"2019","unstructured":"Marguet FPiton NAdle-Biassette HMolecular characteristics of multifocal brain histiocytic sarcoma. Neuropathol Appl Neurobiol. 2019;45(3):309-313."},{"issue":"5","key":"bib25","series-title":"Jpn J Clin Oncol","first-page":"844","article-title":"Histiocytic sarcoma with brainstem and spinal canal involvement detected by [18F]-FDG PET\/CT","volume":"51","author":"Herrera-Mart\u00ednez","year":"2021","unstructured":"Herrera-Mart\u00ednez YFern\u00e1ndez-Rodr\u00edguez PDel Prado Alba CMAcevedo-Ba\u00f1ez I.Histiocytic sarcoma with brainstem and spinal canal involvement detected by [18F]-FDG PET\/CT. Jpn J Clin Oncol. 2021;51(5):844-845."},{"issue":"2","key":"bib26","series-title":"Clin Neuropathol","first-page":"74","article-title":"Primary histiocytic sarcoma of the clivus with focal extension into central nervous system and neurologic manifestations: first description at an unusual site with an overwhelming and rapid progression","volume":"41","author":"Perez","year":"2022","unstructured":"Perez IGokden MDay JDYaziji HPina-Oviedo S.Primary histiocytic sarcoma of the clivus with focal extension into central nervous system and neurologic manifestations: first description at an unusual site with an overwhelming and rapid progression. Clin Neuropathol. 2022;41(2):74-82."},{"issue":"3","key":"bib27","series-title":"Neurol India","first-page":"1254","article-title":"Primary histiocytic sarcoma of brain-illustration of two cases with varied histomorphological features","volume":"70","author":"Rajeshwari","year":"2022","unstructured":"Rajeshwari MSuri VSarkar CGarg ASharma MC.Primary histiocytic sarcoma of brain-illustration of two cases with varied histomorphological features. Neurol India. 2022;70(3):1254-1259."},{"issue":"10","key":"bib28","series-title":"Mult Scler","first-page":"1651","article-title":"A rare neuromyelitis optica mimic: primary CNS histiocytic sarcoma","volume":"28","author":"Rogawski","year":"2022","unstructured":"Rogawski DSNirschl JJMcDonald JA rare neuromyelitis optica mimic: primary CNS histiocytic sarcoma. Mult Scler. 2022;28(10):1651-1654."},{"issue":"4","key":"bib29","series-title":"Radiol Oncol","first-page":"388","article-title":"Advances in the management of craniopharyngioma in children and adults","volume":"53","author":"Jensterle","year":"2019","unstructured":"Jensterle MJazbinsek SBosnjak RAdvances in the management of craniopharyngioma in children and adults. Radiol Oncol. 2019;53(4):388-396."},{"issue":"6","key":"bib30","series-title":"Med Pediatr Oncol","first-page":"547","article-title":"Primary leptomeningeal histiocytic lymphoma in a young child","volume":"27","author":"Torres","year":"1996","unstructured":"Torres CFKorones DNPowers JMVadasz AG.Primary leptomeningeal histiocytic lymphoma in a young child. Med Pediatr Oncol. 1996;27(6):547-550."},{"issue":"2","key":"bib31","series-title":"Cancer Res Treat","first-page":"322","article-title":"Primary histiocytic sarcoma of the central nervous system","volume":"47","author":"So","year":"2015","unstructured":"So HKim SAYoon DHPrimary histiocytic sarcoma of the central nervous system. Cancer Res Treat. 2015;47(2):322-328."},{"issue":"5","key":"bib32","series-title":"Cureus","article-title":"Successful treatment of central nervous system histiocytic sarcoma with craniectomy and adjuvant radiotherapy","volume":"14","author":"Shahrokh","year":"2022","unstructured":"Shahrokh SRakhsha AShahin MSuccessful treatment of central nervous system histiocytic sarcoma with craniectomy and adjuvant radiotherapy. Cureus. 2022;14(5):e24690."},{"issue":"16","key":"bib33","series-title":"Neurology","first-page":"1478","article-title":"Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib","volume":"83","author":"Idbaih","year":"2014","unstructured":"Idbaih AMokhtari KEmile JFDramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib. Neurology. 2014;83(16):1478-1480."},{"issue":"8","key":"bib34","series-title":"Leuk Lymphoma","first-page":"1961","article-title":"High-dose methotrexate-based chemotherapy as treatment for histiocytic sarcoma of the central nervous system","volume":"57","author":"Curry","year":"2016","unstructured":"Curry RCFaivre GAkkari LHigh-dose methotrexate-based chemotherapy as treatment for histiocytic sarcoma of the central nervous system. Leuk Lymphoma. 2016;57(8):1961-1964."},{"issue":"11","key":"bib35","series-title":"Neurol Sci","first-page":"1875","article-title":"An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination","volume":"37","author":"Ueno","year":"2016","unstructured":"Ueno TNishijima HKurotaki HKurose ATomiyama M.An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. Neurol Sci. 2016;37(11):1875-1877."},{"issue":"12","key":"bib36","series-title":"Childs Nerv Syst","first-page":"2363","article-title":"Primary cerebral histiocytic sarcoma in childhood: a case report of protracted survival and review of the literature","volume":"31","author":"Foster","year":"2015","unstructured":"Foster MKamaly-Asl IStivaros SKelsey AGattamenini RKilday JP.Primary cerebral histiocytic sarcoma in childhood: a case report of protracted survival and review of the literature. Childs Nerv Syst. 2015;31(12):2363-2368."},{"issue":"2","key":"bib37","series-title":"Am J Surg Pathol","first-page":"258","article-title":"Histiocytic sarcoma involving the central nervous system: clinical, immunohistochemical, and molecular genetic studies of a case with review of the literature","volume":"27","author":"Sun","year":"2003","unstructured":"Sun WNordberg MLFowler MR.Histiocytic sarcoma involving the central nervous system: clinical, immunohistochemical, and molecular genetic studies of a case with review of the literature. Am J Surg Pathol. 2003;27(2):258-265."},{"issue":"2","key":"bib38","series-title":"Arch Pathol Lab Med","first-page":"301","article-title":"Primary central nervous system histiocytic sarcoma with relapse to mediastinum: a case report and review of the literature","volume":"131","author":"Cao","year":"2007","unstructured":"Cao MEshoa CSchultz CBlack JZu YChang CC.Primary central nervous system histiocytic sarcoma with relapse to mediastinum: a case report and review of the literature. Arch Pathol Lab Med. 2007;131(2):301-305."},{"issue":"10","key":"bib39","series-title":"J Clin Neurosci","first-page":"1456","article-title":"Histiocytic sarcoma of the brain","volume":"19","author":"Gill-Samra","year":"2012","unstructured":"Gill-Samra SNg TDexter MHistiocytic sarcoma of the brain. J Clin Neurosci. 2012;19(10):1456-1458."},{"issue":"7","key":"bib40","series-title":"Clin Neurol Neurosurg","first-page":"1074","article-title":"A case of primary central nervous system histiocytic sarcoma","volume":"114","author":"Wang","year":"2012","unstructured":"Wang JLi TChen HLiu Q.A case of primary central nervous system histiocytic sarcoma. Clin Neurol Neurosurg. 2012;114(7):1074-1076."},{"key":"bib41","series-title":"BMJ Case Rep","first-page":"bcr2014204663","article-title":"Isolated III cranial nerve palsies may point to primary histiocytic sarcoma","volume":"2014","author":"Moulignier","year":"2014","unstructured":"Moulignier AMikol JHeran FGalicier L.Isolated III cranial nerve palsies may point to primary histiocytic sarcoma. BMJ Case Rep. 2014;2014:bcr2014204663."},{"issue":"6","key":"bib42","series-title":"Neurol India","first-page":"684","article-title":"Primary central nervous system histiocytic sarcoma mimicking glioma","volume":"62","author":"Bai","year":"2014","unstructured":"Bai JLi GShen MSui DLin S.Primary central nervous system histiocytic sarcoma mimicking glioma. Neurol India. 2014;62(6):684-685."},{"key":"bib43","series-title":"World Neurosurg","first-page":"1053.e1","article-title":"Infection or glioma? The false dilemma of primary central nervous system histiocytic sarcoma","volume":"106","author":"Clifton","year":"2017","unstructured":"Clifton WAkinduro OOLopez-Chiriboga SWhitaker DAReimer R.Infection or glioma? The false dilemma of primary central nervous system histiocytic sarcoma. World Neurosurg. 2017;106:1053.e1-1053.e5."},{"issue":"6","key":"bib44","series-title":"Neuropathology","first-page":"560","article-title":"Pediatric intracerebral histiocytic sarcoma with rhabdoid features: case report and literature review","volume":"37","author":"Kim","year":"2017","unstructured":"Kim YHYie GTKim NRPediatric intracerebral histiocytic sarcoma with rhabdoid features: case report and literature review. Neuropathology. 2017;37(6):560-568."},{"issue":"6","key":"bib45","series-title":"Clin Neuropathol","first-page":"253","article-title":"Primary central nervous system histiocytic sarcoma with somatic NF2 mutation: case report and review of literature","volume":"41","author":"Wang","year":"2022","unstructured":"Wang WZhang YDong YLi SQin H.Primary central nervous system histiocytic sarcoma with somatic NF2 mutation: case report and review of literature. 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