{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:28:36Z","timestamp":1770114516807,"version":"3.49.0"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"12","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,3,24]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The clinical and radiological evolution of large capillary telangiectasias is largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 30-year-old female presented with progressive ataxia and nystagmus. She was found to have a large, diffuse enhancing pontomedullary lesion with associated hypointensity on susceptibility-weighted imaging consistent with a large capillary telangiectasia. In addition, she had a second capillary telangiectasia in the right frontal lobe, hypertrophic olivary degeneration (HOD), and multiple susceptibility lesions throughout the brain. The patient\u2019s condition continued to deteriorate and she became nonambulatory over 8 years, with right-sided hemiparesis and hemiataxia, nystagmus, palatal myoclonus, and a left abducens palsy. Over the follow-up period, serial MR images showed increased cavitation of the lesion and significant brainstem atrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Capillary telangiectasias are generally small, benign lesions composed of dilated capillaries. However, when large (\u2265 1 cm), they can be symptomatic. The authors present the case of a diffuse capillary telangiectasia of the pons with HOD and a progressively declining course due to brainstem atrophy and enlarging cavitation of the lesion. The radiological evolution of an aggressive capillary telangiectasia has not been previously reported.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE24746\">https:\/\/thejns.org\/doi\/10.3171\/CASE24746<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case24746","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T07:46:09Z","timestamp":1742802369000},"source":"Crossref","is-referenced-by-count":0,"title":["Aggressive giant pontine capillary telangiectasia with hypertrophic olivary degeneration and brainstem atrophy: illustrative case"],"prefix":"10.3171","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6021-1190","authenticated-orcid":true,"given":"Kelly D.","family":"Flemming","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Rinaldo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Lanzino","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"5","key":"bib1","series-title":"Acta Neurochir (Wien)","first-page":"1101","article-title":"Brain capillary telangiectasias: from normal variants to disease","volume":"162","author":"Larson","year":"2020","unstructured":"Larson ASFlemming KDLanzino GBrinjikji W.Brain capillary telangiectasias: from normal variants to disease. Acta Neurochir (Wien). 2020;162(5):1101-1113."},{"issue":"4","key":"bib2","series-title":"J Neurosurg","first-page":"709","article-title":"Capillary telangiectasias: clinical, radiographic, and histopathological features. Clinical article","volume":"113","author":"Sayama","year":"2010","unstructured":"Sayama CMOsborn AGChin SSCouldwell WT.Capillary telangiectasias: clinical, radiographic, and histopathological features. Clinical article. J Neurosurg. 2010;113(4):709-714."},{"issue":"5","key":"bib3","series-title":"JBR-BTR","first-page":"293","article-title":"MRI findings in giant pontine capillary telangiectasis associated with a developmental venous anomaly","volume":"94","author":"Ozcan","year":"2011","unstructured":"Ozcan HNAvcu SDe Bleecker JLemmerling M.MRI findings in giant pontine capillary telangiectasis associated with a developmental venous anomaly. JBR-BTR. 2011;94(5):293-294."},{"issue":"1","key":"bib4","series-title":"J Neurosurg","first-page":"160","article-title":"Symptomatic large or giant capillary telangiectasias: management and outcome in 5 cases","volume":"125","author":"Yu","year":"2016","unstructured":"Yu TSun XYou YSymptomatic large or giant capillary telangiectasias: management and outcome in 5 cases. J Neurosurg. 2016;125(1):160-166."},{"issue":"1","key":"bib5","series-title":"Lancet Neurol","first-page":"35","article-title":"Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial","volume":"22","author":"Lanfranconi","year":"2023","unstructured":"Lanfranconi SScola EMeessen JMTASafety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial. Lancet Neurol. 2023;22(1):35-44."},{"issue":"11","key":"bib6","series-title":"Childs Nerv Syst","first-page":"2261","article-title":"Symptomatic capillary telangiectasia of the pons: three pediatric cases diagnosed by suspectibility-weighted imaging","volume":"32","author":"Orgun","year":"2016","unstructured":"Orgun LTArhan EAyd\u0131n KSerdaroglu AG\u00fcc\u00fcyener K.Symptomatic capillary telangiectasia of the pons: three pediatric cases diagnosed by suspectibility-weighted imaging. Childs Nerv Syst. 2016;32(11):2261-2264."},{"issue":"9","key":"bib7","series-title":"AJNR Am J Neuroradiol","first-page":"1674","article-title":"Clinically aggressive diffuse capillary telangiectasia of the brain stem: a clinical radiologic-pathologic case study","volume":"20","author":"Huddle","year":"1999","unstructured":"Huddle DCChaloupka JCSehgal V.Clinically aggressive diffuse capillary telangiectasia of the brain stem: a clinical radiologic-pathologic case study. AJNR Am J Neuroradiol. 1999;20(9):1674-1677."},{"key":"bib8","series-title":"World Neurosurg","first-page":"e763","article-title":"Hypertrophic olivary degeneration: neurosurgical perspective and literature review","volume":"112","author":"Onen","year":"2018","unstructured":"Onen MRMoore KCikla UHypertrophic olivary degeneration: neurosurgical perspective and literature review. World Neurosurg. 2018;112:e763-e771."},{"issue":"5","key":"bib1","series-title":"Acta Neurochir (Wien)","first-page":"1101","article-title":"Brain capillary telangiectasias: from normal variants to disease","volume":"162","author":"Larson","year":"2020","unstructured":"Larson ASFlemming KDLanzino GBrinjikji W.Brain capillary telangiectasias: from normal variants to disease. Acta Neurochir (Wien). 2020;162(5):1101-1113."},{"issue":"4","key":"bib2","series-title":"J Neurosurg","first-page":"709","article-title":"Capillary telangiectasias: clinical, radiographic, and histopathological features. Clinical article","volume":"113","author":"Sayama","year":"2010","unstructured":"Sayama CMOsborn AGChin SSCouldwell WT.Capillary telangiectasias: clinical, radiographic, and histopathological features. Clinical article. J Neurosurg. 2010;113(4):709-714."},{"issue":"5","key":"bib3","series-title":"JBR-BTR","first-page":"293","article-title":"MRI findings in giant pontine capillary telangiectasis associated with a developmental venous anomaly","volume":"94","author":"Ozcan","year":"2011","unstructured":"Ozcan HNAvcu SDe Bleecker JLemmerling M.MRI findings in giant pontine capillary telangiectasis associated with a developmental venous anomaly. JBR-BTR. 2011;94(5):293-294."},{"issue":"1","key":"bib4","series-title":"J Neurosurg","first-page":"160","article-title":"Symptomatic large or giant capillary telangiectasias: management and outcome in 5 cases","volume":"125","author":"Yu","year":"2016","unstructured":"Yu TSun XYou YSymptomatic large or giant capillary telangiectasias: management and outcome in 5 cases. J Neurosurg. 2016;125(1):160-166."},{"issue":"1","key":"bib5","series-title":"Lancet Neurol","first-page":"35","article-title":"Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial","volume":"22","author":"Lanfranconi","year":"2023","unstructured":"Lanfranconi SScola EMeessen JMTASafety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial. Lancet Neurol. 2023;22(1):35-44."},{"issue":"11","key":"bib6","series-title":"Childs Nerv Syst","first-page":"2261","article-title":"Symptomatic capillary telangiectasia of the pons: three pediatric cases diagnosed by suspectibility-weighted imaging","volume":"32","author":"Orgun","year":"2016","unstructured":"Orgun LTArhan EAyd\u0131n KSerdaroglu AG\u00fcc\u00fcyener K.Symptomatic capillary telangiectasia of the pons: three pediatric cases diagnosed by suspectibility-weighted imaging. Childs Nerv Syst. 2016;32(11):2261-2264."},{"issue":"9","key":"bib7","series-title":"AJNR Am J Neuroradiol","first-page":"1674","article-title":"Clinically aggressive diffuse capillary telangiectasia of the brain stem: a clinical radiologic-pathologic case study","volume":"20","author":"Huddle","year":"1999","unstructured":"Huddle DCChaloupka JCSehgal V.Clinically aggressive diffuse capillary telangiectasia of the brain stem: a clinical radiologic-pathologic case study. AJNR Am J Neuroradiol. 1999;20(9):1674-1677."},{"key":"bib8","series-title":"World Neurosurg","first-page":"e763","article-title":"Hypertrophic olivary degeneration: neurosurgical perspective and literature review","volume":"112","author":"Onen","year":"2018","unstructured":"Onen MRMoore KCikla UHypertrophic olivary degeneration: neurosurgical perspective and literature review. World Neurosurg. 2018;112:e763-e771."}],"container-title":["Journal of Neurosurgery: Case Lessons"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/9\/12\/article-CASE24746.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/9\/12\/article-CASE24746.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/9\/12\/article-CASE24746.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T23:38:56Z","timestamp":1770075536000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/9\/12\/article-CASE24746.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,24]]},"references-count":16,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.3171\/case24746","relation":{},"ISSN":["2694-1902"],"issn-type":[{"value":"2694-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,24]]}}}