{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:51:45Z","timestamp":1780419105903,"version":"3.54.1"},"reference-count":90,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"10","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,3,10]]},"abstract":"\n BACKGROUND<\/jats:title>\n Intramedullary primary spinal melanoma (IPSM) is a rare tumor, with limited reports on its clinical presentation, radiographic features, histopathological and genetic factors, diagnosis, and management.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n A 49-year-old male presented with a 9-month history of intermittent, progressive left upper-extremity radiculopathy and left-sided numbness. Magnetic resonance imaging revealed an intramedullary tumor at the C6\u2013T1 vertebral levels. Intraoperatively, upon opening the dura, the tumor was noted to be dark in appearance. Dorsal column mapping allowed for safe myelotomies above and below the tumor bulk, and a gross-total resection was achieved. The patient awoke with mild decreased lower-extremity sensation and proprioception but full motor strength. Surgical pathology was consistent with melanoma. Further workup ruled out the possibility of alternative primary neoplastic sites, and a diagnosis of IPSM was made. The patient was planned for radiation therapy (RT) and immune checkpoint inhibitor therapy in follow-up.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n Fewer than 40 cases of IPSM have been described in the literature. While patients with IPSM present with progressive symptomology and unique imaging findings, surgical pathology is required for a diagnosis. The optimal treatment paradigm likely includes resection, RT, and\/or systemic therapies. Molecular and genetic markers might enable more efficient diagnosis and optimize therapy for these patients.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE24732<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case24732","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T02:59:43Z","timestamp":1741575583000},"source":"Crossref","is-referenced-by-count":2,"title":["Intramedullary primary spinal cord melanoma: illustrative case"],"prefix":"10.3171","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5617-9009","authenticated-orcid":true,"given":"Akash","family":"Mishra","sequence":"first","affiliation":[{"name":"Zucker School of Medicine at Hofstra University\/Northwell Health, Hempstead, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3330-455X","authenticated-orcid":true,"given":"Danielle","family":"Golub","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Northwell Health, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Northwell Health, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimon","family":"Garrel","sequence":"additional","affiliation":[{"name":"SUNY Downstate College of Medicine, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-6232","authenticated-orcid":true,"given":"Harshal A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Zucker School of Medicine at Hofstra University\/Northwell Health, Hempstead, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyle H.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Northwell Health, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo L.","family":"Sistiaga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Northwell Health, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwell Health, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Ramlal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwell Health, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zuckerberg Cancer Center, Northwell Health, New Hyde Park, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Carvajal","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, Northwell Health, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-434X","authenticated-orcid":true,"given":"Daniel M.","family":"Sciubba","sequence":"additional","affiliation":[{"name":"Zucker School of Medicine at Hofstra University\/Northwell Health, Hempstead, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Fu Larry","family":"Lo","sequence":"additional","affiliation":[{"name":"Zucker School of Medicine at Hofstra University\/Northwell Health, Hempstead, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3","key":"bib1","series-title":"Neurol India","first-page":"413","article-title":"Primary melanocytic tumors of the central nervous system: a neuroradiological and clinicopathological study of five cases and brief review of literature","volume":"59","author":"Jaiswal","year":"2011","unstructured":"Jaiswal SVij MTungria AJaiswal AKSrivastava AKBehari S.Primary melanocytic tumors of the central nervous system: a neuroradiological and clinicopathological study of five cases and brief review of literature. 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