{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:07:52Z","timestamp":1779361672091,"version":"3.51.4"},"reference-count":46,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"20","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurosurg Case Lessons"],"published-print":{"date-parts":[[2026,5,18]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Metastatic dissemination of pituitary neuroendocrine tumors (PitNETs) is uncommon and portends a poor prognosis. Within this spectrum, osseous involvement of the vertebral body is particularly rare, and, specifically for the gonadotroph subtype, cervical vertebral body metastasis has not, to the authors\u2019 knowledge, been documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors report a clinically nonfunctioning gonadotroph PitNET with histologically confirmed C5 vertebral metastasis. A 40-year-old man, who had undergone multiple surgeries for recurrent pitNET, presented with severe axial neck pain and a destructive C5 vertebral body lesion. He underwent an anterior C5 corpectomy with C4\u20136 reconstruction, followed by posterior lateral mass fixation for mechanical stabilization. Pathological analysis demonstrated an SF-1\/follicle-stimulating hormone\u2013positive tumor with a high Ki-67 labeling index of 10%\u201313%, consistent with the previous highly aggressive primary sellar lesion. Postoperative adjuvant therapy consisted of capecitabine-temozolomide and focal radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>This case extends the recognized spectrum of spinal dissemination in PitNETs and underscores the need for whole-axis surveillance and multimodal, multidisciplinary management in clinically aggressive PitNETs.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/thejns.org\/doi\/10.3171\/CASE2672\">https:\/\/thejns.org\/doi\/10.3171\/CASE2672<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case2672","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:56:25Z","timestamp":1779108985000},"source":"Crossref","is-referenced-by-count":0,"title":["Cervical vertebral body metastasis from a gonadotroph pituitary neuroendocrine tumor: illustrative case"],"prefix":"10.3171","volume":"11","author":[{"given":"Chiho","family":"Song","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0905-0330","authenticated-orcid":true,"given":"Jongjoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Chul","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Keun","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4812-565X","authenticated-orcid":true,"given":"Je Beom","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-8977","authenticated-orcid":true,"given":"Hong Gyu","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"6","key":"bib1","series-title":"Eur J Endocrinol","first-page":"R45","article-title":"Revised European Society of Endocrinology Clinical Practice Guideline for the management of aggressive pituitary tumours and pituitary carcinomas","volume":"192","author":"Raverot","year":"2025","unstructured":"Raverot GBurman PAbreu APRevised European Society of Endocrinology Clinical Practice Guideline for the management of aggressive pituitary tumours and pituitary carcinomas. 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