{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:24:31Z","timestamp":1769729071757,"version":"3.49.0"},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"24","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2024,12,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Spinal muscular atrophy (SMA) is an inherited disease that leads to weakness, loss of ambulation, and progressive scoliosis in many patients, frequently requiring early spinal fusion. Nusinersen is a disease-modifying agent that improves symptoms and slows the progression of SMA but requires serial lumbar punctures for intrathecal drug delivery. Spinal fusion for scoliosis has historically been a contraindication for nusinersen therapy, as the fused spinal laminae block access to the thecal sac.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>Here, the authors report a case wherein a patient with SMA and prior scoliosis surgery underwent a one-level lumbar laminectomy with the placement of four titanium microscrews at the corners of the bone window thatfunction as fiducial targets for radiography-guided lumbar punctures. This procedure allowed the patient to receive nusinersen injections easily and successfully on an ongoing basis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Nusinersen is an important novel treatment for children with SMA. Thus, it is imperative to discover new ways to administer intrathecal injections to increase the number of patients able to undergo this therapy. The described one-level laminectomy with microscrew placement for serial lumbar punctures can increase the number of patients able to receive nusinersen and other intrathecal therapies.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE24411\">https:\/\/thejns.org\/doi\/10.3171\/CASE24411<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case24411","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T01:50:37Z","timestamp":1733709037000},"source":"Crossref","is-referenced-by-count":1,"title":["Fiducial-marked laminectomy window for intrathecal medication administration after spinal fusion: illustrative case"],"prefix":"10.3171","volume":"8","author":[{"given":"Megan E. H.","family":"Still","sequence":"first","affiliation":[{"name":"Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason E.","family":"Blatt","sequence":"additional","affiliation":[{"name":"Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"4","key":"bib1","series-title":"J Pediatr Orthop B","first-page":"393","article-title":"Scoliosis and spinal muscular atrophy in the new world of medical therapy: providing lumbar access for intrathecal treatment in patients previously treated or undergoing spinal instrumentation and fusion","volume":"28","author":"Labianca","year":"2019","unstructured":"Labianca LWeinstein SL. Scoliosis and spinal muscular atrophy in the new world of medical therapy: providing lumbar access for intrathecal treatment in patients previously treated or undergoing spinal instrumentation and fusion. J Pediatr Orthop B. 2019;28(4):393-396."},{"issue":"2","key":"bib2","series-title":"Neurology","first-page":"e149","article-title":"Natural course of scoliosis and lifetime risk of scoliosis surgery in spinal muscular atrophy","volume":"93","author":"Wijngaarde","year":"2019","unstructured":"Wijngaarde CABrink RCde Kort FAS, et al. Natural course of scoliosis and lifetime risk of scoliosis surgery in spinal muscular atrophy. Neurology. 2019;93(2):e149-e158."},{"issue":"5","key":"bib3","series-title":"Arch Neurol","first-page":"518","article-title":"Natural history in proximal spinal muscular atrophy. Clinical analysis of 445 patients and suggestions for a modification of existing classifications","volume":"52","author":"Zerres","year":"1995","unstructured":"Zerres KRudnik-Sch\u00f6neborn S. Natural history in proximal spinal muscular atrophy. Clinical analysis of 445 patients and suggestions for a modification of existing classifications. Arch Neurol. 1995;52(5):518-523."},{"issue":"1","key":"bib4","series-title":"J Pediatr Rehabil Med","first-page":"23","article-title":"Management of scoliosis in patients with Duchenne muscular dystrophy and spinal muscular atrophy: a literature review","volume":"9","author":"Garg","year":"2016","unstructured":"Garg S. Management of scoliosis in patients with Duchenne muscular dystrophy and spinal muscular atrophy: a literature review. J Pediatr Rehabil Med. 2016;9(1):23-29."},{"issue":"7","key":"bib5","series-title":"Neurology","first-page":"e620","article-title":"Cervical puncture to deliver nusinersen in patients with spinal muscular atrophy","volume":"91","author":"Veerapandiyan","year":"2018","unstructured":"Veerapandiyan APal RD\u2019Ambrosio S, et al. Cervical puncture to deliver nusinersen in patients with spinal muscular atrophy. Neurology. 2018;91(7):e620-e624."},{"issue":"10","key":"bib6","series-title":"Neuromuscul Disord","first-page":"742","article-title":"Intrathecal administration of nusinersen in adult and adolescent patients with spinal muscular atrophy and scoliosis: transforaminal versus conventional approach","volume":"29","author":"Bortolani","year":"2019","unstructured":"Bortolani SStura GVentilii G, et al. Intrathecal administration of nusinersen in adult and adolescent patients with spinal muscular atrophy and scoliosis: transforaminal versus conventional approach. Neuromuscul Disord. 2019;29(10):742-746."},{"issue":"2","key":"bib7","series-title":"J Nurs Qual Assur","first-page":"41","article-title":"Implementing an interdepartmental QA program in a small rural hospital","volume":"3","author":"Bushy","year":"1989","unstructured":"Bushy ATyler P. Implementing an interdepartmental QA program in a small rural hospital. J Nurs Qual Assur. 1989;3(2):41-51."},{"issue":"10","key":"bib8","series-title":"J Pediatr Orthop","first-page":"e610","article-title":"Preliminary safety and tolerability of a novel subcutaneous intrathecal catheter system for repeated outpatient dosing of nusinersen to children and adults with spinal muscular atrophy","volume":"38","author":"Strauss","year":"2018","unstructured":"Strauss KACarson VJBrigatti KW, et al. Preliminary safety and tolerability of a novel subcutaneous intrathecal catheter system for repeated outpatient dosing of nusinersen to children and adults with spinal muscular atrophy. J Pediatr Orthop. 2018;38(10):e610-e617."},{"issue":"10063","key":"bib9","series-title":"Lancet","first-page":"3017","article-title":"Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study","volume":"388","author":"Finkel","year":"2016","unstructured":"Finkel RSChiriboga CAVajsar J, et al. Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study. Lancet. 2016;388(10063):3017-3026."},{"issue":"10","key":"bib10","series-title":"Expert Rev Neurother","first-page":"955","article-title":"Nusinersen for the treatment of spinal muscular atrophy","volume":"17","author":"Chiriboga","year":"2017","unstructured":"Chiriboga CA. Nusinersen for the treatment of spinal muscular atrophy. Expert Rev Neurother. 2017;17(10):955-962."},{"issue":"3","key":"bib11","series-title":"J Pediatr Pharmacol Ther","first-page":"194","article-title":"Nusinersen: a novel antisense oligonucleotide for the treatment of spinal muscular atrophy","volume":"24","author":"Neil","year":"2019","unstructured":"Neil EEBisaccia EK. Nusinersen: a novel antisense oligonucleotide for the treatment of spinal muscular atrophy. J Pediatr Pharmacol Ther. 2019;24(3):194-203."},{"issue":"4","key":"bib1","series-title":"J Pediatr Orthop B","first-page":"393","article-title":"Scoliosis and spinal muscular atrophy in the new world of medical therapy: providing lumbar access for intrathecal treatment in patients previously treated or undergoing spinal instrumentation and fusion","volume":"28","author":"Labianca","year":"2019","unstructured":"Labianca LWeinstein SL. Scoliosis and spinal muscular atrophy in the new world of medical therapy: providing lumbar access for intrathecal treatment in patients previously treated or undergoing spinal instrumentation and fusion. J Pediatr Orthop B. 2019;28(4):393-396."},{"issue":"2","key":"bib2","series-title":"Neurology","first-page":"e149","article-title":"Natural course of scoliosis and lifetime risk of scoliosis surgery in spinal muscular atrophy","volume":"93","author":"Wijngaarde","year":"2019","unstructured":"Wijngaarde CABrink RCde Kort FAS, et al. Natural course of scoliosis and lifetime risk of scoliosis surgery in spinal muscular atrophy. Neurology. 2019;93(2):e149-e158."},{"issue":"5","key":"bib3","series-title":"Arch Neurol","first-page":"518","article-title":"Natural history in proximal spinal muscular atrophy. Clinical analysis of 445 patients and suggestions for a modification of existing classifications","volume":"52","author":"Zerres","year":"1995","unstructured":"Zerres KRudnik-Sch\u00f6neborn S. Natural history in proximal spinal muscular atrophy. Clinical analysis of 445 patients and suggestions for a modification of existing classifications. Arch Neurol. 1995;52(5):518-523."},{"issue":"1","key":"bib4","series-title":"J Pediatr Rehabil Med","first-page":"23","article-title":"Management of scoliosis in patients with Duchenne muscular dystrophy and spinal muscular atrophy: a literature review","volume":"9","author":"Garg","year":"2016","unstructured":"Garg S. Management of scoliosis in patients with Duchenne muscular dystrophy and spinal muscular atrophy: a literature review. J Pediatr Rehabil Med. 2016;9(1):23-29."},{"issue":"7","key":"bib5","series-title":"Neurology","first-page":"e620","article-title":"Cervical puncture to deliver nusinersen in patients with spinal muscular atrophy","volume":"91","author":"Veerapandiyan","year":"2018","unstructured":"Veerapandiyan APal RD\u2019Ambrosio S, et al. Cervical puncture to deliver nusinersen in patients with spinal muscular atrophy. Neurology. 2018;91(7):e620-e624."},{"issue":"10","key":"bib6","series-title":"Neuromuscul Disord","first-page":"742","article-title":"Intrathecal administration of nusinersen in adult and adolescent patients with spinal muscular atrophy and scoliosis: transforaminal versus conventional approach","volume":"29","author":"Bortolani","year":"2019","unstructured":"Bortolani SStura GVentilii G, et al. Intrathecal administration of nusinersen in adult and adolescent patients with spinal muscular atrophy and scoliosis: transforaminal versus conventional approach. Neuromuscul Disord. 2019;29(10):742-746."},{"issue":"2","key":"bib7","series-title":"J Nurs Qual Assur","first-page":"41","article-title":"Implementing an interdepartmental QA program in a small rural hospital","volume":"3","author":"Bushy","year":"1989","unstructured":"Bushy ATyler P. Implementing an interdepartmental QA program in a small rural hospital. J Nurs Qual Assur. 1989;3(2):41-51."},{"issue":"10","key":"bib8","series-title":"J Pediatr Orthop","first-page":"e610","article-title":"Preliminary safety and tolerability of a novel subcutaneous intrathecal catheter system for repeated outpatient dosing of nusinersen to children and adults with spinal muscular atrophy","volume":"38","author":"Strauss","year":"2018","unstructured":"Strauss KACarson VJBrigatti KW, et al. Preliminary safety and tolerability of a novel subcutaneous intrathecal catheter system for repeated outpatient dosing of nusinersen to children and adults with spinal muscular atrophy. J Pediatr Orthop. 2018;38(10):e610-e617."},{"issue":"10063","key":"bib9","series-title":"Lancet","first-page":"3017","article-title":"Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study","volume":"388","author":"Finkel","year":"2016","unstructured":"Finkel RSChiriboga CAVajsar J, et al. Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study. Lancet. 2016;388(10063):3017-3026."},{"issue":"10","key":"bib10","series-title":"Expert Rev Neurother","first-page":"955","article-title":"Nusinersen for the treatment of spinal muscular atrophy","volume":"17","author":"Chiriboga","year":"2017","unstructured":"Chiriboga CA. Nusinersen for the treatment of spinal muscular atrophy. Expert Rev Neurother. 2017;17(10):955-962."},{"issue":"3","key":"bib11","series-title":"J Pediatr Pharmacol Ther","first-page":"194","article-title":"Nusinersen: a novel antisense oligonucleotide for the treatment of spinal muscular atrophy","volume":"24","author":"Neil","year":"2019","unstructured":"Neil EEBisaccia EK. Nusinersen: a novel antisense oligonucleotide for the treatment of spinal muscular atrophy. J Pediatr Pharmacol Ther. 2019;24(3):194-203."}],"container-title":["Journal of Neurosurgery: Case Lessons"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/8\/24\/article-CASE24411.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/8\/24\/article-CASE24411.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/8\/24\/article-CASE24411.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:52:12Z","timestamp":1769687532000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/8\/24\/article-CASE24411.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":22,"journal-issue":{"issue":"24"},"URL":"https:\/\/doi.org\/10.3171\/case24411","relation":{},"ISSN":["2694-1902"],"issn-type":[{"value":"2694-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,9]]}}}