{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:14:28Z","timestamp":1783437268004,"version":"3.54.6"},"reference-count":56,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"16","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurosurg Case Lessons"],"published-print":{"date-parts":[[2026,4,20]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Cerebral sparganosis is a rare parasitic infection of the CNS caused by the\n                      <jats:italic>Spirometra<\/jats:italic>\n                      species. Pediatric intracranial involvement is exceptionally uncommon and has been reported predominantly from endemic regions in Asia. Preoperative diagnosis is challenging because clinical and radiological features frequently mimic neoplastic lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>\n                      An 11-year-old girl presented with new-onset seizures. MRI demonstrated a small, peripherally enhancing lesion in the right parietal lobe with surrounding vasogenic edema and intralesional calcifications, initially interpreted as a pediatric low-grade glioma. The patient underwent supramarginal resection. Histopathological examination revealed inflammatory changes with parasitic structures consistent with\n                      <jats:italic>Spirometra<\/jats:italic>\n                      species. A structured review of the literature identified 77 pediatric cases, showing a modest male predominance, a mean age of 11.01 years, seizures as the most common presenting symptom, a frontal-parietal predominance of lesions, frequent preoperative misdiagnosis, and inconsistent peripheral eosinophilia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Pediatric cerebral sparganosis can closely mimic low-grade glioma on neuroimaging, especially in nonendemic regions. Absence of peripheral eosinophilia or a clear exposure history does not exclude the diagnosis. Awareness of this entity is critical to avoid misdiagnosis, and complete excision remains the most effective diagnostic and therapeutic strategy in tumor-like presentations.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE264\">https:\/\/thejns.org\/doi\/10.3171\/CASE264<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case264","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:23:02Z","timestamp":1783434182000},"source":"Crossref","is-referenced-by-count":0,"title":["Pediatric cerebral sparganosis mimicking low-grade glioma in a nonendemic region: illustrative case"],"prefix":"10.3171","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3672-7343","authenticated-orcid":true,"given":"Ege Anil","family":"Ucar","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Koc University Hospital, Istanbul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8655-0515","authenticated-orcid":true,"given":"Ekin","family":"Deniz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sisli Hamidiye Etfal Training and Research Hospital, \u0130stanbul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oguz","family":"Baran","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Koc University Hospital, Istanbul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goktug","family":"Akyoldas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Koc University Hospital, Istanbul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9889-2702","authenticated-orcid":true,"given":"Ozgur Can","family":"Eren","sequence":"additional","affiliation":[{"name":"Department of Pathology, Koc University School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-7567","authenticated-orcid":true,"given":"Ibrahim","family":"Kulac","sequence":"additional","affiliation":[{"name":"Department of Pathology, Koc University School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9472-1735","authenticated-orcid":true,"given":"\u0130hsan","family":"Solaroglu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Koc University Hospital, Istanbul"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"1","key":"bib1","series-title":"BMC Infect Dis","first-page":"748","article-title":"Cerebral sparganosis presenting with atypical postcontrast magnetic resonance imaging findings: a case report and literature review","volume":"19","author":"Zhu","year":"2019","unstructured":"Zhu YYe LDing XWu JChen Y.Cerebral sparganosis presenting with atypical postcontrast magnetic resonance imaging findings: a case report and literature review. BMC Infect Dis. 2019;19(1):748. doi:10.1186\/s12879-019-4396-2"},{"key":"bib2","series-title":"Surg Neurol Int","first-page":"189","article-title":"Disseminated and migratory sparganosis in the central nervous system: a case report and literature review of combined spinal and intracranial involvement","volume":"16","author":"Iampreechakul","year":"2025","unstructured":"Iampreechakul PWangtanaphat KAngsusing CDisseminated and migratory sparganosis in the central nervous system: a case report and literature review of combined spinal and intracranial involvement. Surg Neurol Int. 2025;16:189. doi:10.25259\/SNI_146_2025"},{"issue":"12","key":"bib3","series-title":"Animals (Basel)","first-page":"1578","article-title":"Epidemiology, diagnosis, and prevention of sparganosis in Asia","volume":"12","author":"Liu","unstructured":"Liu WGong TChen SEpidemiology, diagnosis, and prevention of sparganosis in Asia. Animals (Basel);12(12):1578. doi:10.3390\/ANI12121578"},{"issue":"44","key":"bib4","series-title":"J Korean Med Sci","first-page":"e273","article-title":"Human sparganosis in Korea","volume":"33","author":"Kim","year":"2018","unstructured":"Kim JGAhn CSSohn WMNawa YKong Y.Human sparganosis in Korea. J Korean Med Sci. 2018;33(44):e273. doi:10.3346\/JKMS.2018.33.E273"},{"issue":"1","key":"bib5","series-title":"Neurol India","article-title":"Sparganosis of the cauda equina: a rare case report and review of the literature","volume":"60","author":"Huang","year":"2012","unstructured":"Huang CTChang MYChang CJHsieh CTHuang JS.Sparganosis of the cauda equina: a rare case report and review of the literature. Neurol India. 2012;60(1):102-103. doi:10.4103\/0028-3886.93598"},{"issue":"9","key":"bib6","series-title":"AJNR Am J Neuroradiol","first-page":"1700","article-title":"CT and MR characteristics of cerebral sparganosis","volume":"28","author":"Song","year":"2007","unstructured":"Song TWang WSZhou BRCT and MR characteristics of cerebral sparganosis. AJNR Am J Neuroradiol. 2007;28(9):1700-1705. doi:10.3174\/ajnr.A0659"},{"issue":"5","key":"bib7","series-title":"J Neurosurg","first-page":"1421","article-title":"Diagnosis and stereotactic aspiration treatment of cerebral sparganosis: summary of 11 cases","volume":"114","author":"Deng","year":"2011","unstructured":"Deng LXiong PQian S.Diagnosis and stereotactic aspiration treatment of cerebral sparganosis: summary of 11 cases. J Neurosurg. 2011;114(5):1421-1425. doi:10.3171\/2010.4.JNS1079"},{"issue":"1","key":"bib8","series-title":"BMC Pediatr","first-page":"155","article-title":"Cerebral sparganosis in children: epidemiological, clinical and MR imaging characteristics","volume":"12","author":"Gong","year":"2012","unstructured":"Gong CLiao WChineah AWang XHou BL.Cerebral sparganosis in children: epidemiological, clinical and MR imaging characteristics. BMC Pediatr. 2012;12(1):155. doi:10.1186\/1471-2431-12-155"},{"issue":"3","key":"bib9","series-title":"Radiology","first-page":"751","article-title":"Cerebral sparganosis: MR imaging versus CT features","volume":"188","author":"Moon","year":"1993","unstructured":"Moon WKChang KHCho SYCerebral sparganosis: MR imaging versus CT features. 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J Neurosurg Pediatr. 2006;105(6)(suppl):470-472. doi:10.3171\/PED.2006.105.6.470"},{"issue":"3","key":"bib15","series-title":"Ceylon Med J","first-page":"93","article-title":"A case of cerebral sparganosis","volume":"52","author":"Alibhoy","year":"2007","unstructured":"Alibhoy ATFernando RPerera F.A case of cerebral sparganosis. Ceylon Med J. 2007;52(3):93-94. doi:10.4038\/cmj.v52i3.968"},{"issue":"7","key":"bib16","series-title":"Clinics (Sao Paulo)","first-page":"849","article-title":"The surgical removal of a live tapeworm with an interesting pathologic finding most likely representing the migration path: a case report of cerebral sparganosis","volume":"67","author":"Wang","year":"2012","unstructured":"Wang PSu XMao QLiu Y.The surgical removal of a live tapeworm with an interesting pathologic finding most likely representing the migration path: a case report of cerebral sparganosis. 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Int J Infect Dis. 2022;117:28-36. doi:10.1016\/j.ijid.2022.01.005"},{"issue":"1","key":"bib23","series-title":"BMC Infect Dis","first-page":"350","article-title":"Cerebral sparganosis in a child with corpus callosum invasion: a case report","volume":"23","author":"Chen","year":"2023","unstructured":"Chen XWu HLu LZhou NChen ZZhang X.Cerebral sparganosis in a child with corpus callosum invasion: a case report. BMC Infect Dis. 2023;23(1):350. doi:10.1186\/s12879-023-08322-9"},{"issue":"4","key":"bib24","series-title":"Ann Indian Acad Neurol","first-page":"443","article-title":"Cerebral sparganosis\u2014an unusual parasitic infection mimicking cerebral tuberculosis: isolation of a live plerocercoid larva of Spirometra mansoni","volume":"27","author":"Rathore","year":"2024","unstructured":"Rathore APadmanabha HMahale RRCerebral sparganosis\u2014an unusual parasitic infection mimicking cerebral tuberculosis: isolation of a live plerocercoid larva of Spirometra mansoni. Ann Indian Acad Neurol. 2024;27(4):443-447. doi:10.4103\/aian.aian_2_24"},{"issue":"6","key":"bib25","series-title":"J Neurosurg","first-page":"1066","article-title":"Cerebral sparganosis: clinical manifestations, treatment, and outcome","volume":"85","author":"Kim","year":"1996","unstructured":"Kim DGPaek ha SHChang KHCerebral sparganosis: clinical manifestations, treatment, and outcome. J Neurosurg. 1996;85(6):1066-1071. doi:10.3171\/jns.1996.85.6.1066"},{"issue":"3","key":"bib26","series-title":"Korean J Parasitol","first-page":"299","article-title":"Human infections with Spirometra decipiens plerocercoids identified by morphologic and genetic analyses in Korea","volume":"53","author":"Jeon","year":"2015","unstructured":"Jeon HKPark HLee DHuman infections with Spirometra decipiens plerocercoids identified by morphologic and genetic analyses in Korea. Korean J Parasitol. 2015;53(3):299-305. doi:10.3347\/kjp.2015.53.3.299"},{"issue":"24","key":"bib27","series-title":"N Engl J Med","first-page":"2327","article-title":"Clinical metagenomic sequencing for diagnosis of meningitis and encephalitis","volume":"380","author":"Wilson","year":"2019","unstructured":"Wilson MRSample HAZorn KCClinical metagenomic sequencing for diagnosis of meningitis and encephalitis. N Engl J Med. 2019;380(24):2327-2340. doi:10.1056\/NEJMoa1803396"},{"issue":"6","key":"bib28","series-title":"Radiol Case Rep","first-page":"1874","article-title":"Diagnosis and management of cerebral sparganosis: an uncommon parasitic infection of the brain","volume":"17","author":"Yang","year":"2022","unstructured":"Yang ELee JPatel V.Diagnosis and management of cerebral sparganosis: an uncommon parasitic infection of the brain. 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