{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:02:02Z","timestamp":1782392522422,"version":"3.54.5"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"8","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,8,25]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      This report presents the first documented case of a live, adult\n                      <jats:italic>Taenia solium<\/jats:italic>\n                      tapeworm discovered within the human brain\u2014a finding that challenges the conventional understanding of neurocysticercosis (NCC), a parasitic disease typically caused by larval cysts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>\n                      A 54-year-old woman with a history of breast cancer presented with seizures, headaches, and photophobia. Initial suspicion of a metastatic brain tumor led to serial MRI studies, which revealed a migrating lesion in the right temporal lobe. During craniotomy, a motile helminth was surgically excised from the brain parenchyma. Histopathological analysis confirmed that the organism was an adult\n                      <jats:italic>T. solium<\/jats:italic>\n                      tapeworm, with taeniid eggs identified within the specimen, marking the first evidence of intracranial adult taeniasis and ectopic cerebral oviposition. The patient\u2019s prior oncological treatments, including mastectomy and postoperative therapies, raise hypotheses about immune or anatomical changes facilitating parasitic neuroinvasion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>The discovery underscores critical gaps in diagnostics, as the lesion mimicked metastatic cancer radiologically, and therapeutics, as standard cysticidal drugs target larval stages, not adult worms. This report highlights the urgent need to investigate interactions between parasitic infections and oncological interventions. It calls for updated clinical guidelines to address this novel pathogenic mechanism and emphasizes the importance of integrating parasitological expertise into neurological care.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE25370\">https:\/\/thejns.org\/doi\/10.3171\/CASE25370<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case25370","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T23:49:23Z","timestamp":1756770563000},"source":"Crossref","is-referenced-by-count":1,"title":["First report of adult Taenia solium in human brain with neurocysticercosis: illustrative case"],"prefix":"10.3171","volume":"10","author":[{"given":"Giorgi","family":"Sekania","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Innova Medical Center, Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3066-7231","authenticated-orcid":true,"given":"Giorgi","family":"Svanishvili","sequence":"additional","affiliation":[{"name":"Anatomical Skills and Research Center, Tbilisi State Medical University, Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irakli","family":"Chelishvili","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Innova Medical Center, Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velodi","family":"Gakharia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, St. Michael\u2019s Hospital, Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"4","key":"bib1","series-title":"Neurohospitalist","first-page":"205","article-title":"Neurocysticercosis","volume":"4","author":"Del Brutto","year":"2014","unstructured":"Del Brutto OH.Neurocysticercosis. Neurohospitalist. 2014;4(4):205-212."},{"key":"bib2","series-title":"Front Vet Sci","first-page":"615703","article-title":"Neurocysticercosis: current perspectives on diagnosis and management","volume":"8","author":"Butala","year":"2021","unstructured":"Butala CBrook TMMajekodunmi AOWelburn SC.Neurocysticercosis: current perspectives on diagnosis and management. Front Vet Sci. 2021;8:615703."},{"issue":"12","key":"bib3","series-title":"Lancet Neurol","first-page":"1202","article-title":"Clinical symptoms, diagnosis, and treatment of neurocysticercosis","volume":"13","author":"Garcia","year":"2014","unstructured":"Garcia HHNash TEDel Brutto OH.Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol. 2014;13(12):1202-1215."},{"issue":"10","key":"bib4","series-title":"Lancet Neurol","first-page":"653","article-title":"Neurocysticercosis: updated concepts about an old disease","volume":"4","author":"Garcia","year":"2005","unstructured":"Garcia HHDel Brutto OH. Cysticercosis Working Group in Peru.Neurocysticercosis: updated concepts about an old disease. Lancet Neurol. 2005;4(10):653-661."},{"issue":"1","key":"bib5","series-title":"PLOS Negl Trop Dis","first-page":"e371","article-title":"Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures","volume":"3","author":"Lescano","year":"2009","unstructured":"Lescano AGGarcia HHGilman RHTaenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures. PLOS Negl Trop Dis. 2009;3(1):e371."},{"issue":"7","key":"bib6","series-title":"Neurology","first-page":"654","article-title":"Neurocysticercosis. Unraveling the nature of the single cysticercal granuloma","volume":"75","author":"Garc\u00eda","year":"2010","unstructured":"Garc\u00eda HHGonzalez AERodriguez SNeurocysticercosis. Unraveling the nature of the single cysticercal granuloma. 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