{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:20:43Z","timestamp":1770110443367,"version":"3.49.0"},"reference-count":34,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"26","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>In this case report, the authors discuss the diagnosis and treatment of a rare primary optic nerve sheath schwannoma (ONSS). Typically, intracranial schwannomas arise from the vestibular division of cranial nerve VIII and seldom cranial nerves V and VII. This case underscores the need for further documentation of ONSS to better understand its origins, refine diagnostic approaches, and optimize management strategies to enable earlier detection and better outcomes for patients\u2019 vision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors present the case of a 36-year-old patient who presented via an ophthalmologist due to visual loss in the left eye. She was initially treated for optic neuritis before further deterioration prompted repeat imaging, demonstrating a left extraorbital lesion distal to the optic chiasm. The patient underwent a complete resection of the lesion via pterional craniotomy in July 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>The authors report the 17th case of ONSS in the literature. Despite the optic nerve\u2019s usual myelination pattern, these tumors can form, likely originating from ectopic Schwann cells or perioptic sympathetic fibers. Resection via a pterional approach enabled complete removal without postoperative complications. Because of the rarity of ONSS, further study is essential to enhance diagnosis, treatment, and surgical strategies.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE25156\">https:\/\/thejns.org\/doi\/10.3171\/CASE25156<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case25156","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T02:53:01Z","timestamp":1751856781000},"source":"Crossref","is-referenced-by-count":0,"title":["Optic nerve sheath schwannoma: illustrative case"],"prefix":"10.3171","volume":"9","author":[{"given":"George","family":"Rudd","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Klinikum rechts der Isar, Technical University Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Kaywan","family":"Aftahy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Klinikum rechts der Isar, Technical University Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6486-7955","authenticated-orcid":true,"given":"Bernhard","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Klinikum rechts der Isar, Technical University Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Wostrack","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Klinikum rechts der Isar, Technical University Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"11","key":"bib1","series-title":"Radiol Case Rep","first-page":"4211","article-title":"Primary optic nerve sheath schwannoma: a case report and literature review","volume":"18","author":"Benzalim","year":"2023","unstructured":"Benzalim MOndima HAlj S.Primary optic nerve sheath schwannoma: a case report and literature review. Radiol Case Rep. 2023;18(11):4211-4213."},{"issue":"32","key":"bib2","series-title":"Oncogene","first-page":"5421","article-title":"Pathomechanisms in schwannoma development and progression","volume":"39","author":"Helbing","year":"2020","unstructured":"Helbing DLSchulz AMorrison H.Pathomechanisms in schwannoma development and progression. Oncogene. 2020;39(32):5421-5429."},{"issue":"5","key":"bib3","series-title":"Orbit","first-page":"419","article-title":"Is primary optic nerve sheath schwannoma a misnomer? Report of two cases and literature review","volume":"38","author":"Kashkouli","year":"2019","unstructured":"Kashkouli MBAbdolalizadeh PJafari SShahrzad SKarimi N.Is primary optic nerve sheath schwannoma a misnomer? Report of two cases and literature review. Orbit. 2019;38(5):419-423."},{"issue":"4","key":"bib4","series-title":"Int Ophthalmol","first-page":"481","article-title":"Orbital schwannoma: a clinicopathologic study","volume":"35","author":"Pushker","year":"2015","unstructured":"Pushker NKhurana SKashyap SOrbital schwannoma: a clinicopathologic study. Int Ophthalmol. 2015;35(4):481-486."},{"issue":"6","key":"bib5","series-title":"J Pak Med Assoc","first-page":"950","article-title":"Optic nerve schwannoma: neurofibromatosus type-1? A case report","volume":"68","author":"Junaid","year":"2018","unstructured":"Junaid MBukhari SSRashid MU.Optic nerve schwannoma: neurofibromatosus type-1? A case report. J Pak Med Assoc. 2018;68(6):950-952."},{"issue":"4","key":"bib6","series-title":"Arch Ophthalmol","first-page":"655","article-title":"Development of myelin in human optic nerve and tract: a light and electron microscopic study","volume":"99","author":"Magoon","year":"1981","unstructured":"Magoon EHRobb RM.Development of myelin in human optic nerve and tract: a light and electron microscopic study. Arch Ophthalmol. 1981;99(4):655-659."},{"issue":"17","key":"bib7","series-title":"J Neurosci","first-page":"5958","article-title":"CNS\/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20\/Egr2 function","volume":"30","author":"Coulpier","year":"2010","unstructured":"Coulpier FDecker LFunalot BCNS\/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20\/Egr2 function. J Neurosci. 2010;30(17):5958-5967."},{"issue":"5","key":"bib8","series-title":"Br J Neurosurg","first-page":"1333","article-title":"Primary optic nerve sheath schwannoma: a case report","volume":"37","author":"Sharma","year":"2023","unstructured":"Sharma ASingh DSaran R.Primary optic nerve sheath schwannoma: a case report. Br J Neurosurg. 2023;37(5):1333-1335."},{"issue":"25","key":"bib9","series-title":"Med (Baltim)","first-page":"e20747","article-title":"Microneurosurgical treatment under the guidance of neuroendoscopy for an intracranial optic nerve schwannoma: a case report","volume":"99","author":"Xiao","year":"2020","unstructured":"Xiao JYe LWang WMicroneurosurgical treatment under the guidance of neuroendoscopy for an intracranial optic nerve schwannoma: a case report. Med (Baltim). 2020;99(25):e20747."},{"issue":"4","key":"bib10","series-title":"J Clin Neuroophthalmol","first-page":"219","article-title":"Schwannoma of the optic sheath","volume":"7","author":"Simpson","year":"1987","unstructured":"Simpson RKJrHarper RLKirkpatrick JBCooper B.Schwannoma of the optic sheath. J Clin Neuroophthalmol. 1987;7(4):219-222."},{"issue":"12","key":"bib11","series-title":"Childs Nerv Syst","first-page":"684","article-title":"Optic sheath schwannomas: report of two cases","volume":"18","author":"Kim","year":"2002","unstructured":"Kim DSChoi JUYang KHJung JM.Optic sheath schwannomas: report of two cases. Childs Nerv Syst. 2002;18(12):684-689."},{"issue":"2","key":"bib12","series-title":"Orbit","first-page":"97","article-title":"Primary orbital optic nerve sheath schwannoma","volume":"9","author":"Saini","year":"1990","unstructured":"Saini JSMohan KSharma A.Primary orbital optic nerve sheath schwannoma. Orbit. 1990;9(2):97-99."},{"issue":"3","key":"bib13","series-title":"J Fr Ophtalmol","first-page":"e49","article-title":"Schwannome du nerf optique","volume":"36","author":"Leruez","year":"2013","unstructured":"Leruez SGohier PMenei PMilea D.Schwannome du nerf optique. Article in French. J Fr Ophtalmol. 2013;36(3):e49-e53."},{"issue":"4","key":"bib14","series-title":"Cureus","first-page":"e265","article-title":"A rare case of optic nerve schwannoma: case report and review of the literature","volume":"7","author":"Ramey","year":"2015","unstructured":"Ramey WLArnold SJChiu ALemole M.A rare case of optic nerve schwannoma: case report and review of the literature. Cureus. 2015;7(4):e265."},{"key":"bib15","series-title":"Int J Surg Case Rep","first-page":"173","article-title":"Uncommon presentation of orbital schwanomma: a case report","volume":"26","author":"Barhmi","year":"2016","unstructured":"Barhmi IMahdoufi RKhallouq AUncommon presentation of orbital schwanomma: a case report. Int J Surg Case Rep. 2016;26:173-175."},{"issue":"1","key":"bib16","series-title":"Br J Neurosurg","first-page":"101","article-title":"Intraconal optic sheath schwannoma: report of two cases","volume":"33","author":"Mahore","year":"2019","unstructured":"Mahore ARamdasi RChagla ATikeykar V.Intraconal optic sheath schwannoma: report of two cases. Br J Neurosurg. 2019;33(1):101-103."},{"issue":"5","key":"bib17","series-title":"Cureus","first-page":"e59824","article-title":"Optic nerve schwannoma: a report of a rare case from India and literature review","volume":"16","author":"Lune","year":"2024","unstructured":"Lune AMagdum RPokle SKotecha MRVatkar V.Optic nerve schwannoma: a report of a rare case from India and literature review. Cureus. 2024;16(5):e59824."},{"issue":"11","key":"bib1","series-title":"Radiol Case Rep","first-page":"4211","article-title":"Primary optic nerve sheath schwannoma: a case report and literature review","volume":"18","author":"Benzalim","year":"2023","unstructured":"Benzalim MOndima HAlj S.Primary optic nerve sheath schwannoma: a case report and literature review. Radiol Case Rep. 2023;18(11):4211-4213."},{"issue":"32","key":"bib2","series-title":"Oncogene","first-page":"5421","article-title":"Pathomechanisms in schwannoma development and progression","volume":"39","author":"Helbing","year":"2020","unstructured":"Helbing DLSchulz AMorrison H.Pathomechanisms in schwannoma development and progression. Oncogene. 2020;39(32):5421-5429."},{"issue":"5","key":"bib3","series-title":"Orbit","first-page":"419","article-title":"Is primary optic nerve sheath schwannoma a misnomer? Report of two cases and literature review","volume":"38","author":"Kashkouli","year":"2019","unstructured":"Kashkouli MBAbdolalizadeh PJafari SShahrzad SKarimi N.Is primary optic nerve sheath schwannoma a misnomer? Report of two cases and literature review. Orbit. 2019;38(5):419-423."},{"issue":"4","key":"bib4","series-title":"Int Ophthalmol","first-page":"481","article-title":"Orbital schwannoma: a clinicopathologic study","volume":"35","author":"Pushker","year":"2015","unstructured":"Pushker NKhurana SKashyap SOrbital schwannoma: a clinicopathologic study. Int Ophthalmol. 2015;35(4):481-486."},{"issue":"6","key":"bib5","series-title":"J Pak Med Assoc","first-page":"950","article-title":"Optic nerve schwannoma: neurofibromatosus type-1? A case report","volume":"68","author":"Junaid","year":"2018","unstructured":"Junaid MBukhari SSRashid MU.Optic nerve schwannoma: neurofibromatosus type-1? A case report. J Pak Med Assoc. 2018;68(6):950-952."},{"issue":"4","key":"bib6","series-title":"Arch Ophthalmol","first-page":"655","article-title":"Development of myelin in human optic nerve and tract: a light and electron microscopic study","volume":"99","author":"Magoon","year":"1981","unstructured":"Magoon EHRobb RM.Development of myelin in human optic nerve and tract: a light and electron microscopic study. Arch Ophthalmol. 1981;99(4):655-659."},{"issue":"17","key":"bib7","series-title":"J Neurosci","first-page":"5958","article-title":"CNS\/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20\/Egr2 function","volume":"30","author":"Coulpier","year":"2010","unstructured":"Coulpier FDecker LFunalot BCNS\/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20\/Egr2 function. J Neurosci. 2010;30(17):5958-5967."},{"issue":"5","key":"bib8","series-title":"Br J Neurosurg","first-page":"1333","article-title":"Primary optic nerve sheath schwannoma: a case report","volume":"37","author":"Sharma","year":"2023","unstructured":"Sharma ASingh DSaran R.Primary optic nerve sheath schwannoma: a case report. Br J Neurosurg. 2023;37(5):1333-1335."},{"issue":"25","key":"bib9","series-title":"Med (Baltim)","first-page":"e20747","article-title":"Microneurosurgical treatment under the guidance of neuroendoscopy for an intracranial optic nerve schwannoma: a case report","volume":"99","author":"Xiao","year":"2020","unstructured":"Xiao JYe LWang WMicroneurosurgical treatment under the guidance of neuroendoscopy for an intracranial optic nerve schwannoma: a case report. Med (Baltim). 2020;99(25):e20747."},{"issue":"4","key":"bib10","series-title":"J Clin Neuroophthalmol","first-page":"219","article-title":"Schwannoma of the optic sheath","volume":"7","author":"Simpson","year":"1987","unstructured":"Simpson RKJrHarper RLKirkpatrick JBCooper B.Schwannoma of the optic sheath. J Clin Neuroophthalmol. 1987;7(4):219-222."},{"issue":"12","key":"bib11","series-title":"Childs Nerv Syst","first-page":"684","article-title":"Optic sheath schwannomas: report of two cases","volume":"18","author":"Kim","year":"2002","unstructured":"Kim DSChoi JUYang KHJung JM.Optic sheath schwannomas: report of two cases. Childs Nerv Syst. 2002;18(12):684-689."},{"issue":"2","key":"bib12","series-title":"Orbit","first-page":"97","article-title":"Primary orbital optic nerve sheath schwannoma","volume":"9","author":"Saini","year":"1990","unstructured":"Saini JSMohan KSharma A.Primary orbital optic nerve sheath schwannoma. Orbit. 1990;9(2):97-99."},{"issue":"3","key":"bib13","series-title":"J Fr Ophtalmol","first-page":"e49","article-title":"Schwannome du nerf optique","volume":"36","author":"Leruez","year":"2013","unstructured":"Leruez SGohier PMenei PMilea D.Schwannome du nerf optique. Article in French. J Fr Ophtalmol. 2013;36(3):e49-e53."},{"issue":"4","key":"bib14","series-title":"Cureus","first-page":"e265","article-title":"A rare case of optic nerve schwannoma: case report and review of the literature","volume":"7","author":"Ramey","year":"2015","unstructured":"Ramey WLArnold SJChiu ALemole M.A rare case of optic nerve schwannoma: case report and review of the literature. Cureus. 2015;7(4):e265."},{"key":"bib15","series-title":"Int J Surg Case Rep","first-page":"173","article-title":"Uncommon presentation of orbital schwanomma: a case report","volume":"26","author":"Barhmi","year":"2016","unstructured":"Barhmi IMahdoufi RKhallouq AUncommon presentation of orbital schwanomma: a case report. Int J Surg Case Rep. 2016;26:173-175."},{"issue":"1","key":"bib16","series-title":"Br J Neurosurg","first-page":"101","article-title":"Intraconal optic sheath schwannoma: report of two cases","volume":"33","author":"Mahore","year":"2019","unstructured":"Mahore ARamdasi RChagla ATikeykar V.Intraconal optic sheath schwannoma: report of two cases. Br J Neurosurg. 2019;33(1):101-103."},{"issue":"5","key":"bib17","series-title":"Cureus","first-page":"e59824","article-title":"Optic nerve schwannoma: a report of a rare case from India and literature review","volume":"16","author":"Lune","year":"2024","unstructured":"Lune AMagdum RPokle SKotecha MRVatkar V.Optic nerve schwannoma: a report of a rare case from India and literature review. 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