{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:22:05Z","timestamp":1789683725716,"version":"4.0.1"},"reference-count":34,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"16","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2024,10,14]]},"abstract":"\n BACKGROUND<\/jats:title>\n Renal cell carcinoma (RCC), the most common kidney cancer, often metastasizes to bones, lungs, liver, and the central nervous system. Intramedullary spinal metastasis from RCC is rare but can cause significant neurological deficits, necessitating prompt diagnosis and treatment through surgical intervention, radiotherapy, and immunotherapy.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n An 86-year-old man presented with progressive right lower-limb weakness and reduced sensation over 3 weeks. His medical history included a right nephrectomy for RCC 15 years earlier and L4\u2013S1 spondylosis. Imaging identified a bleeding lesion in the conus medullaris at T11\u201312 and an incidental left kidney mass. Urgent surgical exploration led to a T12 laminectomy and en bloc removal of the lesion, which was confirmed as RCC metastasis. Postoperatively, the patient received focused radiotherapy and immunotherapy, showing significant motor and sensory improvement before dying 3 months later.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n This case underscores the importance of comprehensive diagnostic imaging for the accurate identification and characterization of spinal lesions. An interdisciplinary approach involving neurosurgeons, oncologists, radiologists, and pathologists is crucial for optimal treatment planning. Urgent surgical intervention can effectively address acute neurological deficits caused by intramedullary lesions. Additionally, adhering to postoperative care instructions, such as deep venous thrombosis prophylaxis, is vital to prevent fatal complications.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE24349<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case24349","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T02:44:50Z","timestamp":1728873890000},"source":"Crossref","is-referenced-by-count":2,"title":["Hemorrhagic intramedullary spinal cord metastasis from renal cell carcinoma: a rare case 15 years after cured renal cell carcinoma. Illustrative case"],"prefix":"10.3171","volume":"8","author":[{"given":"Mohammad","family":"Khalil Al-Barbarawi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Dessau Clinical Center, Academic Hospital of Brandenburg University, Dessau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Badary","sequence":"additional","affiliation":[{"name":"Department of Neurotraumatology and Spine, SRH Wald-Klinikum Gera, Academic Hospital of Jena University, Gera, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Silbermann","sequence":"additional","affiliation":[{"name":"Department of Neurotraumatology and Spine, SRH Wald-Klinikum Gera, Academic Hospital of Jena University, Gera, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oday","family":"Atallah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hannover Medical School, Hannover University, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Kinan Sultan","sequence":"additional","affiliation":[{"name":"Department of Neurotraumatology and Spine, SRH Wald-Klinikum Gera, Academic Hospital of Jena University, Gera, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Neurotraumatology and Spine, SRH Wald-Klinikum Gera, Academic Hospital of Jena University, Gera, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz","family":"Albardan","sequence":"additional","affiliation":[{"name":"Department of Neurotraumatology and Spine, SRH Wald-Klinikum Gera, Academic Hospital of Jena University, Gera, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah","family":"Maksoud","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Darmstadt Clinical Center, Darmstadt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahab","family":"Moustafa","sequence":"additional","affiliation":[{"name":"Department of Neurotraumatology and Spine, SRH Wald-Klinikum Gera, Academic Hospital of Jena University, Gera, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"bib1","series-title":"BioMed Res Int","first-page":"7485020","article-title":"Intramedullary spinal cord metastasis from renal cell carcinoma: a systematic review of the literature","volume":"2018","author":"Weng","year":"2018","unstructured":"Weng YZhan RShen J, et al. Intramedullary spinal cord metastasis from renal cell carcinoma: a systematic review of the literature. BioMed Res Int. 2018;2018:7485020."},{"issue":"3","key":"bib2","series-title":"Scand J Urol Nephrol","first-page":"165","article-title":"Renal cell carcinoma metastases. Review of unusual clinical metastases, metastatic modes and patterns and comparison between clinical and autopsy metastatic series","volume":"30","author":"Pagano","year":"1996","unstructured":"Pagano SFranzoso FRuggeri P. Renal cell carcinoma metastases. Review of unusual clinical metastases, metastatic modes and patterns and comparison between clinical and autopsy metastatic series. Scand J Urol Nephrol. 1996;30(3):165-172."},{"issue":"6","key":"bib3","series-title":"J Cancer Res Clin Oncol","first-page":"605","article-title":"Metastatic patterns of renal carcinoma: an analysis of 687 necropsies","volume":"114","author":"Weiss","year":"1988","unstructured":"Weiss LHarlos JPTorhorst J, et al. Metastatic patterns of renal carcinoma: an analysis of 687 necropsies. J Cancer Res Clin Oncol. 1988;114(6):605-612."},{"issue":"2","key":"bib4","series-title":"Cancer Med","first-page":"169","article-title":"Survival among patients with advanced renal cell carcinoma in the pretargeted versus targeted therapy eras","volume":"5","author":"Li","year":"2016","unstructured":"Li PWong YNArmstrong K, et al. Survival among patients with advanced renal cell carcinoma in the pretargeted versus targeted therapy eras. Cancer Med. 2016;5(2):169-181."},{"issue":"3","key":"bib5","series-title":"Cell","first-page":"595","article-title":"Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal","volume":"173","author":"Turajlic","year":"2018","unstructured":"Turajlic SXu HLitchfield K, et al. Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal. Cell. 2018;173(3):595-610.e11."},{"issue":"5","key":"bib6","series-title":"No Shinkei Geka","first-page":"453","article-title":"Intramedullary spinal cord metastasis associated with hemorrhage: a case report","volume":"28","author":"Li","year":"2000","unstructured":"Li YTakayasu MTakagi TYoshimoto MMitsui YYoshida J. Intramedullary spinal cord metastasis associated with hemorrhage: a case report. Article in Japanese. No Shinkei Geka. 2000;28(5):453-457."},{"key":"bib7","series-title":"Interdiscip Neurosurg","first-page":"100994","article-title":"Spinal metastases from renal cell carcinoma: case note with an overview","volume":"23","author":"Hadgaonkar","year":"2021","unstructured":"Hadgaonkar SZawar ASanghavi SKothari ASancheti PShyam A. Spinal metastases from renal cell carcinoma: case note with an overview. Interdiscip Neurosurg. 2021;23:100994."},{"issue":"5","key":"bib8","series-title":"Glob Spine J","first-page":"425","article-title":"Intramedullary spinal cord tumors: part I\u2014epidemiology, pathophysiology, and diagnosis","volume":"5","author":"Samartzis","year":"2015","unstructured":"Samartzis DGillis CCShih PO\u2019Toole JEFessler RG. Intramedullary spinal cord tumors: part I\u2014epidemiology, pathophysiology, and diagnosis. Glob Spine J. 2015;5(5):425-435."},{"issue":"2","key":"bib9","series-title":"J Korean Neurosurg Soc","first-page":"126","article-title":"Imaging findings of solitary spinal bony lesions and the differential diagnosis of benign and malignant lesions","volume":"52","author":"Kim","year":"2012","unstructured":"Kim YSHan IHLee ISLee JSChoi BK. Imaging findings of solitary spinal bony lesions and the differential diagnosis of benign and malignant lesions. 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No Shinkei Geka. 2000;28(5):453-457."},{"key":"bib7","series-title":"Interdiscip Neurosurg","first-page":"100994","article-title":"Spinal metastases from renal cell carcinoma: case note with an overview","volume":"23","author":"Hadgaonkar","year":"2021","unstructured":"Hadgaonkar SZawar ASanghavi SKothari ASancheti PShyam A. Spinal metastases from renal cell carcinoma: case note with an overview. Interdiscip Neurosurg. 2021;23:100994."},{"issue":"5","key":"bib8","series-title":"Glob Spine J","first-page":"425","article-title":"Intramedullary spinal cord tumors: part I\u2014epidemiology, pathophysiology, and diagnosis","volume":"5","author":"Samartzis","year":"2015","unstructured":"Samartzis DGillis CCShih PO\u2019Toole JEFessler RG. Intramedullary spinal cord tumors: part I\u2014epidemiology, pathophysiology, and diagnosis. Glob Spine J. 2015;5(5):425-435."},{"issue":"2","key":"bib9","series-title":"J Korean Neurosurg Soc","first-page":"126","article-title":"Imaging findings of solitary spinal bony lesions and the differential diagnosis of benign and malignant lesions","volume":"52","author":"Kim","year":"2012","unstructured":"Kim YSHan IHLee ISLee JSChoi BK. Imaging findings of solitary spinal bony lesions and the differential diagnosis of benign and malignant lesions. J Korean Neurosurg Soc. 2012;52(2):126-132."},{"key":"bib10","series-title":"Clin Neurol Neurosurg","first-page":"106105","article-title":"Contrast enhanced ultrasound (CEUS) applications in neurosurgical and neurological settings\u2014new scenarios for brain and spinal cord ultrasonography. A systematic review","volume":"198","author":"Della Pepa","year":"2020","unstructured":"Della Pepa GMMenna GIus T, et al. Contrast enhanced ultrasound (CEUS) applications in neurosurgical and neurological settings\u2014new scenarios for brain and spinal cord ultrasonography. A systematic review. Clin Neurol Neurosurg. 2020;198:106105."},{"issue":"1","key":"bib11","series-title":"Insights Imaging","first-page":"80","article-title":"Bone up on spinal osseous lesions: a case review series","volume":"11","author":"Nguyen","year":"2020","unstructured":"Nguyen TTThelen JCBhatt AA. Bone up on spinal osseous lesions: a case review series. Insights Imaging. 2020;11(1):80."},{"issue":"5","key":"bib12","series-title":"Biomedicines","first-page":"1111","article-title":"Metastatic kidney cancer: does the location of the metastases matter? Moving towards personalized therapy for metastatic renal cell carcinoma","volume":"12","author":"Baston","year":"2024","unstructured":"Baston CParosanu AIStanciu IMNitipir C. Metastatic kidney cancer: does the location of the metastases matter? Moving towards personalized therapy for metastatic renal cell carcinoma. Biomedicines. 2024;12(5):1111."},{"issue":"8","key":"bib13","series-title":"World J Clin Oncol","first-page":"541","article-title":"Combination drug regimens for metastatic clear cell renal cell carcinoma","volume":"11","author":"Khetani","year":"2020","unstructured":"Khetani VVPortal DEShah MRMayer TSinger EA. Combination drug regimens for metastatic clear cell renal cell carcinoma. World J Clin Oncol. 2020;11(8):541-562."},{"issue":"9","key":"bib14","series-title":"J Clin Neurosci","first-page":"1273","article-title":"CyberKnife stereotactic radiosurgery for the treatment of intramedullary spinal cord metastases","volume":"19","author":"Veeravagu","year":"2012","unstructured":"Veeravagu ALieberson REMener A, et al. CyberKnife stereotactic radiosurgery for the treatment of intramedullary spinal cord metastases. J Clin Neurosci. 2012;19(9):1273-1277."},{"issue":"5","key":"bib15","series-title":"Cureus","first-page":"e609","article-title":"Robotic radiosurgery for the treatment of intramedullary spinal cord metastases: a case report and literature review","volume":"8","author":"Garcia","year":"2016","unstructured":"Garcia RSallabanda KSanta-Olalla I, et al. Robotic radiosurgery for the treatment of intramedullary spinal cord metastases: a case report and literature review. Cureus. 2016;8(5):e609."},{"key":"bib16","series-title":"Urol Case Rep","first-page":"54","article-title":"Delayed brain metastasis from renal cell carcinoma","volume":"22","author":"Kolsi","year":"2019","unstructured":"Kolsi FMechergui HKammoun BMellouli MKhrifech MZaher Boudawara M. Delayed brain metastasis from renal cell carcinoma. 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