{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:13:47Z","timestamp":1769724827385,"version":"3.49.0"},"reference-count":62,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"12","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurosurg Case Lessons"],"published-print":{"date-parts":[[2025,9,22]]},"abstract":"\n BACKGROUND<\/jats:title>\n Ewing sarcoma (ES) is a rare malignancy primarily affecting children and adolescents, with cranial involvement representing less than 1% of cases. The sphenoid bone is an exceptionally uncommon site, presenting diagnostic and therapeutic challenges due to its proximity to neurovascular structures.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n We present the case of a 19-year-old male diagnosed at the age of 13 with ES in the sphenoid bone, extending into the anterior cranial fossa and orbit. The patient initially received chemotherapy and radiotherapy, resulting in partial regression; however, the patient experienced disease progression and underwent resection. Postoperative recovery was complicated by osteomyelitis, which was resolved with antibiotics and wound debridement. One year postoperatively, the patient was neurologically intact with stable imaging findings. A systematic review of the literature was conducted to identify similar cases of sphenoid ES and highlight their outcomes.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n ES of the sphenoid bone is a rare pathology that demands a high index of suspicion and a multidisciplinary treatment approach. Despite anatomical challenges, outcomes can be optimized through an aggressive multimodal therapy approach. Continued research is needed to establish standardized treatment protocols and improve long-term survival.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE25427<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case25427","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:27:32Z","timestamp":1758587252000},"source":"Crossref","is-referenced-by-count":0,"title":["Ewing sarcoma of the sphenoid bone: illustrative case"],"prefix":"10.3171","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2090-900X","authenticated-orcid":true,"given":"Yousef","family":"Bassi","sequence":"first","affiliation":[{"name":"College of Medicine, King Abdulaziz University, Jeddah, Makkah Province, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7585-5690","authenticated-orcid":true,"given":"Rakan K.","family":"Alhabib","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thamer Hamad","family":"Alsharif","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, King Abdulaziz Specialist Hospital, Taif, Makkah Province, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulhadi Y.","family":"Algahtani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ministry of the National Guard\u2013Health Affairs, Jeddah, Makkah Province, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Jeddah, Makkah Province, Saudi Arabia"},{"name":"Faculty of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Makkah Province, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"2","key":"bib1","series-title":"CA Cancer J Clin","first-page":"95","article-title":"Classics in oncology. 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Nat Rev Dis Primers. 2018;4(1):1-22."},{"issue":"2","key":"bib4","series-title":"N Engl J Med","first-page":"154","article-title":"Ewing\u2019s sarcoma","volume":"384","author":"Riggi","year":"2021","unstructured":"Riggi NSuv\u00e0 MLStamenkovic I.Ewing\u2019s sarcoma. N Engl J Med. 2021;384(2):154-164."},{"issue":"2","key":"bib5","series-title":"J Clin Diagn Res","first-page":"ED15","article-title":"Primary Ewing sarcoma of sphenoid bone with intracranial extension: a common tumour at an uncommon location","volume":"11","author":"Singh","year":"2017","unstructured":"Singh GRChoudhary VAgrawal R.Primary Ewing sarcoma of sphenoid bone with intracranial extension: a common tumour at an uncommon location. J Clin Diagn Res. 2017;11(2):ED15-ED16."},{"issue":"4","key":"bib6","series-title":"Pediatr Blood Cancer","first-page":"604","article-title":"Management and outcome of Ewing sarcoma of the head and neck","volume":"63","author":"Grevener","year":"2016","unstructured":"Grevener KHaveman LMRanft AManagement and outcome of Ewing sarcoma of the head and neck. Pediatr Blood Cancer. 2016;63(4):604-610."},{"issue":"4","key":"bib7","series-title":"Australas Radiol","first-page":"409","article-title":"MR findings of primary Ewing\u2019s sarcoma of greater wing of sphenoid","volume":"46","author":"Singh","year":"2002","unstructured":"Singh PJain MSingh DPKalra NKhandelwal NSuri S.MR findings of primary Ewing\u2019s sarcoma of greater wing of sphenoid. 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Am J Transl Res. 2022;14(2):927-941."},{"issue":"6","key":"bib18","series-title":"Clin Neurol Neurosurg","first-page":"528","article-title":"Primary Ewing\u2019s sarcoma of the sphenoid bone with unusual imaging features: a case report","volume":"107","author":"Sharma","year":"2005","unstructured":"Sharma AGarg AMishra NKPrimary Ewing\u2019s sarcoma of the sphenoid bone with unusual imaging features: a case report. Clin Neurol Neurosurg. 2005;107(6):528-531."},{"issue":"7","key":"bib19","series-title":"Acta Neurochir (Wien)","first-page":"1477","article-title":"Primary Ewing\u2019s sarcoma of cranial bones: analysis of ten patients","volume":"153","author":"Salunke","year":"2011","unstructured":"Salunke PSGupta KMalik VPrimary Ewing\u2019s sarcoma of cranial bones: analysis of ten patients. Acta Neurochir (Wien). 2011;153(7):1477-1485."},{"issue":"1","key":"bib20","series-title":"Br J Neurosurg","first-page":"53","article-title":"Primary Ewing\u2019s sarcoma of the greater wing of the sphenoid bone","volume":"14","author":"Sharma","year":"2000","unstructured":"Sharma RRNetalkar ALad SD.Primary Ewing\u2019s sarcoma of the greater wing of the sphenoid bone. Br J Neurosurg. 2000;14(1):53-56."},{"key":"bib21","series-title":"Surg Neurol Int","first-page":"500","article-title":"Surgical management of primary Ewing\u2019s sarcoma of the petroclival bone extend into the sphenoid sinus: a case report and review of literatures","volume":"12","author":"Shimabukuro","year":"2021","unstructured":"Shimabukuro TSuzuki KNakano YYamamoto J.Surgical management of primary Ewing\u2019s sarcoma of the petroclival bone extend into the sphenoid sinus: a case report and review of literatures. 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J Cancer Res Ther. 2012;8(4):636-638."},{"issue":"4","key":"bib24","series-title":"J Pediatr Neurosci","first-page":"392","article-title":"Skull and spinal Ewing\u2019s sarcoma in children: an institutional study","volume":"13","author":"Bhattacharjee","year":"2018","unstructured":"Bhattacharjee SVenkata SRUppin MS.Skull and spinal Ewing\u2019s sarcoma in children: an institutional study. J Pediatr Neurosci. 2018;13(4):392-397."},{"issue":"6","key":"bib25","series-title":"Surg Neurol Int","first-page":"6","article-title":"Primary Ewing\u2019s sarcoma of the petroclival bone: a case report and literature review","volume":"11","author":"Schartz","year":"2020","unstructured":"Schartz DDivakar PTafe LPaydarfar J.Primary Ewing\u2019s sarcoma of the petroclival bone: a case report and literature review. Surg Neurol Int. 2020;11(6):6."},{"issue":"6","key":"bib26","series-title":"Int J Clin Exp Pathol","first-page":"7575","article-title":"Multiple primary Ewing's sarcomas in cerebral cranium of a child: a case report and review of the literature","volume":"8","author":"Wang","year":"2015","unstructured":"Wang DGuo Z.Multiple primary Ewing's sarcomas in cerebral cranium of a child: a case report and review of the literature. Int J Clin Exp Pathol. 2015;8(6):7575-7582."},{"issue":"5","key":"bib27","series-title":"Pediatr Radiol","first-page":"311","article-title":"Primary Ewing\u2019s sarcoma of the sphenoid bone: a rare presentation","volume":"28","author":"Varan","year":"1998","unstructured":"Varan ACaner HSa\u011flam SB\u00fcy\u00fckpamuk\u00e7u M.Primary Ewing\u2019s sarcoma of the sphenoid bone: a rare presentation. Pediatr Radiol. 1998;28(5):311."},{"issue":"1","key":"bib28","series-title":"Int Res J Basic Clin Stud","first-page":"1","article-title":"Ewing\u2019s sarcoma of sphenotemporal Bone of skull: a rare presentation","volume":"3","author":"Mukherjee","year":"2015","unstructured":"Mukherjee TRappai TJChaudhary GSMukherjee DDutta R.Ewing\u2019s sarcoma of sphenotemporal Bone of skull: a rare presentation. Int Res J Basic Clin Stud. 2015;3(1):1-4."},{"issue":"16","key":"bib29","series-title":"J Neurosurg Case Lessons","first-page":"CASE22214","article-title":"Primary intracranial extraosseous Ewing\u2019s sarcoma of the skull base in an elderly adult: illustrative case","volume":"4","author":"Ravina","year":"2022","unstructured":"Ravina KWindermere SAZhao QPrimary intracranial extraosseous Ewing\u2019s sarcoma of the skull base in an elderly adult: illustrative case. J Neurosurg Case Lessons. 2022;4(16):CASE22214."},{"issue":"2","key":"bib30","series-title":"J Cancer Res Ther","first-page":"377","article-title":"Primary Ewing\u2019s sarcoma of the cranium: case series and review of literature","volume":"10","author":"Krishnamani","year":"2014","unstructured":"Krishnamani KKumar TNGandhi LVRaghunadharao DSadashivudu GMegha U.Primary Ewing\u2019s sarcoma of the cranium: case series and review of literature. J Cancer Res Ther. 2014;10(2):377-380."},{"key":"bib31","series-title":"World Neurosurg","first-page":"869.e1","article-title":"First case of primary sellar\/suprasellar-intraventricular Ewing sarcoma: case report and review of the literature","volume":"98","author":"Mattogno","year":"2017","unstructured":"Mattogno PPNasi DIaccarino COretti GSantoro LRomano A.First case of primary sellar\/suprasellar-intraventricular Ewing sarcoma: case report and review of the literature. World Neurosurg. 2017;98:869.e1-869.e5."},{"issue":"2","key":"bib1","series-title":"CA Cancer J Clin","first-page":"95","article-title":"Classics in oncology. Diffuse endothelioma of bone. James Ewing. Proceedings of the New York Pathological Society, 1921","volume":"22","author":"Ewing","year":"1972","unstructured":"Ewing J.Classics in oncology. Diffuse endothelioma of bone. James Ewing. Proceedings of the New York Pathological Society, 1921. CA Cancer J Clin. 1972;22(2):95-98."},{"issue":"2","key":"bib2","series-title":"Lancet Oncol","first-page":"184","article-title":"Ewing\u2019s sarcoma","volume":"11","author":"Balamuth","year":"2010","unstructured":"Balamuth NJWomer RB.Ewing\u2019s sarcoma. Lancet Oncol. 2010;11(2):184-192."},{"issue":"1","key":"bib3","series-title":"Nat Rev Dis Primers","first-page":"1","article-title":"Ewing sarcoma","volume":"4","author":"Gr\u00fcnewald","year":"2018","unstructured":"Gr\u00fcnewald TGPCidre-Aranaz FSurdez DEwing sarcoma. Nat Rev Dis Primers. 2018;4(1):1-22."},{"issue":"2","key":"bib4","series-title":"N Engl J Med","first-page":"154","article-title":"Ewing\u2019s sarcoma","volume":"384","author":"Riggi","year":"2021","unstructured":"Riggi NSuv\u00e0 MLStamenkovic I.Ewing\u2019s sarcoma. N Engl J Med. 2021;384(2):154-164."},{"issue":"2","key":"bib5","series-title":"J Clin Diagn Res","first-page":"ED15","article-title":"Primary Ewing sarcoma of sphenoid bone with intracranial extension: a common tumour at an uncommon location","volume":"11","author":"Singh","year":"2017","unstructured":"Singh GRChoudhary VAgrawal R.Primary Ewing sarcoma of sphenoid bone with intracranial extension: a common tumour at an uncommon location. 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