{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:19:30Z","timestamp":1770110370116,"version":"3.49.0"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"19","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,5,12]]},"abstract":"\n BACKGROUND<\/jats:title>\n Diffuse midline glioma (DMG) H3 K27\u2013altered is a rare CNS tumor that predominantly affects midline structures in children. A relatively new subtype of glioma, it was first classified in 2016 and was further expanded in 2021 to include 4 molecular subtypes. While reported on in children, this is the first reported case of an H3.3 K27\u2013mutant subtype of DMG affecting the conus medullaris in adults.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n The authors report the case of a 62-year-old man with gradual onset of bladder and lower-limb dysfunction over a 6-month period. Because of the patient\u2019s synchronous diagnosis of lymphoma, CSF sampling and positron emission tomography (PET) were initially utilized. Ultimately, an open biopsy was required to yield a diagnosis of H3 K27\u2013altered DMG. After multiple disciplinary team discussions and discussions with the patient, radiotherapy was commenced.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n H3 K27\u2013altered DMG affecting the conus medullaris is a very rare tumor that can present with gradual-onset lower-limb dysfunction and can be difficult to diagnose on traditional imaging alone. This case emphasized the continued importance of tissue sampling, with further research required on the utility of PET, CSF sampling, and the significance of molecular subtyping on treatment response and prognosis.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE24879<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case24879","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T20:15:29Z","timestamp":1747080929000},"source":"Crossref","is-referenced-by-count":0,"title":["Adult H3 K27\u2013altered, H3.3 K27\u2013mutant diffuse midline glioma affecting the conus medullaris: illustrative case"],"prefix":"10.3171","volume":"9","author":[{"given":"Andrei","family":"Sincari","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Royal Brisbane and Women\u2019s Hospital, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saif","family":"Yousif","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal Brisbane and Women\u2019s Hospital, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6152-5511","authenticated-orcid":true,"given":"Thomas","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Royal Brisbane and Women\u2019s Hospital, Brisbane, Queensland, Australia"},{"name":"Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Tung Tom","family":"Huang","sequence":"additional","affiliation":[{"name":"Lumus Imaging, St. Vincent\u2019s Private Hospital Northside, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamish","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal Brisbane and Women\u2019s Hospital, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"bib1","article-title":"Spinal Cord Tumor\u2014an overview","unstructured":"Spinal Cord Tumor\u2014an overview. 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