{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:55:26Z","timestamp":1790729726424,"version":"4.1.0"},"reference-count":9,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"13","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurosurg Case Lessons"],"published-print":{"date-parts":[[2026,9,28]]},"abstract":"\n BACKGROUND<\/jats:title>\n Cholesterol granulomas typically arise in the petrous apex of the temporal bone, and involvement of the sphenoid wing has not been reported. This case is notable not only for its rare sphenoid wing origin but also for the ability to document its growth dynamics over long-term imaging follow-up.<\/jats:p>\n <\/jats:sec>\n \n OBSERVATIONS<\/jats:title>\n A 35-year-old man was found to have a mass along the lateral aspect of the left sphenoid wing during evaluation after minor head trauma. Long-term radiological follow-up demonstrated gradual enlargement of the lesion, prompting resection. Histopathological examination revealed cholesterol clefts surrounded by granulomatous tissue, consistent with a diagnosis of cholesterol granuloma originating from the sphenoid wing.<\/jats:p>\n <\/jats:sec>\n \n LESSONS<\/jats:title>\n Although cholesterol granulomas most often occur in pneumatized regions of the skull base, particularly the petrous apex, this lesion developed in an area without bone aeration. Together with the documented long-term growth dynamics, this case suggests that cholesterol granulomas can develop independently of bone pneumatization and highlights the importance of considering alternative pathogenic mechanisms, supported by unique long-term radiological documentation of lesion growth.<\/jats:p>\n \n https:\/\/thejns.org\/doi\/10.3171\/CASE26724<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/case26724","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:03:01Z","timestamp":1790121781000},"source":"Crossref","is-referenced-by-count":0,"title":["Cholesterol granuloma of the sphenoid wing with long-term growth dynamics: illustrative case"],"prefix":"10.3171","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9503-7598","authenticated-orcid":true,"given":"Yoka","family":"Hirano","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2148-8231","authenticated-orcid":true,"given":"Masashi","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Tamai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3752-2406","authenticated-orcid":true,"given":"Kouichi","family":"Misaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ishikawa Prefectural Central Hospital, Kanazawa, Ishikawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-6101","authenticated-orcid":true,"given":"Mitsutoshi","family":"Nakada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"1","key":"bib1","series-title":"Allergy Rhinol (Providence)","first-page":"36","article-title":"Frontal sinus cholesterol granuloma: case report","volume":"5","author":"Deep","year":"2014","unstructured":"Deep NLChaaban MRChaudhry ALWoodworth BA.Frontal sinus cholesterol granuloma: case report. Allergy Rhinol (Providence). 2014;5(1):36-38. doi:10.2500\/ar.2014.5.0073"},{"issue":"1","key":"bib2","series-title":"Otolaryngol Head Neck Surg","first-page":"153","article-title":"An unusual presentation of a cholesterol granuloma in a pneumatized pterygoid process of the sphenoid sinus","volume":"136","author":"Weiland","year":"2007","unstructured":"Weiland DAAygun N.An unusual presentation of a cholesterol granuloma in a pneumatized pterygoid process of the sphenoid sinus. Otolaryngol Head Neck Surg. 2007;136(1):153-154. doi:10.1016\/j.otohns.2006.03.036"},{"issue":"2","key":"bib3","series-title":"Otolaryngol Clin N Am","first-page":"361","article-title":"Cholesterol granuloma and other petrous apex lesions","volume":"48","author":"Isaacson","year":"2015","unstructured":"Isaacson B.Cholesterol granuloma and other petrous apex lesions. Otolaryngol Clin N Am. 2015;48(2):361-373. doi:10.1016\/j.otc.2014.12.009"},{"key":"bib4","series-title":"Case Rep Otolaryngol","first-page":"8872270","article-title":"A case of a nonpetrous cholesterol granuloma presenting as a temporal mass","volume":"2020","author":"Reeve","year":"2020","unstructured":"Reeve NKahane JNg M.A case of a nonpetrous cholesterol granuloma presenting as a temporal mass. Case Rep Otolaryngol. 2020;2020:8872270. doi:10.1155\/2020\/8872270"},{"issue":"12","key":"bib5","series-title":"J Laryngol Otol","first-page":"1041","article-title":"Cholesterol granuloma of the frontal sinus","volume":"116","author":"Shykhon","year":"2002","unstructured":"Shykhon METrotter MIMorgan DWReuser TTHenderson MJ.Cholesterol granuloma of the frontal sinus. 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Turk Neurosurg. 2021;31(1):142-147. doi:10.5137\/1019-5149.JTN.30192-20.2"},{"issue":"5","key":"bib8","series-title":"J Craniofac Surg","first-page":"1870","article-title":"Synchronized \u201cone-step\u201d resection and cranio-orbital reconstruction for spheno-orbital lesions with custom made implant","volume":"32","author":"Bassi","year":"2021","unstructured":"Bassi MAntonelli VTomassini ASynchronized \u201cone-step\u201d resection and cranio-orbital reconstruction for spheno-orbital lesions with custom made implant. J Craniofac Surg. 2021;32(5):1870-1873. doi:10.1097\/SCS.0000000000007385"},{"issue":"4","key":"bib9","series-title":"Brain Sci","article-title":"Optimizing strategies in patients affected by tumors infiltrating the skull: a single center experience","volume":"15","author":"Umana","year":"2025","unstructured":"Umana GERanganathan SMarrone SOptimizing strategies in patients affected by tumors infiltrating the skull: a single center experience. 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