{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T16:07:39Z","timestamp":1776096459429,"version":"3.50.1"},"reference-count":38,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurosurg Case Lessons"],"published-print":{"date-parts":[[2026,1,19]]},"abstract":"\n BACKGROUND<\/jats:title>\n Lymphomas originating from the dura mater of the skull, known as primary dural lymphomas (PDLs), are rare. Among these, cases of chronic lymphocytic leukemia (CLL)\/small lymphocytic lymphoma (SLL) are exceptionally uncommon, and no standardized treatment protocols have been established. The authors report a rare case of CLL\/SLL manifesting as PDL mimicking a skull base meningioma and review the relevant literature.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n A 71-year-old male presented with an extra-axial tumor extending from the petroclival to middle cranial fossa, which demonstrated progressive enlargement over the course of 1 year. The preoperative diagnosis was meningioma, and the patient subsequently underwent preoperative embolization followed by partial tumor resection. Histological examination revealed CLL\/SLL. Postoperatively, the residual lesion was treated with radiation therapy, and no recurrence has been observed for > 3 years.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n CLL\/SLL arising as PDL is difficult to distinguish from meningioma based on clinical and radiological findings. However, it generally shows favorable outcomes when treated with a combination of surgery and low-dose radiation therapy.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE25831<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case25831","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:00:05Z","timestamp":1769083205000},"source":"Crossref","is-referenced-by-count":0,"title":["Primary dural lymphoma of the chronic lymphocytic lymphoma\/small lymphocytic lymphoma\u2013mimicking meningioma: illustrative case"],"prefix":"10.3171","volume":"11","author":[{"given":"Nobuhiko","family":"Kawai","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kita-gun, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4477-7853","authenticated-orcid":true,"given":"Takeshi","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kita-gun, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5332-1316","authenticated-orcid":true,"given":"Osamu","family":"Imataki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa"},{"name":"Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki, Okayama"},{"name":"Department of Laboratory Medicine, Kawasaki Medical School, General Medical Center, Kurashiki, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nachino","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Pathology, Takamatsu Red Cross Hospital, Takamatsu, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Tatano","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kita-gun, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomono","family":"Fuke","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Takamatsu Red Cross Hospital, Takamatsu, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kita-gun, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3178-4197","authenticated-orcid":true,"given":"Kenta","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kita-gun, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1665-4274","authenticated-orcid":true,"given":"Yasunori","family":"Toyota","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kita-gun, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-8275","authenticated-orcid":true,"given":"Daisuke","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kita-gun, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2438-6458","authenticated-orcid":true,"given":"Tetsuhiro","family":"Hatakeyama","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kita-gun, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Okauchi","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kita-gun, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Kawanishi","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kita-gun, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-6486","authenticated-orcid":true,"given":"Keisuke","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kita-gun, Kagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"25","key":"bib1","series-title":"Blood","first-page":"2745","article-title":"iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL","volume":"131","author":"Hallek","year":"2018","unstructured":"Hallek MCheson BDCatovsky DiwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018;131(25):2745-2760."},{"issue":"11","key":"bib2","series-title":"Ann Intern Med","first-page":"1093","article-title":"Primary central nervous system lymphoma","volume":"119","author":"Fine","year":"1993","unstructured":"Fine HAMayer RJ.Primary central nervous system lymphoma. Ann Intern Med. 1993;119(11):1093-1104."},{"issue":"3","key":"bib3","series-title":"Indian J Cancer","first-page":"112","article-title":"Primary central nervous system lymphomas: Indian experience, and review of literature","volume":"45","author":"Paul","year":"2008","unstructured":"Paul TChalla STandon APanigrahi MPurohit A.Primary central nervous system lymphomas: Indian experience, and review of literature. Indian J Cancer. 2008;45(3):112-118."},{"issue":"5","key":"bib4","series-title":"Ann Neurol","first-page":"755","article-title":"International study on low-grade primary central nervous system lymphoma","volume":"59","author":"Jahnke","year":"2006","unstructured":"Jahnke KKorfel AO\u2019Neill BPInternational study on low-grade primary central nervous system lymphoma. Ann Neurol. 2006;59(5):755-762."},{"issue":"11","key":"bib5","series-title":"Arch Pathol Lab Med","first-page":"1830","article-title":"Primary central nervous system lymphoma","volume":"132","author":"Bhagavathi","year":"2008","unstructured":"Bhagavathi SWilson JD.Primary central nervous system lymphoma. Arch Pathol Lab Med. 2008;132(11):1830-1834."},{"issue":"12","key":"bib6","series-title":"Cancer","first-page":"2811","article-title":"Primary dural lymphomas: clinical presentation, management, and outcome","volume":"126","author":"Karschnia","year":"2020","unstructured":"Karschnia PBatchelor TTJordan JTPrimary dural lymphomas: clinical presentation, management, and outcome. Cancer. 2020;126(12):2811-2820."},{"issue":"5","key":"bib7","series-title":"Neurosurg Focus","first-page":"E5","article-title":"Primary dural lymphomas: a review","volume":"21","author":"Iwamoto","year":"2006","unstructured":"Iwamoto FMAbrey LE.Primary dural lymphomas: a review. Neurosurg Focus. 2006;21(5):E5."},{"key":"bib8","series-title":"Case Rep Med","first-page":"2812487","article-title":"Primary dural lymphoma: clinical cases and literature review","volume":"2020","author":"Dobran","year":"2020","unstructured":"Dobran MParacino RMancini FNasi D.Primary dural lymphoma: clinical cases and literature review. Case Rep Med. 2020;2020:2812487."},{"key":"bib9","series-title":"Interdiscip Neurosurg","first-page":"101965","article-title":"Primary dural lymphoma: a case report","volume":"36","author":"Al-hassana Idriss","year":"2024","unstructured":"Al-hassana Idriss IStachys HDossou MWPrimary dural lymphoma: a case report. Interdiscip Neurosurg. 2024;36:101965."},{"issue":"1","key":"bib10","series-title":"Hematol Rep","first-page":"e10","article-title":"Dural MALT lymphoma with disseminated disease","volume":"2","author":"Matmati","year":"2010","unstructured":"Matmati KMatmati NHannun YADural MALT lymphoma with disseminated disease. Hematol Rep. 2010;2(1):e10."},{"issue":"8","key":"bib11","series-title":"Arch Neurol","first-page":"528","article-title":"Primary intracranial lymphoma of the dura","volume":"37","author":"Jazy","year":"1980","unstructured":"Jazy FKShehata WMTew JMMeyer RLBoss HH.Primary intracranial lymphoma of the dura. 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Arch Pathol Lab Med. 1996;120(3):254-260."},{"issue":"7","key":"bib14","series-title":"Leuk Lymphoma","first-page":"1437","article-title":"Primary intracranial dural B cell small lymphocytic lymphoma","volume":"48","author":"Giordano","year":"2007","unstructured":"Giordano APerrone TGuarini APrimary intracranial dural B cell small lymphocytic lymphoma. Leuk Lymphoma. 2007;48(7):1437-1443."},{"issue":"5","key":"bib15","series-title":"Leuk Lymphoma","first-page":"1110","article-title":"Chronic lymphocytic leukemia presenting as an intracranial epidural mass in a patient with myeloproliferative neoplasm associated with JAK2 V617F mutation","volume":"54","author":"Chan","year":"2013","unstructured":"Chan KLMcKelvie PFirkin FBazargan ATam CS.Chronic lymphocytic leukemia presenting as an intracranial epidural mass in a patient with myeloproliferative neoplasm associated with JAK2 V617F mutation. Leuk Lymphoma. 2013;54(5):1110-1112."},{"issue":"8","key":"bib16","series-title":"Clin Neurol Neurosurg","first-page":"1510","article-title":"Primary dural lymphoma mimicking a chronic epidural hematoma. Differential diagnosis of two rare conditions","volume":"115","author":"Iaccarino","year":"2013","unstructured":"Iaccarino CSchiavi PCrafa PPrimary dural lymphoma mimicking a chronic epidural hematoma. Differential diagnosis of two rare conditions. Clin Neurol Neurosurg. 2013;115(8):1510-1513."},{"issue":"8","key":"bib17","series-title":"Cancer Radiother","first-page":"811","article-title":"Primary lymphoma of the skull: Case report and literature review","volume":"20","author":"Issara","year":"2016","unstructured":"Issara KYossi SCaraivan I.Primary lymphoma of the skull: Case report and literature review. Article in French. Cancer Radiother. 2016;20(8):811-814."},{"key":"bib18","series-title":"Front Neurol","first-page":"267","article-title":"A rare case of composite dural extranodal marginal zone lymphoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma","volume":"9","author":"Bustoros","year":"2018","unstructured":"Bustoros MLiechty BZagzag DA rare case of composite dural extranodal marginal zone lymphoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma. Front Neurol. 2018;9:267."},{"issue":"10","key":"bib19","series-title":"Leuk Lymphoma","first-page":"2479","article-title":"Rare case of leptomeningeal small lymphocytic lymphoma with TP53 mutation detected by deep next-generation sequencing","volume":"63","author":"Evans","year":"2022","unstructured":"Evans MGShestakova AHaghighi NRare case of leptomeningeal small lymphocytic lymphoma with TP53 mutation detected by deep next-generation sequencing. Leuk Lymphoma. 2022;63(10):2479-2483."},{"issue":"25","key":"bib1","series-title":"Blood","first-page":"2745","article-title":"iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL","volume":"131","author":"Hallek","year":"2018","unstructured":"Hallek MCheson BDCatovsky DiwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018;131(25):2745-2760."},{"issue":"11","key":"bib2","series-title":"Ann Intern Med","first-page":"1093","article-title":"Primary central nervous system lymphoma","volume":"119","author":"Fine","year":"1993","unstructured":"Fine HAMayer RJ.Primary central nervous system lymphoma. Ann Intern Med. 1993;119(11):1093-1104."},{"issue":"3","key":"bib3","series-title":"Indian J Cancer","first-page":"112","article-title":"Primary central nervous system lymphomas: Indian experience, and review of literature","volume":"45","author":"Paul","year":"2008","unstructured":"Paul TChalla STandon APanigrahi MPurohit A.Primary central nervous system lymphomas: Indian experience, and review of literature. Indian J Cancer. 2008;45(3):112-118."},{"issue":"5","key":"bib4","series-title":"Ann Neurol","first-page":"755","article-title":"International study on low-grade primary central nervous system lymphoma","volume":"59","author":"Jahnke","year":"2006","unstructured":"Jahnke KKorfel AO\u2019Neill BPInternational study on low-grade primary central nervous system lymphoma. Ann Neurol. 2006;59(5):755-762."},{"issue":"11","key":"bib5","series-title":"Arch Pathol Lab Med","first-page":"1830","article-title":"Primary central nervous system lymphoma","volume":"132","author":"Bhagavathi","year":"2008","unstructured":"Bhagavathi SWilson JD.Primary central nervous system lymphoma. Arch Pathol Lab Med. 2008;132(11):1830-1834."},{"issue":"12","key":"bib6","series-title":"Cancer","first-page":"2811","article-title":"Primary dural lymphomas: clinical presentation, management, and outcome","volume":"126","author":"Karschnia","year":"2020","unstructured":"Karschnia PBatchelor TTJordan JTPrimary dural lymphomas: clinical presentation, management, and outcome. Cancer. 2020;126(12):2811-2820."},{"issue":"5","key":"bib7","series-title":"Neurosurg Focus","first-page":"E5","article-title":"Primary dural lymphomas: a review","volume":"21","author":"Iwamoto","year":"2006","unstructured":"Iwamoto FMAbrey LE.Primary dural lymphomas: a review. Neurosurg Focus. 2006;21(5):E5."},{"key":"bib8","series-title":"Case Rep Med","first-page":"2812487","article-title":"Primary dural lymphoma: clinical cases and literature review","volume":"2020","author":"Dobran","year":"2020","unstructured":"Dobran MParacino RMancini FNasi D.Primary dural lymphoma: clinical cases and literature review. Case Rep Med. 2020;2020:2812487."},{"key":"bib9","series-title":"Interdiscip Neurosurg","first-page":"101965","article-title":"Primary dural lymphoma: a case report","volume":"36","author":"Al-hassana Idriss","year":"2024","unstructured":"Al-hassana Idriss IStachys HDossou MWPrimary dural lymphoma: a case report. Interdiscip Neurosurg. 2024;36:101965."},{"issue":"1","key":"bib10","series-title":"Hematol Rep","first-page":"e10","article-title":"Dural MALT lymphoma with disseminated disease","volume":"2","author":"Matmati","year":"2010","unstructured":"Matmati KMatmati NHannun YADural MALT lymphoma with disseminated disease. Hematol Rep. 2010;2(1):e10."},{"issue":"8","key":"bib11","series-title":"Arch Neurol","first-page":"528","article-title":"Primary intracranial lymphoma of the dura","volume":"37","author":"Jazy","year":"1980","unstructured":"Jazy FKShehata WMTew JMMeyer RLBoss HH.Primary intracranial lymphoma of the dura. Arch Neurol. 1980;37(8):528-529."},{"issue":"1","key":"bib12","series-title":"Am J Surg Pathol","first-page":"67","article-title":"Primary meningeal small lymphocytic lymphoma","volume":"13","author":"Nguyen","year":"1989","unstructured":"Nguyen DNathwani BN.Primary meningeal small lymphocytic lymphoma. Am J Surg Pathol. 1989;13(1):67-70."},{"issue":"3","key":"bib13","series-title":"Arch Pathol Lab Med","first-page":"254","article-title":"Stage IE non-Hodgkin\u2019s lymphoma involving the dura: a clinicopathologic study of five cases","volume":"120","author":"Miranda","year":"1996","unstructured":"Miranda RNGlantz LKMyint MAStage IE non-Hodgkin\u2019s lymphoma involving the dura: a clinicopathologic study of five cases. Arch Pathol Lab Med. 1996;120(3):254-260."},{"issue":"7","key":"bib14","series-title":"Leuk Lymphoma","first-page":"1437","article-title":"Primary intracranial dural B cell small lymphocytic lymphoma","volume":"48","author":"Giordano","year":"2007","unstructured":"Giordano APerrone TGuarini APrimary intracranial dural B cell small lymphocytic lymphoma. Leuk Lymphoma. 2007;48(7):1437-1443."},{"issue":"5","key":"bib15","series-title":"Leuk Lymphoma","first-page":"1110","article-title":"Chronic lymphocytic leukemia presenting as an intracranial epidural mass in a patient with myeloproliferative neoplasm associated with JAK2 V617F mutation","volume":"54","author":"Chan","year":"2013","unstructured":"Chan KLMcKelvie PFirkin FBazargan ATam CS.Chronic lymphocytic leukemia presenting as an intracranial epidural mass in a patient with myeloproliferative neoplasm associated with JAK2 V617F mutation. Leuk Lymphoma. 2013;54(5):1110-1112."},{"issue":"8","key":"bib16","series-title":"Clin Neurol Neurosurg","first-page":"1510","article-title":"Primary dural lymphoma mimicking a chronic epidural hematoma. Differential diagnosis of two rare conditions","volume":"115","author":"Iaccarino","year":"2013","unstructured":"Iaccarino CSchiavi PCrafa PPrimary dural lymphoma mimicking a chronic epidural hematoma. Differential diagnosis of two rare conditions. Clin Neurol Neurosurg. 2013;115(8):1510-1513."},{"issue":"8","key":"bib17","series-title":"Cancer Radiother","first-page":"811","article-title":"Primary lymphoma of the skull: Case report and literature review","volume":"20","author":"Issara","year":"2016","unstructured":"Issara KYossi SCaraivan I.Primary lymphoma of the skull: Case report and literature review. Article in French. Cancer Radiother. 2016;20(8):811-814."},{"key":"bib18","series-title":"Front Neurol","first-page":"267","article-title":"A rare case of composite dural extranodal marginal zone lymphoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma","volume":"9","author":"Bustoros","year":"2018","unstructured":"Bustoros MLiechty BZagzag DA rare case of composite dural extranodal marginal zone lymphoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma. 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