{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:59:41Z","timestamp":1790125181830,"version":"4.0.1"},"reference-count":17,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"12","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurosurg Case Lessons"],"published-print":{"date-parts":[[2026,9,21]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>TTF-1 (thyroid transcription factor 1)\u2013positive posterior pituitary tumors are rare low-grade neoplasms and are difficult to diagnose preoperatively because they can mimic other sellar, suprasellar, or third ventricular lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 30-year-old man presented with intermittent headaches, normal visual field testing, normal basal pituitary endocrine function, and normal serum alpha-fetoprotein and human chorionic gonadotropin levels. MRI showed a solid enhancing suprasellar mass closely related to the lamina terminalis and floor of the third ventricle. Gross-total resection (GTR) was achieved through a frontobasal interhemispheric approach with opening of the lamina terminalis under microscopic visualization. Histopathological analysis showed a bland spindle cell neoplasm with nuclear TTF-1 positivity and a low Ki-67 labeling index, supporting a TTF-1\u2013positive posterior pituitary tumor in the pituicytoma\/spindle cell oncocytoma spectrum. The patient had no postoperative diabetes insipidus or neurological deficit, and no recurrence was seen at 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>This entity should be considered for solid enhancing suprasellar or third ventricular floor\u2013associated tumors. TTF-1 immunostaining is essential for diagnosis, and GTR can lead to a favorable outcome.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE26664\">https:\/\/thejns.org\/doi\/10.3171\/CASE26664<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case26664","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:40Z","timestamp":1789516840000},"source":"Crossref","is-referenced-by-count":0,"title":["A third ventricular floor\u2013associated TTF-1\u2013positive posterior pituitary tumor: illustrative case"],"prefix":"10.3171","volume":"12","author":[{"given":"Zhongding","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baimiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianda","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin Guan","family":",","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6356-8336","authenticated-orcid":true,"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai"},{"name":"Department of Pathology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinda","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3","key":"bib1","series-title":"Pituitary","first-page":"60","article-title":"Posterior pituitary tumors: an entity unto itself","volume":"28","author":"Cooper","year":"2025","unstructured":"Cooper O.Posterior pituitary tumors: an entity unto itself. Pituitary. 2025;28(3):60. doi:10.1007\/s11102-025-01535-y"},{"key":"bib2","series-title":"World Neurosurg","first-page":"148","article-title":"Primary tumors of the posterior pituitary gland: a systematic review of the literature in light of the new 2017 World Health Organization classification of pituitary tumors","volume":"145","author":"Whipple","year":"2021","unstructured":"Whipple SGSavardekar ARRao SMahadevan AGuthikonda BKosty JA.Primary tumors of the posterior pituitary gland: a systematic review of the literature in light of the new 2017 World Health Organization classification of pituitary tumors. 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Acta Neuropathol. 2021;142(6):1025-1043. doi:10.1007\/s00401-021-02377-1"},{"issue":"1","key":"bib8","series-title":"Brain Pathol","first-page":"e13307","article-title":"Posterior pituitary tumors and other rare entities involving the pituitary gland","volume":"35","author":"Roncaroli","year":"2025","unstructured":"Roncaroli FGiannini C.Posterior pituitary tumors and other rare entities involving the pituitary gland. Brain Pathol. 2025;35(1):e13307. doi:10.1111\/bpa.13307"},{"issue":"1","key":"bib9","series-title":"Endocr Pathol","first-page":"6","article-title":"Overview of the 2022 WHO classification of pituitary tumors","volume":"33","author":"Asa","year":"2022","unstructured":"Asa SLMete OPerry AOsamura RY.Overview of the 2022 WHO classification of pituitary tumors. 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