{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:55:59Z","timestamp":1788947759633,"version":"build-2803163510"},"reference-count":58,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"10","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,3,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Segmental arterial mediolysis (SAM) is a rare, noninflammatory vascular disease primarily affecting small to medium arteries. Although neurological presentations like subarachnoid hemorrhage (SAH) and ischemic stroke have been reported, awareness of SAM in neurology remains limited. The authors present a unique case of SAM with SAH following chronic internal carotid artery (ICA) dissection and explore the clinical course and potential ethnic implications of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 56-year-old Japanese man with a history of left ICA dissection presented with sudden-onset headache and loss of consciousness. Imaging revealed a diffuse SAH caused by a ruptured vertebral artery aneurysm. Despite initial conservative treatment and subsequent coil embolization, the patient\u2019s condition deteriorated, and he died on day 10. Postmortem examination revealed multiple arterial dissections and medial degeneration, confirming SAM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Physicians specializing in vascular diseases should pay attention to the possibility and management of SAM in patients with multiple arterial lesions, including neurological fields. SAM involving craniocervical vessels presents a high risk of morbidity and mortality. Early recognition and appropriate management are crucial, particularly in neurovascular cases.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE24810\">https:\/\/thejns.org\/doi\/10.3171\/CASE24810<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case24810","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T02:59:49Z","timestamp":1741575589000},"source":"Crossref","is-referenced-by-count":1,"title":["Segmental arterial mediolysis with subarachnoid hemorrhage following chronic internal carotid artery dissection: illustrative case"],"prefix":"10.3171","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7191-4841","authenticated-orcid":true,"given":"Shoji","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan"},{"name":"Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan"},{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"},{"name":"Department of Neurosurgery, Chuno Kosei Hospital, Seki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Egashira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0901-4758","authenticated-orcid":true,"given":"Mamoru","family":"Ogiso","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chuno Kosei Hospital, Seki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6376-6980","authenticated-orcid":true,"given":"Hiroki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chuno Kosei Hospital, Seki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohtaro","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chuno Kosei Hospital, Seki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9537-9632","authenticated-orcid":true,"given":"Munekazu","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gifu University Hospital, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Kotani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chuno Kosei Hospital, Seki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-2046","authenticated-orcid":true,"given":"Tatsuhiko","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gifu University Hospital, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chuno Kosei Hospital, Seki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"1","key":"bib1","series-title":"Lab Invest","first-page":"23","article-title":"Segmental mediolytic arteritis: a clinical pathologic study","volume":"35","author":"Slavin","year":"1976","unstructured":"Slavin REGonzalez-Vitale JC.Segmental mediolytic arteritis: a clinical pathologic study. Lab Invest. 1976;35(1):23-29."},{"issue":"10","key":"bib2","series-title":"J Vasc Interv Radiol","first-page":"1380","article-title":"Segmental arterial mediolysis: clinical and imaging features at presentation and during follow-up","volume":"22","author":"Kalva","year":"2011","unstructured":"Kalva SPSomarouthu BJaff MRWicky S.Segmental arterial mediolysis: clinical and imaging features at presentation and during follow-up. J Vasc Interv Radiol. 2011;22(10):1380-1387."},{"issue":"6","key":"bib3","series-title":"Vasc Med","first-page":"549","article-title":"Segmental arterial mediolysis (SAM): systematic review and analysis of 143 cases","volume":"24","author":"Skeik","year":"2019","unstructured":"Skeik NOlson SLHari GPavia ML.Segmental arterial mediolysis (SAM): systematic review and analysis of 143 cases. Vasc Med. 2019;24(6):549-563."},{"issue":"6","key":"bib4","series-title":"J Vasc Surg","first-page":"1877","article-title":"Natural history and management outcomes of segmental arterial mediolysis","volume":"70","author":"Peng","year":"2019","unstructured":"Peng KXDavila VJStone WMNatural history and management outcomes of segmental arterial mediolysis. J Vasc Surg. 2019;70(6):1877-1886."},{"issue":"1","key":"bib5","series-title":"Ann Vasc Surg","first-page":"269","article-title":"Segmental arterial mediolysis: a systematic review of 85 cases","volume":"28","author":"Shenouda","year":"2014","unstructured":"Shenouda MRiga CNaji YRenton S.Segmental arterial mediolysis: a systematic review of 85 cases. Ann Vasc Surg. 2014;28(1):269-277."},{"issue":"7","key":"bib6","series-title":"Pathol Res Pract","first-page":"493","article-title":"A case of segmental mediolytic arteriopathy involving both intracranial and intraabdominal arteries","volume":"198","author":"Sakata","year":"2002","unstructured":"Sakata NTakebayashi SShimizu KA case of segmental mediolytic arteriopathy involving both intracranial and intraabdominal arteries. Pathol Res Pract. 2002;198(7):493-500."},{"issue":"2","key":"bib7","series-title":"Leg Med (Tokyo)","first-page":"101","article-title":"Non-traumatic rupture of the intracranial vertebral artery of a man found dead in a severe car accident\u2014histopathological differentiation by step-serial sections","volume":"10","author":"Ro","year":"2008","unstructured":"Ro AKageyama NHayashi KShigeta AFukunaga T.Non-traumatic rupture of the intracranial vertebral artery of a man found dead in a severe car accident\u2014histopathological differentiation by step-serial sections. Leg Med (Tokyo). 2008;10(2):101-106."},{"issue":"3","key":"bib8","series-title":"Pathol Int","first-page":"197","article-title":"Aneurysms of the renal arteries associated with segmental arterial mediolysis in a case of polyarteritis nodosa","volume":"59","author":"Soga","year":"2009","unstructured":"Soga YNose MArita NAneurysms of the renal arteries associated with segmental arterial mediolysis in a case of polyarteritis nodosa. Pathol Int. 2009;59(3):197-200."},{"issue":"5","key":"bib9","series-title":"J Neurosurg","first-page":"948","article-title":"Subarachnoid hemorrhage in a case of segmental arterial mediolysis with coexisting intracranial and intraabdominal aneurysms","volume":"116","author":"Matsuda","year":"2012","unstructured":"Matsuda RHironaka YTakeshima YPark YSNakase H.Subarachnoid hemorrhage in a case of segmental arterial mediolysis with coexisting intracranial and intraabdominal aneurysms. 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Interv Neuroradiol. 2017;23(4):378-381."},{"key":"bib13","series-title":"Surg Neurol Int","first-page":"175","article-title":"Unexpected intraabdominal hemorrhage due to segmental arterial mediolysis following subarachnoid hemorrhage: a case of ruptured intracranial and intraabdominal aneurysms","volume":"9","author":"Hayashi","year":"2018","unstructured":"Hayashi SHosoda KNishimoto YUnexpected intraabdominal hemorrhage due to segmental arterial mediolysis following subarachnoid hemorrhage: a case of ruptured intracranial and intraabdominal aneurysms. Surg Neurol Int. 2018;9:175."},{"issue":"3","key":"bib14","series-title":"Clin Neuroradiol","first-page":"445","article-title":"Concomitant retroperitoneal and subarachnoid hemorrhage due to segmental arterial mediolysis: case report and review of the literature","volume":"28","author":"Hellstern","year":"2018","unstructured":"Hellstern VAguilar P\u00e9rez MKohlhof-Meinecke PB\u00e4zner HGanslandt OHenkes H.Concomitant retroperitoneal and subarachnoid hemorrhage due to segmental arterial mediolysis: case report and review of the literature. Clin Neuroradiol. 2018;28(3):445-450."},{"key":"bib15","series-title":"World Neurosurg","first-page":"44","article-title":"Treatment of ruptured vertebral artery dissection and abdominal hemorrhage associated with segmental arterial mediolysis using endovascular coil embolization","volume":"116","author":"Isaji","year":"2018","unstructured":"Isaji TOhshima TMiyachi SMatsuo NKawaguchi RTakayasu M.Treatment of ruptured vertebral artery dissection and abdominal hemorrhage associated with segmental arterial mediolysis using endovascular coil embolization. World Neurosurg. 2018;116:44-49."},{"issue":"5","key":"bib16","series-title":"No Shinkei Geka","first-page":"543","article-title":"A case of segmental arterial mediolysis: subarachnoid hemorrhage followed by abdominal bleeding","volume":"47","author":"Inazuka","year":"2019","unstructured":"Inazuka MImazato DYamazaki KA case of segmental arterial mediolysis: subarachnoid hemorrhage followed by abdominal bleeding. Article in Japanese. 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Article in Japanese. No Shinkei Geka. 2020;48(9):835-840."},{"key":"bib19","series-title":"World Neurosurg","first-page":"79","article-title":"A ruptured blood blister-like aneurysm associated with intraperitoneal hemorrhage due to segmental arterial mediolysis: a case report and literature review","volume":"134","author":"Tanaka","year":"2020","unstructured":"Tanaka KFujiwara MOkuda YIshida FSuzuki H.A ruptured blood blister-like aneurysm associated with intraperitoneal hemorrhage due to segmental arterial mediolysis: a case report and literature review. World Neurosurg. 2020;134:79-85."},{"key":"bib20","series-title":"Surg Neurol Int","first-page":"240","article-title":"A case of segmental arterial mediolysis with subarachnoid hemorrhage due to anterior cerebral artery dissection followed by internal carotid artery dissection","volume":"12","author":"Yasuda","year":"2021","unstructured":"Yasuda SUematsu KYamashita KKuroda TMurase SKumagai M.A case of segmental arterial mediolysis with subarachnoid hemorrhage due to anterior cerebral artery dissection followed by internal carotid artery dissection. Surg Neurol Int. 2021;12:240."},{"issue":"9","key":"bib21","series-title":"Clin Case Rep","first-page":"e6371","article-title":"Intraperitoneal hemorrhage due to segmental arterial mediolysis associated with cerebral vasospasm after subarachnoid hemorrhage","volume":"10","author":"Matsuura","year":"2022","unstructured":"Matsuura CFuchinoue YTerazono SKondo KHarada NSugo N.Intraperitoneal hemorrhage due to segmental arterial mediolysis associated with cerebral vasospasm after subarachnoid hemorrhage. Clin Case Rep. 2022;10(9):e6371."},{"issue":"5","key":"bib22","series-title":"J Neurosurg Case Lessons","first-page":"CASE22233","article-title":"Intra-abdominal hemorrhage due to segmental arterial mediolysis of an ovarian artery pseudoaneurysm and concomitant aneurysmal subarachnoid hemorrhage: illustrative case","volume":"4","author":"Tao","year":"2022","unstructured":"Tao YMatsubara SYagi KIntra-abdominal hemorrhage due to segmental arterial mediolysis of an ovarian artery pseudoaneurysm and concomitant aneurysmal subarachnoid hemorrhage: illustrative case. J Neurosurg Case Lessons. 2022;4(5):CASE22233."},{"key":"bib23","series-title":"Surg Neurol Int","first-page":"175","article-title":"A case of subarachnoid hemorrhage caused by multiple cerebral aneurysms due to segmental arterial mediolysis","volume":"13","author":"Tokuda","year":"2022","unstructured":"Tokuda TTajiri SUeda YOhmori YMukasa A.A case of subarachnoid hemorrhage caused by multiple cerebral aneurysms due to segmental arterial mediolysis. Surg Neurol Int. 2022;13:175."},{"issue":"3","key":"bib24","series-title":"J Neuroendovasc Ther","first-page":"189","volume":"15","author":"Ota","year":"2021","unstructured":"Ota KMatsubara N.A case of segmental arterial mediolysis: hemoperitoneum with hemorrhagic shock due to rupture of a visceral artery aneurysm following subarachnoid hemorrhage. J Neuroendovasc Ther. 2021;15(3):189-194."},{"issue":"12","key":"bib25","series-title":"N Engl J Med","first-page":"898","article-title":"Spontaneous dissection of the carotid and vertebral arteries","volume":"344","author":"Schievink","year":"2001","unstructured":"Schievink WI.Spontaneous dissection of the carotid and vertebral arteries. N Engl J Med. 2001;344(12):898-906."},{"issue":"11","key":"bib26","series-title":"Arthritis Care Res (Hoboken)","first-page":"1655","article-title":"Clinical diagnosis of segmental arterial mediolysis: differentiation from vasculitis and other mimics","volume":"62","author":"Baker-LePain","year":"2010","unstructured":"Baker-LePain JCStone DHMattis ANNakamura MCFye KH.Clinical diagnosis of segmental arterial mediolysis: differentiation from vasculitis and other mimics. Arthritis Care Res (Hoboken). 2010;62(11):1655-1660."},{"issue":"6","key":"bib27","series-title":"Cardiovasc Pathol","first-page":"352","article-title":"Segmental arterial mediolysis: course, sequelae, prognosis, and pathologic-radiologic correlation","volume":"18","author":"Slavin","year":"2009","unstructured":"Slavin RE.Segmental arterial mediolysis: course, sequelae, prognosis, and pathologic-radiologic correlation. Cardiovasc Pathol. 2009;18(6):352-360."},{"issue":"4","key":"bib28","series-title":"J Neuroendovascular Ther","first-page":"161","article-title":"Pathomorphological examination of patients with the simultaneous rupture of dissecting intracranial vertebral and intraperitoneal arteries: involvement of segmental arterial mediolysis in intracranial artery dissection","volume":"12","author":"Ro","year":"2018","unstructured":"Ro AKageyama NMukai T.Pathomorphological examination of patients with the simultaneous rupture of dissecting intracranial vertebral and intraperitoneal arteries: involvement of segmental arterial mediolysis in intracranial artery dissection. J Neuroendovascular Ther. 2018;12(4):161-168."},{"issue":"4","key":"bib29","series-title":"Cardiovasc Pathol","first-page":"334","article-title":"Segmental arterial mediolysis\u2014an iatrogenic vascular disorder induced by ractopamine","volume":"21","author":"Slavin","year":"2012","unstructured":"Slavin REYaeger MJ.Segmental arterial mediolysis\u2014an iatrogenic vascular disorder induced by ractopamine. Cardiovasc Pathol. 2012;21(4):334-338."},{"issue":"1","key":"bib1","series-title":"Lab Invest","first-page":"23","article-title":"Segmental mediolytic arteritis: a clinical pathologic study","volume":"35","author":"Slavin","year":"1976","unstructured":"Slavin REGonzalez-Vitale JC.Segmental mediolytic arteritis: a clinical pathologic study. Lab Invest. 1976;35(1):23-29."},{"issue":"10","key":"bib2","series-title":"J Vasc Interv Radiol","first-page":"1380","article-title":"Segmental arterial mediolysis: clinical and imaging features at presentation and during follow-up","volume":"22","author":"Kalva","year":"2011","unstructured":"Kalva SPSomarouthu BJaff MRWicky S.Segmental arterial mediolysis: clinical and imaging features at presentation and during follow-up. J Vasc Interv Radiol. 2011;22(10):1380-1387."},{"issue":"6","key":"bib3","series-title":"Vasc Med","first-page":"549","article-title":"Segmental arterial mediolysis (SAM): systematic review and analysis of 143 cases","volume":"24","author":"Skeik","year":"2019","unstructured":"Skeik NOlson SLHari GPavia ML.Segmental arterial mediolysis (SAM): systematic review and analysis of 143 cases. Vasc Med. 2019;24(6):549-563."},{"issue":"6","key":"bib4","series-title":"J Vasc Surg","first-page":"1877","article-title":"Natural history and management outcomes of segmental arterial mediolysis","volume":"70","author":"Peng","year":"2019","unstructured":"Peng KXDavila VJStone WMNatural history and management outcomes of segmental arterial mediolysis. J Vasc Surg. 2019;70(6):1877-1886."},{"issue":"1","key":"bib5","series-title":"Ann Vasc Surg","first-page":"269","article-title":"Segmental arterial mediolysis: a systematic review of 85 cases","volume":"28","author":"Shenouda","year":"2014","unstructured":"Shenouda MRiga CNaji YRenton S.Segmental arterial mediolysis: a systematic review of 85 cases. Ann Vasc Surg. 2014;28(1):269-277."},{"issue":"7","key":"bib6","series-title":"Pathol Res Pract","first-page":"493","article-title":"A case of segmental mediolytic arteriopathy involving both intracranial and intraabdominal arteries","volume":"198","author":"Sakata","year":"2002","unstructured":"Sakata NTakebayashi SShimizu KA case of segmental mediolytic arteriopathy involving both intracranial and intraabdominal arteries. Pathol Res Pract. 2002;198(7):493-500."},{"issue":"2","key":"bib7","series-title":"Leg Med (Tokyo)","first-page":"101","article-title":"Non-traumatic rupture of the intracranial vertebral artery of a man found dead in a severe car accident\u2014histopathological differentiation by step-serial sections","volume":"10","author":"Ro","year":"2008","unstructured":"Ro AKageyama NHayashi KShigeta AFukunaga T.Non-traumatic rupture of the intracranial vertebral artery of a man found dead in a severe car accident\u2014histopathological differentiation by step-serial sections. Leg Med (Tokyo). 2008;10(2):101-106."},{"issue":"3","key":"bib8","series-title":"Pathol Int","first-page":"197","article-title":"Aneurysms of the renal arteries associated with segmental arterial mediolysis in a case of polyarteritis nodosa","volume":"59","author":"Soga","year":"2009","unstructured":"Soga YNose MArita NAneurysms of the renal arteries associated with segmental arterial mediolysis in a case of polyarteritis nodosa. Pathol Int. 2009;59(3):197-200."},{"issue":"5","key":"bib9","series-title":"J Neurosurg","first-page":"948","article-title":"Subarachnoid hemorrhage in a case of segmental arterial mediolysis with coexisting intracranial and intraabdominal aneurysms","volume":"116","author":"Matsuda","year":"2012","unstructured":"Matsuda RHironaka YTakeshima YPark YSNakase H.Subarachnoid hemorrhage in a case of segmental arterial mediolysis with coexisting intracranial and intraabdominal aneurysms. J Neurosurg. 2012;116(5):948-951."},{"issue":"5","key":"bib10","series-title":"J Neurointerv Surg","first-page":"478","article-title":"Serial angiographic appearance of segmental arterial mediolysis manifesting as vertebral, internal mammary and intra-abdominal visceral artery aneurysms in a patient presenting with subarachnoid hemorrhage and review of the literature","volume":"5","author":"Cooke","year":"2013","unstructured":"Cooke DLMeisel KMKim WTSerial angiographic appearance of segmental arterial mediolysis manifesting as vertebral, internal mammary and intra-abdominal visceral artery aneurysms in a patient presenting with subarachnoid hemorrhage and review of the literature. J Neurointerv Surg. 2013;5(5):478-482."},{"key":"bib11","series-title":"World Neurosurg","first-page":"694.e5","article-title":"Segmental arterial mediolysis involving both vertebral and middle colic arteries leading to subarachnoid and intraperitoneal hemorrhage","volume":"88","author":"Shinoda","year":"2016","unstructured":"Shinoda NHirai OMikami KSegmental arterial mediolysis involving both vertebral and middle colic arteries leading to subarachnoid and intraperitoneal hemorrhage. World Neurosurg. 2016;88:694.e5-694.e10."},{"issue":"4","key":"bib12","series-title":"Interv Neuroradiol","first-page":"378","article-title":"Subarachnoid and intraperitoneal hemorrhage secondary to segmental arterial mediolysis: a case report and review of the literature","volume":"23","author":"Welch","year":"2017","unstructured":"Welch BTBrinjikji WStockland AHLanzino G.Subarachnoid and intraperitoneal hemorrhage secondary to segmental arterial mediolysis: a case report and review of the literature. 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Surg Neurol Int. 2018;9:175."},{"issue":"3","key":"bib14","series-title":"Clin Neuroradiol","first-page":"445","article-title":"Concomitant retroperitoneal and subarachnoid hemorrhage due to segmental arterial mediolysis: case report and review of the literature","volume":"28","author":"Hellstern","year":"2018","unstructured":"Hellstern VAguilar P\u00e9rez MKohlhof-Meinecke PB\u00e4zner HGanslandt OHenkes H.Concomitant retroperitoneal and subarachnoid hemorrhage due to segmental arterial mediolysis: case report and review of the literature. Clin Neuroradiol. 2018;28(3):445-450."},{"key":"bib15","series-title":"World Neurosurg","first-page":"44","article-title":"Treatment of ruptured vertebral artery dissection and abdominal hemorrhage associated with segmental arterial mediolysis using endovascular coil embolization","volume":"116","author":"Isaji","year":"2018","unstructured":"Isaji TOhshima TMiyachi SMatsuo NKawaguchi RTakayasu M.Treatment of ruptured vertebral artery dissection and abdominal hemorrhage associated with segmental arterial mediolysis using endovascular coil embolization. World Neurosurg. 2018;116:44-49."},{"issue":"5","key":"bib16","series-title":"No Shinkei Geka","first-page":"543","article-title":"A case of segmental arterial mediolysis: subarachnoid hemorrhage followed by abdominal bleeding","volume":"47","author":"Inazuka","year":"2019","unstructured":"Inazuka MImazato DYamazaki KA case of segmental arterial mediolysis: subarachnoid hemorrhage followed by abdominal bleeding. Article in Japanese. 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