{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T09:42:07Z","timestamp":1769938927661,"version":"3.49.0"},"reference-count":54,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,7,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Ewing sarcoma is a rare malignant tumor that primarily affects children and young adults, commonly metastasizing to the lungs, bone, and bone marrow. CNS involvement is extremely rare, especially with the primary presentation of intracranial hemorrhage. Current protocols do not include routine neuroimaging, potentially delaying the detection of brain metastasis. Additionally, Ewing sarcoma patients are at risk of developing chemotherapy-induced thrombocytopenia that can significantly increase the possibility of intracranial hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 19-year-old male with metastatic Ewing sarcoma of the pelvis presented with sudden-onset severe headache, seizures, and unresponsiveness. Imaging revealed a large left frontoparietal intraparenchymal hemorrhage with midline shift requiring emergency surgical decompression. Histopathology confirmed metastatic Ewing sarcoma. Despite proper management, the patient\u2019s medical condition deteriorated, leading to subsequent death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Early and interval brain imaging should be considered in patients diagnosed with Ewing sarcoma, especially those undergoing chemotherapy with thrombocytopenic effects. Earlier detection of CNS involvement may facilitate timely intervention and improve outcomes. Future research should explore optimized surveillance strategies and the connection between metastatic intracranial Ewing sarcoma and the unusual presentation of hemorrhage.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE25246\">https:\/\/thejns.org\/doi\/10.3171\/CASE25246<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case25246","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T02:42:07Z","timestamp":1751856127000},"source":"Crossref","is-referenced-by-count":0,"title":["Ewing sarcoma extraosseous brain metastasis presenting with an intracranial hemorrhage: illustrative case"],"prefix":"10.3171","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6047-7614","authenticated-orcid":true,"given":"Collin","family":"Tanchanco","sequence":"first","affiliation":[{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Ravina","sequence":"additional","affiliation":[{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"Department of Neurosurgery, Carilion Clinic, Roanoke, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"In","sequence":"additional","affiliation":[{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cole","family":"Sloboda","sequence":"additional","affiliation":[{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"Department of Neurosurgery, Carilion Clinic, Roanoke, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7118-3890","authenticated-orcid":true,"given":"Joshua A.","family":"Cuoco","sequence":"additional","affiliation":[{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"Department of Neurosurgery, Carilion Clinic, Roanoke, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Emanuel","sequence":"additional","affiliation":[{"name":"Dominion Pathology Associates, Roanoke, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara M.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"Department of Neurosurgery, Carilion Clinic, Roanoke, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"2","key":"bib1","series-title":"Lancet Oncol","first-page":"184","article-title":"Ewing\u2019s sarcoma","volume":"11","author":"Balamuth","year":"2010","unstructured":"Balamuth NJWomer RB.Ewing\u2019s sarcoma. Lancet Oncol. 2010;11(2):184-192."},{"issue":"3","key":"bib2","series-title":"Br J Cancer","first-page":"397","article-title":"Incidence and survival for cancer in children and young adults in the North of England, 1968-1995: a report from the Northern Region Young Persons\u2019 Malignant Disease Registry","volume":"83","author":"Cotterill","year":"2000","unstructured":"Cotterill SJParker LMalcolm AJReid MMore LCraft AW.Incidence and survival for cancer in children and young adults in the North of England, 1968-1995: a report from the Northern Region Young Persons\u2019 Malignant Disease Registry. Br J Cancer. 2000;83(3):397-403."},{"issue":"1","key":"bib3","series-title":"Clin Case Rep","first-page":"560","article-title":"Secondary brain metastases of Ewing\u2019s sarcoma presenting with collapse after 6 years of complete remission","volume":"9","author":"Poh","year":"2021","unstructured":"Poh JZ.Secondary brain metastases of Ewing\u2019s sarcoma presenting with collapse after 6 years of complete remission. Clin Case Rep. 2021;9(1):560-565."},{"issue":"suppl 2","key":"bib4","series-title":"Pediatr Blood Cancer","first-page":"e28355","article-title":"Ewing sarcoma","volume":"68","author":"Eaton","year":"2021","unstructured":"Eaton BRClaude LIndelicato DJEwing sarcoma. Pediatr Blood Cancer. 2021;68(suppl 2):e28355."},{"issue":"8","key":"bib5","series-title":"J Clin Med","first-page":"1685","article-title":"Ewing sarcoma\u2014diagnosis, treatment, clinical challenges and future perspectives","volume":"10","author":"Z\u00f6llner","year":"2021","unstructured":"Z\u00f6llner SKAmatruda JFBauer SEwing sarcoma\u2014diagnosis, treatment, clinical challenges and future perspectives. J Clin Med. 2021;10(8):1685."},{"issue":"5","key":"bib6","series-title":"Jpn J Clin Oncol","first-page":"245","article-title":"Brain metastases in musculoskeletal sarcomas","volume":"29","author":"Ogose","year":"1999","unstructured":"Ogose AMorita THotta TBrain metastases in musculoskeletal sarcomas. Jpn J Clin Oncol. 1999;29(5):245-247."},{"issue":"3","key":"bib7","series-title":"Cancer","first-page":"859","article-title":"CNS involvement in Ewing\u2019s sarcoma","volume":"33","author":"Mehta","year":"1974","unstructured":"Mehta YHendrickson FR.CNS involvement in Ewing\u2019s sarcoma. Cancer. 1974;33(3):859-862."},{"issue":"5","key":"bib8","series-title":"Neurology","first-page":"1336","article-title":"Metastatic brain involvement in Ewing family of tumors in children","volume":"51","author":"Shuper","year":"1998","unstructured":"Shuper ACohen IJMor CAsh SKornreich LZaizov R.Metastatic brain involvement in Ewing family of tumors in children. Neurology. 1998;51(5):1336-1338."},{"issue":"1","key":"bib9","series-title":"J Neurooncol","first-page":"43","article-title":"Brain metastasis in pediatric extracranial solid tumors: survey and literature review","volume":"71","author":"Kebudi","year":"2005","unstructured":"Kebudi RAyan IG\u00f6rg\u00fcn OA\u011fao\u011flu FYVural SDarendeliler E.Brain metastasis in pediatric extracranial solid tumors: survey and literature review. J Neurooncol. 2005;71(1):43-48."},{"issue":"2","key":"bib10","series-title":"J Natl Compr Canc Netw","first-page":"144","article-title":"The AJCC 8th edition staging system for soft tissue sarcoma of the extremities or trunk: a cohort study of the SEER database","volume":"16","author":"Cates","year":"2018","unstructured":"Cates JMM. The AJCC 8th edition staging system for soft tissue sarcoma of the extremities or trunk: a cohort study of the SEER database. J Natl Compr Canc Netw. 2018;16(2):144-152."},{"issue":"11","key":"bib11","series-title":"J Neurol Neurosurg Psychiatry","first-page":"1295","article-title":"Kernohan\u2019s notch phenomenon demonstrated by diffusion tensor imaging and transcranial magnetic stimulation","volume":"79","author":"Yoo","year":"2008","unstructured":"Yoo WKKim DSKwon YHJang SH.Kernohan\u2019s notch phenomenon demonstrated by diffusion tensor imaging and transcranial magnetic stimulation. J Neurol Neurosurg Psychiatry. 2008;79(11):1295-1297."},{"issue":"5","key":"bib12","series-title":"Virchows Arch","first-page":"599","article-title":"The combination of CD99 and NKX2.2, a transcriptional target of EWSR1-FLI1, is highly specific for the diagnosis of Ewing sarcoma","volume":"465","author":"Shibuya","year":"2014","unstructured":"Shibuya RMatsuyama ANakamoto MShiba EKasai THisaoka M.The combination of CD99 and NKX2.2, a transcriptional target of EWSR1-FLI1, is highly specific for the diagnosis of Ewing sarcoma. Virchows Arch. 2014;465(5):599-605."},{"issue":"12","key":"bib13","series-title":"Am J Surg Pathol","first-page":"1657","article-title":"Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing\u2019s sarcoma\/primitive neuroectodermal tumor","volume":"24","author":"Folpe","year":"2000","unstructured":"Folpe ALHill CEParham DMO\u2019Shea PAWeiss SW.Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing\u2019s sarcoma\/primitive neuroectodermal tumor. Am J Surg Pathol. 2000;24(12):1657-1662."},{"issue":"7","key":"bib14","series-title":"Am J Surg Pathol","first-page":"993","article-title":"NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma","volume":"36","author":"Yoshida","year":"2012","unstructured":"Yoshida ASekine STsuta KFukayama MFuruta KTsuda H.NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma. Am J Surg Pathol. 2012;36(7):993-999."},{"issue":"4","key":"bib15","series-title":"Mod Pathol","first-page":"370","article-title":"Evaluation of NKX2-2 expression in round cell sarcomas and other tumors with EWSR1 rearrangement: imperfect specificity for Ewing sarcoma","volume":"29","author":"Hung","year":"2016","unstructured":"Hung YPFletcher CDMHornick JL.Evaluation of NKX2-2 expression in round cell sarcomas and other tumors with EWSR1 rearrangement: imperfect specificity for Ewing sarcoma. Mod Pathol. 2016;29(4):370-380."},{"issue":"27","key":"bib16","series-title":"J Clin Oncol","first-page":"3036","article-title":"Ewing sarcoma: current management and future approaches through collaboration","volume":"33","author":"Gaspar","year":"2015","unstructured":"Gaspar NHawkins DSDirksen UEwing sarcoma: current management and future approaches through collaboration. J Clin Oncol. 2015;33(27):3036-3046."},{"issue":"373","key":"bib17","series-title":"Clin Orthop Relat Res","first-page":"193","article-title":"Ewing\u2019s sarcoma of the pelvis. Long-term survival and functional outcome","author":"Sucato","year":"2000","unstructured":"Sucato DJRougraff BMcGrath BEEwing\u2019s sarcoma of the pelvis. Long-term survival and functional outcome. Clin Orthop Relat Res. 2000;(373):193-201."},{"issue":"33","key":"bib18","series-title":"J Clin Oncol","first-page":"4148","article-title":"Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children\u2019s Oncology Group","volume":"30","author":"Womer","year":"2012","unstructured":"Womer RBWest DCKrailo MDRandomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children\u2019s Oncology Group. J Clin Oncol. 2012;30(33):4148-4154."},{"issue":"5","key":"bib19","series-title":"Cancer","first-page":"1051","article-title":"Altered pattern of metastasis following treatment of Ewing\u2019s sarcoma with radiotherapy and adjuvant chemotherapy","volume":"27","author":"Marsa","year":"1971","unstructured":"Marsa GWJohnson RE.Altered pattern of metastasis following treatment of Ewing\u2019s sarcoma with radiotherapy and adjuvant chemotherapy. Cancer. 1971;27(5):1051-1054."},{"issue":"6","key":"bib20","series-title":"Haematologica","first-page":"1243","article-title":"Treatment of chemotherapy-induced thrombocytopenia in patients with non-hematologic malignancies","volume":"107","author":"Kuter","year":"2022","unstructured":"Kuter DJ.Treatment of chemotherapy-induced thrombocytopenia in patients with non-hematologic malignancies. Haematologica. 2022;107(6):1243-1263."},{"issue":"4","key":"bib21","series-title":"Int J Radiat Oncol Biol Phys","first-page":"699","article-title":"Actuarial risk of isolated CNS involvement in Ewing\u2019s sarcoma following prophylactic cranial irradiation and intrathecal methotrexate","volume":"11","author":"Trigg","year":"1985","unstructured":"Trigg MEMakuch RGlaubiger D.Actuarial risk of isolated CNS involvement in Ewing\u2019s sarcoma following prophylactic cranial irradiation and intrathecal methotrexate. Int J Radiat Oncol Biol Phys. 1985;11(4):699-702."},{"key":"bib22","series-title":"Chin Neurosurg J","first-page":"31","article-title":"An unusual biconvex epidural lesion: acutely presenting extraosseous intracranial Ewing\u2019s sarcoma","volume":"4","author":"Jan","year":"2018","unstructured":"Jan KKhan EKKhan I.An unusual biconvex epidural lesion: acutely presenting extraosseous intracranial Ewing\u2019s sarcoma. Chin Neurosurg J. 2018;4:31."},{"issue":"1","key":"bib23","series-title":"Pediatr Neurosurg","first-page":"48","article-title":"Ewing\u2019s sarcoma: dural metastases after intracranial hemorrhage","volume":"50","author":"Oz","year":"2015","unstructured":"Oz IISerifoglu IBozay Oz EPiskin EEdebali N.Ewing\u2019s sarcoma: dural metastases after intracranial hemorrhage. Pediatr Neurosurg. 2015;50(1):48-52."},{"issue":"5","key":"bib24","series-title":"J Neurosurg","first-page":"411","article-title":"Primary Ewing sarcoma of the tentorium presenting with intracranial hemorrhage in a child","volume":"107","author":"Navarro","year":"2007","unstructured":"Navarro RLaguna Ade Torres CPrimary Ewing sarcoma of the tentorium presenting with intracranial hemorrhage in a child. J Neurosurg. 2007;107(5suppl):411-415."},{"issue":"1","key":"bib25","series-title":"Neurosurgery","first-page":"143","article-title":"Primary meningeal extraosseous Ewing\u2019s sarcoma: case report","volume":"35","author":"Stechschulte","year":"1994","unstructured":"Stechschulte SUKepes JJHolladay FPMcKittrick RJ.Primary meningeal extraosseous Ewing\u2019s sarcoma: case report. Neurosurgery. 1994;35(1):143-147."},{"issue":"4","key":"bib26","series-title":"Clin Neuropathol","first-page":"184","article-title":"Primary intracranial peripheral primitive neuroectodermal tumor\/Ewing\u2019s sarcoma presenting with acute intracerebral hemorrhage","volume":"24","author":"Bunyaratavej","year":"2005","unstructured":"Bunyaratavej KKhaoroptham SPhonprasert CTanboon JShuangshoti S.Primary intracranial peripheral primitive neuroectodermal tumor\/Ewing\u2019s sarcoma presenting with acute intracerebral hemorrhage. Clin Neuropathol. 2005;24(4):184-190."},{"issue":"6","key":"bib27","series-title":"Pediatr Blood Cancer","first-page":"850","article-title":"Intracranial Ewing sarcoma","volume":"45","author":"Mazur","year":"2005","unstructured":"Mazur MAGururangan SBridge JAIntracranial Ewing sarcoma. Pediatr Blood Cancer. 2005;45(6):850-856."},{"issue":"2","key":"bib1","series-title":"Lancet Oncol","first-page":"184","article-title":"Ewing\u2019s sarcoma","volume":"11","author":"Balamuth","year":"2010","unstructured":"Balamuth NJWomer RB.Ewing\u2019s sarcoma. Lancet Oncol. 2010;11(2):184-192."},{"issue":"3","key":"bib2","series-title":"Br J Cancer","first-page":"397","article-title":"Incidence and survival for cancer in children and young adults in the North of England, 1968-1995: a report from the Northern Region Young Persons\u2019 Malignant Disease Registry","volume":"83","author":"Cotterill","year":"2000","unstructured":"Cotterill SJParker LMalcolm AJReid MMore LCraft AW.Incidence and survival for cancer in children and young adults in the North of England, 1968-1995: a report from the Northern Region Young Persons\u2019 Malignant Disease Registry. Br J Cancer. 2000;83(3):397-403."},{"issue":"1","key":"bib3","series-title":"Clin Case Rep","first-page":"560","article-title":"Secondary brain metastases of Ewing\u2019s sarcoma presenting with collapse after 6 years of complete remission","volume":"9","author":"Poh","year":"2021","unstructured":"Poh JZ.Secondary brain metastases of Ewing\u2019s sarcoma presenting with collapse after 6 years of complete remission. Clin Case Rep. 2021;9(1):560-565."},{"issue":"suppl 2","key":"bib4","series-title":"Pediatr Blood Cancer","first-page":"e28355","article-title":"Ewing sarcoma","volume":"68","author":"Eaton","year":"2021","unstructured":"Eaton BRClaude LIndelicato DJEwing sarcoma. Pediatr Blood Cancer. 2021;68(suppl 2):e28355."},{"issue":"8","key":"bib5","series-title":"J Clin Med","first-page":"1685","article-title":"Ewing sarcoma\u2014diagnosis, treatment, clinical challenges and future perspectives","volume":"10","author":"Z\u00f6llner","year":"2021","unstructured":"Z\u00f6llner SKAmatruda JFBauer SEwing sarcoma\u2014diagnosis, treatment, clinical challenges and future perspectives. J Clin Med. 2021;10(8):1685."},{"issue":"5","key":"bib6","series-title":"Jpn J Clin Oncol","first-page":"245","article-title":"Brain metastases in musculoskeletal sarcomas","volume":"29","author":"Ogose","year":"1999","unstructured":"Ogose AMorita THotta TBrain metastases in musculoskeletal sarcomas. Jpn J Clin Oncol. 1999;29(5):245-247."},{"issue":"3","key":"bib7","series-title":"Cancer","first-page":"859","article-title":"CNS involvement in Ewing\u2019s sarcoma","volume":"33","author":"Mehta","year":"1974","unstructured":"Mehta YHendrickson FR.CNS involvement in Ewing\u2019s sarcoma. Cancer. 1974;33(3):859-862."},{"issue":"5","key":"bib8","series-title":"Neurology","first-page":"1336","article-title":"Metastatic brain involvement in Ewing family of tumors in children","volume":"51","author":"Shuper","year":"1998","unstructured":"Shuper ACohen IJMor CAsh SKornreich LZaizov R.Metastatic brain involvement in Ewing family of tumors in children. Neurology. 1998;51(5):1336-1338."},{"issue":"1","key":"bib9","series-title":"J Neurooncol","first-page":"43","article-title":"Brain metastasis in pediatric extracranial solid tumors: survey and literature review","volume":"71","author":"Kebudi","year":"2005","unstructured":"Kebudi RAyan IG\u00f6rg\u00fcn OA\u011fao\u011flu FYVural SDarendeliler E.Brain metastasis in pediatric extracranial solid tumors: survey and literature review. J Neurooncol. 2005;71(1):43-48."},{"issue":"2","key":"bib10","series-title":"J Natl Compr Canc Netw","first-page":"144","article-title":"The AJCC 8th edition staging system for soft tissue sarcoma of the extremities or trunk: a cohort study of the SEER database","volume":"16","author":"Cates","year":"2018","unstructured":"Cates JMM. The AJCC 8th edition staging system for soft tissue sarcoma of the extremities or trunk: a cohort study of the SEER database. J Natl Compr Canc Netw. 2018;16(2):144-152."},{"issue":"11","key":"bib11","series-title":"J Neurol Neurosurg Psychiatry","first-page":"1295","article-title":"Kernohan\u2019s notch phenomenon demonstrated by diffusion tensor imaging and transcranial magnetic stimulation","volume":"79","author":"Yoo","year":"2008","unstructured":"Yoo WKKim DSKwon YHJang SH.Kernohan\u2019s notch phenomenon demonstrated by diffusion tensor imaging and transcranial magnetic stimulation. J Neurol Neurosurg Psychiatry. 2008;79(11):1295-1297."},{"issue":"5","key":"bib12","series-title":"Virchows Arch","first-page":"599","article-title":"The combination of CD99 and NKX2.2, a transcriptional target of EWSR1-FLI1, is highly specific for the diagnosis of Ewing sarcoma","volume":"465","author":"Shibuya","year":"2014","unstructured":"Shibuya RMatsuyama ANakamoto MShiba EKasai THisaoka M.The combination of CD99 and NKX2.2, a transcriptional target of EWSR1-FLI1, is highly specific for the diagnosis of Ewing sarcoma. Virchows Arch. 2014;465(5):599-605."},{"issue":"12","key":"bib13","series-title":"Am J Surg Pathol","first-page":"1657","article-title":"Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing\u2019s sarcoma\/primitive neuroectodermal tumor","volume":"24","author":"Folpe","year":"2000","unstructured":"Folpe ALHill CEParham DMO\u2019Shea PAWeiss SW.Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing\u2019s sarcoma\/primitive neuroectodermal tumor. Am J Surg Pathol. 2000;24(12):1657-1662."},{"issue":"7","key":"bib14","series-title":"Am J Surg Pathol","first-page":"993","article-title":"NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma","volume":"36","author":"Yoshida","year":"2012","unstructured":"Yoshida ASekine STsuta KFukayama MFuruta KTsuda H.NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma. Am J Surg Pathol. 2012;36(7):993-999."},{"issue":"4","key":"bib15","series-title":"Mod Pathol","first-page":"370","article-title":"Evaluation of NKX2-2 expression in round cell sarcomas and other tumors with EWSR1 rearrangement: imperfect specificity for Ewing sarcoma","volume":"29","author":"Hung","year":"2016","unstructured":"Hung YPFletcher CDMHornick JL.Evaluation of NKX2-2 expression in round cell sarcomas and other tumors with EWSR1 rearrangement: imperfect specificity for Ewing sarcoma. Mod Pathol. 2016;29(4):370-380."},{"issue":"27","key":"bib16","series-title":"J Clin Oncol","first-page":"3036","article-title":"Ewing sarcoma: current management and future approaches through collaboration","volume":"33","author":"Gaspar","year":"2015","unstructured":"Gaspar NHawkins DSDirksen UEwing sarcoma: current management and future approaches through collaboration. J Clin Oncol. 2015;33(27):3036-3046."},{"issue":"373","key":"bib17","series-title":"Clin Orthop Relat Res","first-page":"193","article-title":"Ewing\u2019s sarcoma of the pelvis. Long-term survival and functional outcome","author":"Sucato","year":"2000","unstructured":"Sucato DJRougraff BMcGrath BEEwing\u2019s sarcoma of the pelvis. Long-term survival and functional outcome. Clin Orthop Relat Res. 2000;(373):193-201."},{"issue":"33","key":"bib18","series-title":"J Clin Oncol","first-page":"4148","article-title":"Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children\u2019s Oncology Group","volume":"30","author":"Womer","year":"2012","unstructured":"Womer RBWest DCKrailo MDRandomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children\u2019s Oncology Group. J Clin Oncol. 2012;30(33):4148-4154."},{"issue":"5","key":"bib19","series-title":"Cancer","first-page":"1051","article-title":"Altered pattern of metastasis following treatment of Ewing\u2019s sarcoma with radiotherapy and adjuvant chemotherapy","volume":"27","author":"Marsa","year":"1971","unstructured":"Marsa GWJohnson RE.Altered pattern of metastasis following treatment of Ewing\u2019s sarcoma with radiotherapy and adjuvant chemotherapy. Cancer. 1971;27(5):1051-1054."},{"issue":"6","key":"bib20","series-title":"Haematologica","first-page":"1243","article-title":"Treatment of chemotherapy-induced thrombocytopenia in patients with non-hematologic malignancies","volume":"107","author":"Kuter","year":"2022","unstructured":"Kuter DJ.Treatment of chemotherapy-induced thrombocytopenia in patients with non-hematologic malignancies. Haematologica. 2022;107(6):1243-1263."},{"issue":"4","key":"bib21","series-title":"Int J Radiat Oncol Biol Phys","first-page":"699","article-title":"Actuarial risk of isolated CNS involvement in Ewing\u2019s sarcoma following prophylactic cranial irradiation and intrathecal methotrexate","volume":"11","author":"Trigg","year":"1985","unstructured":"Trigg MEMakuch RGlaubiger D.Actuarial risk of isolated CNS involvement in Ewing\u2019s sarcoma following prophylactic cranial irradiation and intrathecal methotrexate. Int J Radiat Oncol Biol Phys. 1985;11(4):699-702."},{"key":"bib22","series-title":"Chin Neurosurg J","first-page":"31","article-title":"An unusual biconvex epidural lesion: acutely presenting extraosseous intracranial Ewing\u2019s sarcoma","volume":"4","author":"Jan","year":"2018","unstructured":"Jan KKhan EKKhan I.An unusual biconvex epidural lesion: acutely presenting extraosseous intracranial Ewing\u2019s sarcoma. Chin Neurosurg J. 2018;4:31."},{"issue":"1","key":"bib23","series-title":"Pediatr Neurosurg","first-page":"48","article-title":"Ewing\u2019s sarcoma: dural metastases after intracranial hemorrhage","volume":"50","author":"Oz","year":"2015","unstructured":"Oz IISerifoglu IBozay Oz EPiskin EEdebali N.Ewing\u2019s sarcoma: dural metastases after intracranial hemorrhage. Pediatr Neurosurg. 2015;50(1):48-52."},{"issue":"5","key":"bib24","series-title":"J Neurosurg","first-page":"411","article-title":"Primary Ewing sarcoma of the tentorium presenting with intracranial hemorrhage in a child","volume":"107","author":"Navarro","year":"2007","unstructured":"Navarro RLaguna Ade Torres CPrimary Ewing sarcoma of the tentorium presenting with intracranial hemorrhage in a child. J Neurosurg. 2007;107(5suppl):411-415."},{"issue":"1","key":"bib25","series-title":"Neurosurgery","first-page":"143","article-title":"Primary meningeal extraosseous Ewing\u2019s sarcoma: case report","volume":"35","author":"Stechschulte","year":"1994","unstructured":"Stechschulte SUKepes JJHolladay FPMcKittrick RJ.Primary meningeal extraosseous Ewing\u2019s sarcoma: case report. Neurosurgery. 1994;35(1):143-147."},{"issue":"4","key":"bib26","series-title":"Clin Neuropathol","first-page":"184","article-title":"Primary intracranial peripheral primitive neuroectodermal tumor\/Ewing\u2019s sarcoma presenting with acute intracerebral hemorrhage","volume":"24","author":"Bunyaratavej","year":"2005","unstructured":"Bunyaratavej KKhaoroptham SPhonprasert CTanboon JShuangshoti S.Primary intracranial peripheral primitive neuroectodermal tumor\/Ewing\u2019s sarcoma presenting with acute intracerebral hemorrhage. Clin Neuropathol. 2005;24(4):184-190."},{"issue":"6","key":"bib27","series-title":"Pediatr Blood Cancer","first-page":"850","article-title":"Intracranial Ewing sarcoma","volume":"45","author":"Mazur","year":"2005","unstructured":"Mazur MAGururangan SBridge JAIntracranial Ewing sarcoma. Pediatr Blood Cancer. 2005;45(6):850-856."}],"container-title":["Journal of Neurosurgery: Case Lessons"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/10\/1\/article-CASE25246.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/10\/1\/article-CASE25246.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/10\/1\/article-CASE25246.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:10:33Z","timestamp":1769685033000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/10\/1\/article-CASE25246.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":54,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/case25246","relation":{},"ISSN":["2694-1902"],"issn-type":[{"value":"2694-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]}}}