{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:30:38Z","timestamp":1769725838295,"version":"3.49.0"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"25","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurosurg Case Lessons"],"published-print":{"date-parts":[[2025,12,22]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Dural sealants, widely used in neurosurgical practice, have been associated with few complications, mostly relating to the expansive nature of the hydrogel. Although generally well tolerated, DuraSeal expands up to 150% after application, and rare reports have described complications from mass effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>This report presents the case of a 34-year-old female with a past surgical history of multiple operations for a Chiari type 1 malformation. After a thorough workup, intraoperative images and histological findings revealed a concealed hematoma-like mass at the patient\u2019s previous surgical site, likely due to the DuraSeal system. Imaging revealed that the DuraSeal was mostly hyperintense on T2-weighted MRI with focal spots of hypo-\/isointensity, similar in appearance to an abscess or hematoma. Histological analysis showed exuberant fibrosis, granulation tissue, and a granulomatous response to the foreign material used for the dural patch and seal rather than the wall of an infectious abscess.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>This case adds to the growing body of literature on DuraSeal, highlighting the imaging and histological characteristics of \u201cdural sealant-omas\u201d and their expansile nature that can lead to the formation of a mass mimicking an abscess or a hematoma. In areas susceptible to compression, clinicians ought to be vigilant to identify findings consistent with the appearance of these dural sealant-omas.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE25574\">https:\/\/thejns.org\/doi\/10.3171\/CASE25574<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case25574","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:59:56Z","timestamp":1769083196000},"source":"Crossref","is-referenced-by-count":0,"title":["\u201cDural sealant-oma\u201d after posterior fossa surgery: illustrative case"],"prefix":"10.3171","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4007-4018","authenticated-orcid":true,"given":"Nathan","family":"Fredricks","sequence":"first","affiliation":[{"name":"John Sealy School of Medicine, The University of Texas Medical Branch at Galveston, Texas"},{"name":"Department of Neurosurgery, The University of Texas Medical Branch at Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8927-3384","authenticated-orcid":true,"given":"Anthony M.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"File","sequence":"additional","affiliation":[{"name":"John Sealy School of Medicine, The University of Texas Medical Branch at Galveston, Texas"},{"name":"Department of Neurosurgery, The University of Texas Medical Branch at Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preston","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The University of Texas Medical Branch at Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The University of Texas Medical Branch at Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Heymann","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Texas Medical Branch at Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7123-6884","authenticated-orcid":true,"given":"Gerald","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Texas Medical Branch at Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, HCA Houston Clear Lake, Webster, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The University of Texas Medical Branch at Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"3","key":"bib1","series-title":"J Neurosurg","first-page":"642","article-title":"Application of a hydrogel sealant improves watertight closures of duraplasty onlay grafts in a canine craniotomy model","volume":"107","author":"Preul","year":"2007","unstructured":"Preul MCCampbell PKBichard WDSpetzler RF.Application of a hydrogel sealant improves watertight closures of duraplasty onlay grafts in a canine craniotomy model. J Neurosurg. 2007;107(3):642-650."},{"issue":"2","key":"bib2","series-title":"J Neurosurg","first-page":"428","article-title":"The safety and effectiveness of a dural sealant system for use with nonautologous duraplasty materials","volume":"112","author":"Weinstein","year":"2010","unstructured":"Weinstein JSLiu KCDelashaw JBThe safety and effectiveness of a dural sealant system for use with nonautologous duraplasty materials. J Neurosurg. 2010;112(2):428-433."},{"issue":"23","key":"bib3","series-title":"Spine (Phila Pa 1976)","first-page":"1906","article-title":"Polyethylene glycol hydrogel spinal sealant (DuraSeal spinal sealant) as an adjunct to sutured dural repair in the spine: results of a prospective, multicenter, randomized controlled study","volume":"36","author":"Kim","year":"2011","unstructured":"Kim KDWright NM.Polyethylene glycol hydrogel spinal sealant (DuraSeal spinal sealant) as an adjunct to sutured dural repair in the spine: results of a prospective, multicenter, randomized controlled study. Spine (Phila Pa 1976). 2011;36(23):1906-1912."},{"issue":"1","key":"bib4","series-title":"Spine (Phila Pa 1976)","first-page":"E25","article-title":"Postoperative cervical cord compression induced by hydrogel (DuraSeal): a possible complication","volume":"35","author":"Thavarajah","year":"2010","unstructured":"Thavarajah DDe Lacy PHussain RRedfern RM.Postoperative cervical cord compression induced by hydrogel (DuraSeal): a possible complication. Spine (Phila Pa 1976). 2010;35(1):E25-E26."},{"issue":"6","key":"bib5","series-title":"Clin Orthop Relat Res","first-page":"1640","article-title":"Cauda equina syndrome after a TLIF resulting from postoperative expansion of a hydrogel dural sealant","volume":"470","author":"Neuman","year":"2012","unstructured":"Neuman BJRadcliff KRihn J.Cauda equina syndrome after a TLIF resulting from postoperative expansion of a hydrogel dural sealant. Clin Orthop Relat Res. 2012;470(6):1640-1645."},{"issue":"1","key":"bib6","series-title":"Korean J Spine","first-page":"44","article-title":"Postoperative cervical cord compression induced by hydrogel dural sealant (DuraSeal\u00ae)","volume":"10","author":"Lee","year":"2013","unstructured":"Lee SHPark CWLee SGKim WK.Postoperative cervical cord compression induced by hydrogel dural sealant (DuraSeal\u00ae). Korean J Spine. 2013;10(1):44-46."},{"issue":"1","key":"bib7","series-title":"Spine J","first-page":"75","article-title":"MRI appearance of adjunct surgical material used in spine surgery","volume":"22","author":"Altorfer","year":"2022","unstructured":"Altorfer FCSSutter RFarshad MSpirig JMFarshad-Amacker NA.MRI appearance of adjunct surgical material used in spine surgery. Spine J. 2022;22(1):75-83."},{"issue":"25","key":"bib8","series-title":"Spine (Phila Pa 1976)","first-page":"E1522","article-title":"DuraSeal-hematoma: concealed hematoma causing spinal cord compression","volume":"35","author":"Lee","year":"2010","unstructured":"Lee GLee CKBynevelt M.DuraSeal-hematoma: concealed hematoma causing spinal cord compression. Spine (Phila Pa 1976). 2010;35(25):E1522-E1524."},{"issue":"8","key":"bib9","series-title":"Spine J","first-page":"1892","article-title":"Duraseal thecal sac compression after lumbar discectomy causing radiculopathy","volume":"15","author":"Tseng","year":"2015","unstructured":"Tseng WLXiao F.Duraseal thecal sac compression after lumbar discectomy causing radiculopathy. Spine J. 2015;15(8):1892-1893."},{"issue":"4","key":"bib10","series-title":"J Neurosurg Pediatr","first-page":"302","article-title":"Hydrogel-induced cervicomedullary compression after posterior fossa decompression for Chiari malformation: case report","volume":"106","author":"Blackburn","year":"2007","unstructured":"Blackburn SLSmyth MD.Hydrogel-induced cervicomedullary compression after posterior fossa decompression for Chiari malformation: case report. J Neurosurg Pediatr. 2007;106(4)(suppl):302-304."},{"issue":"3","key":"bib1","series-title":"J Neurosurg","first-page":"642","article-title":"Application of a hydrogel sealant improves watertight closures of duraplasty onlay grafts in a canine craniotomy model","volume":"107","author":"Preul","year":"2007","unstructured":"Preul MCCampbell PKBichard WDSpetzler RF.Application of a hydrogel sealant improves watertight closures of duraplasty onlay grafts in a canine craniotomy model. J Neurosurg. 2007;107(3):642-650."},{"issue":"2","key":"bib2","series-title":"J Neurosurg","first-page":"428","article-title":"The safety and effectiveness of a dural sealant system for use with nonautologous duraplasty materials","volume":"112","author":"Weinstein","year":"2010","unstructured":"Weinstein JSLiu KCDelashaw JBThe safety and effectiveness of a dural sealant system for use with nonautologous duraplasty materials. J Neurosurg. 2010;112(2):428-433."},{"issue":"23","key":"bib3","series-title":"Spine (Phila Pa 1976)","first-page":"1906","article-title":"Polyethylene glycol hydrogel spinal sealant (DuraSeal spinal sealant) as an adjunct to sutured dural repair in the spine: results of a prospective, multicenter, randomized controlled study","volume":"36","author":"Kim","year":"2011","unstructured":"Kim KDWright NM.Polyethylene glycol hydrogel spinal sealant (DuraSeal spinal sealant) as an adjunct to sutured dural repair in the spine: results of a prospective, multicenter, randomized controlled study. Spine (Phila Pa 1976). 2011;36(23):1906-1912."},{"issue":"1","key":"bib4","series-title":"Spine (Phila Pa 1976)","first-page":"E25","article-title":"Postoperative cervical cord compression induced by hydrogel (DuraSeal): a possible complication","volume":"35","author":"Thavarajah","year":"2010","unstructured":"Thavarajah DDe Lacy PHussain RRedfern RM.Postoperative cervical cord compression induced by hydrogel (DuraSeal): a possible complication. Spine (Phila Pa 1976). 2010;35(1):E25-E26."},{"issue":"6","key":"bib5","series-title":"Clin Orthop Relat Res","first-page":"1640","article-title":"Cauda equina syndrome after a TLIF resulting from postoperative expansion of a hydrogel dural sealant","volume":"470","author":"Neuman","year":"2012","unstructured":"Neuman BJRadcliff KRihn J.Cauda equina syndrome after a TLIF resulting from postoperative expansion of a hydrogel dural sealant. Clin Orthop Relat Res. 2012;470(6):1640-1645."},{"issue":"1","key":"bib6","series-title":"Korean J Spine","first-page":"44","article-title":"Postoperative cervical cord compression induced by hydrogel dural sealant (DuraSeal\u00ae)","volume":"10","author":"Lee","year":"2013","unstructured":"Lee SHPark CWLee SGKim WK.Postoperative cervical cord compression induced by hydrogel dural sealant (DuraSeal\u00ae). Korean J Spine. 2013;10(1):44-46."},{"issue":"1","key":"bib7","series-title":"Spine J","first-page":"75","article-title":"MRI appearance of adjunct surgical material used in spine surgery","volume":"22","author":"Altorfer","year":"2022","unstructured":"Altorfer FCSSutter RFarshad MSpirig JMFarshad-Amacker NA.MRI appearance of adjunct surgical material used in spine surgery. Spine J. 2022;22(1):75-83."},{"issue":"25","key":"bib8","series-title":"Spine (Phila Pa 1976)","first-page":"E1522","article-title":"DuraSeal-hematoma: concealed hematoma causing spinal cord compression","volume":"35","author":"Lee","year":"2010","unstructured":"Lee GLee CKBynevelt M.DuraSeal-hematoma: concealed hematoma causing spinal cord compression. Spine (Phila Pa 1976). 2010;35(25):E1522-E1524."},{"issue":"8","key":"bib9","series-title":"Spine J","first-page":"1892","article-title":"Duraseal thecal sac compression after lumbar discectomy causing radiculopathy","volume":"15","author":"Tseng","year":"2015","unstructured":"Tseng WLXiao F.Duraseal thecal sac compression after lumbar discectomy causing radiculopathy. Spine J. 2015;15(8):1892-1893."},{"issue":"4","key":"bib10","series-title":"J Neurosurg Pediatr","first-page":"302","article-title":"Hydrogel-induced cervicomedullary compression after posterior fossa decompression for Chiari malformation: case report","volume":"106","author":"Blackburn","year":"2007","unstructured":"Blackburn SLSmyth MD.Hydrogel-induced cervicomedullary compression after posterior fossa decompression for Chiari malformation: case report. 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