{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T16:02:12Z","timestamp":1770393732725,"version":"3.49.0"},"reference-count":46,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"21","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2025,5,26]]},"abstract":"\n BACKGROUND<\/jats:title>\n Myxopapillary ependymomas (MPEs) are a relatively rare subtype of ependymoma that occur almost exclusively at the conus medullaris and filum terminale in the lumbosacral spine. Intracranial occurrences of this tumor are rare, and of those, localization to the cerebellopontine angle (CPA) is an exceptional event. To the authors\u2019 knowledge, this is the fifthreported MPE in the CPA and only the third reported instance of an MPE in the CPA at the initial presentation.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n The authors describe an adult patient with an initial presentation of MPE at the CPA, originally thought to be a schwannoma on radiological imaging. Follow-up imaging later revealed additional clinically asymptomatic spinal masses consistent with MPEs. This case is particularly unique not only because of the patient\u2019s presenting symptoms being exclusive to tinnitus and ear fullness without any spinal symptoms, but also because it is the first case, to the authors\u2019 knowledge, in which DNA methylation profiling results have been reported to confirm the diagnosis of MPE in the CPA.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n This case highlights the importance of considering a broad differential diagnosis for lesions in the CPA.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE2586<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case2586","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T20:17:44Z","timestamp":1748290664000},"source":"Crossref","is-referenced-by-count":0,"title":["An adult patient with initial presentation of myxopapillary ependymoma at the cerebellopontine angle: illustrative case"],"prefix":"10.3171","volume":"9","author":[{"given":"Khatcher O.","family":"Margossian","sequence":"first","affiliation":[{"name":"Department of Pathology, Rush University Medical Center, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Marciniak","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7470-0366","authenticated-orcid":true,"given":"Akram","family":"Al-warqi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rush University Medical Center, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Aldape","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Kocak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rush University Medical Center, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Munoz","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Rush University Medical Center, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Michaelides","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5742-2031","authenticated-orcid":true,"given":"Michael S.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rush University Medical Center, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"4","key":"bib1","series-title":"Neuro Oncol","first-page":"588","article-title":"Long-term outcome of patients with spinal myxopapillary ependymoma: treatment results from the MD Anderson Cancer Center and institutions from the Rare Cancer Network","volume":"17","author":"Weber","year":"2015","unstructured":"Weber DCWang YMiller RLong-term outcome of patients with spinal myxopapillary ependymoma: treatment results from the MD Anderson Cancer Center and institutions from the Rare Cancer Network. 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J Neurooncol. 2016;126(1):165-174."},{"issue":"10","key":"bib4","series-title":"Childs Nerv Syst","first-page":"1209","article-title":"Myxopapillary ependymoma of lumbosacral region with metastasis to both cerebellopontine angles: report of a rare case","volume":"23","author":"Mridha","year":"2007","unstructured":"Mridha ARSharma MCSarkar CMyxopapillary ependymoma of lumbosacral region with metastasis to both cerebellopontine angles: report of a rare case. Childs Nerv Syst. 2007;23(10):1209-1213."},{"issue":"4","key":"bib5","series-title":"HNO","first-page":"298","article-title":"Metastasis of a spinal myxopapillary ependymoma to the inner auditory canal","volume":"49","author":"Kittel","year":"2001","unstructured":"Kittel KGjuric MNiedobitek G.Metastasis of a spinal myxopapillary ependymoma to the inner auditory canal. HNO. 2001;49(4):298-302."},{"issue":"2","key":"bib6","series-title":"Clin Neurol Neurosurg","first-page":"211","article-title":"Myxopapillary ependymoma of the fourth ventricle","volume":"108","author":"Lim","year":"2006","unstructured":"Lim SCJang SJ.Myxopapillary ependymoma of the fourth ventricle. Clin Neurol Neurosurg. 2006;108(2):211-214."},{"issue":"1","key":"bib7","series-title":"Brain Tumor Pathol","first-page":"25","article-title":"Primary myxopapillary ependymoma of the fourth ventricle with cartilaginous metaplasia: a case report and review of the literature","volume":"29","author":"Chakraborti","year":"2012","unstructured":"Chakraborti SGovindan AAlapatt JPRadhakrishnan MSantosh V.Primary myxopapillary ependymoma of the fourth ventricle with cartilaginous metaplasia: a case report and review of the literature. 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J Natl Compr Canc Netw; 2020;18(11):1537-1570."},{"issue":"3","key":"bib16","series-title":"Rare Tumors","first-page":"e42","article-title":"Stabilization of metastatic myxopapillary ependymoma with sorafenib","volume":"4","author":"Fegerl","year":"2012","unstructured":"Fegerl GMarosi C.Stabilization of metastatic myxopapillary ependymoma with sorafenib. Rare Tumors. 2012;4(3):e42."},{"issue":"2","key":"bib17","series-title":"J Neurooncol","first-page":"177","article-title":"Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M.D. Anderson Cancer Center","volume":"80","author":"Akyurek","year":"2006","unstructured":"Akyurek SChang ELYu TKSpinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M.D. Anderson Cancer Center. J Neurooncol. 2006;80(2):177-183."},{"issue":"4","key":"bib18","series-title":"Int J Radiat Oncol Biol Phys","first-page":"1114","article-title":"The results of surgery, with or without radiotherapy, for primary spinal myxopapillary ependymoma: a retrospective study from the rare cancer network","volume":"74","author":"Pica","year":"2009","unstructured":"Pica AMiller RVill\u00e0 SThe results of surgery, with or without radiotherapy, for primary spinal myxopapillary ependymoma: a retrospective study from the rare cancer network. Int J Radiat Oncol Biol Phys. 2009;74(4):1114-1120."},{"issue":"3","key":"bib19","series-title":"Neurosurg Rev","first-page":"321","article-title":"Long term outcomes following surgical resection of myxopapillary ependymomas","volume":"32","author":"Bagley","year":"2009","unstructured":"Bagley CAWilson SKothbauer KFBookland MJEpstein FJallo GI.Long term outcomes following surgical resection of myxopapillary ependymomas. 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Pediatr Blood Cancer. 2012;59(4):746-748."},{"issue":"4","key":"bib1","series-title":"Neuro Oncol","first-page":"588","article-title":"Long-term outcome of patients with spinal myxopapillary ependymoma: treatment results from the MD Anderson Cancer Center and institutions from the Rare Cancer Network","volume":"17","author":"Weber","year":"2015","unstructured":"Weber DCWang YMiller RLong-term outcome of patients with spinal myxopapillary ependymoma: treatment results from the MD Anderson Cancer Center and institutions from the Rare Cancer Network. Neuro Oncol. 2015;17(4):588-595."},{"key":"bib2","series-title":"StatPearls Publishing LLC","article-title":"Myxopapillary ependymoma","author":"Limaiem","year":"2024","unstructured":"Limaiem FDas JM.Myxopapillary ependymoma. 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Childs Nerv Syst. 2007;23(10):1209-1213."},{"issue":"4","key":"bib5","series-title":"HNO","first-page":"298","article-title":"Metastasis of a spinal myxopapillary ependymoma to the inner auditory canal","volume":"49","author":"Kittel","year":"2001","unstructured":"Kittel KGjuric MNiedobitek G.Metastasis of a spinal myxopapillary ependymoma to the inner auditory canal. HNO. 2001;49(4):298-302."},{"issue":"2","key":"bib6","series-title":"Clin Neurol Neurosurg","first-page":"211","article-title":"Myxopapillary ependymoma of the fourth ventricle","volume":"108","author":"Lim","year":"2006","unstructured":"Lim SCJang SJ.Myxopapillary ependymoma of the fourth ventricle. Clin Neurol Neurosurg. 2006;108(2):211-214."},{"issue":"1","key":"bib7","series-title":"Brain Tumor Pathol","first-page":"25","article-title":"Primary myxopapillary ependymoma of the fourth ventricle with cartilaginous metaplasia: a case report and review of the literature","volume":"29","author":"Chakraborti","year":"2012","unstructured":"Chakraborti SGovindan AAlapatt JPRadhakrishnan MSantosh V.Primary myxopapillary ependymoma of the fourth ventricle with cartilaginous metaplasia: a case report and review of the literature. Brain Tumor Pathol. 2012;29(1):25-30."},{"issue":"22","key":"bib8","series-title":"J Neurosurg Case Lessons","first-page":"CASE24571","article-title":"Isolated myxopapillary ependymoma of the fourth ventricle: illustrative case","volume":"8","author":"Mldie","year":"2024","unstructured":"Mldie AABaleh ASMolla HTYesuf EFMekuria BH.Isolated myxopapillary ependymoma of the fourth ventricle: illustrative case. 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Br J Neurosurg. 2011;25(1):122-123."},{"issue":"2","key":"bib13","series-title":"Neurosurg Rev","first-page":"241","article-title":"Primary myxopapillary ependymoma of the cerebellopontine angle: report of a case","volume":"32","author":"Sparaco","year":"2009","unstructured":"Sparaco MMorelli LPiscioli IDonato SCatalucci ALicci S.Primary myxopapillary ependymoma of the cerebellopontine angle: report of a case. Neurosurg Rev. 2009;32(2):241-244."},{"issue":"2","key":"bib14","series-title":"Acta Neuropathol","first-page":"305","article-title":"Molecular characterization of histopathological ependymoma variants","volume":"139","author":"Neumann","year":"2020","unstructured":"Neumann JESpohn MObrecht DMolecular characterization of histopathological ependymoma variants. Acta Neuropathol. 2020;139(2):305-318."},{"issue":"11","key":"bib15","series-title":"J Natl Compr Canc Netw","first-page":"1537","article-title":"Central Nervous System Cancers, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology","volume":"18","author":"Nabors","year":"2020","unstructured":"Nabors LBPortnow JAhluwalia MCentral Nervous System Cancers, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw; 2020;18(11):1537-1570."},{"issue":"3","key":"bib16","series-title":"Rare Tumors","first-page":"e42","article-title":"Stabilization of metastatic myxopapillary ependymoma with sorafenib","volume":"4","author":"Fegerl","year":"2012","unstructured":"Fegerl GMarosi C.Stabilization of metastatic myxopapillary ependymoma with sorafenib. 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