{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:46:12Z","timestamp":1790837172173,"version":"4.1.0"},"reference-count":48,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"10","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurosurg Case Lessons"],"published-print":{"date-parts":[[2025,9,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Anaplastic lymphoma kinase (ALK)\u2013positive primary CNS anaplastic large cell lymphoma (ALCL) is an extremely rare pediatric malignancy. Its radiological appearance often mimics infectious or glial lesions, complicating diagnosis and delaying treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors report the case of a 10-year-old immunocompetent female who presented with absence seizures and vomiting. Brain MRI revealed a left frontal lesion with peripheral contrast enhancement and diffusion restriction, suggestive of a cerebral abscess. She was started on antibiotics and underwent resection. Histopathology confirmed ALK-positive primary CNS ALCL. The patient was treated with NHL-BFM (non-Hodgkin lymphoma\u2013Berlin-Frankfurt-M\u00fcnster) chemotherapy, the ALK inhibitor lorlatinib, and focal cranial radiotherapy (18 Gy\/22 fractions). She remains in complete remission at 18 months. A systematic review of 15 pediatric ALK-positive CNS ALCL cases revealed male predominance, supratentorial location, and inconsistent treatment protocols. Methotrexate-based chemotherapy was most common treatment; the role of radiotherapy and surgery varied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>ALK-positive primary CNS ALCL should be considered in the differential diagnosis of pediatric intracranial masses with atypical imaging. Early histological confirmation is essential. While chemotherapy remains central to treatment, targeted therapies and radiation-sparing approaches require further investigation to improve outcomes and reduce long-term morbidity in children.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE25522\">https:\/\/thejns.org\/doi\/10.3171\/CASE25522<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case25522","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:39:43Z","timestamp":1757313583000},"source":"Crossref","is-referenced-by-count":2,"title":["Anaplastic lymphoma kinase\u2013positive primary CNS anaplastic large cell lymphoma in a pediatric patient: illustrative case"],"prefix":"10.3171","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6929-4401","authenticated-orcid":true,"given":"Duygu","family":"Dolen Burak","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9246-1378","authenticated-orcid":true,"given":"Cafer Ikbal","family":"Gulsever","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hakkari State Hospital, Hakkari, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alperen","family":"Poyraz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-7851","authenticated-orcid":true,"given":"Gokcen","family":"Unverengil","sequence":"additional","affiliation":[{"name":"Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-219X","authenticated-orcid":true,"given":"Gulcin","family":"Yegen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulcan","family":"Erbas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugrul Cem","family":"Unal","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altay","family":"Sencer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"11","key":"bib1","series-title":"Arch Pathol Lab Med","first-page":"127","article-title":"Primary central nervous system lymphoma","volume":"132","author":"Batchelor","year":"2008","unstructured":"Batchelor TTFerreri AJM.Primary central nervous system lymphoma. Arch Pathol Lab Med. 2008;132(11):127-137."},{"issue":"21","key":"bib2","series-title":"J Clin Oncol","first-page":"2410","article-title":"Primary CNS lymphoma","volume":"35","author":"Grommes","year":"2017","unstructured":"Grommes CDeAngelis LM.Primary CNS lymphoma. J Clin Oncol. 2017;35(21):2410-2418."},{"issue":"2","key":"bib3","series-title":"Am J Clin Pathol","first-page":"300","article-title":"Primary central nervous system anaplastic large cell lymphoma, ALK positive","volume":"158","author":"Ahrendsen","year":"2022","unstructured":"Ahrendsen JTTa RLi JPrimary central nervous system anaplastic large cell lymphoma, ALK positive. Am J Clin Pathol. 2022;158(2):300-310."},{"issue":"3","key":"bib4","series-title":"Br J Haematol","first-page":"384","article-title":"Diagnostic markers for CNS lymphoma in blood and cerebrospinal fluid: a systematic review","volume":"182","author":"van Westrhenen","year":"2018","unstructured":"van Westrhenen ASmidt LCASeute TDiagnostic markers for CNS lymphoma in blood and cerebrospinal fluid: a systematic review. Br J Haematol. 2018;182(3):384-403."},{"issue":"7","key":"bib5","series-title":"Lancet Haematol","first-page":"e540","article-title":"Molecular diagnosis of primary CNS lymphoma in 2024 using MYD88Leu265Pro and IL-10","volume":"11","author":"Calimeri","year":"2024","unstructured":"Calimeri TAnzalone NCangi MGMolecular diagnosis of primary CNS lymphoma in 2024 using MYD88Leu265Pro and IL-10. Lancet Haematol. 2024;11(7):e540-e549."},{"issue":"4","key":"bib6","series-title":"Mol Clin Oncol","first-page":"655","article-title":"Clinical presentation of anaplastic large-cell lymphoma in the central nervous system","volume":"1","author":"Nomura","year":"2013","unstructured":"Nomura MNarita YMiyakita YClinical presentation of anaplastic large-cell lymphoma in the central nervous system. Mol Clin Oncol. 2013;1(4):655-660."},{"issue":"1","key":"bib7","series-title":"Neurooncol Adv","first-page":"vdaf005","article-title":"High-dose MTX-based polychemotherapy for primary CNS lymphoma in younger patients: long-term efficacy of the modified Bonn protocol","volume":"7","author":"Zeyen","year":"2025","unstructured":"Zeyen TWeller JSchneider MHigh-dose MTX-based polychemotherapy for primary CNS lymphoma in younger patients: long-term efficacy of the modified Bonn protocol. Neurooncol Adv. 2025;7(1):vdaf005."},{"issue":"2","key":"bib8","series-title":"J Clin Oncol","first-page":"266","article-title":"Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience","volume":"21","author":"Ferreri","year":"2003","unstructured":"Ferreri AJMBlay JYReni MPrognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience. J Clin Oncol. 2003;21(2):266-272."},{"issue":"24","key":"bib9","series-title":"Blood Adv","first-page":"4291","article-title":"Primary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents","volume":"3","author":"Attarbaschi","year":"2019","unstructured":"Attarbaschi AAbla ORonceray LPrimary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents. Blood Adv. 2019;3(24):4291-4297."},{"issue":"6","key":"bib10","series-title":"Pediatr Blood Cancer","first-page":"1227","article-title":"Treatment of primary CNS lymphoma with high-dose methotrexate in immunocompetent pediatric patients","volume":"55","author":"Shah","year":"2010","unstructured":"Shah ACKelly DRNabors LBOakes WJHilliard LMReddy AT.Treatment of primary CNS lymphoma with high-dose methotrexate in immunocompetent pediatric patients. Pediatr Blood Cancer. 2010;55(6):1227-1230."},{"key":"bib11","series-title":"Front Oncol","article-title":"Atypical teratoid rhabdoid tumor: current therapy and future directions","volume":"2","author":"Ginn","year":"2012","unstructured":"Ginn KFGajjar A.Atypical teratoid rhabdoid tumor: current therapy and future directions. Front Oncol. 2012;2 SEP."},{"issue":"3","key":"bib12","series-title":"J Neurosurg Pediatr","first-page":"311","article-title":"High-dose methotrexate monotherapy followed by radiation for CD30-positive, anaplastic lymphoma kinase-1-positive anaplastic large-cell lymphoma in the brain of a child: case report","volume":"14","author":"Furuya","year":"2014","unstructured":"Furuya KTakanashi SOgawa ATakahashi YNakagomi T.High-dose methotrexate monotherapy followed by radiation for CD30-positive, anaplastic lymphoma kinase-1-positive anaplastic large-cell lymphoma in the brain of a child: case report. J Neurosurg Pediatr. 2014;14(3):311-315."},{"issue":"4","key":"bib13","series-title":"Am J Clin Pathol","first-page":"496","article-title":"Primary Ki-1 (anaplastic large cell) lymphoma of the brain and spinal cord","volume":"103","author":"Havlioglu","year":"1995","unstructured":"Havlioglu NManepalli AGalindo LSotelo-Avila CGrosso L.Primary Ki-1 (anaplastic large cell) lymphoma of the brain and spinal cord. Am J Clin Pathol. 1995;103(4):496-499."},{"issue":"5","key":"bib14","series-title":"Pediatr Neurosurg","first-page":"250","article-title":"Primary Ki-1-positive T-cell lymphoma of the brain in a child","volume":"29","author":"Buxton","year":"1998","unstructured":"Buxton NPunt JHewitt M.Primary Ki-1-positive T-cell lymphoma of the brain in a child. Pediatr Neurosurg. 1998;29(5):250-252."},{"issue":"8","key":"bib15","series-title":"Hum Pathol","first-page":"978","article-title":"Primary anaplastic large cell lymphoma of the central nervous system","volume":"30","author":"Abdulkader","year":"1999","unstructured":"Abdulkader ICameselle-Teijeiro JFraga MRodriguez-N\u00fa\u00f1ez AAllut AGForteza J.Primary anaplastic large cell lymphoma of the central nervous system. Hum Pathol. 1999;30(8):978-981."},{"issue":"4","key":"bib16","series-title":"Am J Surg Pathol","first-page":"487","article-title":"Primary anaplastic large cell lymphoma of the central nervous system: prognostic effect of ALK-1 expression","volume":"27","author":"George","year":"2003","unstructured":"George DHScheithauer BWAker FVPrimary anaplastic large cell lymphoma of the central nervous system: prognostic effect of ALK-1 expression. Am J Surg Pathol. 2003;27(4):487-493."},{"issue":"4","key":"bib17","series-title":"J Postgrad Med","first-page":"326","article-title":"Primary anaplastic large cell lymphoma of central nervous system\u2014a case report","volume":"51","author":"Rupani","year":"2005","unstructured":"Rupani AModi CDesai SRege J.Primary anaplastic large cell lymphoma of central nervous system\u2014a case report. J Postgrad Med. 2005;51(4):326-327."},{"issue":"6","key":"bib18","series-title":"Pediatr Neurosurg","first-page":"516","article-title":"Primary cerebral ALK-1-positive anaplastic large cell lymphoma in a child. Case report and literature review","volume":"43","author":"Karikari","year":"2007","unstructured":"Karikari IOThomas KKLagoo ACummings TJGeorge TM.Primary cerebral ALK-1-positive anaplastic large cell lymphoma in a child. Case report and literature review. Pediatr Neurosurg. 2007;43(6):516-521."},{"issue":"12","key":"bib19","series-title":"J Pediatr Hematol Oncol","first-page":"963","article-title":"Primary leptomeningeal ALK+ lymphoma in a 13-year-old child","volume":"30","author":"Merlin","year":"2008","unstructured":"Merlin EChabrier SVerkarre VCramer EDelabesse ESt\u00e9phan JL.Primary leptomeningeal ALK+ lymphoma in a 13-year-old child. J Pediatr Hematol Oncol. 2008;30(12):963-967."},{"issue":"2","key":"bib20","series-title":"J Pediatr Hematol Oncol","first-page":"128","article-title":"Favorable outcome of primary CNS anaplastic large cell lymphoma in an immunocompetent patient","volume":"31","author":"Ozkaynak","year":"2009","unstructured":"Ozkaynak MF.Favorable outcome of primary CNS anaplastic large cell lymphoma in an immunocompetent patient. J Pediatr Hematol Oncol. 2009;31(2):128-130."},{"issue":"3","key":"bib21","series-title":"Pediatr Neurosurg","first-page":"145","article-title":"Evolution of a pediatric primary cerebral ALK-1-positive anaplastic large cell lymphoma on serial MRI","volume":"50","author":"Dunbar","year":"2015","unstructured":"Dunbar MJSinghal ARassekh SRDunham C.Evolution of a pediatric primary cerebral ALK-1-positive anaplastic large cell lymphoma on serial MRI. Pediatr Neurosurg. 2015;50(3):145-151."},{"issue":"29","key":"bib22","series-title":"Medicine","first-page":"e21115","article-title":"Primary anaplastic large cell lymphoma of the central nervous system in a child: a case report","volume":"99","author":"Feng","year":"2020","unstructured":"Feng SChen QChen JZheng PMa KTan B.Primary anaplastic large cell lymphoma of the central nervous system in a child: a case report. Medicine. 2020;99(29):e21115."},{"key":"bib23","series-title":"World Neurosurg","first-page":"415","article-title":"Dural-based primary central nervous system lymphoma with bone invasion","volume":"139","author":"Lee","year":"2020","unstructured":"Lee SWJung TYBaek HJKim SKLee KH.Dural-based primary central nervous system lymphoma with bone invasion. World Neurosurg. 2020;139:415-418."},{"key":"bib24","series-title":"Int J Immunopathol Pharmacol","first-page":"2058738420941756","article-title":"Primary central nervous system ALK-positive anaplastic large cell lymphoma with CD56 abnormally expression in a Chinese child: challenge in diagnostic practice","volume":"34","author":"Liu","year":"2020","unstructured":"Liu QChen XLi GPrimary central nervous system ALK-positive anaplastic large cell lymphoma with CD56 abnormally expression in a Chinese child: challenge in diagnostic practice. Int J Immunopathol Pharmacol. 2020;34:2058738420941756."},{"issue":"11","key":"bib1","series-title":"Arch Pathol Lab Med","first-page":"127","article-title":"Primary central nervous system lymphoma","volume":"132","author":"Batchelor","year":"2008","unstructured":"Batchelor TTFerreri AJM.Primary central nervous system lymphoma. Arch Pathol Lab Med. 2008;132(11):127-137."},{"issue":"21","key":"bib2","series-title":"J Clin Oncol","first-page":"2410","article-title":"Primary CNS lymphoma","volume":"35","author":"Grommes","year":"2017","unstructured":"Grommes CDeAngelis LM.Primary CNS lymphoma. J Clin Oncol. 2017;35(21):2410-2418."},{"issue":"2","key":"bib3","series-title":"Am J Clin Pathol","first-page":"300","article-title":"Primary central nervous system anaplastic large cell lymphoma, ALK positive","volume":"158","author":"Ahrendsen","year":"2022","unstructured":"Ahrendsen JTTa RLi JPrimary central nervous system anaplastic large cell lymphoma, ALK positive. Am J Clin Pathol. 2022;158(2):300-310."},{"issue":"3","key":"bib4","series-title":"Br J Haematol","first-page":"384","article-title":"Diagnostic markers for CNS lymphoma in blood and cerebrospinal fluid: a systematic review","volume":"182","author":"van Westrhenen","year":"2018","unstructured":"van Westrhenen ASmidt LCASeute TDiagnostic markers for CNS lymphoma in blood and cerebrospinal fluid: a systematic review. Br J Haematol. 2018;182(3):384-403."},{"issue":"7","key":"bib5","series-title":"Lancet Haematol","first-page":"e540","article-title":"Molecular diagnosis of primary CNS lymphoma in 2024 using MYD88Leu265Pro and IL-10","volume":"11","author":"Calimeri","year":"2024","unstructured":"Calimeri TAnzalone NCangi MGMolecular diagnosis of primary CNS lymphoma in 2024 using MYD88Leu265Pro and IL-10. Lancet Haematol. 2024;11(7):e540-e549."},{"issue":"4","key":"bib6","series-title":"Mol Clin Oncol","first-page":"655","article-title":"Clinical presentation of anaplastic large-cell lymphoma in the central nervous system","volume":"1","author":"Nomura","year":"2013","unstructured":"Nomura MNarita YMiyakita YClinical presentation of anaplastic large-cell lymphoma in the central nervous system. Mol Clin Oncol. 2013;1(4):655-660."},{"issue":"1","key":"bib7","series-title":"Neurooncol Adv","first-page":"vdaf005","article-title":"High-dose MTX-based polychemotherapy for primary CNS lymphoma in younger patients: long-term efficacy of the modified Bonn protocol","volume":"7","author":"Zeyen","year":"2025","unstructured":"Zeyen TWeller JSchneider MHigh-dose MTX-based polychemotherapy for primary CNS lymphoma in younger patients: long-term efficacy of the modified Bonn protocol. Neurooncol Adv. 2025;7(1):vdaf005."},{"issue":"2","key":"bib8","series-title":"J Clin Oncol","first-page":"266","article-title":"Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience","volume":"21","author":"Ferreri","year":"2003","unstructured":"Ferreri AJMBlay JYReni MPrognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience. J Clin Oncol. 2003;21(2):266-272."},{"issue":"24","key":"bib9","series-title":"Blood Adv","first-page":"4291","article-title":"Primary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents","volume":"3","author":"Attarbaschi","year":"2019","unstructured":"Attarbaschi AAbla ORonceray LPrimary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents. Blood Adv. 2019;3(24):4291-4297."},{"issue":"6","key":"bib10","series-title":"Pediatr Blood Cancer","first-page":"1227","article-title":"Treatment of primary CNS lymphoma with high-dose methotrexate in immunocompetent pediatric patients","volume":"55","author":"Shah","year":"2010","unstructured":"Shah ACKelly DRNabors LBOakes WJHilliard LMReddy AT.Treatment of primary CNS lymphoma with high-dose methotrexate in immunocompetent pediatric patients. Pediatr Blood Cancer. 2010;55(6):1227-1230."},{"key":"bib11","series-title":"Front Oncol","article-title":"Atypical teratoid rhabdoid tumor: current therapy and future directions","volume":"2","author":"Ginn","year":"2012","unstructured":"Ginn KFGajjar A.Atypical teratoid rhabdoid tumor: current therapy and future directions. Front Oncol. 2012;2 SEP."},{"issue":"3","key":"bib12","series-title":"J Neurosurg Pediatr","first-page":"311","article-title":"High-dose methotrexate monotherapy followed by radiation for CD30-positive, anaplastic lymphoma kinase-1-positive anaplastic large-cell lymphoma in the brain of a child: case report","volume":"14","author":"Furuya","year":"2014","unstructured":"Furuya KTakanashi SOgawa ATakahashi YNakagomi T.High-dose methotrexate monotherapy followed by radiation for CD30-positive, anaplastic lymphoma kinase-1-positive anaplastic large-cell lymphoma in the brain of a child: case report. J Neurosurg Pediatr. 2014;14(3):311-315."},{"issue":"4","key":"bib13","series-title":"Am J Clin Pathol","first-page":"496","article-title":"Primary Ki-1 (anaplastic large cell) lymphoma of the brain and spinal cord","volume":"103","author":"Havlioglu","year":"1995","unstructured":"Havlioglu NManepalli AGalindo LSotelo-Avila CGrosso L.Primary Ki-1 (anaplastic large cell) lymphoma of the brain and spinal cord. Am J Clin Pathol. 1995;103(4):496-499."},{"issue":"5","key":"bib14","series-title":"Pediatr Neurosurg","first-page":"250","article-title":"Primary Ki-1-positive T-cell lymphoma of the brain in a child","volume":"29","author":"Buxton","year":"1998","unstructured":"Buxton NPunt JHewitt M.Primary Ki-1-positive T-cell lymphoma of the brain in a child. Pediatr Neurosurg. 1998;29(5):250-252."},{"issue":"8","key":"bib15","series-title":"Hum Pathol","first-page":"978","article-title":"Primary anaplastic large cell lymphoma of the central nervous system","volume":"30","author":"Abdulkader","year":"1999","unstructured":"Abdulkader ICameselle-Teijeiro JFraga MRodriguez-N\u00fa\u00f1ez AAllut AGForteza J.Primary anaplastic large cell lymphoma of the central nervous system. Hum Pathol. 1999;30(8):978-981."},{"issue":"4","key":"bib16","series-title":"Am J Surg Pathol","first-page":"487","article-title":"Primary anaplastic large cell lymphoma of the central nervous system: prognostic effect of ALK-1 expression","volume":"27","author":"George","year":"2003","unstructured":"George DHScheithauer BWAker FVPrimary anaplastic large cell lymphoma of the central nervous system: prognostic effect of ALK-1 expression. Am J Surg Pathol. 2003;27(4):487-493."},{"issue":"4","key":"bib17","series-title":"J Postgrad Med","first-page":"326","article-title":"Primary anaplastic large cell lymphoma of central nervous system\u2014a case report","volume":"51","author":"Rupani","year":"2005","unstructured":"Rupani AModi CDesai SRege J.Primary anaplastic large cell lymphoma of central nervous system\u2014a case report. J Postgrad Med. 2005;51(4):326-327."},{"issue":"6","key":"bib18","series-title":"Pediatr Neurosurg","first-page":"516","article-title":"Primary cerebral ALK-1-positive anaplastic large cell lymphoma in a child. Case report and literature review","volume":"43","author":"Karikari","year":"2007","unstructured":"Karikari IOThomas KKLagoo ACummings TJGeorge TM.Primary cerebral ALK-1-positive anaplastic large cell lymphoma in a child. Case report and literature review. Pediatr Neurosurg. 2007;43(6):516-521."},{"issue":"12","key":"bib19","series-title":"J Pediatr Hematol Oncol","first-page":"963","article-title":"Primary leptomeningeal ALK+ lymphoma in a 13-year-old child","volume":"30","author":"Merlin","year":"2008","unstructured":"Merlin EChabrier SVerkarre VCramer EDelabesse ESt\u00e9phan JL.Primary leptomeningeal ALK+ lymphoma in a 13-year-old child. J Pediatr Hematol Oncol. 2008;30(12):963-967."},{"issue":"2","key":"bib20","series-title":"J Pediatr Hematol Oncol","first-page":"128","article-title":"Favorable outcome of primary CNS anaplastic large cell lymphoma in an immunocompetent patient","volume":"31","author":"Ozkaynak","year":"2009","unstructured":"Ozkaynak MF.Favorable outcome of primary CNS anaplastic large cell lymphoma in an immunocompetent patient. J Pediatr Hematol Oncol. 2009;31(2):128-130."},{"issue":"3","key":"bib21","series-title":"Pediatr Neurosurg","first-page":"145","article-title":"Evolution of a pediatric primary cerebral ALK-1-positive anaplastic large cell lymphoma on serial MRI","volume":"50","author":"Dunbar","year":"2015","unstructured":"Dunbar MJSinghal ARassekh SRDunham C.Evolution of a pediatric primary cerebral ALK-1-positive anaplastic large cell lymphoma on serial MRI. Pediatr Neurosurg. 2015;50(3):145-151."},{"issue":"29","key":"bib22","series-title":"Medicine","first-page":"e21115","article-title":"Primary anaplastic large cell lymphoma of the central nervous system in a child: a case report","volume":"99","author":"Feng","year":"2020","unstructured":"Feng SChen QChen JZheng PMa KTan B.Primary anaplastic large cell lymphoma of the central nervous system in a child: a case report. Medicine. 2020;99(29):e21115."},{"key":"bib23","series-title":"World Neurosurg","first-page":"415","article-title":"Dural-based primary central nervous system lymphoma with bone invasion","volume":"139","author":"Lee","year":"2020","unstructured":"Lee SWJung TYBaek HJKim SKLee KH.Dural-based primary central nervous system lymphoma with bone invasion. World Neurosurg. 2020;139:415-418."},{"key":"bib24","series-title":"Int J Immunopathol Pharmacol","first-page":"2058738420941756","article-title":"Primary central nervous system ALK-positive anaplastic large cell lymphoma with CD56 abnormally expression in a Chinese child: challenge in diagnostic practice","volume":"34","author":"Liu","year":"2020","unstructured":"Liu QChen XLi GPrimary central nervous system ALK-positive anaplastic large cell lymphoma with CD56 abnormally expression in a Chinese child: challenge in diagnostic practice. Int J Immunopathol Pharmacol. 2020;34:2058738420941756."}],"container-title":["Journal of Neurosurgery: Case Lessons"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/10\/10\/article-CASE25522.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/10\/10\/article-CASE25522.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/10\/10\/article-CASE25522.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:12:24Z","timestamp":1769685144000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/10\/10\/article-CASE25522.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":48,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.3171\/case25522","relation":{},"ISSN":["2694-1902"],"issn-type":[{"value":"2694-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,8]]}}}