{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:24:31Z","timestamp":1769729071710,"version":"3.49.0"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"24","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2024,12,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Endometrial papillary serous carcinoma (EPSC) is a rare gynecological malignancy that often metastasizes before the presentation of symptoms or diagnosis of the primary disease. The most common locations of metastases for this malignancy are the lungs, liver, and bones. Metastases to the central nervous system (CNS) are rare. Solitary CNS metastases without other anatomical site spread are exceedingly rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 65-year-old female with a past medical history of EPSC presented with right-sided weakness, gait instability, and progressive dysarthria. Neurological evaluation revealed right hemiparesis and dysarthria. Head computed tomography showed an ovoid area of hypoattenuation in the left pons. Magnetic resonance imaging confirmed a 2.6-cm pontine lesion. A biopsy revealed histomorphology and immunophenotype consistent with metastasis of previously diagnosed serous carcinoma of the endometrium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Gynecological malignancies, in particular EPSC, can metastasize to atypical locations even without evidence of systemic disease. The authors hypothesize that this may be due to hematogenous spread through the Batson venous plexus.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE24513\">https:\/\/thejns.org\/doi\/10.3171\/CASE24513<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case24513","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T01:50:43Z","timestamp":1733709043000},"source":"Crossref","is-referenced-by-count":0,"title":["Unusual pontine metastasis of endometrial papillary serous carcinoma: illustrative case"],"prefix":"10.3171","volume":"8","author":[{"given":"Daniel","family":"Hettrick","sequence":"first","affiliation":[{"name":"Tufts School of Medicine, Tufts University, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Harrison Snyder","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Tufts Medical Center, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knarik","family":"Arkun","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Tufts Medical Center, Boston, Massachusetts"},{"name":"Departments of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suriya","family":"Jeyapalan","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Neuro-oncology, Tufts Medical Center, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Gynecologic Oncology, Tufts Medical Center, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Mignano","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Tufts Medical Center, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Roguski","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Tufts Medical Center, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"4","key":"bib1","series-title":"Rev Bras Ginecol Obstet","first-page":"264","article-title":"Brain metastasis in papillary serous adenocarcinoma of the endometrium. Met\u00e1stase cerebral do adenocarcinoma seroso-papil\u00edfero do endom\u00e9trio","volume":"41","author":"Eul\u00e1lio Filho","year":"2019","unstructured":"Eul\u00e1lio Filho WMNF\u00e9 TSMRodrigues RMMLima MSOVieira SC. Brain metastasis in papillary serous adenocarcinoma of the endometrium. Met\u00e1stase cerebral do adenocarcinoma seroso-papil\u00edfero do endom\u00e9trio. Rev Bras Ginecol Obstet. 2019;41(4):264-267."},{"key":"bib2","series-title":"World Neurosurg","first-page":"e32","article-title":"Brain metastases from endometrial cancer: clinical characteristics, outcomes, and review of the literature","volume":"147","author":"Bhambhvani","year":"2021","unstructured":"Bhambhvani HPZhou OCattle CTaiwo RDiver EHayden Gephart M. Brain metastases from endometrial cancer: clinical characteristics, outcomes, and review of the literature. World Neurosurg. 2021;147:e32-e39."},{"issue":"4","key":"bib3","series-title":"BJR Case Rep","first-page":"20200157","article-title":"Rare brain metastasis with unusual characteristics in a late recurrence of stage IIIA uterine papillary serous carcinoma","volume":"7","author":"Crain","year":"2021","unstructured":"Crain CNNgwanyam RPunch G. Rare brain metastasis with unusual characteristics in a late recurrence of stage IIIA uterine papillary serous carcinoma. BJR Case Rep. 2021;7(4):20200157."},{"issue":"1","key":"bib4","series-title":"Gynecol Oncol","first-page":"70","article-title":"Primary brain metastases of endometrial cancer: a report of 18 cases and review of the literature","volume":"142","author":"Uccella","year":"2016","unstructured":"Uccella SMorris JMMultinu F, et al. Primary brain metastases of endometrial cancer: a report of 18 cases and review of the literature. Gynecol Oncol. 2016;142(1):70-75."},{"issue":"2","key":"bib5","series-title":"Gynecol Oncol","first-page":"524","article-title":"Brain metastases from endometrial carcinoma: a retrospective study","volume":"93","author":"Gien","year":"2004","unstructured":"Gien LTKwon JSDsouza DP, et al. Brain metastases from endometrial carcinoma: a retrospective study. Gynecol Oncol. 2004;93(2):524-528."},{"key":"bib6","series-title":"Gynecol Oncol Rep","first-page":"87","article-title":"Brain metastases in patients with low-grade endometrial carcinoma","volume":"26","author":"Cybulska","year":"2018","unstructured":"Cybulska PStasenko MAlter R, et al. Brain metastases in patients with low-grade endometrial carcinoma. Gynecol Oncol Rep. 2018;26:87-90."},{"issue":"1","key":"bib7","series-title":"Gynecol Oncol","first-page":"79","article-title":"Multimodal therapy improves survival in patients with CNS metastasis from uterine cancer: a retrospective analysis and literature review","volume":"107","author":"Chura","year":"2007","unstructured":"Chura JCMarushin RBoyd AGhebre RGeller MAArgenta PA. Multimodal therapy improves survival in patients with CNS metastasis from uterine cancer: a retrospective analysis and literature review. Gynecol Oncol. 2007;107(1):79-85."},{"issue":"6","key":"bib8","series-title":"Pathologe","first-page":"549","article-title":"Metastatic mechanisms of uterine malignancies and therapeutic consequences. Metastasierung von Malignomen des Uterus und therapeutische Konsequenzen","volume":"37","author":"Lax","year":"2016","unstructured":"Lax SFTamussino KFLang PF. Metastatic mechanisms of uterine malignancies and therapeutic consequences. Metastasierung von Malignomen des Uterus und therapeutische Konsequenzen. Pathologe. 2016;37(6):549-556."},{"issue":"7","key":"bib9","series-title":"Arch Neurol","first-page":"741","article-title":"Distribution of brain metastases","volume":"45","author":"Delattre","year":"1988","unstructured":"Delattre JYKrol GThaler HTPosner JB. Distribution of brain metastases. Arch Neurol. 1988;45(7):741-744."},{"key":"bib10","series-title":"Gynecol Oncol Rep","first-page":"79","article-title":"Clinical presentation of brain metastases from endometrial carcinoma: a case series","volume":"28","author":"Moroney","year":"2019","unstructured":"Moroney MRWheeler LJCorr BR. Clinical presentation of brain metastases from endometrial carcinoma: a case series. Gynecol Oncol Rep. 2019;28:79-83."},{"issue":"5","key":"bib11","series-title":"J Neurosurg","first-page":"846","article-title":"Long-term survival in a patient with brain metastases preceding the diagnosis of endometrial cancer. Report of two cases and review of the literature","volume":"94","author":"Petru","year":"2001","unstructured":"Petru ELax SKurschel SG\u00fccer FSutter B. Long-term survival in a patient with brain metastases preceding the diagnosis of endometrial cancer. Report of two cases and review of the literature. J Neurosurg. 2001;94(5):846-848."},{"issue":"3","key":"bib12","series-title":"Gynecol Oncol","first-page":"557","article-title":"The efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UPSC)","volume":"99","author":"Dietrich","year":"2005","unstructured":"Dietrich CSIIIModesitt SCDePriest PD, et al. The efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UPSC). Gynecol Oncol. 2005;99(3):557-563."},{"issue":"3","key":"bib13","series-title":"Gynecol Oncol Case Rep","first-page":"94","article-title":"Her-2 targeting in uterine papillary serous carcinoma","volume":"2","author":"Talwar","year":"2012","unstructured":"Talwar SCohen S. Her-2 targeting in uterine papillary serous carcinoma. Gynecol Oncol Case Rep. 2012;2(3):94-96."},{"key":"bib14","series-title":"Surg Neurol Int","first-page":"111","article-title":"Multiple brain metastases in a patient with uterine papillary serous adenocarcinoma: treatment options for this rarely seen metastatic brain tumor","volume":"4","author":"Gulsen","year":"2013","unstructured":"Gulsen STerzi A. Multiple brain metastases in a patient with uterine papillary serous adenocarcinoma: treatment options for this rarely seen metastatic brain tumor. Surg Neurol Int. 2013;4:111."},{"key":"bib15","series-title":"Gynecol Oncol Rep","first-page":"34","article-title":"Brain metastasis from uterine serous carcinoma: a case report and review of literature","volume":"11","author":"Sierra","year":"2015","unstructured":"Sierra TNguyen LMascitelli JKalir TFishman D. Brain metastasis from uterine serous carcinoma: a case report and review of literature. Gynecol Oncol Rep. 2015;11:34-37."},{"key":"bib16","series-title":"Gynecol Oncol Rep","first-page":"1","article-title":"Brain metastasis in two patients with stage IA papillary serous carcinoma of the uterus","volume":"13","author":"Narasimhulu","year":"2015","unstructured":"Narasimhulu DMKhulpateea NMeritz KXu Y. Brain metastasis in two patients with stage IA papillary serous carcinoma of the uterus. Gynecol Oncol Rep. 2015;13:1-4."},{"issue":"3","key":"bib17","series-title":"J Neurooncol","first-page":"515","article-title":"Gamma knife radiosurgery for the treatment of gynecologic malignancies metastasizing to the brain: clinical article","volume":"120","author":"Shepard","year":"2014","unstructured":"Shepard MJFezeu FLee CCSheehan JP. Gamma knife radiosurgery for the treatment of gynecologic malignancies metastasizing to the brain: clinical article. J Neurooncol. 2014;120(3):515-522."},{"key":"bib18","series-title":"World Neurosurg","first-page":"e363","article-title":"Gamma knife surgery for brain metastases from uterine malignant tumor","volume":"139","author":"Ogino","year":"2020","unstructured":"Ogino AHirai TSerizawa TYoshino A. Gamma knife surgery for brain metastases from uterine malignant tumor. World Neurosurg. 2020;139:e363-e372."},{"key":"bib19","series-title":"StatPearls","article-title":"Spinal metastasis","author":"Ziu","year":"2024","unstructured":"Ziu EViswanathan VKMesfin FB. Spinal metastasis. In: StatPearls. 2024."},{"issue":"1","key":"bib20","series-title":"Med Mycol Case Rep","first-page":"9","article-title":"Aspergillus osteomyelitis of the lumbar spine complicated with orbital apex syndrome: a potential role of the Batson\u2019s plexus in disease propagation","volume":"1","author":"Camargo","year":"2012","unstructured":"Camargo JFSeriburi VTenner MEl Khoury MY. Aspergillus osteomyelitis of the lumbar spine complicated with orbital apex syndrome: a potential role of the Batson\u2019s plexus in disease propagation. Med Mycol Case Rep. 2012;1(1):9-12."},{"issue":"4","key":"bib1","series-title":"Rev Bras Ginecol Obstet","first-page":"264","article-title":"Brain metastasis in papillary serous adenocarcinoma of the endometrium. Met\u00e1stase cerebral do adenocarcinoma seroso-papil\u00edfero do endom\u00e9trio","volume":"41","author":"Eul\u00e1lio Filho","year":"2019","unstructured":"Eul\u00e1lio Filho WMNF\u00e9 TSMRodrigues RMMLima MSOVieira SC. Brain metastasis in papillary serous adenocarcinoma of the endometrium. Met\u00e1stase cerebral do adenocarcinoma seroso-papil\u00edfero do endom\u00e9trio. Rev Bras Ginecol Obstet. 2019;41(4):264-267."},{"key":"bib2","series-title":"World Neurosurg","first-page":"e32","article-title":"Brain metastases from endometrial cancer: clinical characteristics, outcomes, and review of the literature","volume":"147","author":"Bhambhvani","year":"2021","unstructured":"Bhambhvani HPZhou OCattle CTaiwo RDiver EHayden Gephart M. Brain metastases from endometrial cancer: clinical characteristics, outcomes, and review of the literature. World Neurosurg. 2021;147:e32-e39."},{"issue":"4","key":"bib3","series-title":"BJR Case Rep","first-page":"20200157","article-title":"Rare brain metastasis with unusual characteristics in a late recurrence of stage IIIA uterine papillary serous carcinoma","volume":"7","author":"Crain","year":"2021","unstructured":"Crain CNNgwanyam RPunch G. Rare brain metastasis with unusual characteristics in a late recurrence of stage IIIA uterine papillary serous carcinoma. BJR Case Rep. 2021;7(4):20200157."},{"issue":"1","key":"bib4","series-title":"Gynecol Oncol","first-page":"70","article-title":"Primary brain metastases of endometrial cancer: a report of 18 cases and review of the literature","volume":"142","author":"Uccella","year":"2016","unstructured":"Uccella SMorris JMMultinu F, et al. Primary brain metastases of endometrial cancer: a report of 18 cases and review of the literature. Gynecol Oncol. 2016;142(1):70-75."},{"issue":"2","key":"bib5","series-title":"Gynecol Oncol","first-page":"524","article-title":"Brain metastases from endometrial carcinoma: a retrospective study","volume":"93","author":"Gien","year":"2004","unstructured":"Gien LTKwon JSDsouza DP, et al. Brain metastases from endometrial carcinoma: a retrospective study. Gynecol Oncol. 2004;93(2):524-528."},{"key":"bib6","series-title":"Gynecol Oncol Rep","first-page":"87","article-title":"Brain metastases in patients with low-grade endometrial carcinoma","volume":"26","author":"Cybulska","year":"2018","unstructured":"Cybulska PStasenko MAlter R, et al. Brain metastases in patients with low-grade endometrial carcinoma. Gynecol Oncol Rep. 2018;26:87-90."},{"issue":"1","key":"bib7","series-title":"Gynecol Oncol","first-page":"79","article-title":"Multimodal therapy improves survival in patients with CNS metastasis from uterine cancer: a retrospective analysis and literature review","volume":"107","author":"Chura","year":"2007","unstructured":"Chura JCMarushin RBoyd AGhebre RGeller MAArgenta PA. Multimodal therapy improves survival in patients with CNS metastasis from uterine cancer: a retrospective analysis and literature review. Gynecol Oncol. 2007;107(1):79-85."},{"issue":"6","key":"bib8","series-title":"Pathologe","first-page":"549","article-title":"Metastatic mechanisms of uterine malignancies and therapeutic consequences. Metastasierung von Malignomen des Uterus und therapeutische Konsequenzen","volume":"37","author":"Lax","year":"2016","unstructured":"Lax SFTamussino KFLang PF. Metastatic mechanisms of uterine malignancies and therapeutic consequences. Metastasierung von Malignomen des Uterus und therapeutische Konsequenzen. Pathologe. 2016;37(6):549-556."},{"issue":"7","key":"bib9","series-title":"Arch Neurol","first-page":"741","article-title":"Distribution of brain metastases","volume":"45","author":"Delattre","year":"1988","unstructured":"Delattre JYKrol GThaler HTPosner JB. Distribution of brain metastases. Arch Neurol. 1988;45(7):741-744."},{"key":"bib10","series-title":"Gynecol Oncol Rep","first-page":"79","article-title":"Clinical presentation of brain metastases from endometrial carcinoma: a case series","volume":"28","author":"Moroney","year":"2019","unstructured":"Moroney MRWheeler LJCorr BR. Clinical presentation of brain metastases from endometrial carcinoma: a case series. Gynecol Oncol Rep. 2019;28:79-83."},{"issue":"5","key":"bib11","series-title":"J Neurosurg","first-page":"846","article-title":"Long-term survival in a patient with brain metastases preceding the diagnosis of endometrial cancer. Report of two cases and review of the literature","volume":"94","author":"Petru","year":"2001","unstructured":"Petru ELax SKurschel SG\u00fccer FSutter B. Long-term survival in a patient with brain metastases preceding the diagnosis of endometrial cancer. Report of two cases and review of the literature. J Neurosurg. 2001;94(5):846-848."},{"issue":"3","key":"bib12","series-title":"Gynecol Oncol","first-page":"557","article-title":"The efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UPSC)","volume":"99","author":"Dietrich","year":"2005","unstructured":"Dietrich CSIIIModesitt SCDePriest PD, et al. The efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UPSC). Gynecol Oncol. 2005;99(3):557-563."},{"issue":"3","key":"bib13","series-title":"Gynecol Oncol Case Rep","first-page":"94","article-title":"Her-2 targeting in uterine papillary serous carcinoma","volume":"2","author":"Talwar","year":"2012","unstructured":"Talwar SCohen S. Her-2 targeting in uterine papillary serous carcinoma. Gynecol Oncol Case Rep. 2012;2(3):94-96."},{"key":"bib14","series-title":"Surg Neurol Int","first-page":"111","article-title":"Multiple brain metastases in a patient with uterine papillary serous adenocarcinoma: treatment options for this rarely seen metastatic brain tumor","volume":"4","author":"Gulsen","year":"2013","unstructured":"Gulsen STerzi A. Multiple brain metastases in a patient with uterine papillary serous adenocarcinoma: treatment options for this rarely seen metastatic brain tumor. Surg Neurol Int. 2013;4:111."},{"key":"bib15","series-title":"Gynecol Oncol Rep","first-page":"34","article-title":"Brain metastasis from uterine serous carcinoma: a case report and review of literature","volume":"11","author":"Sierra","year":"2015","unstructured":"Sierra TNguyen LMascitelli JKalir TFishman D. Brain metastasis from uterine serous carcinoma: a case report and review of literature. Gynecol Oncol Rep. 2015;11:34-37."},{"key":"bib16","series-title":"Gynecol Oncol Rep","first-page":"1","article-title":"Brain metastasis in two patients with stage IA papillary serous carcinoma of the uterus","volume":"13","author":"Narasimhulu","year":"2015","unstructured":"Narasimhulu DMKhulpateea NMeritz KXu Y. Brain metastasis in two patients with stage IA papillary serous carcinoma of the uterus. Gynecol Oncol Rep. 2015;13:1-4."},{"issue":"3","key":"bib17","series-title":"J Neurooncol","first-page":"515","article-title":"Gamma knife radiosurgery for the treatment of gynecologic malignancies metastasizing to the brain: clinical article","volume":"120","author":"Shepard","year":"2014","unstructured":"Shepard MJFezeu FLee CCSheehan JP. Gamma knife radiosurgery for the treatment of gynecologic malignancies metastasizing to the brain: clinical article. J Neurooncol. 2014;120(3):515-522."},{"key":"bib18","series-title":"World Neurosurg","first-page":"e363","article-title":"Gamma knife surgery for brain metastases from uterine malignant tumor","volume":"139","author":"Ogino","year":"2020","unstructured":"Ogino AHirai TSerizawa TYoshino A. Gamma knife surgery for brain metastases from uterine malignant tumor. World Neurosurg. 2020;139:e363-e372."},{"key":"bib19","series-title":"StatPearls","article-title":"Spinal metastasis","author":"Ziu","year":"2024","unstructured":"Ziu EViswanathan VKMesfin FB. Spinal metastasis. In: StatPearls. 2024."},{"issue":"1","key":"bib20","series-title":"Med Mycol Case Rep","first-page":"9","article-title":"Aspergillus osteomyelitis of the lumbar spine complicated with orbital apex syndrome: a potential role of the Batson\u2019s plexus in disease propagation","volume":"1","author":"Camargo","year":"2012","unstructured":"Camargo JFSeriburi VTenner MEl Khoury MY. Aspergillus osteomyelitis of the lumbar spine complicated with orbital apex syndrome: a potential role of the Batson\u2019s plexus in disease propagation. Med Mycol Case Rep. 2012;1(1):9-12."}],"container-title":["Journal of Neurosurgery: Case Lessons"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/8\/24\/article-CASE24513.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/8\/24\/article-CASE24513.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/8\/24\/article-CASE24513.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:52:14Z","timestamp":1769687534000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/8\/24\/article-CASE24513.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":40,"journal-issue":{"issue":"24"},"URL":"https:\/\/doi.org\/10.3171\/case24513","relation":{},"ISSN":["2694-1902"],"issn-type":[{"value":"2694-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,9]]}}}