{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T01:05:37Z","timestamp":1779843937941,"version":"3.53.1"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"21","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurosurg Case Lessons"],"published-print":{"date-parts":[[2026,5,25]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The coexistence of pituitary adenoma and sellar abscess is exceedingly rare, posing diagnostic challenges due to nonspecific clinical and imaging features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 47-year-old female presented with a 6-month progressive visual decline. MRI revealed a 2.5-cm multicystic sellar-suprasellar lesion with irregular rim enhancement, suspicious for adenoma or craniopharyngioma. Endoscopic endonasal resection revealed typical adenoma tissue in the sellar region and a suprasellar abscess with thick yellow pus. Both lesions were completely resected in a single stage. Histopathological analysis confirmed nonfunctioning pituitary adenoma with concurrent acute suppurative inflammation. Cultures were negative. The patient received 6 weeks of intravenous antibiotic therapy. Postoperatively, transient diabetes insipidus and fever resolved spontaneously. At the 6-month follow-up, MRI showed complete resection with no recurrence, and the patient\u2019s vision significantly improved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Pituitary abscess can rarely coexist with adenoma and mimic common sellar lesions. Single-stage endoscopic endonasal surgery enables simultaneous diagnosis and management of both pathologies. Prolonged antibiotic therapy based on histopathological evidence is essential even with negative cultures.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE26194\">https:\/\/thejns.org\/doi\/10.3171\/CASE26194<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case26194","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:52:37Z","timestamp":1779288757000},"source":"Crossref","is-referenced-by-count":0,"title":["Expanded endoscopic endonasal transsphenoidal resection of a rare concurrent sellar pituitary adenoma and suprasellar abscess: illustrative case"],"prefix":"10.3171","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0840-198X","authenticated-orcid":true,"given":"Minglu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2763-2628","authenticated-orcid":true,"given":"Hongjin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9645-8475","authenticated-orcid":true,"given":"Xiaoning","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"1","key":"bib1","series-title":"Orphanet J Rare Dis","first-page":"165","article-title":"Pituitary abscess: a case report and systematic review of 488 cases","volume":"18","author":"Stringer","year":"2023","unstructured":"Stringer FFoong YCTan APituitary abscess: a case report and systematic review of 488 cases. Orphanet J Rare Dis. 2023;18(1):165. doi:10.1186\/s13023-023-02788-1"},{"issue":"1","key":"bib2","series-title":"J Neurol Neurosurg Psychiatry","first-page":"66","article-title":"Abscess formation in a pituitary adenoma","volume":"15","author":"Whalley","year":"1952","unstructured":"Whalley N.Abscess formation in a pituitary adenoma. J Neurol Neurosurg Psychiatry. 1952;15(1):66-67. doi:10.1136\/jnnp.15.1.66"},{"issue":"3","key":"bib3","series-title":"J Neurooncol","first-page":"469","article-title":"Etiology, prognosis, and management of secondary pituitary abscesses forming in underlying pituitary adenomas","volume":"117","author":"Awad","year":"2014","unstructured":"Awad AJRowland NCMian MHiniker ATate MAghi MK.Etiology, prognosis, and management of secondary pituitary abscesses forming in underlying pituitary adenomas. J Neurooncol. 2014;117(3):469-476. doi:10.1007\/s11060-013-1285-1"},{"key":"bib4","series-title":"World Neurosurg","first-page":"281","article-title":"Secondary pituitary abscess inside adenoma: a case report and review of literature","volume":"137","author":"Zhang","year":"2020","unstructured":"Zhang XYu GDu ZTran VZhu WHua W.Secondary pituitary abscess inside adenoma: a case report and review of literature. World Neurosurg. 2020;137:281-285. doi:10.1016\/j.wneu.2020.02.057"},{"issue":"3","key":"bib5","series-title":"Neurosurgery","first-page":"331","article-title":"Abscess formation within pituitary tumors","volume":"12","author":"Nelson","year":"1983","unstructured":"Nelson PBHaverkos HMartinez AJRobinson AG.Abscess formation within pituitary tumors. Neurosurgery. 1983;12(3):331-333. doi:10.1227\/00006123-198303000-00016"},{"key":"bib6","series-title":"Endotext","article-title":"Infections","author":"Pekic","year":"","unstructured":"Pekic SMiljic DPopovic V.Infections of the hypothalamic-pituitary region. In: Feingold KR, Adler RA, Ahmed SF, et al., eds. Endotext [Internet]. MDText.com; 2024. Accessed on April 14, 2026.https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK532083\/"},{"key":"bib7","series-title":"World Neurosurg","first-page":"408","article-title":"A systematic review of prophylactic antibiotic use in endoscopic endonasal transsphenoidal surgery for pituitary lesions","volume":"128","author":"Moldovan","year":"2019","unstructured":"Moldovan IDAgbi CKilty SAlkherayf F.A systematic review of prophylactic antibiotic use in endoscopic endonasal transsphenoidal surgery for pituitary lesions. World Neurosurg. 2019;128:408-414. doi:10.1016\/j.wneu.2019.05.082"},{"issue":"10","key":"bib8","series-title":"Gland Surg","first-page":"1759","article-title":"Summary of best evidence on prevention of intracranial infection after endoscopic endonasal transsphenoidal pituitary neoplasm resection","volume":"13","author":"Wang","year":"2024","unstructured":"Wang JYu PChen QSummary of best evidence on prevention of intracranial infection after endoscopic endonasal transsphenoidal pituitary neoplasm resection. Gland Surg. 2024;13(10):1759-1769. doi:10.21037\/gs-24-415"},{"issue":"2","key":"bib9","series-title":"J Neurosurg","first-page":"233","article-title":"Diagnosis and management of pituitary abscess: a review of twenty-four cases","volume":"95","author":"Vates","year":"2001","unstructured":"Vates GEBerger MSWilson CB.Diagnosis and management of pituitary abscess: a review of twenty-four cases. J Neurosurg. 2001;95(2):233-241. doi:10.3171\/jns.2001.95.2.0233"},{"issue":"3","key":"bib10","series-title":"Br J Neurosurg","first-page":"731","article-title":"Primary pituitary abscess: case report and suggested management algorithm","volume":"38","author":"Machado","year":"2024","unstructured":"Machado MJRamos RPereira HPrimary pituitary abscess: case report and suggested management algorithm. Br J Neurosurg. 2024;38(3):731-734. doi:10.1080\/02688697.2021.1967877"},{"issue":"1","key":"bib1","series-title":"Orphanet J Rare Dis","first-page":"165","article-title":"Pituitary abscess: a case report and systematic review of 488 cases","volume":"18","author":"Stringer","year":"2023","unstructured":"Stringer FFoong YCTan APituitary abscess: a case report and systematic review of 488 cases. Orphanet J Rare Dis. 2023;18(1):165. doi:10.1186\/s13023-023-02788-1"},{"issue":"1","key":"bib2","series-title":"J Neurol Neurosurg Psychiatry","first-page":"66","article-title":"Abscess formation in a pituitary adenoma","volume":"15","author":"Whalley","year":"1952","unstructured":"Whalley N.Abscess formation in a pituitary adenoma. J Neurol Neurosurg Psychiatry. 1952;15(1):66-67. doi:10.1136\/jnnp.15.1.66"},{"issue":"3","key":"bib3","series-title":"J Neurooncol","first-page":"469","article-title":"Etiology, prognosis, and management of secondary pituitary abscesses forming in underlying pituitary adenomas","volume":"117","author":"Awad","year":"2014","unstructured":"Awad AJRowland NCMian MHiniker ATate MAghi MK.Etiology, prognosis, and management of secondary pituitary abscesses forming in underlying pituitary adenomas. J Neurooncol. 2014;117(3):469-476. doi:10.1007\/s11060-013-1285-1"},{"key":"bib4","series-title":"World Neurosurg","first-page":"281","article-title":"Secondary pituitary abscess inside adenoma: a case report and review of literature","volume":"137","author":"Zhang","year":"2020","unstructured":"Zhang XYu GDu ZTran VZhu WHua W.Secondary pituitary abscess inside adenoma: a case report and review of literature. World Neurosurg. 2020;137:281-285. doi:10.1016\/j.wneu.2020.02.057"},{"issue":"3","key":"bib5","series-title":"Neurosurgery","first-page":"331","article-title":"Abscess formation within pituitary tumors","volume":"12","author":"Nelson","year":"1983","unstructured":"Nelson PBHaverkos HMartinez AJRobinson AG.Abscess formation within pituitary tumors. Neurosurgery. 1983;12(3):331-333. doi:10.1227\/00006123-198303000-00016"},{"key":"bib6","series-title":"Endotext","article-title":"Infections","author":"Pekic","year":"","unstructured":"Pekic SMiljic DPopovic V.Infections of the hypothalamic-pituitary region. In: Feingold KR, Adler RA, Ahmed SF, et al., eds. Endotext [Internet]. MDText.com; 2024. Accessed on April 14, 2026.https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK532083\/"},{"key":"bib7","series-title":"World Neurosurg","first-page":"408","article-title":"A systematic review of prophylactic antibiotic use in endoscopic endonasal transsphenoidal surgery for pituitary lesions","volume":"128","author":"Moldovan","year":"2019","unstructured":"Moldovan IDAgbi CKilty SAlkherayf F.A systematic review of prophylactic antibiotic use in endoscopic endonasal transsphenoidal surgery for pituitary lesions. World Neurosurg. 2019;128:408-414. doi:10.1016\/j.wneu.2019.05.082"},{"issue":"10","key":"bib8","series-title":"Gland Surg","first-page":"1759","article-title":"Summary of best evidence on prevention of intracranial infection after endoscopic endonasal transsphenoidal pituitary neoplasm resection","volume":"13","author":"Wang","year":"2024","unstructured":"Wang JYu PChen QSummary of best evidence on prevention of intracranial infection after endoscopic endonasal transsphenoidal pituitary neoplasm resection. Gland Surg. 2024;13(10):1759-1769. doi:10.21037\/gs-24-415"},{"issue":"2","key":"bib9","series-title":"J Neurosurg","first-page":"233","article-title":"Diagnosis and management of pituitary abscess: a review of twenty-four cases","volume":"95","author":"Vates","year":"2001","unstructured":"Vates GEBerger MSWilson CB.Diagnosis and management of pituitary abscess: a review of twenty-four cases. J Neurosurg. 2001;95(2):233-241. doi:10.3171\/jns.2001.95.2.0233"},{"issue":"3","key":"bib10","series-title":"Br J Neurosurg","first-page":"731","article-title":"Primary pituitary abscess: case report and suggested management algorithm","volume":"38","author":"Machado","year":"2024","unstructured":"Machado MJRamos RPereira HPrimary pituitary abscess: case report and suggested management algorithm. Br J Neurosurg. 2024;38(3):731-734. doi:10.1080\/02688697.2021.1967877"}],"container-title":["Journal of Neurosurgery: Case Lessons"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/11\/21\/article-CASE26194.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/11\/21\/article-CASE26194.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/11\/21\/article-CASE26194.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:39:38Z","timestamp":1779842378000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/11\/21\/article-CASE26194.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":20,"journal-issue":{"issue":"21"},"URL":"https:\/\/doi.org\/10.3171\/case26194","relation":{},"ISSN":["2694-1902"],"issn-type":[{"value":"2694-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]}}}