{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T16:08:24Z","timestamp":1776096504236,"version":"3.50.1"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"15","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurosurg Case Lessons"],"published-print":{"date-parts":[[2026,4,13]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Eosinophilic granuloma (EG) is a localized subtype of Langerhans cell histiocytosis (LCH) that involves infiltration of tissues by a clonal proliferation of Langerhans cells. EG is a rare tumor of the orbit and most commonly presents in childhood. This tumor is known to regress after minimal intervention (including biopsy), and management includes curettage and intralesional corticosteroids. The natural history of EG is not well understood, and true spontaneous regression of the lesion without intervention has rarely been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>Herein, the authors present a unique case of an adult patient with presumed orbitocranial EG with true spontaneous regression over a 4-month period. Biopsy of the residual mass revealed reactive changes and no evidence of neoplasia, consistent with resolved EG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Adult patients with EG may experience regression of the lesion without intervention.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE25426\">https:\/\/thejns.org\/doi\/10.3171\/CASE25426<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case25426","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:27:33Z","timestamp":1776094053000},"source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous regression of a presumed orbitocranial eosinophilic granuloma in an adult patient: illustrative case"],"prefix":"10.3171","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1215-4571","authenticated-orcid":true,"given":"Lisa Y.","family":"Lin","sequence":"first","affiliation":[{"name":"Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina A.","family":"Chiou","sequence":"additional","affiliation":[{"name":"Ophthalmic Plastic Surgery Service, Department of Surgery, Brown University Warren Alpert Medical School, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron","family":"Rolle","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Stagner","sequence":"additional","affiliation":[{"name":"David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bob","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"4","key":"bib1","series-title":"Surv Ophthalmol","first-page":"332","article-title":"Langerhans cell histiocytosis","volume":"53","author":"Margo","year":"2008","unstructured":"Margo CEGoldman DR.Langerhans cell histiocytosis. Surv Ophthalmol. 2008;53(4):332-358. doi:10.1016\/j.survophthal.2008.04.007"},{"issue":"12","key":"bib2","series-title":"Graefes Arch Clin Exp Ophthalmol","first-page":"2341","article-title":"Histopathologic features of a resolving orbital Langerhans cell histiocytosis","volume":"253","author":"van Zyl","year":"2015","unstructured":"van Zyl TStagner AMJakobiec FAYoon MK.Histopathologic features of a resolving orbital Langerhans cell histiocytosis. Graefes Arch Clin Exp Ophthalmol. 2015;253(12):2341-2343. doi:10.1007\/s00417-015-3086-z"},{"issue":"11","key":"bib3","series-title":"Arch Ophthalmol","first-page":"1606","article-title":"Classification and incidence of space-occupying lesions of the orbit. A survey of 645 biopsies","volume":"102","author":"Shields","year":"1984","unstructured":"Shields JABakewell BAugsburger JJFlanagan JC.Classification and incidence of space-occupying lesions of the orbit. A survey of 645 biopsies. Arch Ophthalmol. 1984;102(11):1606-1611. doi:10.1001\/archopht.1984.01040031296011"},{"issue":"1","key":"bib4","series-title":"Orbit","first-page":"39","article-title":"Biopsy-confirmed spontaneous resolution of orbital Langerhans cell histiocytosis","volume":"24","author":"Rajendram","year":"2005","unstructured":"Rajendram RRose GELuthert PJPlowman PNPearson AR.Biopsy-confirmed spontaneous resolution of orbital Langerhans cell histiocytosis. Orbit. 2005;24(1):39-41. doi:10.1080\/01676830590889893"},{"issue":"4","key":"bib5","series-title":"Surv Ophthalmol","first-page":"330","article-title":"Langerhans cell histiocytosis of the orbit: five clinicopathologic cases and review of the literature","volume":"58","author":"Herwig","year":"2013","unstructured":"Herwig MCWojno TZhang QGrossniklaus HE.Langerhans cell histiocytosis of the orbit: five clinicopathologic cases and review of the literature. Surv Ophthalmol. 2013;58(4):330-340. doi:10.1016\/j.survophthal.2012.09.004"},{"issue":"8","key":"bib6","series-title":"Ophthalmology","first-page":"1569","article-title":"Orbital Langerhans cell histiocytosis in adults","volume":"114","author":"Cheung","year":"2007","unstructured":"Cheung NSelva DMcNab AA.Orbital Langerhans cell histiocytosis in adults. Ophthalmology. 2007;114(8):1569-1573. doi:10.1016\/j.ophtha.2006.10.056"},{"issue":"6","key":"bib7","series-title":"Ophthal Plast Reconstr Surg","first-page":"429","article-title":"Eosinophilic granuloma of the orbit: understanding the paradox of aggressive destruction responsive to minimal intervention","volume":"19","author":"Woo","year":"2003","unstructured":"Woo KIHarris GJ.Eosinophilic granuloma of the orbit: understanding the paradox of aggressive destruction responsive to minimal intervention. Ophthal Plast Reconstr Surg. 2003;19(6):429-439. doi:10.1097\/01.IOP.0000092800.86282.27"},{"issue":"8","key":"bib8","series-title":"Indian J Ophthalmol","first-page":"1604","article-title":"Clinical spectrum and management outcomes of Langerhans cell histiocytosis of the orbit","volume":"68","author":"Koka","year":"2020","unstructured":"Koka KAlam MSSubramanian NSubramanian KBiswas JMukherjee B.Clinical spectrum and management outcomes of Langerhans cell histiocytosis of the orbit. Indian J Ophthalmol. 2020;68(8):1604-1608. doi:10.4103\/ijo.IJO_1375_19"},{"issue":"3","key":"bib9","series-title":"J Neurol Surg Rep","first-page":"e90","article-title":"Resolution and re-ossification of orbital-wall Langerhans cell histiocytosis following stereotactic needle biopsy","volume":"83","author":"Broaddus","year":"2022","unstructured":"Broaddus WCSomasundaram ACarr MTResolution and re-ossification of orbital-wall Langerhans cell histiocytosis following stereotactic needle biopsy. J Neurol Surg Rep. 2022;83(3):e90-e94. doi:10.1055\/a-1847-8245"},{"issue":"2","key":"bib10","series-title":"Acta Neurochir","first-page":"301","article-title":"Early adult-onset orbital apex Langerhans cell histiocytosis histologically confirmed during \u201ctruly spontaneous\u201d regression","volume":"154","author":"Satoh","year":"2012","unstructured":"Satoh KTada MShimizu HYoneoka Y.Early adult-onset orbital apex Langerhans cell histiocytosis histologically confirmed during \u201ctruly spontaneous\u201d regression. Acta Neurochir. 2012;154(2):301-302. doi:10.1007\/s00701-011-1250-8"},{"issue":"9","key":"bib11","series-title":"Acta Med Port","first-page":"617","article-title":"A case of orbital Langerhans cell histiocytosis in an adult","volume":"32","author":"Carneiro","year":"2019","unstructured":"Carneiro IFriande AAra\u00fajo M.A case of orbital Langerhans cell histiocytosis in an adult. Acta Med Port. 2019;32(9):617-620. doi:10.20344\/amp.10179"},{"issue":"1","key":"bib12","series-title":"Am J Ophthalmol","first-page":"119","article-title":"Spontaneous regression of orbital Langerhans cell granulomatosis in a three-year-old girl","volume":"128","author":"Smith","year":"1999","unstructured":"Smith JHFulton LO\u2019Brien JM.Spontaneous regression of orbital Langerhans cell granulomatosis in a three-year-old girl. Am J Ophthalmol. 1999;128(1):119-121. doi:10.1016\/S0002-9394(99)00055-0"},{"issue":"8","key":"bib13","series-title":"Ophthalmology","first-page":"1008","article-title":"Eosinophilic granuloma of the orbit with spontaneous healing","volume":"94","author":"Glover","year":"1987","unstructured":"Glover ATGrove AS.Eosinophilic granuloma of the orbit with spontaneous healing. Ophthalmology. 1987;94(8):1008-1012. doi:10.1016\/S0161-6420(87)33352-4"},{"issue":"9","key":"bib14","series-title":"J Fr Ophtalmol","first-page":"983","article-title":"Solitary eosinophilic granuloma of the orbit: a case report","volume":"28","author":"Harzallah","year":"2005","unstructured":"Harzallah LBraham NBen Ch\u00e9rifa LSolitary eosinophilic granuloma of the orbit: a case report. Article in French. J Fr Ophtalmol. 2005;28(9):983. doi:10.1016\/s0181-5512(05)81127-1"},{"issue":"305","key":"bib15","series-title":"Bull Soc Belge Ophtalmol","first-page":"33","article-title":"Solitary eosinophilic granuloma of the orbit: a case report","author":"El Ayadi","year":"2007","unstructured":"El Ayadi CBenharbit MLezrek MTachfouti SBoutimzine NDaoudi R.Solitary eosinophilic granuloma of the orbit: a case report. Article in French. Bull Soc Belge Ophtalmol. 2007;(305):33-36."},{"issue":"4","key":"bib1","series-title":"Surv Ophthalmol","first-page":"332","article-title":"Langerhans cell histiocytosis","volume":"53","author":"Margo","year":"2008","unstructured":"Margo CEGoldman DR.Langerhans cell histiocytosis. Surv Ophthalmol. 2008;53(4):332-358. doi:10.1016\/j.survophthal.2008.04.007"},{"issue":"12","key":"bib2","series-title":"Graefes Arch Clin Exp Ophthalmol","first-page":"2341","article-title":"Histopathologic features of a resolving orbital Langerhans cell histiocytosis","volume":"253","author":"van Zyl","year":"2015","unstructured":"van Zyl TStagner AMJakobiec FAYoon MK.Histopathologic features of a resolving orbital Langerhans cell histiocytosis. Graefes Arch Clin Exp Ophthalmol. 2015;253(12):2341-2343. doi:10.1007\/s00417-015-3086-z"},{"issue":"11","key":"bib3","series-title":"Arch Ophthalmol","first-page":"1606","article-title":"Classification and incidence of space-occupying lesions of the orbit. A survey of 645 biopsies","volume":"102","author":"Shields","year":"1984","unstructured":"Shields JABakewell BAugsburger JJFlanagan JC.Classification and incidence of space-occupying lesions of the orbit. A survey of 645 biopsies. Arch Ophthalmol. 1984;102(11):1606-1611. doi:10.1001\/archopht.1984.01040031296011"},{"issue":"1","key":"bib4","series-title":"Orbit","first-page":"39","article-title":"Biopsy-confirmed spontaneous resolution of orbital Langerhans cell histiocytosis","volume":"24","author":"Rajendram","year":"2005","unstructured":"Rajendram RRose GELuthert PJPlowman PNPearson AR.Biopsy-confirmed spontaneous resolution of orbital Langerhans cell histiocytosis. Orbit. 2005;24(1):39-41. doi:10.1080\/01676830590889893"},{"issue":"4","key":"bib5","series-title":"Surv Ophthalmol","first-page":"330","article-title":"Langerhans cell histiocytosis of the orbit: five clinicopathologic cases and review of the literature","volume":"58","author":"Herwig","year":"2013","unstructured":"Herwig MCWojno TZhang QGrossniklaus HE.Langerhans cell histiocytosis of the orbit: five clinicopathologic cases and review of the literature. Surv Ophthalmol. 2013;58(4):330-340. doi:10.1016\/j.survophthal.2012.09.004"},{"issue":"8","key":"bib6","series-title":"Ophthalmology","first-page":"1569","article-title":"Orbital Langerhans cell histiocytosis in adults","volume":"114","author":"Cheung","year":"2007","unstructured":"Cheung NSelva DMcNab AA.Orbital Langerhans cell histiocytosis in adults. Ophthalmology. 2007;114(8):1569-1573. doi:10.1016\/j.ophtha.2006.10.056"},{"issue":"6","key":"bib7","series-title":"Ophthal Plast Reconstr Surg","first-page":"429","article-title":"Eosinophilic granuloma of the orbit: understanding the paradox of aggressive destruction responsive to minimal intervention","volume":"19","author":"Woo","year":"2003","unstructured":"Woo KIHarris GJ.Eosinophilic granuloma of the orbit: understanding the paradox of aggressive destruction responsive to minimal intervention. Ophthal Plast Reconstr Surg. 2003;19(6):429-439. doi:10.1097\/01.IOP.0000092800.86282.27"},{"issue":"8","key":"bib8","series-title":"Indian J Ophthalmol","first-page":"1604","article-title":"Clinical spectrum and management outcomes of Langerhans cell histiocytosis of the orbit","volume":"68","author":"Koka","year":"2020","unstructured":"Koka KAlam MSSubramanian NSubramanian KBiswas JMukherjee B.Clinical spectrum and management outcomes of Langerhans cell histiocytosis of the orbit. Indian J Ophthalmol. 2020;68(8):1604-1608. doi:10.4103\/ijo.IJO_1375_19"},{"issue":"3","key":"bib9","series-title":"J Neurol Surg Rep","first-page":"e90","article-title":"Resolution and re-ossification of orbital-wall Langerhans cell histiocytosis following stereotactic needle biopsy","volume":"83","author":"Broaddus","year":"2022","unstructured":"Broaddus WCSomasundaram ACarr MTResolution and re-ossification of orbital-wall Langerhans cell histiocytosis following stereotactic needle biopsy. J Neurol Surg Rep. 2022;83(3):e90-e94. doi:10.1055\/a-1847-8245"},{"issue":"2","key":"bib10","series-title":"Acta Neurochir","first-page":"301","article-title":"Early adult-onset orbital apex Langerhans cell histiocytosis histologically confirmed during \u201ctruly spontaneous\u201d regression","volume":"154","author":"Satoh","year":"2012","unstructured":"Satoh KTada MShimizu HYoneoka Y.Early adult-onset orbital apex Langerhans cell histiocytosis histologically confirmed during \u201ctruly spontaneous\u201d regression. Acta Neurochir. 2012;154(2):301-302. doi:10.1007\/s00701-011-1250-8"},{"issue":"9","key":"bib11","series-title":"Acta Med Port","first-page":"617","article-title":"A case of orbital Langerhans cell histiocytosis in an adult","volume":"32","author":"Carneiro","year":"2019","unstructured":"Carneiro IFriande AAra\u00fajo M.A case of orbital Langerhans cell histiocytosis in an adult. Acta Med Port. 2019;32(9):617-620. doi:10.20344\/amp.10179"},{"issue":"1","key":"bib12","series-title":"Am J Ophthalmol","first-page":"119","article-title":"Spontaneous regression of orbital Langerhans cell granulomatosis in a three-year-old girl","volume":"128","author":"Smith","year":"1999","unstructured":"Smith JHFulton LO\u2019Brien JM.Spontaneous regression of orbital Langerhans cell granulomatosis in a three-year-old girl. Am J Ophthalmol. 1999;128(1):119-121. doi:10.1016\/S0002-9394(99)00055-0"},{"issue":"8","key":"bib13","series-title":"Ophthalmology","first-page":"1008","article-title":"Eosinophilic granuloma of the orbit with spontaneous healing","volume":"94","author":"Glover","year":"1987","unstructured":"Glover ATGrove AS.Eosinophilic granuloma of the orbit with spontaneous healing. Ophthalmology. 1987;94(8):1008-1012. doi:10.1016\/S0161-6420(87)33352-4"},{"issue":"9","key":"bib14","series-title":"J Fr Ophtalmol","first-page":"983","article-title":"Solitary eosinophilic granuloma of the orbit: a case report","volume":"28","author":"Harzallah","year":"2005","unstructured":"Harzallah LBraham NBen Ch\u00e9rifa LSolitary eosinophilic granuloma of the orbit: a case report. Article in French. J Fr Ophtalmol. 2005;28(9):983. doi:10.1016\/s0181-5512(05)81127-1"},{"issue":"305","key":"bib15","series-title":"Bull Soc Belge Ophtalmol","first-page":"33","article-title":"Solitary eosinophilic granuloma of the orbit: a case report","author":"El Ayadi","year":"2007","unstructured":"El Ayadi CBenharbit MLezrek MTachfouti SBoutimzine NDaoudi R.Solitary eosinophilic granuloma of the orbit: a case report. Article in French. Bull Soc Belge Ophtalmol. 2007;(305):33-36."}],"container-title":["Journal of Neurosurgery: Case Lessons"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/11\/15\/article-CASE25426.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/11\/15\/article-CASE25426.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/11\/15\/article-CASE25426.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:27:34Z","timestamp":1776094054000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/11\/15\/article-CASE25426.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":30,"journal-issue":{"issue":"15"},"URL":"https:\/\/doi.org\/10.3171\/case25426","relation":{},"ISSN":["2694-1902"],"issn-type":[{"value":"2694-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]}}}