{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:28:37Z","timestamp":1770110917120,"version":"3.49.0"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"15","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,4,14]]},"abstract":"\n BACKGROUND<\/jats:title>\n A mild malformation of cortical development (MCD) with oligodendroglial hyperplasia and epilepsy (MOGHE) is characterized by increased Olig2-positive atypical cells in the white matter and is associated with drug-resistant intractable epilepsy, typically the frontal and temporal lobes. MOGHE is a newly classified subtype of focal cortical dysplasia associated with epilepsy, according to the latest International League Against Epilepsy guidelines. There have been no reports of MOGHE without epilepsy and associated with extensive lesions.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n \n A 31-year-old man was incidentally diagnosed with an extensive right cerebral hemispheric lesion on MRI. Pathological examination of the biopsy sample showed no evidence of an invasive tumor but revealed an increase in Olig2-positive cells, consistent with MOGHE. Sanger sequencing showed no\n IDH1\/2<\/jats:italic>\n , histone H3\n TERT<\/jats:italic>\n promoter, or\n SLC35A2<\/jats:italic>\n mutations. Electroencephalography showed no evidence of epilepsy.\n <\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n This case suggests the existence of a condition with similar histological findings to MOGHE but without epilepsy. The authors propose naming this condition \u201cmild malformation of cortical development with oligodendroglial hyperplasia and no epilepsy.\u201d<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE24827<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case24827","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T20:16:42Z","timestamp":1744661802000},"source":"Crossref","is-referenced-by-count":0,"title":["Asymptomatic extensive right cerebral hemispheric lesion in an adult with histopathological findings consistent with mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy: illustrative case"],"prefix":"10.3171","volume":"9","author":[{"given":"Ryohei","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichiro","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Koiso","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mito Saiseikai General Hospital, Mito, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7255-9776","authenticated-orcid":true,"given":"Narushi","family":"Sugii","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Central Laboratory, Hachioji Medical Center, Tokyo Medical University, Hachioji, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2551-5978","authenticated-orcid":true,"given":"Hajime","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Research Institute for Brain and Blood Vessels, Akita Cerebrospinal and Cardiovascular Center, Akita, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"bib1","series-title":"Brain Pathol","first-page":"26","article-title":"Mild malformation of cortical development with oligodendroglial hyperplasia in frontal lobe epilepsy: a new clinico-pathological entity","volume":"27","author":"Schurr","year":"2017","unstructured":"Schurr JCoras RR\u00f6ssler KMild malformation of cortical development with oligodendroglial hyperplasia in frontal lobe epilepsy: a new clinico-pathological entity. Brain Pathol. 2017;27(1):26-35."},{"key":"bib2","series-title":"Epilepsy Behav","first-page":"68","article-title":"Age-related MR characteristics in mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE)","volume":"91","author":"Hartlieb","year":"2019","unstructured":"Hartlieb TWinkler PCoras RAge-related MR characteristics in mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE). Epilepsy Behav. 2019;91:68-74."},{"issue":"4","key":"bib3","series-title":"J Neurol Neurosurg Psychiatry","first-page":"369","article-title":"Focal dysplasia of the cerebral cortex in epilepsy","volume":"34","author":"Taylor","year":"1971","unstructured":"Taylor DCFalconer MABruton CJCorsellis JA.Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry. 1971;34(4):369-387."},{"issue":"6","key":"bib4","series-title":"Neurology","first-page":"S2","article-title":"Terminology and classification of the cortical dysplasias","volume":"62","author":"Palmini","year":"2004","unstructured":"Palmini ANajm IAvanzini GTerminology and classification of the cortical dysplasias. Neurology. 2004;62(6suppl 3):S2-S8."},{"issue":"1","key":"bib5","series-title":"Epilepsia","first-page":"158","article-title":"The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission","volume":"52","author":"Bl\u00fcmcke","year":"2011","unstructured":"Bl\u00fcmcke IThom MAronica EThe clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. 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Acta Neuropathol Commun. 2021;9(1):3."},{"issue":"5","key":"bib7","series-title":"Epileptic Disord","first-page":"662","article-title":"Clinical characteristics and multimodal imaging can help diagnosing and treating mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy","volume":"26","author":"Dimova","year":"2024","unstructured":"Dimova PSMetodiev DTodorov TClinical characteristics and multimodal imaging can help diagnosing and treating mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy. 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