{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:54:05Z","timestamp":1778820845729,"version":"3.51.4"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"20","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2024,11,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Idiopathic intracranial hypertension is caused by an elevation of intracranial pressure and can present with slowly progressive visual deterioration from bilateral papilledema. Unilateral papilledema is an exceedingly rare phenomenon, and the mechanisms underlying asymmetric optic nerve involvement remain unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 42-year-old woman presented with acute left-eye blurred vision and extraocular pain. Examination revealed unilateral left optic disc edema with an enlarged blind spot, while the right optic disc appeared flat. Neuroimaging examination was suggestive of intracranial hypertension, characterized by flattening of the posterior globes and narrowing of bilateral distal transverse sinuses. Increased intracranial pressure was confirmed by lumbar puncture. Acetazolamide and weight loss yielded initial improvement, but recurrence prompted cerebral arteriography, revealing a transstenotic gradient in the right distal transverse sinus and hypoplastic left sigmoid and transverse sinuses with extensive collateralization to the left cavernous sinus. Stenting of the right transverse sinus successfully alleviated the optic disc swelling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>This case highlights the intricate interplay between venous sinus dynamics and unilateral papilledema, underscoring the importance of tailored interventions.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE24385\">https:\/\/thejns.org\/doi\/10.3171\/CASE24385<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case24385","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T01:45:59Z","timestamp":1731289559000},"source":"Crossref","is-referenced-by-count":1,"title":["Unilateral papilledema: illustrative case"],"prefix":"10.3171","volume":"8","author":[{"given":"George A.","family":"Villatoro","sequence":"first","affiliation":[{"name":"Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Pannell","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Diego, La Jolla, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Savino","sequence":"additional","affiliation":[{"name":"Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"6","key":"bib1","series-title":"JAMA Neurol","first-page":"693","article-title":"The idiopathic intracranial hypertension treatment trial: clinical profile at baseline","volume":"71","author":"Wall","year":"2014","unstructured":"Wall MKupersmith MJKieburtz KD, et al. The idiopathic intracranial hypertension treatment trial: clinical profile at baseline. JAMA Neurol. 2014;71(6):693-701."},{"issue":"5","key":"bib2","series-title":"Semin Neurol","first-page":"527","article-title":"Update on the diagnosis and treatment of idiopathic intracranial hypertension","volume":"35","author":"Bidot","year":"2015","unstructured":"Bidot SBruce BB. Update on the diagnosis and treatment of idiopathic intracranial hypertension. Semin Neurol. 2015;35(5):527-538."},{"issue":"1","key":"bib3","series-title":"Neurol Clin","first-page":"45","article-title":"Update on idiopathic intracranial hypertension","volume":"35","author":"Wall","year":"2017","unstructured":"Wall M. Update on idiopathic intracranial hypertension. Neurol Clin. 2017;35(1):45-57."},{"issue":"4","key":"bib4","series-title":"Surv Ophthalmol","first-page":"1135","article-title":"Papilledema: a review of etiology, pathophysiology, diagnosis, and management","volume":"67","author":"Xie","year":"2022","unstructured":"Xie JSDonaldson LMargolin E. Papilledema: a review of etiology, pathophysiology, diagnosis, and management. Surv Ophthalmol. 2022;67(4):1135-1159."},{"issue":"3","key":"bib5","series-title":"J Neurosurg","first-page":"538","article-title":"Dural sinus stent placement for idiopathic intracranial hypertension","volume":"116","author":"Kumpe","year":"2012","unstructured":"Kumpe DABennett JLSeinfeld JPelak VSChawla ATierney M. Dural sinus stent placement for idiopathic intracranial hypertension. J Neurosurg. 2012;116(3):538-548."},{"issue":"2","key":"bib6","series-title":"Can J Neurol Sci","first-page":"278","article-title":"Unilateral papilledema in idiopathic intracranial hypertension: a case series","volume":"49","author":"Swinkin","year":"2022","unstructured":"Swinkin EJabehdar Maralani PSundaram AN. Unilateral papilledema in idiopathic intracranial hypertension: a case series. Can J Neurol Sci. 2022;49(2):278-281."},{"issue":"2","key":"bib7","series-title":"J Neurosurg","first-page":"347","article-title":"Incidence and predictors of dural venous sinus pressure gradient in idiopathic intracranial hypertension and non-idiopathic intracranial hypertension headache patients: results from 164 cerebral venograms","volume":"126","author":"Levitt","year":"2017","unstructured":"Levitt MRHlubek RJMoon K, et al. Incidence and predictors of dural venous sinus pressure gradient in idiopathic intracranial hypertension and non-idiopathic intracranial hypertension headache patients: results from 164 cerebral venograms. J Neurosurg. 2017;126(2):347-353."},{"issue":"1","key":"bib8","series-title":"Korean J Ophthalmol","first-page":"33","article-title":"Analysis of the causes of optic disc swelling","volume":"25","author":"Jung","year":"2011","unstructured":"Jung JJBaek SHKim US. Analysis of the causes of optic disc swelling. Korean J Ophthalmol. 2011;25(1):33-36."},{"issue":"3","key":"bib9","series-title":"Neurology","first-page":"676","article-title":"Unilateral and highly asymmetric papilledema in pseudotumor cerebri","volume":"42","author":"Lepore","year":"1992","unstructured":"Lepore FE. Unilateral and highly asymmetric papilledema in pseudotumor cerebri. Neurology. 1992;42(3Pt 1):676-678."},{"issue":"1","key":"bib10","series-title":"J Neuroophthalmol","first-page":"31","article-title":"Asymmetric papilledema in idiopathic intracranial hypertension","volume":"35","author":"Bidot","year":"2015","unstructured":"Bidot SBruce BBSaindane AMNewman NJBiousse V. Asymmetric papilledema in idiopathic intracranial hypertension. J Neuroophthalmol. 2015;35(1):31-36."},{"issue":"6","key":"bib1","series-title":"JAMA Neurol","first-page":"693","article-title":"The idiopathic intracranial hypertension treatment trial: clinical profile at baseline","volume":"71","author":"Wall","year":"2014","unstructured":"Wall MKupersmith MJKieburtz KD, et al. The idiopathic intracranial hypertension treatment trial: clinical profile at baseline. 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Can J Neurol Sci. 2022;49(2):278-281."},{"issue":"2","key":"bib7","series-title":"J Neurosurg","first-page":"347","article-title":"Incidence and predictors of dural venous sinus pressure gradient in idiopathic intracranial hypertension and non-idiopathic intracranial hypertension headache patients: results from 164 cerebral venograms","volume":"126","author":"Levitt","year":"2017","unstructured":"Levitt MRHlubek RJMoon K, et al. Incidence and predictors of dural venous sinus pressure gradient in idiopathic intracranial hypertension and non-idiopathic intracranial hypertension headache patients: results from 164 cerebral venograms. J Neurosurg. 2017;126(2):347-353."},{"issue":"1","key":"bib8","series-title":"Korean J Ophthalmol","first-page":"33","article-title":"Analysis of the causes of optic disc swelling","volume":"25","author":"Jung","year":"2011","unstructured":"Jung JJBaek SHKim US. Analysis of the causes of optic disc swelling. 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