{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:13:07Z","timestamp":1769728387241,"version":"3.49.0"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"8","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,8,25]]},"abstract":"\n BACKGROUND<\/jats:title>\n Chondrosarcomas are rare malignancies arising from the bone, primarily from the mobile spine. Multimodal treatment is the standard of care, with surgery as a cornerstone for local control since incomplete resection is the main driving factor for progression and disease-related mortality.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n Here, the authors present the case of a patient who underwent an initial subtotal resection and adjuvant proton beam radiation therapy. Subsequent salvage surgery with aggressive resection was planned in an interdisciplinary setting, resulting in complete resection without recurrence. Despite incomplete resection initially, this case represents an example for reconsidering salvage surgery in an interdisciplinary setting and center of expertise even for cases with residual tumor burden.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n By highlighting the current literature and setting this clinical case in this context, the authors present a case with a 10-year long-term follow-up, showing that surgical salvage therapy is a possible treatment path with predictable surgery-related morbidity in patients with spinal chondrosarcomas.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE25317<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case25317","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T23:49:18Z","timestamp":1756770558000},"source":"Crossref","is-referenced-by-count":0,"title":["Long-term follow-up after cervical en bloc resection as salvage surgery of spinal chondrosarcoma: illustrative case"],"prefix":"10.3171","volume":"10","author":[{"given":"Stefanie","family":"Ott","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, Orthocentrum Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malte","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Heinz","family":"Frosch","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"},{"name":"Department of Trauma and Orthopaedic Surgery, BG Klinikum Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Hansen-Algenstaedt","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Orthocentrum Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"8","key":"bib1","series-title":"Spine (Phila Pa 1976)","first-page":"678","article-title":"Surgical management of spinal chondrosarcomas","volume":"41","author":"Fisher","year":"2016","unstructured":"Fisher CGVersteeg ALDea NSurgical management of spinal chondrosarcomas. Spine (Phila Pa 1976). 2016;41(8):678-685."},{"issue":"12","key":"bib2","series-title":"Spine J","first-page":"2078","article-title":"Chondrosarcoma of the spine: a narrative review","volume":"21","author":"Pennington","year":"2021","unstructured":"Pennington ZEhresman JPittman PDChondrosarcoma of the spine: a narrative review. Spine J. 2021;21(12):2078-2096."},{"key":"bib3","series-title":"World Neurosurg","first-page":"e316","article-title":"Incidence, management, and outcomes of adult patients with spinal chondrosarcoma in the United States","volume":"149","author":"Nunna","year":"2021","unstructured":"Nunna RSPatel SPatil SNIncidence, management, and outcomes of adult patients with spinal chondrosarcoma in the United States. World Neurosurg. 2021;149:e316-e328."},{"issue":"22","key":"bib4","series-title":"Spine (Phila Pa 1976)","first-page":"E1192","article-title":"A competing risk-based prognostic model to predict cancer-specific death of patients with spinal and pelvic chondrosarcoma","volume":"46","author":"Dong","year":"2021","unstructured":"Dong YXie LKang HA competing risk-based prognostic model to predict cancer-specific death of patients with spinal and pelvic chondrosarcoma. Spine (Phila Pa 1976). 2021;46(22):E1192-E1201."},{"key":"bib5","series-title":"Clin Neurol Neurosurg","first-page":"106999","article-title":"Refractory recurrent spinal chondrosarcoma: what is the role of salvage surgery?","volume":"210","author":"Zhang","year":"2021","unstructured":"Zhang YHe SBi YXu YMiao WWei H.Refractory recurrent spinal chondrosarcoma: what is the role of salvage surgery? Clin Neurol Neurosurg. 2021;210:106999."},{"issue":"22","key":"bib6","series-title":"Spine (Phila Pa 1976)","first-page":"S48","article-title":"Challenges of local recurrence and cure in low grade malignant tumors of the spine","volume":"34","author":"Boriani","year":"2009","unstructured":"Boriani SSaravanja DYamada YVarga PPBiagini RFisher CG.Challenges of local recurrence and cure in low grade malignant tumors of the spine. Spine (Phila Pa 1976). 2009;34(22)(suppl):S48-S57."},{"issue":"20","key":"bib7","series-title":"Spine (Phila Pa 1976)","first-page":"2233","article-title":"Long-term clinical outcomes following en bloc resections for sacral chordomas and chondrosarcomas: a series of twenty consecutive patients","volume":"34","author":"Hsieh","year":"2009","unstructured":"Hsieh PCXu RSciubba DMLong-term clinical outcomes following en bloc resections for sacral chordomas and chondrosarcomas: a series of twenty consecutive patients. Spine (Phila Pa 1976). 2009;34(20):2233-2239."},{"issue":"7","key":"bib8","series-title":"Cancer","first-page":"1201","article-title":"Prognostic factors and outcome of pelvic, sacral, and spinal chondrosarcomas: a center-based study of 69 cases","volume":"91","author":"Bergh","year":"2001","unstructured":"Bergh PGunterberg BMeis-Kindblom JMKindblom LG.Prognostic factors and outcome of pelvic, sacral, and spinal chondrosarcomas: a center-based study of 69 cases. Cancer. 2001;91(7):1201-1212."},{"issue":"9","key":"bib9","series-title":"Spine (Phila Pa 1976)","first-page":"644","article-title":"Chondrosarcoma of the osseous spine: an analysis of epidemiology, patient outcomes, and prognostic factors using the SEER registry from 1973 to 2012","volume":"42","author":"Arshi","year":"2017","unstructured":"Arshi ASharim JPark DYChondrosarcoma of the osseous spine: an analysis of epidemiology, patient outcomes, and prognostic factors using the SEER registry from 1973 to 2012. Spine (Phila Pa 1976). 2017;42(9):644-652."},{"issue":"11","key":"bib10","series-title":"Spine J","first-page":"2608","article-title":"En bloc resections for primary spinal tumors in 20 years of experience: effectiveness and safety","volume":"14","author":"Amendola","year":"2014","unstructured":"Amendola LCappuccio MDe Iure FBandiera SGasbarrini ABoriani S.En bloc resections for primary spinal tumors in 20 years of experience: effectiveness and safety. Spine J. 2014;14(11):2608-2617."},{"issue":"17","key":"bib11","series-title":"J Am Acad Orthop Surg","first-page":"e1106","article-title":"Spinal tumors: diagnosis and treatment","volume":"30","author":"Goodwin","year":"2022","unstructured":"Goodwin MLBuchowski JMSchwab JHSciubba DM.Spinal tumors: diagnosis and treatment. J Am Acad Orthop Surg. 2022;30(17):e1106-e1121."},{"key":"bib12","series-title":"World Neurosurg","first-page":"329","article-title":"Salvage revision surgery after inappropriate approach for primary spine tumors: long term follow-up in 56 cases","volume":"98","author":"Luzzati","year":"2017","unstructured":"Luzzati AScotto GPerrucchini GBaaj AAZoccali C.Salvage revision surgery after inappropriate approach for primary spine tumors: long term follow-up in 56 cases. World Neurosurg. 2017;98:329-333."},{"issue":"3","key":"bib13","series-title":"Clin Orthop Relat Res","first-page":"631","article-title":"Is treatment at a high-volume center associated with an improved survival for primary malignant bone tumors?","volume":"478","author":"Malik","year":"2020","unstructured":"Malik ATAlexander JHKhan SNScharschmidt TJ.Is treatment at a high-volume center associated with an improved survival for primary malignant bone tumors? Clin Orthop Relat Res. 2020;478(3):631-642."},{"issue":"12","key":"bib14","series-title":"Spine (Phila Pa 1976)","first-page":"1454","article-title":"A report on the safety of unilateral vertebral artery ligation during cervical spine surgery","volume":"21","author":"Hoshino","year":"1996","unstructured":"Hoshino YKurokawa TNakamura KA report on the safety of unilateral vertebral artery ligation during cervical spine surgery. Spine (Phila Pa 1976). 1996;21(12):1454-1457."},{"issue":"8","key":"bib15","series-title":"Orthop Surg","first-page":"1753","article-title":"Intentional dural resection during en bloc spinal resection could provide a secure surgical margin for patients with recurrent spinal tumors","volume":"16","author":"Du","year":"2024","unstructured":"Du ZTang XCai ZWang HWei RWang J.Intentional dural resection during en bloc spinal resection could provide a secure surgical margin for patients with recurrent spinal tumors. Orthop Surg. 2024;16(8):1753-1760."},{"issue":"12","key":"bib16","series-title":"Spine (Phila Pa 1976)","first-page":"789","article-title":"Multi-level en bloc resection as a preferred salvage therapy for recurrent thoracolumbar chondrosarcoma: a comparative study with piecemeal resection","volume":"45","author":"Wang","year":"2020","unstructured":"Wang TJia QFan RMulti-level en bloc resection as a preferred salvage therapy for recurrent thoracolumbar chondrosarcoma: a comparative study with piecemeal resection. Spine (Phila Pa 1976). 2020;45(12):789-797."},{"issue":"7","key":"bib17","series-title":"J Clin Med","first-page":"2506","article-title":"Chondrosarcoma: a clinical review","volume":"12","author":"Gazendam","year":"2023","unstructured":"Gazendam APopovic SParasu NGhert M.Chondrosarcoma: a clinical review. J Clin Med. 2023;12(7):2506."},{"issue":"3","key":"bib18","series-title":"Eur Spine J","first-page":"994","article-title":"Gross total resection of spinal chondrosarcoma is associated with improved locoregional relapse-free survival and overall survival","volume":"32","author":"Abunimer","year":"2023","unstructured":"Abunimer AMHammoudeh LDee ECGross total resection of spinal chondrosarcoma is associated with improved locoregional relapse-free survival and overall survival. Eur Spine J. 2023;32(3):994-1002."},{"issue":"8","key":"bib1","series-title":"Spine (Phila Pa 1976)","first-page":"678","article-title":"Surgical management of spinal chondrosarcomas","volume":"41","author":"Fisher","year":"2016","unstructured":"Fisher CGVersteeg ALDea NSurgical management of spinal chondrosarcomas. Spine (Phila Pa 1976). 2016;41(8):678-685."},{"issue":"12","key":"bib2","series-title":"Spine J","first-page":"2078","article-title":"Chondrosarcoma of the spine: a narrative review","volume":"21","author":"Pennington","year":"2021","unstructured":"Pennington ZEhresman JPittman PDChondrosarcoma of the spine: a narrative review. Spine J. 2021;21(12):2078-2096."},{"key":"bib3","series-title":"World Neurosurg","first-page":"e316","article-title":"Incidence, management, and outcomes of adult patients with spinal chondrosarcoma in the United States","volume":"149","author":"Nunna","year":"2021","unstructured":"Nunna RSPatel SPatil SNIncidence, management, and outcomes of adult patients with spinal chondrosarcoma in the United States. World Neurosurg. 2021;149:e316-e328."},{"issue":"22","key":"bib4","series-title":"Spine (Phila Pa 1976)","first-page":"E1192","article-title":"A competing risk-based prognostic model to predict cancer-specific death of patients with spinal and pelvic chondrosarcoma","volume":"46","author":"Dong","year":"2021","unstructured":"Dong YXie LKang HA competing risk-based prognostic model to predict cancer-specific death of patients with spinal and pelvic chondrosarcoma. Spine (Phila Pa 1976). 2021;46(22):E1192-E1201."},{"key":"bib5","series-title":"Clin Neurol Neurosurg","first-page":"106999","article-title":"Refractory recurrent spinal chondrosarcoma: what is the role of salvage surgery?","volume":"210","author":"Zhang","year":"2021","unstructured":"Zhang YHe SBi YXu YMiao WWei H.Refractory recurrent spinal chondrosarcoma: what is the role of salvage surgery? Clin Neurol Neurosurg. 2021;210:106999."},{"issue":"22","key":"bib6","series-title":"Spine (Phila Pa 1976)","first-page":"S48","article-title":"Challenges of local recurrence and cure in low grade malignant tumors of the spine","volume":"34","author":"Boriani","year":"2009","unstructured":"Boriani SSaravanja DYamada YVarga PPBiagini RFisher CG.Challenges of local recurrence and cure in low grade malignant tumors of the spine. Spine (Phila Pa 1976). 2009;34(22)(suppl):S48-S57."},{"issue":"20","key":"bib7","series-title":"Spine (Phila Pa 1976)","first-page":"2233","article-title":"Long-term clinical outcomes following en bloc resections for sacral chordomas and chondrosarcomas: a series of twenty consecutive patients","volume":"34","author":"Hsieh","year":"2009","unstructured":"Hsieh PCXu RSciubba DMLong-term clinical outcomes following en bloc resections for sacral chordomas and chondrosarcomas: a series of twenty consecutive patients. Spine (Phila Pa 1976). 2009;34(20):2233-2239."},{"issue":"7","key":"bib8","series-title":"Cancer","first-page":"1201","article-title":"Prognostic factors and outcome of pelvic, sacral, and spinal chondrosarcomas: a center-based study of 69 cases","volume":"91","author":"Bergh","year":"2001","unstructured":"Bergh PGunterberg BMeis-Kindblom JMKindblom LG.Prognostic factors and outcome of pelvic, sacral, and spinal chondrosarcomas: a center-based study of 69 cases. Cancer. 2001;91(7):1201-1212."},{"issue":"9","key":"bib9","series-title":"Spine (Phila Pa 1976)","first-page":"644","article-title":"Chondrosarcoma of the osseous spine: an analysis of epidemiology, patient outcomes, and prognostic factors using the SEER registry from 1973 to 2012","volume":"42","author":"Arshi","year":"2017","unstructured":"Arshi ASharim JPark DYChondrosarcoma of the osseous spine: an analysis of epidemiology, patient outcomes, and prognostic factors using the SEER registry from 1973 to 2012. Spine (Phila Pa 1976). 2017;42(9):644-652."},{"issue":"11","key":"bib10","series-title":"Spine J","first-page":"2608","article-title":"En bloc resections for primary spinal tumors in 20 years of experience: effectiveness and safety","volume":"14","author":"Amendola","year":"2014","unstructured":"Amendola LCappuccio MDe Iure FBandiera SGasbarrini ABoriani S.En bloc resections for primary spinal tumors in 20 years of experience: effectiveness and safety. Spine J. 2014;14(11):2608-2617."},{"issue":"17","key":"bib11","series-title":"J Am Acad Orthop Surg","first-page":"e1106","article-title":"Spinal tumors: diagnosis and treatment","volume":"30","author":"Goodwin","year":"2022","unstructured":"Goodwin MLBuchowski JMSchwab JHSciubba DM.Spinal tumors: diagnosis and treatment. J Am Acad Orthop Surg. 2022;30(17):e1106-e1121."},{"key":"bib12","series-title":"World Neurosurg","first-page":"329","article-title":"Salvage revision surgery after inappropriate approach for primary spine tumors: long term follow-up in 56 cases","volume":"98","author":"Luzzati","year":"2017","unstructured":"Luzzati AScotto GPerrucchini GBaaj AAZoccali C.Salvage revision surgery after inappropriate approach for primary spine tumors: long term follow-up in 56 cases. World Neurosurg. 2017;98:329-333."},{"issue":"3","key":"bib13","series-title":"Clin Orthop Relat Res","first-page":"631","article-title":"Is treatment at a high-volume center associated with an improved survival for primary malignant bone tumors?","volume":"478","author":"Malik","year":"2020","unstructured":"Malik ATAlexander JHKhan SNScharschmidt TJ.Is treatment at a high-volume center associated with an improved survival for primary malignant bone tumors? Clin Orthop Relat Res. 2020;478(3):631-642."},{"issue":"12","key":"bib14","series-title":"Spine (Phila Pa 1976)","first-page":"1454","article-title":"A report on the safety of unilateral vertebral artery ligation during cervical spine surgery","volume":"21","author":"Hoshino","year":"1996","unstructured":"Hoshino YKurokawa TNakamura KA report on the safety of unilateral vertebral artery ligation during cervical spine surgery. Spine (Phila Pa 1976). 1996;21(12):1454-1457."},{"issue":"8","key":"bib15","series-title":"Orthop Surg","first-page":"1753","article-title":"Intentional dural resection during en bloc spinal resection could provide a secure surgical margin for patients with recurrent spinal tumors","volume":"16","author":"Du","year":"2024","unstructured":"Du ZTang XCai ZWang HWei RWang J.Intentional dural resection during en bloc spinal resection could provide a secure surgical margin for patients with recurrent spinal tumors. Orthop Surg. 2024;16(8):1753-1760."},{"issue":"12","key":"bib16","series-title":"Spine (Phila Pa 1976)","first-page":"789","article-title":"Multi-level en bloc resection as a preferred salvage therapy for recurrent thoracolumbar chondrosarcoma: a comparative study with piecemeal resection","volume":"45","author":"Wang","year":"2020","unstructured":"Wang TJia QFan RMulti-level en bloc resection as a preferred salvage therapy for recurrent thoracolumbar chondrosarcoma: a comparative study with piecemeal resection. Spine (Phila Pa 1976). 2020;45(12):789-797."},{"issue":"7","key":"bib17","series-title":"J Clin Med","first-page":"2506","article-title":"Chondrosarcoma: a clinical review","volume":"12","author":"Gazendam","year":"2023","unstructured":"Gazendam APopovic SParasu NGhert M.Chondrosarcoma: a clinical review. J Clin Med. 2023;12(7):2506."},{"issue":"3","key":"bib18","series-title":"Eur Spine J","first-page":"994","article-title":"Gross total resection of spinal chondrosarcoma is associated with improved locoregional relapse-free survival and overall survival","volume":"32","author":"Abunimer","year":"2023","unstructured":"Abunimer AMHammoudeh LDee ECGross total resection of spinal chondrosarcoma is associated with improved locoregional relapse-free survival and overall survival. Eur Spine J. 2023;32(3):994-1002."}],"container-title":["Journal of Neurosurgery: Case Lessons"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/10\/8\/article-CASE25317.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/10\/8\/article-CASE25317.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/10\/8\/article-CASE25317.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:09:58Z","timestamp":1769684998000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/10\/8\/article-CASE25317.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":36,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.3171\/case25317","relation":{},"ISSN":["2694-1902"],"issn-type":[{"value":"2694-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,25]]}}}