{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:07:23Z","timestamp":1779361643194,"version":"3.51.4"},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"20","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurosurg Case Lessons"],"published-print":{"date-parts":[[2026,5,18]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Peripheral aneurysms may develop along collateral pathways in patients with moyamoya disease (MMD); however, their optimal management remains unclear. The authors report a case of a lateral posterior choroidal artery aneurysm associated with MMD that ruptured three times within a short period, along with a review of the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 54-year-old woman with MMD, who had remained asymptomatic for 19 years, developed an intraventricular hemorrhage 1 month after periventricular aneurysm dilation was detected on annual imaging follow-up. Rebleeding occurred on days 7 and 10, and vertebral angiography revealed a 6-mm aneurysm in the distal segment of the left posterior choroidal artery. Transarterial embolization using liquid material achieved complete occlusion of the aneurysm; however, the patient developed right hemiparesis due to a left corona radiata infarction and was transferred to a rehabilitation hospital, with a modified Rankin Scale score of 5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Rebleeding from peripheral aneurysms associated with MMD is a predictor of poor prognosis, and spontaneous aneurysm regression during observational management or after bypass surgery requires several months. Accordingly, when such peripheral aneurysms are detected, early revascularization should be planned. However, in cases of rupture, prompt aneurysm-directed treatment, including endovascular or microsurgical intervention, is warranted to prevent clinical deterioration.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE26167\">https:\/\/thejns.org\/doi\/10.3171\/CASE26167<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case26167","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:56:05Z","timestamp":1779108965000},"source":"Crossref","is-referenced-by-count":0,"title":["Moyamoya disease presenting with repeated ruptures of a lateral posterior choroidal artery aneurysm: illustrative case"],"prefix":"10.3171","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3512-072X","authenticated-orcid":true,"given":"Rie","family":"Hashizume","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8913-7289","authenticated-orcid":true,"given":"Masaki","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Egashira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0019-7029","authenticated-orcid":true,"given":"Yukiko","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Izumo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"2","key":"bib1","series-title":"Neurosurg Rev","first-page":"1127","article-title":"Location-based treatment of intracranial aneurysms in moyamoya disease: a systematic review and descriptive analysis","volume":"44","author":"Larson","year":"2021","unstructured":"Larson ASRinaldo LBrinjikji WLanzino G.Location-based treatment of intracranial aneurysms in moyamoya disease: a systematic review and descriptive analysis. Neurosurg Rev. 2021;44(2):1127-1139. doi:10.1007\/s10143-020-01307-1"},{"issue":"4","key":"bib2","series-title":"J Clin Neurol","first-page":"624","article-title":"Clinical features and outcomes of intracranial aneurysm associated with moyamoya disease","volume":"16","author":"Kim","year":"2020","unstructured":"Kim SJang CKPark EKClinical features and outcomes of intracranial aneurysm associated with moyamoya disease. J Clin Neurol. 2020;16(4):624-632. doi:10.3988\/jcn.2020.16.4.624"},{"issue":"11","key":"bib3","series-title":"Lancet Neurol","first-page":"1056","article-title":"Moyamoya disease: current concepts and future perspectives","volume":"7","author":"Kuroda","year":"2008","unstructured":"Kuroda SHoukin K.Moyamoya disease: current concepts and future perspectives. Lancet Neurol. 2008;7(11):1056-1066. doi:10.1016\/S1474-4422(08)70240-0"},{"issue":"1","key":"bib4","series-title":"Acta Neurochir (Wien)","first-page":"116","article-title":"Pathological changes in the lenticulostriate artery indicate the mechanisms leading to intracranial hemorrhage in moyamoya disease: a case report","volume":"166","author":"Hashio","year":"2024","unstructured":"Hashio AHamano EOzaki SPathological changes in the lenticulostriate artery indicate the mechanisms leading to intracranial hemorrhage in moyamoya disease: a case report. Acta Neurochir (Wien). 2024;166(1):116. doi:10.1007\/s00701-024-05992-5"},{"issue":"1","key":"bib5","series-title":"Stroke","first-page":"50","article-title":"Histopathology of the brain vascular network in moyamoya disease","volume":"14","author":"Yamashita","year":"1983","unstructured":"Yamashita MOka KTanaka K.Histopathology of the brain vascular network in moyamoya disease. Stroke. 1983;14(1):50-58. doi:10.1161\/01.str.14.1.50"},{"issue":"11","key":"bib6","series-title":"Acta Neurochir (Wien)","first-page":"1287","article-title":"Characteristics of intracranial aneurysms associated with moyamoya disease. A review of 111 cases","volume":"138","author":"Kawaguchi","year":"1996","unstructured":"Kawaguchi SSakaki TMorimoto TKakizaki TKamada K.Characteristics of intracranial aneurysms associated with moyamoya disease. A review of 111 cases. Acta Neurochir (Wien). 1996;138(11):1287-1294. doi:10.1007\/BF01411057"},{"issue":"3","key":"bib7","series-title":"J Stroke","first-page":"360","article-title":"Ruptured peripheral cerebral aneurysms associated with moyamoya disease: a systematic review","volume":"26","author":"Feng","year":"2024","unstructured":"Feng ZChang YFu C.Ruptured peripheral cerebral aneurysms associated with moyamoya disease: a systematic review. J Stroke. 2024;26(3):360-370. doi:10.5853\/jos.2024.02061"},{"key":"bib8","series-title":"World Neurosurg","first-page":"123783","article-title":"Outcomes and complications of endovascular treatment in patients with moyamoya disease: a systematic review","volume":"196","author":"Tsuchiya","year":"2025","unstructured":"Tsuchiya THirano YMiyawaki SOutcomes and complications of endovascular treatment in patients with moyamoya disease: a systematic review. World Neurosurg. 2025;196:123783. doi:10.1016\/j.wneu.2025.123783"},{"issue":"1","key":"bib9","series-title":"J Neuroendovasc Ther","first-page":"2024-0077","article-title":"A case of n-butyl-2-cyanoacrylate embolization of a lateral posterior choroidal artery aneurysm associated with internal carotid artery occlusion","volume":"19","author":"Aoka","year":"2024","unstructured":"Aoka TYanai KKoizumi SA case of n-butyl-2-cyanoacrylate embolization of a lateral posterior choroidal artery aneurysm associated with internal carotid artery occlusion. J Neuroendovasc Ther. 2024;19(1):2024-0077. doi:10.5797\/jnet.cr.2024-0077"},{"key":"bib10","series-title":"World Neurosurg","first-page":"199","article-title":"Massive primary intraventricular hemorrhage due to idiopathic lateral posterior choroidal artery aneurysm: case illustration","volume":"112","author":"Bozkurt","year":"2018","unstructured":"Bozkurt GYaman ME\u00c7evik SK\u0131rba\u015f \u0130Ya\u011fmurlu B.Massive primary intraventricular hemorrhage due to idiopathic lateral posterior choroidal artery aneurysm: case illustration. 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Neurosurgery. 2009;65(5):1000-1004. doi:10.1227\/01.NEU.0000345648.46096.CE"},{"issue":"3","key":"bib13","series-title":"J Neurosurg","first-page":"637","article-title":"Treatment of ruptured aneurysms of the choroidal collateral system in moyamoya disease: a systematic review and data analysis","volume":"136","author":"Wiedmann","year":"2021","unstructured":"Wiedmann MKHDavidoff CLo Presti ATreatment of ruptured aneurysms of the choroidal collateral system in moyamoya disease: a systematic review and data analysis. J Neurosurg. 2021;136(3):637-646. doi:10.3171\/2021.1.JNS203936"},{"key":"bib14","series-title":"World Neurosurg","first-page":"513","article-title":"Intracranial aneurysms associated with moyamoya disease in children: clinical features and long-term surgical outcome","volume":"94","author":"Liu","year":"2016","unstructured":"Liu PLv XLLiu AHIntracranial aneurysms associated with moyamoya disease in children: clinical features and long-term surgical outcome. World Neurosurg. 2016;94:513-520. doi:10.1016\/j.wneu.2016.05.039"},{"issue":"6","key":"bib15","series-title":"J Neurosurg","first-page":"1813","article-title":"Treatment of aneurysms in patients with moyamoya disease: a 10-year single-center experience","volume":"128","author":"Ni","year":"2018","unstructured":"Ni WJiang HXu BTreatment of aneurysms in patients with moyamoya disease: a 10-year single-center experience. J Neurosurg. 2018;128(6):1813-1822. doi:10.3171\/2017.3.JNS162290"},{"key":"bib16","series-title":"Acta Neurol Scand Suppl","first-page":"85","article-title":"Regression of moyamoya vessels and hemodynamic changes after successful revascularization in childhood moyamoya disease","volume":"166","author":"Kashiwagi","year":"1996","unstructured":"Kashiwagi SYamashita TKatoh SRegression of moyamoya vessels and hemodynamic changes after successful revascularization in childhood moyamoya disease. Acta Neurol Scand Suppl. 1996;166:85-88. doi:10.1111\/j.1600-0404.1996.tb00557.x"},{"issue":"2","key":"bib1","series-title":"Neurosurg Rev","first-page":"1127","article-title":"Location-based treatment of intracranial aneurysms in moyamoya disease: a systematic review and descriptive analysis","volume":"44","author":"Larson","year":"2021","unstructured":"Larson ASRinaldo LBrinjikji WLanzino G.Location-based treatment of intracranial aneurysms in moyamoya disease: a systematic review and descriptive analysis. Neurosurg Rev. 2021;44(2):1127-1139. doi:10.1007\/s10143-020-01307-1"},{"issue":"4","key":"bib2","series-title":"J Clin Neurol","first-page":"624","article-title":"Clinical features and outcomes of intracranial aneurysm associated with moyamoya disease","volume":"16","author":"Kim","year":"2020","unstructured":"Kim SJang CKPark EKClinical features and outcomes of intracranial aneurysm associated with moyamoya disease. J Clin Neurol. 2020;16(4):624-632. doi:10.3988\/jcn.2020.16.4.624"},{"issue":"11","key":"bib3","series-title":"Lancet Neurol","first-page":"1056","article-title":"Moyamoya disease: current concepts and future perspectives","volume":"7","author":"Kuroda","year":"2008","unstructured":"Kuroda SHoukin K.Moyamoya disease: current concepts and future perspectives. Lancet Neurol. 2008;7(11):1056-1066. doi:10.1016\/S1474-4422(08)70240-0"},{"issue":"1","key":"bib4","series-title":"Acta Neurochir (Wien)","first-page":"116","article-title":"Pathological changes in the lenticulostriate artery indicate the mechanisms leading to intracranial hemorrhage in moyamoya disease: a case report","volume":"166","author":"Hashio","year":"2024","unstructured":"Hashio AHamano EOzaki SPathological changes in the lenticulostriate artery indicate the mechanisms leading to intracranial hemorrhage in moyamoya disease: a case report. 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Acta Neurochir (Wien). 1996;138(11):1287-1294. doi:10.1007\/BF01411057"},{"issue":"3","key":"bib7","series-title":"J Stroke","first-page":"360","article-title":"Ruptured peripheral cerebral aneurysms associated with moyamoya disease: a systematic review","volume":"26","author":"Feng","year":"2024","unstructured":"Feng ZChang YFu C.Ruptured peripheral cerebral aneurysms associated with moyamoya disease: a systematic review. J Stroke. 2024;26(3):360-370. doi:10.5853\/jos.2024.02061"},{"key":"bib8","series-title":"World Neurosurg","first-page":"123783","article-title":"Outcomes and complications of endovascular treatment in patients with moyamoya disease: a systematic review","volume":"196","author":"Tsuchiya","year":"2025","unstructured":"Tsuchiya THirano YMiyawaki SOutcomes and complications of endovascular treatment in patients with moyamoya disease: a systematic review. World Neurosurg. 2025;196:123783. doi:10.1016\/j.wneu.2025.123783"},{"issue":"1","key":"bib9","series-title":"J Neuroendovasc Ther","first-page":"2024-0077","article-title":"A case of n-butyl-2-cyanoacrylate embolization of a lateral posterior choroidal artery aneurysm associated with internal carotid artery occlusion","volume":"19","author":"Aoka","year":"2024","unstructured":"Aoka TYanai KKoizumi SA case of n-butyl-2-cyanoacrylate embolization of a lateral posterior choroidal artery aneurysm associated with internal carotid artery occlusion. 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