{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:48:22Z","timestamp":1770115702173,"version":"3.49.0"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"22","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,6,2]]},"abstract":"\n BACKGROUND<\/jats:title>\n Tisseel is a widely used fibrin sealant often used in cranial surgery to control bleeding from the cavernous sinus, often with successful results.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n The authors present the case of a 10-year-old female patient who developed anaphylaxis during a re-resection of a craniopharyngioma, shortly after the application of Tisseel in the cavernous sinus. This reaction included a strong drop in blood pressure, rise in pulse, increase in oxygen requirements, and diffuse erythema and urticaria soon after after the use of Tisseel. Symptoms normalized after administration of adrenaline, clemastine, and hydrocortisone. A skin prick test later confirmed that the allergic reaction had not been to a single component of Tisseel but to a combination of its components.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n This case and the accompanied literature can aid in recognizing patients at risk for an anaphylactic reaction against aprotinin. It also serves to remind us that medicine used locally in the surgical field can also cause anaphylaxis.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE2517<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case2517","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T19:46:15Z","timestamp":1749498375000},"source":"Crossref","is-referenced-by-count":0,"title":["Anaphylaxis associated with Tisseel fibrin sealant during re-resection of a craniopharyngioma: illustrative case"],"prefix":"10.3171","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-6955","authenticated-orcid":true,"given":"Niek","family":"Djuric","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochem K. H.","family":"Spoor","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Erasmus University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Paediatric Neurosurgery, Erasmus Medical Center Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalie D.","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Erasmus Medical Center Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica L. T. van den","family":"Akker","sequence":"additional","affiliation":[{"name":"Department of Peadiatric Endocrinology, Sophia Children Hospital, Erasmus MC, University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce A. M.","family":"Emons","sequence":"additional","affiliation":[{"name":"Department of Peadiatric Allergology, Sophia Children Hospital, Erasmus MC, University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-0644","authenticated-orcid":true,"given":"Ruben","family":"Dammers","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Erasmus University Medical Center, Rotterdam, The Netherlands"},{"name":"Center for Complex Microvascular Surgery, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"12","key":"bib1","series-title":"J Biomed Mater Res B Appl Biomater","first-page":"2779","article-title":"Composition, host responses and clinical applications of bioadhesives","volume":"110","author":"Dhandapani","year":"2022","unstructured":"Dhandapani VRinguette VDesrochers MSirois MVermette P.Composition, host responses and clinical applications of bioadhesives. J Biomed Mater Res B Appl Biomater. 2022;110(12):2779-2797."},{"key":"bib2","series-title":"Int J Biol Macromol","first-page":"95","article-title":"Recent developments and clinical applications of surgical glues: an overview","volume":"137","author":"Jain","year":"2019","unstructured":"Jain RWairkar S.Recent developments and clinical applications of surgical glues: an overview. Int J Biol Macromol. 2019;137:95-106."},{"issue":"5","key":"bib3","series-title":"Neurosurgery","first-page":"1102","article-title":"Use of Tisseel fibrin sealant in neurosurgical procedures: incidence of cerebrospinal fluid leaks and cost-benefit analysis in a retrospective study","volume":"52","author":"Kassam","year":"2003","unstructured":"Kassam AHorowitz MCarrau RUse of Tisseel fibrin sealant in neurosurgical procedures: incidence of cerebrospinal fluid leaks and cost-benefit analysis in a retrospective study. Neurosurgery. 2003;52(5):1102-1105."},{"issue":"2","key":"bib4","series-title":"Oper Neurosurg (Hagerstown)","first-page":"224","article-title":"Effect of fibrin glue injection into the cavernous sinus for hemostasis during transcavernous surgery on the cerebral venous draining system","volume":"13","author":"Toyooka","year":"2017","unstructured":"Toyooka TOtani NWada KEffect of fibrin glue injection into the cavernous sinus for hemostasis during transcavernous surgery on the cerebral venous draining system. Oper Neurosurg (Hagerstown). 2017;13(2):224-231."},{"issue":"4","key":"bib5","series-title":"Neurosurgery","first-page":"E408","article-title":"Surgical technique to retract the tentorial edge during subtemporal approach: technical note","volume":"57","author":"Hernesniemi","year":"2005","unstructured":"Hernesniemi JIshii KKaratas ASurgical technique to retract the tentorial edge during subtemporal approach: technical note. Neurosurgery. 2005;57(4suppl):E408."},{"issue":"3","key":"bib6","series-title":"Neurosurgery","first-page":"E52","article-title":"Taming the cavernous sinus: technique of hemostasis using fibrin glue","volume":"61","author":"Krayenb\u00fchl","year":"2007","unstructured":"Krayenb\u00fchl NHafez AHernesniemi JAKrisht AF.Taming the cavernous sinus: technique of hemostasis using fibrin glue. Neurosurgery. 2007;61(3suppl):E52."},{"issue":"suppl 1","key":"bib7","series-title":"Anaesthesia","first-page":"46","article-title":"The current place of aprotinin in the management of bleeding","volume":"70","author":"Royston","year":"2015","unstructured":"Royston D.The current place of aprotinin in the management of bleeding. Anaesthesia. 2015;70(suppl 1):46-49."},{"issue":"1","key":"bib8","series-title":"Plast Reconstr Surg Glob Open","first-page":"e3382","article-title":"Recalcitrant anaphylaxis associated with fibrin sealant: treatment with \u201cTISSEEL-ectomy\u201d","volume":"9","author":"Saffarzadeh","year":"2021","unstructured":"Saffarzadeh MMulpuri AArneja JS.Recalcitrant anaphylaxis associated with fibrin sealant: treatment with \u201cTISSEEL-ectomy\u201d. Plast Reconstr Surg Glob Open. 2021;9(1):e3382."},{"issue":"2","key":"bib9","series-title":"Ann Thorac Surg","first-page":"741","article-title":"Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions","volume":"79","author":"Beierlein","year":"2005","unstructured":"Beierlein WScheule AMDietrich WZiemer G.Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions. Ann Thorac Surg. 2005;79(2):741-748."},{"issue":"8","key":"bib10","series-title":"Curr Med Res Opin","first-page":"559","article-title":"Serial use of aprotinin and incidence of allergic reactions","volume":"8","author":"Freeman","year":"1983","unstructured":"Freeman JGTurner GAVenables CWLatner AL.Serial use of aprotinin and incidence of allergic reactions. Curr Med Res Opin. 1983;8(8):559-561."},{"issue":"5","key":"bib11","series-title":"J Gastroenterol","first-page":"702","article-title":"Effects of high-dose intraperitoneal aprotinin treatment on complement activation and acute phase response in acute severe pancreatitis","volume":"31","author":"Berling","year":"1996","unstructured":"Berling ROhlsson K.Effects of high-dose intraperitoneal aprotinin treatment on complement activation and acute phase response in acute severe pancreatitis. J Gastroenterol. 1996;31(5):702-709."},{"issue":"4","key":"bib12","series-title":"J Cardiothorac Vasc Anesth","first-page":"477","article-title":"Anaphylactic reaction to aprotinin","volume":"9","author":"Ceriana","year":"1995","unstructured":"Ceriana PMaurelli MLocatelli ABianchi TMaccario RDe Amici M.Anaphylactic reaction to aprotinin. J Cardiothorac Vasc Anesth. 1995;9(4):477-478."},{"issue":"2","key":"bib13","series-title":"Ann Fr Anesth Reanim","first-page":"96","article-title":"Allergic risk of aprotinin","volume":"19","author":"Laxenaire","year":"2000","unstructured":"Laxenaire MCDewachter PPecquet C.Allergic risk of aprotinin. Article in French. Ann Fr Anesth Reanim. 2000;19(2):96-104."},{"issue":"4","key":"bib14","series-title":"Ann Thorac Surg","first-page":"971","article-title":"Aprotinin therapy in cardiac operations: a report on use in 41 cardiac centers in the United Kingdom","volume":"55","author":"Bidstrup","year":"1993","unstructured":"Bidstrup BPHarrison JRoyston DTaylor KMTreasure T.Aprotinin therapy in cardiac operations: a report on use in 41 cardiac centers in the United Kingdom. Ann Thorac Surg. 1993;55(4):971-976."},{"issue":"1","key":"bib15","series-title":"J Thorac Cardiovasc Surg","first-page":"194","article-title":"Prevalence of anaphylactic reactions to aprotinin: analysis of two hundred forty-eight reexposures to aprotinin in heart operations","volume":"113","author":"Dietrich","year":"1997","unstructured":"Dietrich WSp\u00e4th PEbell ARichter JA.Prevalence of anaphylactic reactions to aprotinin: analysis of two hundred forty-eight reexposures to aprotinin in heart operations. 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Gastrointest Endosc. 1998;48(1):83-85."},{"issue":"4","key":"bib18","series-title":"J Thorac Cardiovasc Surg","first-page":"883","article-title":"Fibrin sealant, aprotinin, and immune response in children undergoing operations for congenital heart disease","volume":"115","author":"Scheule","year":"1998","unstructured":"Scheule AMBeierlein WWendel HPEckstein FSHeinemann MKZiemer G.Fibrin sealant, aprotinin, and immune response in children undergoing operations for congenital heart disease. J Thorac Cardiovasc Surg. 1998;115(4):883-889."},{"issue":"2","key":"bib19","series-title":"Eur J Cardiothorac Surg","first-page":"307","article-title":"Hypersensitivity reactions to aprotinin re-exposure in paediatric surgery","volume":"37","author":"Siehr","year":"2010","unstructured":"Siehr SStuth ETweddell JHypersensitivity reactions to aprotinin re-exposure in paediatric surgery. Eur J Cardiothorac Surg. 2010;37(2):307-311."},{"issue":"1","key":"bib20","series-title":"Nat Rev Dis Primers","first-page":"61","article-title":"Urticaria","volume":"8","author":"Kolkhir","year":"2022","unstructured":"Kolkhir PGim\u00e9nez-Arnau AMKulthanan KPeter JMetz MMaurer M.Urticaria. Nat Rev Dis Primers. 2022;8(1):61."},{"issue":"12","key":"bib1","series-title":"J Biomed Mater Res B Appl Biomater","first-page":"2779","article-title":"Composition, host responses and clinical applications of bioadhesives","volume":"110","author":"Dhandapani","year":"2022","unstructured":"Dhandapani VRinguette VDesrochers MSirois MVermette P.Composition, host responses and clinical applications of bioadhesives. 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Neurosurgery. 2003;52(5):1102-1105."},{"issue":"2","key":"bib4","series-title":"Oper Neurosurg (Hagerstown)","first-page":"224","article-title":"Effect of fibrin glue injection into the cavernous sinus for hemostasis during transcavernous surgery on the cerebral venous draining system","volume":"13","author":"Toyooka","year":"2017","unstructured":"Toyooka TOtani NWada KEffect of fibrin glue injection into the cavernous sinus for hemostasis during transcavernous surgery on the cerebral venous draining system. Oper Neurosurg (Hagerstown). 2017;13(2):224-231."},{"issue":"4","key":"bib5","series-title":"Neurosurgery","first-page":"E408","article-title":"Surgical technique to retract the tentorial edge during subtemporal approach: technical note","volume":"57","author":"Hernesniemi","year":"2005","unstructured":"Hernesniemi JIshii KKaratas ASurgical technique to retract the tentorial edge during subtemporal approach: technical note. Neurosurgery. 2005;57(4suppl):E408."},{"issue":"3","key":"bib6","series-title":"Neurosurgery","first-page":"E52","article-title":"Taming the cavernous sinus: technique of hemostasis using fibrin glue","volume":"61","author":"Krayenb\u00fchl","year":"2007","unstructured":"Krayenb\u00fchl NHafez AHernesniemi JAKrisht AF.Taming the cavernous sinus: technique of hemostasis using fibrin glue. Neurosurgery. 2007;61(3suppl):E52."},{"issue":"suppl 1","key":"bib7","series-title":"Anaesthesia","first-page":"46","article-title":"The current place of aprotinin in the management of bleeding","volume":"70","author":"Royston","year":"2015","unstructured":"Royston D.The current place of aprotinin in the management of bleeding. Anaesthesia. 2015;70(suppl 1):46-49."},{"issue":"1","key":"bib8","series-title":"Plast Reconstr Surg Glob Open","first-page":"e3382","article-title":"Recalcitrant anaphylaxis associated with fibrin sealant: treatment with \u201cTISSEEL-ectomy\u201d","volume":"9","author":"Saffarzadeh","year":"2021","unstructured":"Saffarzadeh MMulpuri AArneja JS.Recalcitrant anaphylaxis associated with fibrin sealant: treatment with \u201cTISSEEL-ectomy\u201d. Plast Reconstr Surg Glob Open. 2021;9(1):e3382."},{"issue":"2","key":"bib9","series-title":"Ann Thorac Surg","first-page":"741","article-title":"Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions","volume":"79","author":"Beierlein","year":"2005","unstructured":"Beierlein WScheule AMDietrich WZiemer G.Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions. Ann Thorac Surg. 2005;79(2):741-748."},{"issue":"8","key":"bib10","series-title":"Curr Med Res Opin","first-page":"559","article-title":"Serial use of aprotinin and incidence of allergic reactions","volume":"8","author":"Freeman","year":"1983","unstructured":"Freeman JGTurner GAVenables CWLatner AL.Serial use of aprotinin and incidence of allergic reactions. Curr Med Res Opin. 1983;8(8):559-561."},{"issue":"5","key":"bib11","series-title":"J Gastroenterol","first-page":"702","article-title":"Effects of high-dose intraperitoneal aprotinin treatment on complement activation and acute phase response in acute severe pancreatitis","volume":"31","author":"Berling","year":"1996","unstructured":"Berling ROhlsson K.Effects of high-dose intraperitoneal aprotinin treatment on complement activation and acute phase response in acute severe pancreatitis. J Gastroenterol. 1996;31(5):702-709."},{"issue":"4","key":"bib12","series-title":"J Cardiothorac Vasc Anesth","first-page":"477","article-title":"Anaphylactic reaction to aprotinin","volume":"9","author":"Ceriana","year":"1995","unstructured":"Ceriana PMaurelli MLocatelli ABianchi TMaccario RDe Amici M.Anaphylactic reaction to aprotinin. J Cardiothorac Vasc Anesth. 1995;9(4):477-478."},{"issue":"2","key":"bib13","series-title":"Ann Fr Anesth Reanim","first-page":"96","article-title":"Allergic risk of aprotinin","volume":"19","author":"Laxenaire","year":"2000","unstructured":"Laxenaire MCDewachter PPecquet C.Allergic risk of aprotinin. Article in French. Ann Fr Anesth Reanim. 2000;19(2):96-104."},{"issue":"4","key":"bib14","series-title":"Ann Thorac Surg","first-page":"971","article-title":"Aprotinin therapy in cardiac operations: a report on use in 41 cardiac centers in the United Kingdom","volume":"55","author":"Bidstrup","year":"1993","unstructured":"Bidstrup BPHarrison JRoyston DTaylor KMTreasure T.Aprotinin therapy in cardiac operations: a report on use in 41 cardiac centers in the United Kingdom. Ann Thorac Surg. 1993;55(4):971-976."},{"issue":"1","key":"bib15","series-title":"J Thorac Cardiovasc Surg","first-page":"194","article-title":"Prevalence of anaphylactic reactions to aprotinin: analysis of two hundred forty-eight reexposures to aprotinin in heart operations","volume":"113","author":"Dietrich","year":"1997","unstructured":"Dietrich WSp\u00e4th PEbell ARichter JA.Prevalence of anaphylactic reactions to aprotinin: analysis of two hundred forty-eight reexposures to aprotinin in heart operations. 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