{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:59:54Z","timestamp":1770116394837,"version":"3.49.0"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"16","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,4,21]]},"abstract":"\n BACKGROUND<\/jats:title>\n The formation of a tumor bed cyst (TBC) is an infrequent complication that can occur following surgery for brain glioma. In this case report, the authors present the first documented occurrence of TBC associated with a postoperative epidural hematoma in a patient who underwent glioma surgery.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n A 48-year-old right-handed male with right frontal lobe glioma underwent surgery, and an epidural hematoma was detected on CT 2 hours postcraniotomy. Subsequently, the patient exhibited progressive deterioration of consciousness. Reassessment via CT revealed no significant increase in the epidural hematoma size; however, there was evidence of a TBC within the cavity and aggravated peripheral edema. An urgent evacuation procedure was performed to remove the epidural hematoma, accompanied by an external dura opening to address the TBC. This resulted in a jet overflow of cyst fluid and a rapid reduction in tumor cavity size. After the patient regained consciousness from anesthesia, he exhibited normal motor function and maintained a lucid state of mind.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n The presence of epidural hematoma can contribute to the formation of a TBC. During reoperation for epidural hematoma removal, the compressive effect of the TBC went unnoticed, leading to its nontreatment.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE24899<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case24899","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T20:10:28Z","timestamp":1745266228000},"source":"Crossref","is-referenced-by-count":0,"title":["Epidural hematoma associated with a closed capsule in the tumor cavity: illustrative case"],"prefix":"10.3171","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-2288","authenticated-orcid":true,"given":"Jian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6956-3226","authenticated-orcid":true,"given":"Huan","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9953-0647","authenticated-orcid":true,"given":"Yanjin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"bib1","series-title":"Cancer Lett","first-page":"1","article-title":"Immunotherapy for glioma: current management and future application","volume":"476","author":"Xu","year":"2020","unstructured":"Xu STang LLi XFan FLiu Z.Immunotherapy for glioma: current management and future application. Cancer Lett. 2020;476:1-12."},{"issue":"1","key":"bib2","series-title":"J Neurosurg","first-page":"9","article-title":"Insular glioma surgery: an evolution of thought and practice","volume":"130","author":"Hervey-Jumper","year":"2019","unstructured":"Hervey-Jumper SLBerger MS.Insular glioma surgery: an evolution of thought and practice. J Neurosurg. 2019;130(1):9-16."},{"issue":"5","key":"bib3","series-title":"Neurosurg Focus","article-title":"Patterns in neurosurgical adverse events: intracranial neoplasm surgery","volume":"33","author":"Wong","year":"2012","unstructured":"Wong JMPanchmatia JRZiewacz JEet al.Patterns in neurosurgical adverse events: intracranial neoplasm surgery. Neurosurg Focus. 2012;33(5):E16."},{"issue":"1","key":"bib4","series-title":"J Neurol Surg A Cent Eur Neurosurg","first-page":"25","article-title":"Postoperative extradural hematomas","volume":"74","author":"Pichierri","year":"2013","unstructured":"Pichierri ARuggeri ADonnarumma PDelfini R.Postoperative extradural hematomas. J Neurol Surg A Cent Eur Neurosurg. 2013;74(1):25-28."},{"issue":"3","key":"bib5","series-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban","first-page":"273","article-title":"Effect of epidural drainage and dural tenting suture on epidural hematoma in 145 cases of craniotomy","volume":"35","author":"Zhao","year":"2010","unstructured":"Zhao JLiu ZLiu Yet al.Effect of epidural drainage and dural tenting suture on epidural hematoma in 145 cases of craniotomy. Article in Chinese.Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010;35(3):273-276."},{"issue":"6","key":"bib6","series-title":"J Neurosurg","first-page":"783","article-title":"Extradural hematoma during craniotomy. 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Br J Neurosurg. 2011;25(5):641-643."},{"issue":"8","key":"bib19","series-title":"Acta Neurochir (Wien)","first-page":"2041","article-title":"Synthetic vascular grafts as a new treatment option for space-occupying tumor bed cysts","volume":"164","author":"Schieferdecker","year":"2022","unstructured":"Schieferdecker SBeez TRapp MH\u00e4nggi DKamp MSabel M.Synthetic vascular grafts as a new treatment option for space-occupying tumor bed cysts. Acta Neurochir (Wien). 2022;164(8):2041-2047."},{"key":"bib20","series-title":"World Neurosurg","first-page":"160","article-title":"A rare case of postoperative symptomatic cyst formation after resection of a large convexity meningioma","volume":"127","author":"Fujimori","year":"2019","unstructured":"Fujimori TShindo AOgawa Det al.A rare case of postoperative symptomatic cyst formation after resection of a large convexity meningioma. 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J Neurol Surg A Cent Eur Neurosurg. 2013;74(1):25-28."},{"issue":"3","key":"bib5","series-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban","first-page":"273","article-title":"Effect of epidural drainage and dural tenting suture on epidural hematoma in 145 cases of craniotomy","volume":"35","author":"Zhao","year":"2010","unstructured":"Zhao JLiu ZLiu Yet al.Effect of epidural drainage and dural tenting suture on epidural hematoma in 145 cases of craniotomy. Article in Chinese.Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010;35(3):273-276."},{"issue":"6","key":"bib6","series-title":"J Neurosurg","first-page":"783","article-title":"Extradural hematoma during craniotomy. Report of five cases","volume":"40","author":"Troupp","year":"1974","unstructured":"Troupp H.Extradural hematoma during craniotomy. Report of five cases. J Neurosurg. 1974;40(6):783-785."},{"key":"bib7","series-title":"World Neurosurg","first-page":"509","article-title":"Space-occupying tumor bed cysts as a complication of modern treatment for high-grade glioma","volume":"104","author":"Beez","year":"2017","unstructured":"Beez TBurgula SKamp MRapp MSteiger HJSabel M.Space-occupying tumor bed cysts as a complication of modern treatment for high-grade glioma. World Neurosurg. 2017;104:509-515."},{"issue":"3","key":"bib8","series-title":"J Clin Neurosci","first-page":"347","article-title":"Space-occupying cyst development in the resection cavity of malignant gliomas following Gliadel(R) implantation\u2014incidence, therapeutic strategies, and outcome","volume":"18","author":"D\u00f6rner","year":"2011","unstructured":"D\u00f6rner LUlmer SRohr AMehdorn HMNabavi A.Space-occupying cyst development in the resection cavity of malignant gliomas following Gliadel(R) implantation\u2014incidence, therapeutic strategies, and outcome. J Clin Neurosci. 2011;18(3):347-351."},{"issue":"3","key":"bib9","series-title":"Zentralbl Neurochir","first-page":"87","article-title":"Occurrence and therapy of space-occupying cystic lesions after brain tumor surgery","volume":"62","author":"Korinth","year":"2001","unstructured":"Korinth MCWeinzierl MRKrings TGilsbach JM.Occurrence and therapy of space-occupying cystic lesions after brain tumor surgery. Zentralbl Neurochir. 2001;62(3):87-92."},{"key":"bib10","series-title":"World Neurosurg","first-page":"213","article-title":"Endoscopic visualization of an iatrogenic valve mechanism: elucidating the pathogenesis of postoperative tumor bed cysts","volume":"115","author":"Beez","year":"2018","unstructured":"Beez TRemmel DSteiger HJ.Endoscopic visualization of an iatrogenic valve mechanism: elucidating the pathogenesis of postoperative tumor bed cysts. World Neurosurg. 2018;115:213-215."},{"issue":"6","key":"bib11","series-title":"Neurol Med Chir (Tokyo)","first-page":"270","article-title":"Symptomatic remote cyst after BCNU wafer implantation for malignant glioma","volume":"58","author":"Matsumura","year":"2018","unstructured":"Matsumura HIshikawa EMatsuda Met al.Symptomatic remote cyst after BCNU wafer implantation for malignant glioma. Neurol Med Chir (Tokyo). 2018;58(6):270-276."},{"issue":"1","key":"bib12","series-title":"J Neurooncol","first-page":"119","article-title":"Evaluation of serial changes on computed tomography and magnetic resonance imaging after implantation of carmustine wafers in patients with malignant gliomas for differential diagnosis of tumor recurrence","volume":"126","author":"Ohue","year":"2016","unstructured":"Ohue SKohno SInoue Aet al.Evaluation of serial changes on computed tomography and magnetic resonance imaging after implantation of carmustine wafers in patients with malignant gliomas for differential diagnosis of tumor recurrence. J Neurooncol. 2016;126(1):119-126."},{"key":"bib13","series-title":"J Clin Neurosci","first-page":"67","article-title":"The influence of carmustine wafer implantation on tumor bed cysts and peritumoral brain edema","volume":"31","author":"Hasegawa","year":"2016","unstructured":"Hasegawa YIuchi TSakaida TYokoi SKawasaki K.The influence of carmustine wafer implantation on tumor bed cysts and peritumoral brain edema. J Clin Neurosci. 2016;31:67-71."},{"issue":"5","key":"bib14","series-title":"J Neurosurg","first-page":"941","article-title":"Management of tumor bed cysts after chemotherapeutic wafer implantation. Report of four cases","volume":"96","author":"McGirt","year":"2002","unstructured":"McGirt MJVillavicencio ATBulsara KRFriedman HSFriedman AH.Management of tumor bed cysts after chemotherapeutic wafer implantation. Report of four cases. J Neurosurg. 2002;96(5):941-945."},{"issue":"3","key":"bib15","series-title":"Surg Neurol","first-page":"220","article-title":"Tumor bed cyst formation after BCNU wafer implantation: report of two cases","volume":"53","author":"Engelhard","year":"2000","unstructured":"Engelhard HH.Tumor bed cyst formation after BCNU wafer implantation: report of two cases. Surg Neurol. 2000;53(3):220-224."},{"key":"bib16","series-title":"Case Rep Med","first-page":"634839","article-title":"Reoperation as a result of raised intracranial pressure associated with cyst formation in tumor cavity after intracranial tumor resection: a report of two cases","volume":"2010","author":"Yu","year":"2010","unstructured":"Yu JXiong WQu LHuang H.Reoperation as a result of raised intracranial pressure associated with cyst formation in tumor cavity after intracranial tumor resection: a report of two cases. 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Br J Neurosurg. 2011;25(5):641-643."},{"issue":"8","key":"bib19","series-title":"Acta Neurochir (Wien)","first-page":"2041","article-title":"Synthetic vascular grafts as a new treatment option for space-occupying tumor bed cysts","volume":"164","author":"Schieferdecker","year":"2022","unstructured":"Schieferdecker SBeez TRapp MH\u00e4nggi DKamp MSabel M.Synthetic vascular grafts as a new treatment option for space-occupying tumor bed cysts. Acta Neurochir (Wien). 2022;164(8):2041-2047."},{"key":"bib20","series-title":"World Neurosurg","first-page":"160","article-title":"A rare case of postoperative symptomatic cyst formation after resection of a large convexity meningioma","volume":"127","author":"Fujimori","year":"2019","unstructured":"Fujimori TShindo AOgawa Det al.A rare case of postoperative symptomatic cyst formation after resection of a large convexity meningioma. 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