{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:54:18Z","timestamp":1782867258835,"version":"3.54.5"},"reference-count":90,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"26","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurosurg Case Lessons"],"published-print":{"date-parts":[[2026,6,29]]},"abstract":"\n BACKGROUND<\/jats:title>\n \n CNS solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that arise from the meninges and are characterized by a\n NAB2-STAT6<\/jats:italic>\n gene fusion and abundant STAT6 nuclear expression on immunohistochemistry. On imaging, SFTs can mimic meningiomas, but they differ in their clinical behavior. CNS SFTs have a propensity to recur locally and metastases, although rare, have been described.\n <\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n \n The authors report the case of a 76-year-old male with a history of a lower cervical spine SFT treated with surgery and radiation therapy. He presented with progressively worsening gait and balance, and headaches. Imaging showed a fourth ventricular mass that was resected via a midline suboccipital craniectomy. Pathological analysis showed a WHO grade 2 epithelioid SFT, confirmed by STAT6 expression and a rare\n NAB2ex5-STAT6ex17<\/jats:italic>\n fusion variant. The histology slides from 22 years prior were compared and found to be similar, suggesting metastasis of the original tumor.\n <\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n To the authors\u2019 knowledge, this is the first reported case of a spinal SFT with metastasis to the fourth ventricle and the first epithelioid SFT presenting within the fourth ventricle. Long-term follow-up is recommended due to the risk of local recurrence and metastases.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE25414<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case25414","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:05:55Z","timestamp":1782864355000},"source":"Crossref","is-referenced-by-count":0,"title":["Spinal solitary fibrous tumor metastatic to the fourth ventricle: illustrative case"],"prefix":"10.3171","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-7004","authenticated-orcid":true,"given":"Ryan","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Clinical Neurological Sciences, Western University, London, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shervin","family":"Pejhan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Western University, London, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire I.","family":"Coire","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Cyn","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Western University, London, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Megyesi","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Clinical Neurological Sciences, Western University, London, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"bib1","series-title":"WHO Classification of Tumours of the Central Nervous System","author":"WHO Classification of Tumours Editorial Board","year":"2021","unstructured":"WHO Classification of Tumours Editorial Board.WHO Classification of Tumours of the Central Nervous System. 5th ed. 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