{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T09:06:14Z","timestamp":1780131974684,"version":"3.54.0"},"reference-count":64,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:sec>\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>Stereotactic radiosurgery (SRS) with the Gamma Knife (GK) is a rapidly emerging surgical modality in the management of medically refractory idiopathic trigeminal neuralgia (TN). The current study examines the long-term outcome in patients with drug-resistant idiopathic TN who underwent GK surgery at the authors\u2018 institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and six consecutive patients (38 men and 68 women) with proven medically refractory idiopathic TN were included in this retrospective study. Their ages were 41\u201382 years (mean 72.3 years). All patients underwent SRS with prescribed maximal radiation doses ranging from 70 to 85 Gy. Isocenters 1\u20133 were used and plugging was used selectively. The follow-up period was 12\u201372 months (mean 34.3 months). The patients were divided into 2 groups according to their history of previous surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The initial response rate in patients with no history of previous surgery was 92.9%; in those who had undergone previous surgery, the initial response rate was 85.7%. At the end of the 1st posttreatment year, an excellent outcome was achieved in 82.5% of patients who had not had previous surgery, and in 69.4% of those who had. The respective outcome rates for the 2nd posttreatment year were 78 and 63.5%, respectively. The most common complication was the development of persistent paresthesia, which occurred in 15.8% of patients with no previous surgery and 16.3% of those with previous surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Stereotactic radiosurgery with the GK is a safe and effective treatment option for patients with medically refractory idiopathic TN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/foc-07\/12\/e8","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T12:02:05Z","timestamp":1197633725000},"page":"E7","source":"Crossref","is-referenced-by-count":33,"title":["Gamma Knife stereotactic radiosurgical treatment of idiopathic trigeminal neuralgia: long-term outcome and complications"],"prefix":"10.3171","volume":"23","author":[{"given":"Kostas N.","family":"Fountas","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca R.","family":"Cantrell","sequence":"additional","affiliation":[{"name":"Southeast Gamma Knife Center, Medical College of Georgia, Augusta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Chris","family":"Sheils","sequence":"additional","affiliation":[{"name":"Radiation Oncology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3 Suppl","key":"b1-0230008","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3171\/jns.2000.93.supplement_3.0159","article-title":"Gamma knife radiosurgery for primary management for trigeminal neuralgia","volume":"93","author":"Brisman","year":"2000"},{"key":"b2-0230008","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"848","DOI":"10.3171\/jns.2004.100.5.0848","article-title":"Gamma knife surgery with a dose of 75 to 76.8 Gray for trigeminal neuralgia","volume":"100","author":"Brisman","year":"2004"},{"issue":"3 Suppl","key":"b3-0230008","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3171\/jns.2000.93.supplement_3.0155","article-title":"Gamma knife radiosurgery for trigeminal neuralgia: 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